Published in Proc Natl Acad Sci U S A on June 01, 1978
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J (1987) 4.56
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L. Biochem J (1987) 1.44
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated. J Cell Biol (1985) 1.41
Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney. J Cancer Res Clin Oncol (1997) 1.38
The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor. Biochem J (1989) 1.36
Platelet-derived growth factor-modulated translatable mRNAs. Mol Cell Biol (1983) 1.30
The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes. Proc Natl Acad Sci U S A (1986) 1.21
Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts. Mol Cell Biol (1991) 1.14
Identification of a BALB/c-3T3 cell protein modulated by platelet-derived growth factor. Mol Cell Biol (1983) 1.14
Quantification of cathepsins B and L in cells. Biochem J (1998) 1.09
Regulation of the transcript for a lysosomal protein: evidence for a gene program modified by platelet-derived growth factor. Mol Cell Biol (1985) 1.04
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest (1988) 1.02
Isolation and sequence of a cDNA for human pro-(cathepsin L). Biochem J (1988) 1.02
Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin. Biochem J (1987) 1.01
Transformation stimulates glucose transporter gene expression in the absence of protein kinase C. Proc Natl Acad Sci U S A (1989) 0.95
Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts. Biochem J (1990) 0.95
An acid protease secreted by transformed cells interferes with antigen processing. J Cell Biol (1988) 0.94
Transformation-related antigens identified by monoclonal antibodies. Proc Natl Acad Sci U S A (1980) 0.91
Modulation of the transport of a lysosomal enzyme by PDGF. J Cell Biol (1990) 0.91
Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein. Mol Cell Biol (1985) 0.90
Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease. Mol Cell Biol (1988) 0.90
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells. Proc Natl Acad Sci U S A (1982) 0.89
Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C. Proc Natl Acad Sci U S A (1989) 0.84
Cathepsin L targeting in cancer treatment. Pharmacol Ther (2015) 0.79
Effect of carbohydrate position on lysosomal transport of procathepsin L. Mol Biol Cell (1998) 0.78
Altered processing of a major secreted phosphoprotein correlates with tumorigenicity in Rous sarcoma virus-transformed mammalian cells. J Virol (1985) 0.76
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem (1974) 113.22
Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. Eur J Biochem (1975) 56.72
Analysis of bacteriophage T7 early RNAs and proteins on slab gels. J Mol Biol (1973) 30.17
Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc Natl Acad Sci U S A (1973) 6.98
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci U S A (1975) 6.59
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses. J Exp Med (1973) 4.99
Anchorage and growth regulation in normal and virus-transformed cells. Int J Cancer (1968) 3.97
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
Variant forms of mitochondrial translation products in yeast: evidence for location of determinants on mitochondrial DNA. Proc Natl Acad Sci U S A (1976) 3.45
Isolation of a major cell surface glycoprotein from fibroblasts. Proc Natl Acad Sci U S A (1974) 3.30
A factor from a transformed cell line that affects cell migration. Proc Natl Acad Sci U S A (1973) 2.53
Mechanism of the decrease in the major cell surface protein of chick embryo fibroblasts after transformation. Cell (1977) 2.42
The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts. Arch Biochem Biophys (1972) 2.30
A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication-stimulating activity for embryo fibroblasts. J Cell Physiol (1973) 1.93
Loss of ability to synthesize collagen in fibroblasts transformed by rous sarcoma virus. J Natl Cancer Inst (1975) 1.55
Tumor angiogenesis activity in cells grown in tissue culture. Cancer Res (1976) 1.48
Synthesis of types I and III procollagen and collagen by monkey aortic smooth muscle cells in vitro. Biochemistry (1977) 1.44
Plasminogen-independent fibrinolysis by proteases produced by transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1975) 1.32
Morphologic revertants of murine sarcoma virus transformed nonproducer BALB-3T3: selective techniques for isolation and biologic properties in vitro and in vivo. Virology (1974) 1.20
MIF-like activity in simian virus 40-transformed 3T3 fibroblast cultures. Science (1974) 1.08
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 8.53
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A (1987) 7.38
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol (1999) 6.62
Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A (1987) 5.65
Genetics and function of DNA ligase in Escherichia coli. J Mol Biol (1973) 4.52
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci U S A (1987) 4.43
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (1992) 3.41
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet (1985) 3.23
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science (1986) 3.22
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res (1985) 3.15
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem (1987) 3.13
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem (1986) 2.93
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry (1998) 2.87
Is the multidrug transporter a flippase? Trends Biochem Sci (1992) 2.68
Characterization of bacteriophage lambda reverse as an Escherichia coli phage carrying a unique set of host-derived recombination functions. J Mol Biol (1974) 2.64
Fluorescent cellular indicators are extruded by the multidrug resistance protein. J Biol Chem (1993) 2.52
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci U S A (1988) 2.44
alpha-Galactosidase A deficient mice: a model of Fabry disease. Proc Natl Acad Sci U S A (1997) 2.43
Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet (1986) 2.27
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs. Cancer Res (1986) 2.12
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A (1997) 2.10
Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. Proc Natl Acad Sci U S A (1986) 2.08
