Published in Acta Neuropathol on January 01, 1983
Prions. Proc Natl Acad Sci U S A (1998) 27.80
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A (1996) 4.75
Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A (1987) 4.04
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci U S A (1986) 3.14
Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A (1987) 2.61
The toxicity in vitro of beta-amyloid protein. Biochem J (1995) 2.17
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis. J Virol (1991) 2.11
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95
Mutational analysis of the propensity for amyloid formation by a globular protein. EMBO J (2000) 1.86
Alzheimer's paired helical filaments share epitopes with neurofilament side arms. EMBO J (1986) 1.81
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J (1991) 1.74
Solvent effects on self-assembly of beta-amyloid peptide. Biophys J (1995) 1.74
Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proc Natl Acad Sci U S A (2008) 1.63
2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.49
Ultrastructural organization of amyloid fibrils by atomic force microscopy. Biophys J (2000) 1.46
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol (1990) 1.43
Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nat Protoc (2010) 1.40
Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide. Biophys J (1994) 1.28
Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. J Biol Chem (2010) 1.28
Light scattering analysis of fibril growth from the amino-terminal fragment beta(1-28) of beta-amyloid peptide. Biophys J (1993) 1.25
A kinetic study of beta-lactoglobulin amyloid fibril formation promoted by urea. Protein Sci (2002) 1.22
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain. Protein Sci (2001) 1.13
Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein. Proc Natl Acad Sci U S A (1986) 1.04
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Front Cell Neurosci (2013) 1.00
Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex. Proc Natl Acad Sci U S A (1988) 1.00
Lectin histochemistry of scrapie amyloid plaques. Acta Neuropathol (1986) 0.98
Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease. Acta Neuropathol (1988) 0.97
Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar? Am J Pathol (1993) 0.94
On the biology of prions. Acta Neuropathol (1987) 0.87
Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease. Acta Neuropathol (1989) 0.85
Urea modulation of beta-amyloid fibril growth: experimental studies and kinetic models. Protein Sci (2004) 0.84
The comparative immunoreactivities of brain amyloids in Alzheimer's disease and scrapie. Acta Neuropathol (1987) 0.84
Measurement of amyloid formation by turbidity assay-seeing through the cloud. Biophys Rev (2016) 0.81
The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr Neuropharmacol (2006) 0.80
The N-terminal helix controls the transition between the soluble and amyloid states of an FF domain. PLoS One (2013) 0.77
Trifluoroethanol modulates amyloid formation by the all α-helical URN1 FF domain. Int J Mol Sci (2013) 0.77
Amyloid plaque structure and cell surface interactions of β-amyloid fibrils revealed by electron tomography. Sci Rep (2017) 0.75
Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia. Neurochem Res (2016) 0.75
Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential. Inflamm Res (2017) 0.75
LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci (2017) 0.75
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13
Imaging beta-amyloid burden in aging and dementia. Neurology (2007) 7.70
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol (1987) 7.05
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol (1979) 5.53
Abnormal fibrils from scrapie-infected brain. Acta Neuropathol (1981) 5.35
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A (1987) 3.97
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol (1985) 3.83
The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience (2000) 3.40
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett (1986) 3.36
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology (1988) 3.28
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem (1996) 3.10
Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res (1989) 3.10
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A (2001) 2.97
Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition. Acta Neuropathol (1984) 2.97
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med (1997) 2.95
Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF. Neurology (1999) 2.74
Alzheimer paired helical filaments: immunochemical identification of polypeptides. Acta Neuropathol (1984) 2.70
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol Aging (1997) 2.68
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol (2000) 2.66
Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s). Acta Neuropathol (1984) 2.58
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia (2008) 2.58
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. Brain (2006) 2.54
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol (1979) 2.50
Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain (1978) 2.49
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med (1996) 2.46
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
Infection-specific particle from the unconventional slow virus diseases. Science (1984) 2.34
Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol (2007) 2.31
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem (1993) 2.30
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet (1979) 2.22
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19
Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry (2008) 2.12
Scrapie-associated fibrils in Creutzfeldt-Jakob disease. Nature (1984) 2.11
Amyloid, aluminium and the aetiology of Alzheimer's disease. Med J Aust (1995) 2.09
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol (1999) 2.08
Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem (1993) 2.05
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem (1992) 2.04
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem (2000) 2.00
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology (2010) 1.99
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis (1980) 1.96
Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease. Ann Neurol (1999) 1.96
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol (1986) 1.95
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys (1993) 1.90
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90
Defective brain microtubule assembly in Alzheimer's disease. Lancet (1986) 1.89
MRI of entorhinal cortex in mild Alzheimer's disease. Lancet (1999) 1.86
Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle. J Neuropathol Exp Neurol (1984) 1.86
Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J Neurochem (1995) 1.86
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience (2007) 1.86
The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease. Brain (1981) 1.80
Adult fragile X syndrome. Clinico-neuropathologic findings. Acta Neuropathol (1985) 1.80
Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm (Vienna) (2004) 1.78
The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol (1986) 1.77
Alzheimer's disease in Down's syndrome: clinicopathologic studies. Neurology (1985) 1.75
Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents. J Gen Virol (1985) 1.75
Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study. Lancet (1999) 1.74
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci U S A (1997) 1.73
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron (1992) 1.72
Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol (1992) 1.71