Published in Proc Natl Acad Sci U S A on May 01, 1987
Free radical adducts induce alterations in DNA cytosine methylation. Proc Natl Acad Sci U S A (1994) 1.38
Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine. EMBO J (1988) 0.99
Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28
DNA methylation and gene activity. Annu Rev Biochem (1983) 9.23
The somatic replication of DNA methylation. Cell (1981) 4.42
Hypomethylation of DNA from benign and malignant human colon neoplasms. Science (1985) 3.72
5-methylcytosine, gene regulation, and cancer. Adv Cancer Res (1983) 3.27
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A (1984) 3.22
The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis. Prog Nucleic Acid Res Mol Biol (1975) 2.93
DNA methylation decreases in aging but not in immortal cells. Science (1983) 2.67
Unusual methylation pattern of the alpha 2 (l) collagen gene. Cell (1982) 2.36
Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci U S A (1982) 1.95
Inhibition of DNA methylation by chemical carcinogens in vitro. Cell (1983) 1.68
Methylation, expression and chromosomal position of genes in mammals. Biochim Biophys Acta (1984) 1.49
Genomic hypomethylation and far-5' sequence alterations are associated with carcinogen-induced activation of the hamster thymidine kinase gene. Mol Cell Biol (1986) 1.48
DNA methylation and cancer. Cancer Res (1986) 1.47
In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat Res (1979) 1.34
Variable effects of DNA-synthesis inhibitors upon DNA methylation in mammalian cells. Nucleic Acids Res (1986) 1.34
A new theory of carcinogenesis. Br J Cancer (1979) 1.34
Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res (1981) 1.33
Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. Cell (1982) 1.30
In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated. Cell (1983) 1.26
Formation of highly stable complexes between 5-azacytosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression. J Biol Chem (1985) 1.16
Transcription in oocytes of highly methylated rDNA from Xenopus laevis sperm. Nature (1984) 1.01
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proc Natl Acad Sci U S A (1984) 1.01
On a possible epigenetic mechanism(s) of tumor cell heterogeneity. The role of DNA methylation. Cancer Metastasis Rev (1983) 0.95
Genomic 5-methylcytosine determination by 32P-postlabeling analysis. Anal Biochem (1986) 0.95
Differences in metabolism of chemical carcinogens in cultured human epithelial tissues and cells. J Cell Biochem (1982) 0.94
Induction of hepatitis B virus core gene in human cells by cytosine demethylation in the promoter. Science (1985) 0.94
Patterns of DNA methylation and gene expression in human tumor cell lines. Cancer Res (1986) 0.92
Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro. Proc Natl Acad Sci U S A (1985) 0.92
DNA methylase inhibition in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res (1980) 0.91
Inhibition of DNA methyltransferases in vitro by benzo[a]pyrene diol epoxide-modified substrates. J Biol Chem (1984) 0.89
Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea. Carcinogenesis (1981) 0.86
Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/3T3 cells. Carcinogenesis (1984) 0.86
Possible epigenetic mechanisms of tumor progression: induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment. J Cell Physiol Suppl (1984) 0.85
Impaired enzymatic methylation of BPDE-modified DNA. Carcinogenesis (1984) 0.85
Inhibition of DNA methylation by S-adenosylethionine with the production of methyl-deficient DNA in regenerating rat liver. Cancer Res (1977) 0.85
Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity. Cancer Res (1986) 0.80
Enzymatic methylation of DNA and poly(dG-dC) X poly(dG-dC) modified by 4-acetoxyaminoquinoline-1-oxide, the ultimate carcinogen of 4-nitroquinoline-1-oxide. FEBS Lett (1983) 0.80
Mechanism of rat liver DNA methyltransferase interaction with anti-benzo[a]pyrenediol epoxide modified DNA templates. Biochemistry (1984) 0.79
In vitro enzymatic methylation of DNA substituted by N-2-aminofluorene. FEBS Lett (1984) 0.78
Inactivation of mammalian DNA methylase activities by n-methyl-n'-nitro-n-nitrosoguanidine. Eur J Cancer (1975) 0.78
Effect of carcinogen ethionine on enzymatic methylation of DNA sequences with various degrees of repetitiveness. Eur J Cancer (1979) 0.78
Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea. Cancer Res (1986) 0.77
p53 mutations in human cancers. Science (1991) 31.96
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res (1994) 11.29
Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer (2001) 6.16
Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature (1991) 6.16
Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res (1994) 5.64
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Overlapping genes at the cheA locus of Escherichia coli. Proc Natl Acad Sci U S A (1980) 4.82
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A (1994) 3.76
A novel method for prediction of long-term outcome of women with T1a, T1b, and 10-14 mm invasive breast cancers: a prospective study. Lancet (2000) 3.76
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet (2001) 3.76
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res (1998) 3.74
Two classes of PDGF receptor recognize different isoforms of PDGF. Science (1988) 3.59
Efficacy of breast cancer screening by age. New results from the Swedish Two-County Trial. Cancer (1995) 3.32
The Swedish Two-County Trial twenty years later. Updated mortality results and new insights from long-term follow-up. Radiol Clin North Am (2000) 3.18
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem (2000) 3.12
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1986) 2.93
American Cancer Society guidelines for screening and surveillance for early detection of colorectal polyps and cancer: update 1997. American Cancer Society Detection and Treatment Advisory Group on Colorectal Cancer. CA Cancer J Clin (1997) 2.89
Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol (1987) 2.87
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women. J Natl Cancer Inst (1999) 2.83
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet (2001) 2.82
GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A (1999) 2.80
Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem (1987) 2.74
Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility patterns and antimicrobial management. Pediatr Infect Dis J (1995) 2.73
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene (2007) 2.71
