Published in Proc Natl Acad Sci U S A on August 01, 1987
The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. EMBO J (1987) 3.06
Mechanism of aromatic amino acid hydroxylation. Biochemistry (2003) 2.78
Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc Natl Acad Sci U S A (1988) 1.82
Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines. Proc Natl Acad Sci U S A (1988) 1.61
Structure and function of the aromatic amino acid hydroxylases. Biochem J (1995) 1.51
Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase. Protein Sci (1993) 1.22
Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry. Biochemistry (2010) 1.12
An efficient strategy for cloning 5' extremities of rare transcripts permits isolation of multiple 5'-untranslated regions of rat tryptophan hydroxylase mRNA. Nucleic Acids Res (1989) 1.04
Mutation detection in phenylketonuria by using chemical cleavage of mismatch: importance of using probes from both normal and patient samples. Am J Hum Genet (1991) 1.01
Identification by hydrogen/deuterium exchange of structural changes in tyrosine hydroxylase associated with regulation. Biochemistry (2009) 0.98
Phenylketonuria in U.S. blacks: molecular analysis of the phenylalanine hydroxylase gene. Am J Hum Genet (1991) 0.98
Screening for mutations in the phenylalanine hydroxylase gene from Italian patients with phenylketonuria by using the chemical cleavage method: a new splice mutation. Am J Hum Genet (1991) 0.97
Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11. Nucleic Acids Res (1988) 0.96
Effects of phosphorylation by protein kinase A on binding of catecholamines to the human tyrosine hydroxylase isoforms. J Neurochem (2004) 0.95
A monoclonal antibody to aromatic amino acid hydroxylases. Identification of the epitope. Biochem J (1988) 0.94
Effects of ligands on the mobility of an active-site loop in tyrosine hydroxylase as monitored by fluorescence anisotropy. Biochemistry (2006) 0.93
Localization of cofactor binding sites with monoclonal anti-idiotype antibodies: phenylalanine hydroxylase. Proc Natl Acad Sci U S A (1991) 0.93
A flexible loop in tyrosine hydroxylase controls coupling of amino acid hydroxylation to tetrahydropterin oxidation. J Mol Biol (2006) 0.91
Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site. Biochemistry (2014) 0.90
Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. J Pineal Res (2008) 0.89
Kinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity. Biochemistry (2008) 0.86
Substrate regulation of serotonin and dopamine synthesis in Drosophila. Invert Neurosci (2004) 0.86
Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am J Hum Genet (1992) 0.86
Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain. Sci Rep (2016) 0.86
Complex molecular regulation of tyrosine hydroxylase. J Neural Transm (Vienna) (2014) 0.85
High-level expression and deletion mutagenesis of human tryptophan hydroxylase. Proc Natl Acad Sci U S A (1994) 0.84
Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad. Arch Biochem Biophys (2008) 0.82
Deletion mutants of tyrosine hydroxylase identify a region critical for heparin binding. Protein Sci (1995) 0.81
Mechanisms of tryptophan and tyrosine hydroxylase. IUBMB Life (2013) 0.80
Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase. Biochemistry (2013) 0.79
Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase. Biochem J (1997) 0.79
Immunological detection of phenylalanine hydroxylase protein in Drosophila melanogaster. Biochem J (1992) 0.79
Molecular analysis of contiguous exons of the phenylalanine hydroxylase gene: identification of a new PKU mutation. J Med Genet (1993) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene (1984) 56.23
Efficient isolation of genes by using antibody probes. Proc Natl Acad Sci U S A (1983) 34.00
Analysis of chromosomal integration and deletions of yeast plasmids. Nucleic Acids Res (1977) 16.66
Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels. Nucleic Acids Res (1979) 9.33
The origin and evolution of protein superfamilies. Fed Proc (1976) 6.22
Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase. Biochemistry (1985) 4.78
Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla. J Biol Chem (1971) 2.85
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM. Br J Pharmacol Chemother (1963) 2.36
5-hydroxytryptamine participation in the vagal inhibitory innervation of the stomach. J Physiol (1967) 2.18
Complete coding sequence of rat tyrosine hydroxylase mRNA. Proc Natl Acad Sci U S A (1985) 2.01
Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA. Proc Natl Acad Sci U S A (1982) 1.69
Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Mol Pharmacol (1967) 1.62
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J Biol Chem (1972) 1.53
Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor. Science (1967) 1.49
Complete nucleotide and deduced amino acid sequence of bovine phenylethanolamine N-methyltransferase: partial amino acid homology with rat tyrosine hydroxylase. Proc Natl Acad Sci U S A (1986) 1.34
Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains. Biochemistry (1985) 1.24
Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase. J Biol Chem (1986) 1.19
The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties. J Biol Chem (1984) 1.12
