Published in N Engl J Med on December 17, 1987
The acute respiratory distress syndrome. J Clin Invest (2012) 5.61
Nonventilatory treatments for acute lung injury and ARDS. Chest (2007) 3.02
Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med (2006) 2.47
Therapeutic strategies for severe acute lung injury. Crit Care Med (2010) 2.12
Recommendations for sepsis management in resource-limited settings. Intensive Care Med (2012) 2.03
Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv (2010) 1.78
SARS: systematic review of treatment effects. PLoS Med (2006) 1.74
Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med (2005) 1.69
Pro/con clinical debate: steroids are a key component in the treatment of SARS. Pro: Yes, steroids are a key component of the treatment regimen for SARS. Crit Care (2004) 1.45
Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care (2014) 1.43
Extracorporeal membrane oxygenation for severe acute respiratory failure. Crit Care (2000) 1.41
Aspiration-induced lung injury. Crit Care Med (2011) 1.40
Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med (2007) 1.36
Cellular mechanisms of acute lung injury: implications for future treatment in the adult respiratory distress syndrome. Thorax (1992) 1.28
Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis. Can J Surg (2009) 1.24
Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem (2008) 1.13
Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables. Gut (1995) 1.13
Development of animal models for the acute respiratory distress syndrome. Dis Model Mech (2009) 1.10
Role of the pulmonary epithelium and inflammatory signals in acute lung injury. Expert Rev Clin Immunol (2009) 1.10
Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol (2012) 1.07
Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J Clin Invest (2006) 1.06
In silico simulation of corticosteroids effect on an NFkB- dependent physicochemical model of systemic inflammation. PLoS One (2009) 1.04
Surfactant therapy for acute lung injury and acute respiratory distress syndrome. Crit Care Clin (2011) 1.04
Steroids in late ARDS? Crit Care (2007) 1.03
Acute respiratory distress syndrome: A clinical review. Pulm Circ (2011) 1.02
Acute respiratory distress syndrome: pathophysiology and therapeutic options. J Clin Med Res (2012) 1.01
Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis. Intensive Care Med (2015) 1.00
Clinical review: Acute respiratory distress syndrome - clinical ventilator management and adjunct therapy. Crit Care (2013) 0.96
The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010. PLoS Negl Trop Dis (2013) 0.94
Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): A prospective, randomized, double-blind, parallel group study. Nutr Metab (Lond) (2011) 0.94
Steroids for acute respiratory distress syndrome? Clin Chest Med (2014) 0.93
The pulmonary physician in critical care - part 9: non-ventilatory strategies in ARDS. Thorax (2002) 0.93
Variation in sepsis care: a wake-up call. Crit Care (2003) 0.93
Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res (2011) 0.92
The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) (2015) 0.90
Low-dose corticosteroid treatment and mortality in refractory abdominal septic shock after emergency laparotomy. Ann Intensive Care (2015) 0.84
The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med (2013) 0.83
The effectiveness of Corticosteroids on mortality in patients with acute respiratory distress syndrome or acute lung injury: a secondary analysis. Sci Rep (2015) 0.83
Inflammatory predictors for the development of the adult respiratory distress syndrome. Thorax (1995) 0.83
Surfactant medication for acute respiratory distress syndrome. Thorax (1997) 0.82
Δ(9) Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells. Br J Pharmacol (2015) 0.82
Acute respiratory distress syndrome in the septic surgical patient. World J Surg (2003) 0.81
Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets (2014) 0.81
Creation of lung-targeted dexamethasone immunoliposome and its therapeutic effect on bleomycin-induced lung injury in rats. PLoS One (2013) 0.81
Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care (2013) 0.81
Corticosteroid therapy in acute respiratory distress syndrome. CMAJ (2012) 0.80
Trauma, inflammatory cells and ARDS. Arch Emerg Med (1993) 0.79
Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1beta in rats. Lung (2004) 0.78
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy. J Cardiothorac Surg (2013) 0.78
Dose-response comparisons of five lung surfactant factor (LSF) preparations in an animal model of adult respiratory distress syndrome (ARDS). Br J Pharmacol (1995) 0.78
Pharmacological interventions in acute respiratory distress syndrome. Ann Intensive Care (2013) 0.77
Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India (2011) 0.77
Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury. Clinics (Sao Paulo) (2008) 0.77
Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats. Int J Clin Exp Med (2014) 0.77
Predictors of response to corticosteroid treatment in patients with early acute respiratory distress syndrome: results of a pilot study. Yonsei Med J (2015) 0.77
Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans. Br J Clin Pharmacol (2016) 0.77
Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase. Br J Pharmacol (2005) 0.77
Early application of low-dose glucocorticoid improves acute respiratory distress syndrome: A meta-analysis of randomized controlled trials. Exp Ther Med (2017) 0.76
