Published in J Biol Chem on May 15, 1986
Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase. J Cell Biol (1988) 2.72
Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome. J Clin Invest (1996) 1.35
Signaling processes for initiating smooth muscle contraction upon neural stimulation. J Biol Chem (2009) 1.23
Contractile elements and myosin light chain phosphorylation in myometrial tissue from nonpregnant and pregnant women. J Clin Invest (1993) 1.12
Studies on fenestral contraction in rat liver endothelial cells in culture. Am J Pathol (1996) 1.07
Mechanisms of Ca2+ sensitization of force production by noradrenaline in rat mesenteric small arteries. J Physiol (1998) 1.01
Vascular smooth muscle contractile elements. Cellular regulation. Hypertension (1991) 1.01
Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion. J Biol Chem (2009) 0.97
Phosphorylation of a single head of smooth muscle myosin activates the whole molecule. Biochemistry (2006) 0.97
Cooperativity between two heads of dictyostelium myosin II in in vitro motility and ATP hydrolysis. Biophys J (1999) 0.95
Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery. Br J Pharmacol (2003) 0.93
Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery. Br J Pharmacol (1993) 0.93
NH2-terminal fragments of the 130 kDa subunit of myosin phosphatase increase the Ca2+ sensitivity of porcine renal artery. J Physiol (1999) 0.92
Time-dependent changes in Ca2+ sensitivity during phasic contraction of canine antral smooth muscle. J Physiol (1991) 0.92
Mechanisms of vasoconstriction induced by endothelin-1 in smooth muscle of rabbit mesenteric artery. J Physiol (1994) 0.85
Effect of a peptide inhibitor of protein kinase C on G-protein-mediated increase in myofilament Ca(2+)-sensitivity in rabbit arterial skinned muscle. Br J Pharmacol (1994) 0.85
Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure. Am J Physiol Heart Circ Physiol (2013) 0.83
Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. Br J Pharmacol (2001) 0.82
Alteration of the [Ca(2+)](i)-force relationship during the vasorelaxation induced by a Ca(2+) channel blocker SR33805 in the porcine coronary artery. Br J Pharmacol (2000) 0.81
Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus. Br J Pharmacol (2007) 0.81
{alpha}-Adrenoceptor constrictor responses and their modulation in slow-twitch and fast-twitch mouse skeletal muscle. J Physiol (2004) 0.81
Heparin inhibits Ca2+/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells. Biochem J (1998) 0.81
Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries. PLoS One (2013) 0.81
Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. J Physiol (2014) 0.80
Modeling smooth muscle myosin's two heads: long-lived enzymatic roles and phosphorylation-dependent equilibria. Biophys J (2010) 0.79
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries. Br J Pharmacol (2010) 0.79
Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein. PLoS One (2016) 0.75
V-1 regulates capping protein activity in vivo. Proc Natl Acad Sci U S A (2016) 0.75
Physiological versus pharmacological signalling to myosin phosphorylation in airway smooth muscle. J Physiol (2017) 0.75
The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol (1985) 4.80
Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem (2000) 3.89
Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci U S A (1998) 3.00
Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. Am J Physiol (1993) 2.81
Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2000) 2.49
The EF-hand family of calcium-modulated proteins. Trends Neurosci (1989) 2.12
Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc Natl Acad Sci U S A (1996) 2.06
Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies. Nat Cell Biol (1999) 2.01
Regulation of smooth muscle contractile elements by second messengers. Annu Rev Physiol (1989) 1.98
The effect of myosin phosphorylation on the contractile properties of skinned rabbit skeletal muscle fibers. J Biol Chem (1985) 1.95
Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction. Proc Natl Acad Sci U S A (1990) 1.87
Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments. Biophys J (1996) 1.75
Measurement of cyclic 3',5'-denosine monophosphate by the activation of skeletal muscle protein kinase. J Biol Chem (1971) 1.72
Phosphorylation of the inhibitor component of troponin by phosphorylase kinase. J Biol Chem (1972) 1.71
Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proc Natl Acad Sci U S A (1994) 1.67
Myosin light chain kinases. J Muscle Res Cell Motil (1997) 1.67
Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells. Am J Physiol (1986) 1.66
Molecular characterization of a mammalian smooth muscle myosin light chain kinase. J Biol Chem (1991) 1.59
nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle. Physiol Genomics (2000) 1.54
Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation. J Biol Chem (2000) 1.50
Molecular mechanisms of beta-adrenergic relaxation of airway smooth muscle. Annu Rev Physiol (1996) 1.49
The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle. FEBS Lett (1974) 1.49
Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle. Am J Physiol (1998) 1.46
Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin. Biochemistry (1980) 1.43
Phosphorylation of cardiac troponin by cyclic adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1977) 1.41
Structures of calmodulin and a functional myosin light chain kinase in the activated complex: a neutron scattering study. Biochemistry (1997) 1.41
Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads. Science (1981) 1.40
Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells. J Biol Chem (1994) 1.40
Myosin light chain kinase phosphorylation in tracheal smooth muscle. J Biol Chem (1990) 1.37
Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. J Biol Chem (1993) 1.35
Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev (2001) 1.35
Ca2+, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle. Am J Physiol (1983) 1.31
Myosin light chain phosphorylation in fast and slow skeletal muscles in situ. Am J Physiol (1984) 1.31
GTP gamma S-dependent regulation of smooth muscle contractile elements. Am J Physiol (1992) 1.29
Localization and activity of myosin light chain kinase isoforms during the cell cycle. J Cell Biol (2000) 1.29
Measurement of chemical phosphate in proteins. Methods Enzymol (1983) 1.29
Activation of smooth muscle contraction: relation between myosin phosphorylation and stiffness. Science (1986) 1.27
Myosin light chain phosphorylation and phosphorylase A activity in rat extensor digitorum longus muscle. Biochem Biophys Res Commun (1979) 1.27
Sites phosphorylated in myosin light chain in contracting smooth muscle. J Biol Chem (1988) 1.27
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles. Physiol Genomics (2001) 1.25
Phosphorylation of myosin in perfused rabbit and rat hearts. Am J Physiol (1980) 1.25
Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide. FEBS Lett (1998) 1.23
Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells. J Biol Chem (1992) 1.20
Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle. Am J Physiol (1982) 1.18
Frequency-dependent myosin light chain phosphorylation in isolated myocardium. J Mol Cell Cardiol (1986) 1.17
Myosin phosphorylation, force, and maximal shortening velocity in neurally stimulated tracheal smooth muscle. Am J Physiol (1985) 1.16
Effects of pH, ionic strength, and temperature on activation by calmodulin an catalytic activity of myosin light chain kinase. Biochemistry (1982) 1.15
Identification of a novel actin binding motif in smooth muscle myosin light chain kinase. J Biol Chem (1999) 1.13
Contractile elements and myosin light chain phosphorylation in myometrial tissue from nonpregnant and pregnant women. J Clin Invest (1993) 1.12
Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains. J Struct Biol (1998) 1.12
Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle. Am J Physiol (1982) 1.11
Ordered phosphorylation of the two 20 000 molecular weight light chains of smooth muscle myosin. Biochemistry (1983) 1.11
Properties of filament-bound myosin light chain kinase. J Biol Chem (1999) 1.07
Phosphorylation of smooth muscle myosin heavy and light chains. Effects of phorbol dibutyrate and agonists. J Biol Chem (1989) 1.07
Substrate specificity of myosin light chain kinases. J Biol Chem (1992) 1.07
Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol. Curr Biol (2000) 1.07
Domain characterization of rabbit skeletal muscle myosin light chain kinase. J Biol Chem (1990) 1.06
Calcium dependence of myosin light chain phosphorylation in smooth muscle cells. J Biol Chem (1988) 1.06
Activation properties of myosin light chain kinase during contraction/relaxation cycles of tonic and phasic smooth muscles. J Biol Chem (1994) 1.06
Regulation of phosphorylase activation in skeletal muscle in vivo. J Biol Chem (1971) 1.05
Modulation of myosin filament conformation by physiological levels of divalent cation. J Mol Biol (1984) 1.05
Calmodulin directly gates gap junction channels. J Biol Chem (2000) 1.04
Phosphorylation of skeletal muscle contractile proteins in vivo. Biochem Biophys Res Commun (1977) 1.03
Binding of myosin light chain kinase to cellular actin-myosin filaments. J Biol Chem (1997) 1.03
A molecular mechanism for autoinhibition of myosin light chain kinases. J Biol Chem (1993) 1.03
Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers. J Struct Biol (1998) 1.02
Phosphorylation of contractile proteins in relation to muscle function. Adv Cyclic Nucleotide Res (1980) 1.02
Phosphorylation-dependent structural changes in the regulatory light chain domain of smooth muscle heavy meromyosin. J Biol Chem (1999) 1.01
Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization. Mol Cell Biochem (1993) 1.01
Vascular smooth muscle contractile elements. Cellular regulation. Hypertension (1991) 1.01
Myosin phosphorylation in smooth and skeletal muscles: regulation and function. Prog Clin Biol Res (1990) 1.01
Small-angle X-ray scattering studies of calmodulin mutants with deletions in the linker region of the central helix indicate that the linker region retains a predominantly alpha-helical conformation. Biochemistry (1991) 1.00
Interference with lysosomal proteolysis fails to reduce cardiac myosin degradation. Biochem Biophys Res Commun (1980) 1.00
Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. Am J Physiol Cell Physiol (2001) 0.99
Okadaic acid uncouples myosin light chain phosphorylation and tension in smooth muscle. FEBS Lett (1990) 0.99
Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem (1986) 0.98
Regulation of myosin light chain and phosphorylase phosphorylation in tracheal smooth muscle. J Biol Chem (1982) 0.98
Myosin phosphorylation during contraction and relaxation of tracheal smooth muscle. J Biol Chem (1980) 0.98
The effect of low frequency stimulation on myosin light chain phosphorylation in skeletal muscle. J Biol Chem (1982) 0.98
Regulation of contraction by myosin phosphorylation. A comparison between smooth and skeletal muscles. Biochem Pharmacol (1980) 0.97
Molecular characterization of rat skeletal muscle myosin light chain kinase. Am J Physiol (1989) 0.97
Myosin phosphorylation regulates the ATPase activity of permeable skeletal muscle fibers. FEBS Lett (1982) 0.96
Effects of cGMP on [Ca2+]i, myosin light chain phosphorylation, and contraction in human myometrium. Am J Physiol (1991) 0.96
Biochemical events associated with activation of smooth muscle contraction. J Biol Chem (1988) 0.96
Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases. J Biol Chem (1992) 0.96