Published in EMBO J on December 01, 1987
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Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell (1984) 13.91
Polyoma virus transforming protein associates with the product of the c-src cellular gene. Nature (1983) 7.20
Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein. Nature (1981) 6.70
Growth of factor-dependent hemopoietic precursor cell lines. J Exp Med (1980) 5.80
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation. EMBO J (1985) 5.14
Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem (1977) 3.74
The complex of polyoma virus middle-T antigen and pp60c-src. EMBO J (1984) 3.57
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src. Mol Cell Biol (1985) 3.39
Association of the polyomavirus middle-T antigen with c-yes protein. Nature (1987) 2.78
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell (1985) 2.59
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell (1985) 2.55
Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell (1985) 2.36
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src. Mol Cell Biol (1985) 2.25
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. Proc Natl Acad Sci U S A (1986) 1.75
Autocrine growth induced by src-related oncogenes in transformed chicken myeloid cells. Cell (1984) 1.68
Expression of cellular oncogenes during embryonic and fetal development of the mouse. Proc Natl Acad Sci U S A (1984) 1.68
In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF. J Cell Physiol (1986) 1.44
Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus. Proc Natl Acad Sci U S A (1985) 1.34
Different colony-stimulating factors are detected by the "interleukin-3"-dependent cell lines FDC-Pl and 32D cl-23. Blood (1984) 1.21
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature (1985) 7.10
Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science (1992) 6.80
How the lambda repressor and cro work. Cell (1980) 6.65
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit beta-globin. Cell (1980) 6.20
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell (1990) 6.12
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell (1987) 5.87
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell (1987) 5.84
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell (1992) 5.77
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86
Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell (1987) 4.70
Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature (1984) 4.46
Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell (1984) 4.41
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A (1994) 4.19
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 4.19
Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03
Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA. Cell (1979) 3.78
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (1997) 3.73
A general method for maximizing the expression of a cloned gene. Proc Natl Acad Sci U S A (1979) 3.67
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A (1988) 3.52
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J (1985) 3.30
Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29
Oncogenes, growth factors, and signal transduction. N Engl J Med (1989) 3.18
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell (1995) 3.17
Sequence of Cro gene of bacteriophage lambda. Nature (1977) 2.78
Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science (1994) 2.74
Nucleotide sequence of cDNA clones of the murine myb proto-oncogene. EMBO J (1985) 2.73
Determination of the nuclear DNA content of Saccharomyces cerevisiae and implications for the organization of DNA in yeast chromosomes. J Mol Biol (1977) 2.67
Phosphatidylinositol metabolism and polyoma-mediated transformation. Proc Natl Acad Sci U S A (1986) 2.62
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell (1985) 2.55
Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell (1993) 2.52
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity (1998) 2.42
Regulation of intracellular pH by immortalized human intrahepatic biliary epithelial cell lines. Am J Physiol (1994) 2.36
Isolation of ras GTP-binding mutants using an in situ colony-binding assay. Proc Natl Acad Sci U S A (1986) 2.35
Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol (1998) 2.30
Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production. J Virol (1986) 2.27
Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell (1987) 2.23
Hematopoietic regulators: redundancy or subtlety? Blood (1993) 2.13
A plasmid cloning vehicle allowing a positive selection for inserted fragments. Gene (1980) 2.08
The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol (1997) 2.08
DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev (1997) 2.06
Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol (1997) 2.01
Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A (1993) 1.96
The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters. EMBO J (1985) 1.95
Plants and soils as indicators of metals in the air. Nature (1971) 1.94
A novel method to map transcripts: evidence for homology between an adenovirus mRNA and discrete multiple regions of the viral genome. Cell (1977) 1.93
Cell biology. A signal chain of events. Nature (1992) 1.93
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc Natl Acad Sci U S A (1992) 1.91
An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. J Virol (1991) 1.90
Expression of the human fibroblast interferon gene in Escherichia coli. Proc Natl Acad Sci U S A (1980) 1.84
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A (2000) 1.83
Maximizing gene expression on a plasmid using recombination in vitro. Methods Enzymol (1979) 1.78
Cellular proteins that associate with the middle and small T antigens of polyomavirus. J Virol (1988) 1.78
Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood (2000) 1.75
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. Proc Natl Acad Sci U S A (1986) 1.75
Synthesis of simian virus 40 t antigen in Escherichia coli. Proc Natl Acad Sci U S A (1979) 1.70
In situ hybridization of adenovirus RNA and DNA. Nature (1972) 1.66
Caenorhabditis elegans spermatozoan locomotion: amoeboid movement with almost no actin. J Cell Biol (1982) 1.66
The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc Natl Acad Sci U S A (1993) 1.63
Purification of biologically active simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A (1983) 1.61
"Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection. Blood (2000) 1.59
Reconstitution in vitro of the motile apparatus from the amoeboid sperm of Ascaris shows that filament assembly and bundling move membranes. Cell (1996) 1.57
Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol (1988) 1.55
Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci U S A (1994) 1.55
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med (2001) 1.55
Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo. Biochem J (1991) 1.54
Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways. J Biol Chem (1996) 1.53
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol (1997) 1.52
Characterization of pp85, a target of oncogenes and growth factor receptors. Mol Cell Biol (1990) 1.51
Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J (1995) 1.50
Monoclonal antibodies that recognize a polypeptide antigenic determinant shared by multiple Caenorhabditis elegans sperm-specific proteins. J Cell Biol (1986) 1.47
Membrane and cytoplasmic proteins are transported in the same organelle complex during nematode spermatogenesis. J Cell Biol (1986) 1.47
Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1993) 1.46
Polyoma virus major capsid protein, VP1. Purification after high level expression in Escherichia coli. J Biol Chem (1985) 1.46
Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo. Mol Cell Biol (1986) 1.45
Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor. J Clin Invest (1998) 1.44
Identification of Lck-binding elements in tip of herpesvirus saimiri. J Biol Chem (1995) 1.43
Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line. Neuron (1990) 1.42
The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A (1993) 1.41
Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. Mol Cell Biol (1991) 1.41
Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science (1994) 1.41
Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity (2001) 1.41
Lead contamination around secondary smelters: estimation of dispersal and accumulation by humans. Science (1974) 1.39
Cell biology of nematode sperm. Methods Cell Biol (1995) 1.35
Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J Virol (1995) 1.34
Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors. Proc Natl Acad Sci U S A (1991) 1.32
Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis. Am J Respir Crit Care Med (2001) 1.31
Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene (1992) 1.30
Expression of polyoma early gene products in E. coli. Nucleic Acids Res (1985) 1.29
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol (1990) 1.29
The 5' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production. J Virol (1999) 1.28
Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood (1990) 1.28
Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. EMBO J (1994) 1.27