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Acute respiratory distress syndrome. BMJ Clin Evid (2010) 0.76
The pulmonary physician and critical care. 4. A new look at the pulmonary circulation in acute lung injury. Thorax (1992) 0.76
Steroids in early ARDS? Crit Care (2007) 0.76
Effects of acute and chronic administration of methylprednisolone on oxidative stress in rat lungs. J Bras Pneumol (2014) 0.76
Corticosteroids and acute respiratory distress syndrome: the debate continues. Crit Care Med (2013) 0.75
Acute respiratory distress syndrome. Yale J Biol Med (2000) 0.75
The pulmonary physician and critical care. 3. Pharmacotherapy in lung injury. Thorax (1992) 0.75
Argument against the Routine Use of Steroids for Pediatric Acute Respiratory Distress Syndrome. Front Pediatr (2016) 0.75
Acute respiratory distress syndrome. BMJ Clin Evid (2007) 0.75
Prescribing Patterns of Drugs in Acute Respiratory Distress Syndrome (ARDS): An Observational Study. J Clin Diagn Res (2015) 0.75
Prolonged Glucocorticoid Treatment in ARDS: Impact on Intensive Care Unit-Acquired Weakness. Front Pediatr (2016) 0.75
Clinical Practice Guideline of Acute Respiratory Distress Syndrome. Tuberc Respir Dis (Seoul) (2016) 0.75
Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med (2017) 0.75
Salmonella Typhi-Induced Septic Shock and Acute Respiratory Distress Syndrome in a Previously Healthy Teenage Patient Treated With High-Dose Dexamethasone. J Investig Med High Impact Case Rep (2016) 0.75
Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. J Trauma Acute Care Surg (2017) 0.75
Current Concepts of ARDS: A Narrative Review. Int J Mol Sci (2016) 0.75
Acute respiratory distress syndrome caused by Mycoplasma pneumoniae without elevated pulmonary vascular permeability: a case report. J Thorac Dis (2016) 0.75
The clinical practice guideline for the management of ARDS in Japan. J Intensive Care (2017) 0.75
A novel human glucocorticoid receptor SNP results in increased transactivation potential. Biochem Biophys Rep (2016) 0.75
Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med (1998) 13.94
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med (1995) 10.29
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med (1991) 9.99
An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis (1988) 7.43
A look into the nature and causes of human errors in the intensive care unit. Crit Care Med (1995) 5.14
Clinical antecedents to in-hospital cardiopulmonary arrest. Chest (1990) 4.94
A novel progressive spongiform encephalopathy in cattle. Vet Rec (1987) 4.39
The ACCP-SCCM consensus conference on sepsis and organ failure. Chest (1992) 4.35
Consequences of queuing for care at a public hospital emergency department. JAMA (1991) 3.98
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med (1987) 3.89
Increasing incidence of withholding and withdrawal of life support from the critically ill. Am J Respir Crit Care Med (1997) 3.64
A national survey of end-of-life care for critically ill patients. Am J Respir Crit Care Med (1998) 3.48
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1989) 3.41
Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA (1993) 3.23
Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature (1996) 3.09
Hypothermia in the sepsis syndrome and clinical outcome. The Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1992) 2.99
Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet (2015) 2.70
Definitions for sepsis and organ failure. Crit Care Med (1992) 2.69
Aerosolised pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet (1987) 2.68
Sedation in the intensive care unit: a systematic review. JAMA (2000) 2.65
Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis (1983) 2.63
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns. Emerg Infect Dis (2001) 2.62
Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med (2001) 2.57
UK National Guidelines on the Management of Syphilis 2008. Int J STD AIDS (2008) 2.53
Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective randomized trial. Ann Intern Med (1986) 2.53
Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM). Intensive Care Med (2012) 2.49
Peripheral nerve function in sepsis and multiple organ failure. Chest (1991) 2.46
The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med (1984) 2.37
Plasma cortisol levels in patients with septic shock. Crit Care Med (1990) 2.33
Adult respiratory-distress syndrome: changing concepts of lung injury and repair. N Engl J Med (1982) 2.30
Decisions about resuscitation: inequities among patients with different diseases but similar prognoses. Ann Intern Med (1989) 2.25
Evaluation of Institutional Review Board review and informed consent in publications of human research in critical care medicine. Crit Care Med (1998) 2.14
Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry (1984) 2.14
Recommendations for end-of-life care in the intensive care unit: The Ethics Committee of the Society of Critical Care Medicine. Crit Care Med (2001) 2.12
Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet (2015) 2.05
Energy and environment. Methane leaks from North American natural gas systems. Science (2014) 2.05
How to use an article on therapy or prevention: pneumonia prevention using subglottic secretion drainage. Crit Care Med (1997) 2.03
Patients readmitted to the intensive care unit during the same hospitalization: clinical features and outcomes. Crit Care Med (1998) 2.00
