Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

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Published in EMBO J on December 01, 1990

Authors

R C Nicholson1, S Mader, S Nagpal, M Leid, C Rochette-Egly, P Chambon

Author Affiliations

1: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

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Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci U S A (1984) 3.25

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J (1989) 3.23

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell (1994) 3.16

An enhancer element is located 340 base pairs upstream from the adenovirus-2 E1A capsite. Nucleic Acids Res (1983) 3.11

Structure of transcribing chromatin. Prog Nucleic Acid Res Mol Biol (1980) 3.09

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J (1994) 3.00

Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development (1994) 2.98

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A (1993) 2.96

Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development (1996) 2.96