Published in Proc Natl Acad Sci U S A on November 01, 1981
Compilation of published signal sequences. Nucleic Acids Res (1984) 11.33
Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci U S A (1983) 7.52
Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens. Proc Natl Acad Sci U S A (1982) 3.30
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
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High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli. Proc Natl Acad Sci U S A (1984) 1.65
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Isolation and sequence characterization of a cDNA clone of human antithrombin III. Proc Natl Acad Sci U S A (1983) 1.56
Cloning and expression of the cDNA for human antithrombin III. Nucleic Acids Res (1982) 1.55
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Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice. Nucleic Acids Res (1987) 1.51
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Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor. Proc Natl Acad Sci U S A (1988) 1.17
Tissue-specific expression of the human alpha 1-antitrypsin gene is controlled by multiple cis-regulatory elements. Nucleic Acids Res (1987) 1.15
Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene. Mol Cell Biol (1988) 1.09
Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution. Proc Natl Acad Sci U S A (1987) 1.08
DNA restriction-site polymorphisms associated with the alpha 1-antitrypsin gene. Am J Hum Genet (1987) 1.05
Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele. Am J Hum Genet (1988) 0.95
Expression of human alpha 1-antitrypsin cDNA in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 0.87
Structural comparisons of the native and reactive-centre-cleaved forms of alpha 1-antitrypsin by neutron- and X-ray-scattering in solution. Biochem J (1990) 0.87
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Additional N-glycosylation in the N-terminal region of recombinant human alpha-1 antitrypsin enhances the circulatory half-life in Sprague-Dawley rats. Glycoconj J (2016) 0.77
Chemical modification of human alpha 1-proteinase inhibitor by tetranitromethane. Structure-function relationship. Biochem J (1987) 0.75
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Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis. Proc Natl Acad Sci U S A (1987) 0.75
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
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Sequence data handling by computer. Nucleic Acids Res (1977) 45.33
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A simple method for DNA restriction site mapping. Nucleic Acids Res (1976) 22.24
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell (1981) 12.26
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Sequence of chicken ovalbumin mRNA. Nature (1978) 6.73
Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J Biol Chem (1980) 3.14
Post-translational processing of full-length presecretory proteins with canine pancreatic signal peptidase. Ann N Y Acad Sci (1980) 2.23
Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency. Proc Natl Acad Sci U S A (1976) 2.00
A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor. Biochem Biophys Res Commun (1980) 1.92
Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor. J Biol Chem (1978) 1.79
A new method for determination of alpha-1-antitrypsin phenotypes using isoelectric focusing on polyacrylamide gel slabs. Am J Clin Pathol (1974) 1.73
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Amino acid substitution Glu leads to Lys alpha1-antitrypsin PiZ. FEBS Lett (1976) 1.35
Purification and properties of normal human alpha 1-antitrypsin. Arch Biochem Biophys (1973) 1.30
Cloning and analysis of a cDNA coding for bovine prothrombin. Proc Natl Acad Sci U S A (1980) 1.28
Studies on the oligosaccharide chains of human alpha 1-protease inhibitor. II. Structure of oligosaccharides. J Biol Chem (1980) 1.26
Characterization of a cDNA clone coding for the beta chain of bovine fibrinogen. Proc Natl Acad Sci U S A (1981) 1.19
Formation and dissociation of the covalent complexes between trypsin and two homologous inhibitors, alpha 1-antitrypsin and antithrombin III. Eur J Biochem (1980) 1.10
The thrombin cleavage site in bovine antithrombin. FEBS Lett (1979) 1.05
Interaction of human alpha-1-antitrypsin with porcine trypsin. Biochemistry (1978) 0.97
Primary structure of human alpha1-protease inhibitor. The complete amino acid sequence of cyanogen bromide fragment II. J Biol Chem (1978) 0.95
Characterization of the inactive fragment resulting from limited proteolysis of human alpha1-proteinase inhibitor by Crotalus adamanteus proteinase II. J Biol Chem (1979) 0.93
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Carboxy terminal fragment of human alpha-1-antitrypsin from hydroxylamine cleavage: homology with antithrombin III. Biochem Biophys Res Commun (1979) 0.88
Active site of alpha 1-antitrypsin: homologous site in antithrombin-III. Biochem Biophys Res Commun (1980) 0.88
Amino acid sequences containing half-cystine residues in ovalbumin. Aust J Biol Sci (1978) 0.85
The abnormality of the S variant of human alpha-1-antitrypsin. Biochim Biophys Acta (1976) 0.81
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Nucleotide sequence of the gene for human factor IX (antihemophilic factor B). Biochemistry (1985) 11.80
The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet (1967) 7.24
Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase. Biochemistry (1985) 4.78
alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene. Nature (1983) 4.38
Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Clinical, microbiologic, neurologic and pathologic features. Am J Med (1967) 4.08
Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. Proc Natl Acad Sci U S A (1987) 4.03
The preparation and testing of horse antidog and antihuman antilymphoid plasma or serum and its protein fractions. Surg Gynecol Obstet (1967) 3.86
Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria. Am J Hum Genet (1985) 3.77
Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant. Biochemistry (1984) 3.75
Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A (1998) 3.50