Effect of noninvasive positive pressure ventilation on mortality in patients admitted with acute respiratory failure: a meta-analysis. Crit Care Med (1997) 1.95
Critically ill polyneuropathy: electrophysiological studies and differentiation from Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry (1986) 1.95
Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats. Crit Care Med (1997) 1.91
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med (1996) 1.89
Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo. Neuron (1996) 1.87
Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines. J Pediatr (1992) 1.85
Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group. Crit Care Med (1991) 1.83
The Southwestern Ontario Joint Replacement Pilot Project: electronic point-of-care data collection. Southwestern Ontario Study Group. Can J Surg (2001) 1.82
Diagnostic utility of fiberoptic bronchoscopy in patients with Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome. Am Rev Respir Dis (1983) 1.79
Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA (1992) 1.79
Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding. Ann Thorac Surg (2001) 1.74
Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels. J Infect Dis (1992) 1.73
Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest (1990) 1.71
Noninvasive positive pressure ventilation in the setting of severe, acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive. Crit Care Med (2000) 1.71
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Respir Dis (1982) 1.70
Application of SOFA score to trauma patients. Sequential Organ Failure Assessment. Intensive Care Med (1999) 1.66
Withdrawal and withholding of life support in the intensive care unit: a comparison of teaching and community hospitals. The Southwestern Ontario Critical Care Research Network. Crit Care Med (1998) 1.65
Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am Rev Respir Dis (1988) 1.65
Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Chest (1997) 1.63
Intensive care of patients with the acquired immunodeficiency syndrome. Outcome and changing patterns of utilization. Am Rev Respir Dis (1986) 1.61
Dopexamine attenuates flow motion in ileal mucosal arterioles in normotensive sepsis. Crit Care Med (1999) 1.60
A retrospective review of a large cohort of patients undergoing the process of withholding or withdrawal of life support. Crit Care Med (1997) 1.58
Interobserver variability in data collection of the APACHE II score in teaching and community hospitals. Crit Care Med (1999) 1.57
Clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure ulcers. JAMA (1993) 1.57
Does implementing pulse oximetry in a critical care unit result in substantial arterial blood gas savings? Chest (1993) 1.54
The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA (1996) 1.53
Living related donation in lung transplantation. Ethical considerations. Arch Intern Med (1995) 1.53
Pulmonary artery catheterization. Can there be an integrated strategy for guideline development and research promotion? JAMA (1993) 1.51
Why have new effective therapies for sepsis not been developed? Crit Care Med (1994) 1.50
Life-sustaining treatment for patients with AIDS. Chest (1989) 1.50
The ecology of childhood overweight: a 12-year longitudinal analysis. Int J Obes (Lond) (2007) 1.48
Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow. Crit Care Med (2000) 1.48
Changes in myocardial blood flow rates during hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need. Crit Care Med (1993) 1.47
Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. Am Rev Respir Dis (1990) 1.46
Influence of feeding regimen on body condition in the cat. J Small Anim Pract (2000) 1.45
Respiratory complications of obesity. Chest (1980) 1.45
Show me the evidence: a critical appraisal of the Pulmonary Artery Catheter Consensus Conference and other musings on how critical care practitioners need to improve the way we conduct business. Crit Care Med (1997) 1.44
Polymyxin-dextran antiendotoxin pretreatment in an ovine model of normotensive sepsis. Crit Care Med (1997) 1.44
Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome. Chest (1987) 1.43
Blast lung injury from an explosion on a civilian bus. Chest (1999) 1.42
Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res (1996) 1.41
HA-1A in septic patients with ARDS: results from the pivotal trial. Intensive Care Med (1994) 1.40
The Hammer and the Heritage. Can Med Assoc J (1962) 1.39
Acquired immunodeficiency syndrome and critical care. Crit Care Med (1990) 1.39
Update in critical care medicine. Ann Intern Med (1996) 1.38
A global paleoclimate observing system. Science (2001) 1.38
SQUID-based microwave cavity search for dark-matter axions. Phys Rev Lett (2010) 1.36
Definition of sepsis. Intensive Care Med (2001) 1.34
A look into the nature and causes of human errors in the intensive care unit. 1995. Qual Saf Health Care (2003) 1.31
Frequency of myocardial injury after blunt chest trauma as evaluated by radionuclide angiography. Am J Cardiol (1983) 1.27
Incidence of acute mountain sickness at intermediate altitude. JAMA (1989) 1.25
Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension. J Neurosurg (1983) 1.25
Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Respir Dis (1982) 1.25
Listeria monocytogenes infection in bovine mastitis. Vet Rec (1980) 1.25
1755 and all that: a historical primer of transmissible spongiform encephalopathy. BMJ (1999) 1.24