Evidence for the existence of homologous gene coding regions for the catecholamine biosynthetic enzymes. Cold Spring Harb Symp Quant Biol (1983) 1.05
Biochemical characterization of recombinant human phenylalanine hydroxylase produced in Escherichia coli. J Biol Chem (1987) 1.04
Production of antibodies to rat liver phenylalanine hydroxylase. Cross-reactivity with other pterin-dependent hydroxylases. Mol Pharmacol (1972) 0.98
Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity. J Biol Chem (1980) 0.96
Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties. Eur J Biochem (1982) 0.94
Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain. J Biol Chem (1975) 0.92
Isolation of a rat pineal gland cDNA clone homologous to tyrosine and phenylalanine hydroxylases. FEBS Lett (1986) 0.90
Some properties of bovine pineal tryptophan hydroxylase. Adv Exp Med Biol (1976) 0.83
Activation of brain tryptophan hydroxylase by a phosphorylating system. J Neurosci Res (1978) 0.82
Serotonin and tryptophan hydroxylase in isolated hypothalamic and brain stem nuclei of rats exposed to acute and repeated immobilization stress. Exp Clin Endocrinol (1984) 0.80
Regulatory properties of phenylalanine, tyrosine and tryptophan hydroxylases. Biochem Soc Trans (1985) 0.79
Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase. Biochemistry (1985) 4.78
alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene. Nature (1983) 4.38
Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria. Am J Hum Genet (1985) 3.77
Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant. Biochemistry (1984) 3.75
Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria. Nature (1986) 3.29
Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther (1993) 3.02
Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria. Nature (1984) 2.82
Polymorphic DNA haplotypes at the human phenylalanine hydroxylase locus and their relationship with phenylketonuria. Hum Genet (1987) 2.73
DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effect of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments. Nucleic Acids Res (1992) 2.71
Complete nucleotide sequence of the chicken chromosomal ovalbumin gene and its biological significance. Biochemistry (1981) 2.67
Screening for phenylketonuria mutations by DNA amplification with the polymerase chain reaction. Lancet (1988) 2.67
Regional mapping of the phenylalanine hydroxylase gene and the phenylketonuria locus in the human genome. Proc Natl Acad Sci U S A (1985) 2.58
The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene. Cell (1979) 2.56
A sensitive and rapid method for recombinant phage screening. Methods Enzymol (1979) 2.52
Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene. Biochemistry (1986) 2.49
Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. Biochemistry (1975) 2.42
An amino-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2. Nature (1987) 2.37
The importance of quadriceps and hamstring muscle loading on knee kinematics and in-situ forces in the ACL. J Biomech (1999) 2.31
Physical and chemical characterization of purified ovalbumin messenger RNA. J Biol Chem (1975) 2.28
Definition of 5' and 3' structural boundaries of the chromatin domain containing the ovalbumin multigene family. J Biol Chem (1982) 2.22
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A (1991) 2.19
Linkage relationships of the human methylmalonyl CoA mutase to the HLA and D6S4 loci on chromosome 6. Genomics (1988) 2.16
Influences of flexor sheath continuity and early motion on tendon healing in dogs. J Hand Surg Am (1990) 2.14
A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum. J Biol Chem (1988) 2.11
The synthesis and properties of the complete complementary DNA transcript of ovalbumin mRNA. Biochemistry (1976) 2.08
DNA restriction fragments associated with alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z. Nature (1985) 2.03
The chick ovomucoid gene contains at least six intervening sequences. Nature (1979) 2.01
Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction. Genomics (1989) 1.98
A new method for determining cross-sectional shape and area of soft tissues. J Biomech Eng (1988) 1.96
Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther (1992) 1.92
Assignment of the alpha 1-antitrypsin gene and a sequence-related gene to human chromosome 14 by molecular hybridization. Am J Hum Genet (1983) 1.91
Cloning and sequence of cDNA coding for alpha 1-antitrypsin. Proc Natl Acad Sci U S A (1981) 1.91
The development of mature gait. J Bone Joint Surg Am (1980) 1.91
Effects of postmortem storage by freezing on ligament tensile behavior. J Biomech (1986) 1.89
Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. J Cell Biol (1978) 1.88
GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria. Nucleic Acids Res (1987) 1.86
Polymerase chain reaction amplification from dried blood spots on Guthrie cards. Lancet (1990) 1.86
Effects of immobilization on joints. Clin Orthop Relat Res (1987) 1.84
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol (1990) 1.80
The natural ovalbumin gene contains seven intervening sequences. Nature (1978) 1.79
Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. J Biol Chem (1983) 1.79
Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene. Proc Natl Acad Sci U S A (1980) 1.77
Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice. J Clin Invest (1989) 1.72