In vitro assembly of homopolymer and copolymer filaments from intermediate filament subunits of muscle and fibroblastic cells. Proc Natl Acad Sci U S A (1981) 2.02
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem (1987) 1.99
Acquisition of a determinant for chloramphenicol resistance by coliphage lambda. Proc Natl Acad Sci U S A (1975) 1.93
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem (1989) 1.89
Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol (1986) 1.89
CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin. Cell (1980) 1.88
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J Biol Chem (1990) 1.86
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin Pharmacol Ther (2009) 1.77
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry (1998) 1.75
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells. J Biol Chem (1986) 1.74
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun (1986) 1.71
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A (1992) 1.70
Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1985) 1.66
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A (1988) 1.60
MDR1 gene expression in lung cancer. J Natl Cancer Inst (1989) 1.57
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet (1997) 1.55
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem (1990) 1.54
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. Clin Cancer Res (1999) 1.54
Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP. Somatic Cell Genet (1980) 1.52
The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity. Biochem Biophys Res Commun (1986) 1.50
Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA. Cell (1980) 1.50
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. FASEB J (1987) 1.50
The major excreted protein of transformed fibroblasts is an activable acid-protease. J Biol Chem (1986) 1.48
Phosphorylation of the 10-nm filament protein from Chinese hamster ovary cells. J Biol Chem (1979) 1.46
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. J Natl Cancer Inst (1990) 1.44
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L. Biochem J (1987) 1.44
Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. J Biol Chem (1996) 1.43
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated. J Cell Biol (1985) 1.41
Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions. Hum Gene Ther (1998) 1.41
Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin. Proc Natl Acad Sci U S A (1981) 1.41
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem (1987) 1.40
Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem (1996) 1.40
Expression of cathepsin L in human tumors. Cancer Res (1991) 1.37
Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem (1990) 1.37
Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells. J Natl Cancer Inst (1992) 1.36
Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene. J Clin Oncol (1987) 1.35
A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. Proc Natl Acad Sci U S A (1993) 1.35
Rous sarcoma virus transformed cells are resistant to cyclic AMP. J Cell Physiol (1982) 1.33
Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine. J Biol Chem (1989) 1.33
Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells. Cell Growth Differ (1990) 1.32
Multidrug resistance. Annu Rev Med (1991) 1.31
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science (1987) 1.28
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem (1989) 1.24
Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J Biol Chem (1992) 1.24
Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli. J Biol Chem (1989) 1.23
Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry (1999) 1.22
The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes. Proc Natl Acad Sci U S A (1986) 1.21
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proc Natl Acad Sci U S A (1987) 1.21
New att mutants of phage lambda. Virology (1976) 1.20
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. Br J Cancer (1995) 1.16
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer. Br J Cancer (1996) 1.16
Intermediate filaments from Chinese hamster ovary cells contain a single protein. Comparison with more complex systems from baby hamster kidney and mouse epidermal cells. J Biol Chem (1981) 1.16
Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. Mol Pharmacol (1988) 1.15
The role of cathepsin L in malignant transformation. Semin Cancer Biol (1990) 1.15
MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J Natl Cancer Inst (1994) 1.15
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. Proc Natl Acad Sci U S A (1985) 1.15
Purification and characterization of a transformation-dependent protein secreted by cultured murine fibroblasts. Biochemistry (1981) 1.13
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. Biochemistry (1990) 1.13
Mutations in alpha- and beta-tubulin affect spindle formation in Chinese hamster ovary cells. J Cell Biol (1983) 1.12
The predominant secreted protein of transformed murine fibroblasts carries the lysosomal mannose 6-phosphate recognition marker. J Biol Chem (1982) 1.12
Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines. Br J Cancer (2003) 1.12
Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Mol Biol Cell (1992) 1.12
Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry (1988) 1.11
Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells. J Histochem Cytochem (1987) 1.11
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Mol Biol Cell (1996) 1.11
P-glycoproteins: mediators of multidrug resistance. Semin Cell Biol (1993) 1.11
Genetic basis of multidrug resistance of tumor cells. J Bioenerg Biomembr (1990) 1.11
Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity. J Biol Chem (1983) 1.11
High frequency of mutation to tubercidin resistance in CHO cells. Somatic Cell Genet (1979) 1.10
Multidrug resistance in human cancer. Crit Rev Oncol Hematol (1992) 1.10
A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol. Biochemistry (1999) 1.10
Induction of specific protein synthesis by phorbol esters in mouse epidermal cell culture. Cancer Res (1981) 1.08
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation. J Biol Chem (1988) 1.07
Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease. Hum Gene Ther (1995) 1.07
Expression of the multidrug resistance, MDR1, gene in neuroblastomas. J Clin Oncol (1990) 1.07
The Devi case and more. Science (1995) 1.07