Published in CMAJ on November 12, 2012
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. N Engl J Med (2005) 8.65
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest (2007) 7.49
Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med (2009) 4.90
Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA (1998) 4.21
Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med (2002) 3.70
Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet (2005) 3.70
Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network. JAMA (2000) 2.69
Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ (2007) 2.33
High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med (1987) 2.32
Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J Clin Endocrinol Metab (2003) 1.92
Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Respir Dis (1991) 1.84
The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids (2005) 1.83
Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ (2008) 1.75
Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci (2009) 1.68
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax (2008) 1.62
Cutaneous vasoconstrictor response to glucocorticoids in asthma. Lancet (1991) 1.61
Mechanisms generating diversity in glucocorticoid receptor signaling. Ann N Y Acad Sci (2009) 1.56
Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids. Am J Respir Crit Care Med (2002) 1.52
Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J Clin Invest (1983) 1.41
Use of corticosteroids in treating infectious diseases. Arch Intern Med (2008) 1.39
Corticosteroid-induced adverse events in adults: frequency, screening and prevention. Drug Saf (2007) 1.38
Wide variation in lymphocyte steroid sensitivity among healthy human volunteers. J Clin Endocrinol Metab (1999) 1.36
Precise evaluation of topically applied corticosteroid potency. Modification of the Stoughton-McKenzie assay. Arch Dermatol (1970) 1.36
Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med (2007) 1.36
Early steroid therapy for respiratory failure. Arch Surg (1985) 1.31
Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment. Am J Respir Crit Care Med (1998) 1.23
Glucocorticoids for ARDS: Just Do It! Chest (2007) 1.21
Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses. J Rheumatol (1991) 1.12
Steroid-resistant asthma: immunologic and pharmacologic features. J Allergy Clin Immunol (1992) 1.11
Serious adverse events in academic critical care research. CMAJ (2008) 1.08
Correlation of the vasoconstriction assay and clinical activity in psoriasis. Arch Dermatol (1985) 1.08
Do glucocorticoids decrease mortality in acute respiratory distress syndrome? A meta-analysis. Respirology (2007) 1.05
Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials. J Crit Care (2009) 1.03
Alveolo-capillary permeability in human septic ARDS. Effect of high-dose corticosteroid therapy. Chest (1981) 1.02
Corticosteroids influence the mortality and morbidity of acute critical illness. Crit Care (2006) 0.99
Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury. Am J Respir Crit Care Med (2003) 0.98
Systemic inflammation-associated glucocorticoid resistance and outcome of ARDS. Ann N Y Acad Sci (2004) 0.96
Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2. J Clin Endocrinol Metab (2005) 0.95
An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Mol Cell Endocrinol (2004) 0.95
A comparison of in vitro bioassays to determine cellular glucocorticoid sensitivity. Eur J Endocrinol (2004) 0.94
Differential adaptation of glucocorticoid sensitivity of peripheral blood mononuclear leukocytes in patients with sepsis or septic shock. J Clin Endocrinol Metab (1995) 0.92
Prolonged glucocorticoid treatment in acute respiratory distress syndrome: Evidence supporting effectiveness and safety. Crit Care Med (2009) 0.92
Corticosteroids for ARDS. Minerva Anestesiol (2010) 0.91
Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production. J Neuroimmunol (2004) 0.91
Glucocorticoid sensitivity in young healthy individuals: in vitro and in vivo studies. J Clin Endocrinol Metab (2005) 0.87
Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphism. J Clin Pharmacol (2006) 0.81
[Effect of high-dose prednisolone on lung fluid in patients with non-cardiogenic lung edema]. Wien Klin Wochenschr (1987) 0.76
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med (2011) 4.59
Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion (2004) 4.48
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med (2014) 2.78
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64
Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ (2009) 2.44
Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med (2015) 2.16
Therapeutic strategies for severe acute lung injury. Crit Care Med (2010) 2.12