Disruption of phase during PCR amplification and cloning of heterozygous target sequences. Nucleic Acids Res (1990) 1.72
Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes. Nature (1982) 1.70
Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA. Proc Natl Acad Sci U S A (1982) 1.69
Molecular cloning of ovomucoid gene sequences from partially purified ovomucoid messenger RNA. Biochemistry (1978) 1.67
Regulation of casein messenger RNA during the development of the rat mammary gland. Biochemistry (1975) 1.66
Prenatal diagnosis of classic phenylketonuria by DNA analysis. Lancet (1985) 1.64
Chitinase gene expression during mycoparasitic interaction of Trichoderma harzianum with its host. Fungal Genet Biol (1999) 1.64
Nonlinear material properties of intact cornea and sclera. Exp Eye Res (1972) 1.63
The ovalbumin gene: cloning and molecular organization of the entire natural gene. Proc Natl Acad Sci U S A (1979) 1.61
DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem Biophys Res Commun (1985) 1.57
Isolation and sequence characterization of a cDNA clone of human antithrombin III. Proc Natl Acad Sci U S A (1983) 1.56
In situ forces in the anterior cruciate ligament and its bundles in response to anterior tibial loads. J Orthop Res (1997) 1.55
Cloning large segments of genomic DNA using cosmid vectors. Methods Enzymol (1987) 1.55
Tetanus toxin interactions with thyroid plasma membranes. Implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J Biol Chem (1977) 1.53
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice. Nucleic Acids Res (1987) 1.51
Phenylalanine hydroxylase deficiency caused by a single base substitution in an exon of the human phenylalanine hydroxylase gene. Biochemistry (1988) 1.50
Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription. J Biol Chem (1982) 1.50
Effects of early intermittent passive mobilization on healing canine flexor tendons. J Hand Surg Am (1982) 1.50
Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther (1994) 1.50
Genes from mycoparasitic fungi as a source for improving plant resistance to fungal pathogens. Proc Natl Acad Sci U S A (1998) 1.50
The forces in the anterior cruciate ligament and knee kinematics during a simulated pivot shift test: A human cadaveric study using robotic technology. Arthroscopy (2000) 1.49
Tensile and viscoelastic properties of human patellar tendon. J Orthop Res (1994) 1.49
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc Natl Acad Sci U S A (1976) 1.48
Hamstrings--an anterior cruciate ligament protagonist. An in vitro study. Am J Sports Med (1993) 1.48
Importance of the medial meniscus in the anterior cruciate ligament-deficient knee. J Orthop Res (2000) 1.47
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci U S A (1994) 1.46
Gene transfer and expression of human phenylalanine hydroxylase. Science (1985) 1.46
Isodisomy of chromosome 6 in a newborn with methylmalonic acidemia and agenesis of pancreatic beta cells causing diabetes mellitus. J Clin Invest (1994) 1.46
The biomechanical and biochemical properties of swine tendons--long term effects of exercise on the digital extensors. Connect Tissue Res (1980) 1.46
A functional comparison of animal anterior cruciate ligament models to the human anterior cruciate ligament. Ann Biomed Eng (1998) 1.45
Collation of RFLP haplotypes at the human phenylalanine hydroxylase (PAH) locus. Am J Hum Genet (1988) 1.45
Missense mutations associated with RFLP haplotypes 1 and 4 of the human phenylalanine hydroxylase gene. Am J Hum Genet (1990) 1.45
Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology (1995) 1.44
Ovalbumin gene. Action of restriction endonucleases upon DNA coding sequence. J Biol Chem (1977) 1.44
Immobility effects on synovial joints the pathomechanics of joint contracture. Biorheology (1980) 1.44
Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions. Proc Natl Acad Sci U S A (1987) 1.44
Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III. Biochemistry (1983) 1.43
The PKU locus in man is on chromosome 12. Am J Hum Genet (1984) 1.42
The ovalbumin gene: structural sequences in native chicken DNA are not contiguous. Proc Natl Acad Sci U S A (1978) 1.42
Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc Natl Acad Sci U S A (2000) 1.42
Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther (1996) 1.41
Associations between mutations and a VNTR in the human phenylalanine hydroxylase gene. Am J Hum Genet (1992) 1.41
Cobalamin deficiency associated with methylmalonic acidemia in a cat. J Am Vet Med Assoc (1992) 1.40
Quantitative analysis of human cruciate ligament insertions. Arthroscopy (1999) 1.40
THE ADMINISTRATION OF FERROUS IODIDE AND LINOLEIC ACID TO RATS DEPRIVED OF VITAMIN A. Science (1932) 1.39
The effects of multiple-strand suture methods on the strength and excursion of repaired intrasynovial flexor tendons: a biomechanical study in dogs. J Hand Surg Am (1998) 1.38
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther (2000) 1.37
Mechanical properties of tendons and ligaments. II. The relationships of immobilization and exercise on tissue remodeling. Biorheology (1982) 1.36
A single polymorphic STR system in the human phenylalanine hydroxylase gene permits rapid prenatal diagnosis and carrier screening for phenylketonuria. Hum Mol Genet (1993) 1.35