Cloning and characterization of two cDNAs coding for human von Willebrand factor. Proc Natl Acad Sci U S A (1985) 3.41
The human tissue plasminogen activator gene. J Biol Chem (1986) 3.35
Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria. Nature (1986) 3.29
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Isolation and characterization of a cDNA coding for human factor IX. Proc Natl Acad Sci U S A (1982) 3.14
Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther (1993) 3.02
Chronic survival after human renal homotransplantation. Lymphocyte-antigen matching, pathology and influence of thymectomy. Ann Surg (1965) 3.00
Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry (1977) 2.96
Preparation and properties of bovine factor VIII (antihemophilic factor). Biochemistry (1980) 2.89
Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria. Nature (1984) 2.82
A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry (1977) 2.77
Polymorphic DNA haplotypes at the human phenylalanine hydroxylase locus and their relationship with phenylketonuria. Hum Genet (1987) 2.73
DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effect of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments. Nucleic Acids Res (1992) 2.71
Complete nucleotide sequence of the chicken chromosomal ovalbumin gene and its biological significance. Biochemistry (1981) 2.67
Screening for phenylketonuria mutations by DNA amplification with the polymerase chain reaction. Lancet (1988) 2.67
Regional mapping of the phenylalanine hydroxylase gene and the phenylketonuria locus in the human genome. Proc Natl Acad Sci U S A (1985) 2.58
Studies of blood flow and ultrastructural changes in rejecting and nonrejecting canine orthotopic liver homografts. Surgery (1968) 2.58
The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene. Cell (1979) 2.56
A sensitive and rapid method for recombinant phage screening. Methods Enzymol (1979) 2.52
Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin. Biochemistry (1983) 2.49
Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene. Biochemistry (1986) 2.49
Isolation and characterization of human Factor VIII (antihemophilic factor). J Biol Chem (1973) 2.46
Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. Biochemistry (1975) 2.42
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The importance of quadriceps and hamstring muscle loading on knee kinematics and in-situ forces in the ACL. J Biomech (1999) 2.31
Physical and chemical characterization of purified ovalbumin messenger RNA. J Biol Chem (1975) 2.28
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The nucleotide sequence of the gene for human protein C. Proc Natl Acad Sci U S A (1985) 2.24
Heterologous antilymphocyte glubulin, histoincompatiblity matching, and human renal homotransplantation. Surg Gynecol Obstet (1968) 2.23
Definition of 5' and 3' structural boundaries of the chromatin domain containing the ovalbumin multigene family. J Biol Chem (1982) 2.22
The role of serine proteases in the blood coagulation cascade. Adv Enzymol Relat Areas Mol Biol (1979) 2.21
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Influences of flexor sheath continuity and early motion on tendon healing in dogs. J Hand Surg Am (1990) 2.14
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A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum. J Biol Chem (1988) 2.11
The synthesis and properties of the complete complementary DNA transcript of ovalbumin mRNA. Biochemistry (1976) 2.08
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Isolation and characterization of bovine factor IX (Christmas factor). Biochemistry (1973) 2.04
DNA restriction fragments associated with alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z. Nature (1985) 2.03
Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood (1988) 2.01
The chick ovomucoid gene contains at least six intervening sequences. Nature (1979) 2.01
Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature (1999) 1.97
A new method for determining cross-sectional shape and area of soft tissues. J Biomech Eng (1988) 1.96
Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor. Biochemistry (1985) 1.94
Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci U S A (1996) 1.93
Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther (1992) 1.92
Nucleotide sequence of the gene for human prothrombin. Biochemistry (1987) 1.92
Assignment of the alpha 1-antitrypsin gene and a sequence-related gene to human chromosome 14 by molecular hybridization. Am J Hum Genet (1983) 1.91
The development of mature gait. J Bone Joint Surg Am (1980) 1.91
Effects of postmortem storage by freezing on ligament tensile behavior. J Biomech (1986) 1.89
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A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochemistry (1988) 1.89
Nucleotide sequence of the gene for the gamma chain of human fibrinogen. Biochemistry (1985) 1.88
Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. J Cell Biol (1978) 1.88
GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria. Nucleic Acids Res (1987) 1.86
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Polymerase chain reaction amplification from dried blood spots on Guthrie cards. Lancet (1990) 1.86
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Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. J Biol Chem (1983) 1.79
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Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins. Proc Natl Acad Sci U S A (1979) 1.77
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Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. Proc Natl Acad Sci U S A (1985) 1.75
Molecular cloning of a full-length cDNA for human alcohol dehydrogenase. Proc Natl Acad Sci U S A (1985) 1.74
Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization. J Biol Chem (1983) 1.73
Bovine factors X 1 and X 2 (Stuart factor). Isolation and characterization. Biochemistry (1972) 1.73
Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma. Biochemistry (1979) 1.73
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The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence. Proc Natl Acad Sci U S A (1988) 1.70