A prospective study to determine whether cover gowns in addition to gloves decrease nosocomial transmission of vancomycin-resistant enterococci in an intensive care unit. Infect Control Hosp Epidemiol (2002) 2.08
Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol (2006) 1.88
Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med (2005) 1.87
Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model. Am J Physiol Lung Cell Mol Physiol (2008) 1.59
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med (2015) 1.58
Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study. J Crit Care (2005) 1.50
A replicable method for blood glucose control in critically Ill patients. Crit Care Med (2008) 1.50
Standardizing Predicted Body Weight Equations for Mechanical Ventilation Tidal Volume Settings. Chest (2015) 1.48
A framework for resolving disagreement during end of life care in the critical care unit. Clin Invest Med (2010) 1.44
Weaning critically ill adults from invasive mechanical ventilation: a national survey. Can J Anaesth (2009) 1.43
The correlation between esophageal and abdominal pressures in mechanically ventilated patients undergoing laparoscopic surgery. Respir Care (2013) 1.39
Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol (2003) 1.38
Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study. Arch Intern Med (2008) 1.28
Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury. Am J Respir Crit Care Med (2008) 1.21
Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Transl Res (2007) 1.21
Occult pneumothoraces in critical care: a prospective multicenter randomized controlled trial of pleural drainage for mechanically ventilated trauma patients with occult pneumothoraces. J Trauma Acute Care Surg (2013) 1.18
Redox imbalance and ventilator-induced lung injury. Antioxid Redox Signal (2007) 1.10
Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol (2007) 1.05
Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials. J Crit Care (2009) 1.03
Clinical practice guidelines in the intensive care unit: a survey of Canadian clinicians' attitudes. Can J Anaesth (2007) 1.00
The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients. J Crit Care (2010) 1.00
Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors. Crit Care (2008) 0.96
Multicenter clinical research in adult critical care. Crit Care Med (2002) 0.94
Mortality in sepsis versus non-sepsis induced acute lung injury. Crit Care (2009) 0.94
Pulmonary vs nonpulmonary sepsis and mortality in acute lung injury. Chest (2008) 0.92
Prediction scores do not correlate with clinically adjudicated categories of pulmonary embolism in critically ill patients. Can Respir J (2013) 0.87
The evolution of eProtocols that enable reproducible clinical research and care methods. J Clin Monit Comput (2012) 0.87
Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists. Crit Care (2004) 0.86
PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan. J Crit Care (2011) 0.85
Semiquantitative dipyridamole myocardial stress perfusion imaging for cardiac risk assessment before noncardiac vascular surgery: a meta-analysis. J Vasc Surg (2002) 0.85
Partial ventilatory support modalities in acute lung injury and acute respiratory distress syndrome-a systematic review. PLoS One (2012) 0.85
Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study. Crit Care (2011) 0.84
The ten diseases that look like ARDS. Intensive Care Med (2014) 0.83
Tidal volumes in acute respiratory distress syndrome--one size does not fit all. Crit Care Med (2006) 0.82
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient. Crit Care Med (2016) 0.81
Metaanalysis of tidal volume in ARDS. Am J Respir Crit Care Med (2003) 0.81
Vasopressor stewardship: a case report and lesson shared. Dynamics (2014) 0.80
Estimating the Causal Effect of Low Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury. J R Stat Soc Ser C Appl Stat (2011) 0.80
Nitric oxide donors in sepsis: a systematic review of clinical and in vivo preclinical data. Shock (2008) 0.79
Cervical spine clearance in obtunded patients after blunt traumatic injury: a systematic review. Ann Intern Med (2015) 0.76
Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences. Crit Care (2013) 0.76
Prevalence and Prognostic Association of Circulating Troponin in the Acute Respiratory Distress Syndrome. Crit Care Med (2017) 0.75
Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption. Crit Care Med (2015) 0.75
146: EVALUATION OF UTILIZATION AND COST SAVINGS OF INHALED EPOPROSTENOL COMPARED TO INHALED NITRIC OXIDE. Crit Care Med (2016) 0.75
559: THE DONATE-CONSENT STUDY. Crit Care Med (2016) 0.75
High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators. Pediatr Crit Care Med (2017) 0.75
Research ethics board approval for an international thromboprophylaxis trial. J Crit Care (2012) 0.75
1448: CHLORIDE CONCENTRATION OF COMMONLY AVAILABLE 5% HUMAN ALBUMIN SOLUTIONS. Crit Care Med (2016) 0.75