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr (1999) 2.71
Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy. Nature (1981) 2.71
DNA methylation decreases in aging but not in immortal cells. Science (1983) 2.67
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res (1996) 2.65
Current results of the retrosigmoid approach to acoustic neurinoma. J Neurosurg (1992) 2.62
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med (2001) 2.47
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer. Mutat Res (1999) 2.36
Increasing physician productivity and the hospitalization characteristics of practices using Medex. A progress report. Northwest Med (1971) 2.34
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res (2000) 2.31
Quantifying the potential problem of overdiagnosis of ductal carcinoma in situ in breast cancer screening. Eur J Cancer (2003) 2.26
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology (2004) 2.26
The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem Biophys Res Commun (1979) 2.26
The relative contributions of screen-detected in situ and invasive breast carcinomas in reducing mortality from the disease. Eur J Cancer (2003) 2.24
Benefit of screening mammography in women aged 40-49: a new meta-analysis of randomized controlled trials. J Natl Cancer Inst Monogr (1997) 2.24
Probing proton dynamics in molecules on an attosecond time scale. Science (2006) 2.24
Lymphedema: current issues in research and management. CA Cancer J Clin (2000) 2.21
Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene (1999) 2.19
Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res (1997) 2.17
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res (1998) 2.15
Pressure support ventilation decreases inspiratory work of breathing during general anesthesia and spontaneous ventilation. Anesth Analg (1992) 2.14
Improved SPECT quantification using compensation for scattered photons. J Nucl Med (1984) 2.14
Benefit of mammography screening in women ages 40 to 49 years. Current evidence from randomized controlled trials. Cancer (1995) 2.13
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene (1999) 2.12
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J Natl Cancer Inst (1999) 2.10
Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci U S A (1990) 2.07
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A (2001) 2.00
Ribonucleic acid-protein fractions of virulent Salmonella typhimurium as protective immunogens. Infect Immun (1972) 1.99
A study guided by the Health Belief Model of the predictors of breast cancer screening of women ages 40 and older. Public Health Rep (1991) 1.97
Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp Cell Res (1974) 1.94
Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans. Proc Natl Acad Sci U S A (2001) 1.90
Determination of inorganic phosphate in the presence of labile organic phosphates. Anal Biochem (1969) 1.89
Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science (1985) 1.88
Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res (1991) 1.88
The active form of tumor necrosis factor is a trimer. J Biol Chem (1987) 1.86
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem (1999) 1.84
Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res (1996) 1.84
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci U S A (1993) 1.84
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis (1993) 1.84
Planning for the future: the experience of implementing a children's day assessment unit in a district general hospital. Arch Dis Child (1997) 1.83
Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev (2000) 1.82
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res (2000) 1.81
The pressure reversal of general anesthesia and the critical volume hypothesis. Mol Pharmacol (1973) 1.79
Twenty-year follow-up of the breast cancers diagnosed during the Breast Cancer Detection Demonstration Project. CA Cancer J Clin (1997) 1.75
Intranasal Teeth. Report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol (1979) 1.73
Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory. Dev Psychobiol (1988) 1.72
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
Inhibition of DNA methylation by chemical carcinogens in vitro. Cell (1983) 1.68
High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science (1983) 1.67
Relationship between symptoms and disordered continence mechanisms in women with idiopathic faecal incontinence. Gut (2005) 1.67
Comparing the quality of death for hospice and non-hospice cancer patients. Med Care (1988) 1.67
Hemodynamic and gas exchange alterations during Intralipid infusion in patients with adult respiratory distress syndrome. Chest (1989) 1.66
Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. Cancer Res (1985) 1.66
Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res (1996) 1.65
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res (1995) 1.64
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation (1988) 1.64
Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res (1998) 1.64
Detection of delayed hypersensitivity in mice injected with ribonucleic acid-protein fractions of Salmonella typhimurium. Infect Immun (1972) 1.64
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev (1996) 1.63
Methionine synthesis from 5'-methylthioadenosine in rat liver. J Biol Chem (1981) 1.63
Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer. J Pathol (1999) 1.62
Expression of calf prochymosin in Saccharomyces cerevisiae. Gene (1984) 1.61
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A (1997) 1.60
Asbestos-associated chromosomal changes in human mesothelial cells. Proc Natl Acad Sci U S A (1985) 1.60
Ultrasensitive enzymatic radioimmunoassay: application to detection of cholera toxin and rotavirus. Proc Natl Acad Sci U S A (1979) 1.58
Heterologous protein secretion from yeast. Science (1985) 1.58
Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int J Cancer (1994) 1.57
Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J Clin Oncol (2000) 1.56
p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet (1994) 1.56
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nat Med (1998) 1.55
Expression cloning and signaling properties of the rat glucagon receptor. Science (1993) 1.54
Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A (1985) 1.54
Physicochemical approaches to the mode of action of general anesthetics. Anesthesiology (1972) 1.53
Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet (1992) 1.53