Published in Nature on June 11, 1986
Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria. EMBO J (1987) 2.08
Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes. EMBO J (1989) 2.00
Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process. Microbiol Rev (1989) 1.99
Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. EMBO J (1988) 1.82
Unfolding and refolding of a purified precursor protein during import into isolated mitochondria. EMBO J (1988) 1.75
Point mutations destabilizing a precursor protein enhance its post-translational import into mitochondria. EMBO J (1988) 1.58
Linking functional domains of the human insulin receptor with the bacterial aspartate receptor. Proc Natl Acad Sci U S A (1986) 0.94
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J Biol Chem (1982) 12.07
Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A (1984) 7.39
Biogenesis of mitochondria. Annu Rev Cell Biol (1988) 6.96
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature (1986) 5.58
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. J Biol Chem (1982) 4.25
Protein translocation across membranes. Science (1988) 4.12
Properties of avian retrovirus particles defective in viral protease. J Virol (1990) 4.03
How are proteins imported into mitochondria? Cell (1983) 3.69
The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix. EMBO J (1984) 3.69
Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J (1999) 3.58
Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell (1992) 3.42
Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent. J Biol Chem (1982) 3.26
A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus. EMBO J (1984) 2.96
A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. EMBO J (1986) 2.91
Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides. J Biol Chem (1983) 2.81
The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix. FEBS Lett (1984) 2.75
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein. EMBO J (1990) 2.56
Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins. EMBO J (1983) 2.55
Cytochrome c oxidase from bakers' yeast. I. Isolation and properties. J Biol Chem (1973) 2.50
The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles. EMBO J (1983) 2.48
Import of proteins into mitochondria. Energy-dependent, two-step processing of the intermembrane space enzyme cytochrome b2 by isolated yeast mitochondria. J Biol Chem (1982) 2.46
Immunogenicity of hepatitis B Vaccines. Implications for persons at occupational risk of hepatitis B virus infection. Am J Prev Med (1998) 2.41
Imported mitochondrial proteins cytochrome b2 and cytochrome c1 are processed in two steps. Proc Natl Acad Sci U S A (1982) 2.39
Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria. Nature (1991) 2.37
Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptides. J Biol Chem (1982) 2.34
Import of proteins into mitochondria: a 70 kilodalton outer membrane protein with a large carboxy-terminal deletion is still transported to the outer membrane. EMBO J (1983) 2.33
Isolation of the nuclear yeast genes for citrate synthase and fifteen other mitochondrial proteins by a new screening method. EMBO J (1984) 2.33
Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science (1998) 2.27
Sequential action of mitochondrial chaperones in protein import into the matrix. EMBO J (1991) 2.27
Heme is necessary for the accumulation and assembly of cytochrome c oxidase subunits in Saccharomyces cerevisiae. J Biol Chem (1978) 2.25
Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70. EMBO J (1990) 2.22
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature (1989) 2.18
Mitochondrial presequences. J Biol Chem (1988) 2.18
The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting. Cell (1986) 2.14
Energy-dependent processing of cytoplasmically made precursors to mitochondrial proteins. Proc Natl Acad Sci U S A (1979) 2.14
Import of proteins into mitochondria. Extramitochondrial pools and post-translational import of mitochondrial protein precursors in vivo. J Biol Chem (1982) 2.12
Artificial mitochondrial presequences. Proc Natl Acad Sci U S A (1986) 2.11
Both ATP and an energized inner membrane are required to import a purified precursor protein into mitochondria. EMBO J (1987) 2.08
The first twelve amino acids of a yeast mitochondrial outer membrane protein can direct a nuclear-coded cytochrome oxidase subunit to the mitochondrial inner membrane. EMBO J (1985) 2.06
A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen. Proc Natl Acad Sci U S A (1986) 2.01
A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria. EMBO J (1984) 1.99
Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins. J Cell Biol (1989) 1.98
Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein. EMBO J (1984) 1.97
Import of proteins into mitochondria: nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane. EMBO J (1983) 1.97
MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J (1988) 1.95
DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature (1989) 1.95
Amphiphilicity is essential for mitochondrial presequence function. EMBO J (1988) 1.93
Mas37p, a novel receptor subunit for protein import into mitochondria. J Cell Biol (1995) 1.89
A two-subunit cytochrome c oxidase (cytochrome aa3) from Paracoccus dentrificans. Proc Natl Acad Sci U S A (1980) 1.88
Mitochondria: a historical review. J Cell Biol (1981) 1.88
Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A (1994) 1.87
Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. EMBO J (1988) 1.87
Mitochondrial assembly in respiration-deficient mutants of Saccharomyces cerevisiae. II. Effect of nuclear and extrachromosomal mutations on the formation of cytochrome c oxidase. J Biol Chem (1973) 1.85
ATP-dependent proteases that also chaperone protein biogenesis. Trends Biochem Sci (1997) 1.85
Protein unfolding and the energetics of protein translocation across biological membranes. Cell (1988) 1.84
Import of proteins into mitochondria. Annu Rev Genet (1991) 1.84
A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites. J Cell Biol (1988) 1.83
A yeast mitochondrial outer membrane protein essential for protein import and cell viability. Nature (1990) 1.82
Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science (1994) 1.82
Promitochondria of anaerobically grown yeast. I. Isolation and biochemical properties. Biochemistry (1969) 1.79
Unfolding and refolding of a purified precursor protein during import into isolated mitochondria. EMBO J (1988) 1.75
The cytoplasmically-made subunit IV is necessary for assembly of cytochrome c oxidase in yeast. EMBO J (1985) 1.75
Cytochrome c oxidase from bakers' yeast. II. Site of translation of the protein components. J Biol Chem (1973) 1.71
Functional cooperation of mitochondrial protein import receptors in yeast. EMBO J (1993) 1.71
Import of proteins into mitochondria. Translatable mRNAs for imported mitochondrial proteins are present in free as well as mitochondria-bound cytoplasmic polysomes. J Biol Chem (1982) 1.70
Energy transfer and charge separation kinetics in photosystem I: Part 1: Picosecond transient absorption and fluorescence study of cyanobacterial photosystem I particles. Biophys J (1993) 1.69
Cytochrome c oxidase from bakers' yeast. III. Physical characterization of isolated subunits and chemical evidence for two different classes of polypeptides. J Biol Chem (1975) 1.68
The protein import receptor of mitochondria. Trends Biochem Sci (1995) 1.68
Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A (1992) 1.67
A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. EMBO J (1985) 1.66
Active unfolding of precursor proteins during mitochondrial protein import. EMBO J (1997) 1.62
Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence. EMBO J (1984) 1.61
Cytochrome c oxidase from bakers' yeast. IV. Immunological evidence for the participation of a mitochondrially synthesized subunit in enzymatic activity. J Biol Chem (1975) 1.61
Cyclophilin catalyzes protein folding in yeast mitochondria. Proc Natl Acad Sci U S A (1995) 1.60
17th Sir Hans Krebs lecture. Signals guiding proteins to their correct locations in mitochondria. Eur J Biochem (1987) 1.60
A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J (1994) 1.60
Point mutations destabilizing a precursor protein enhance its post-translational import into mitochondria. EMBO J (1988) 1.58
Biosynthesis and assembly of the proton-translocating adenosine triphosphatase complex from chloroplasts. Proc Natl Acad Sci U S A (1980) 1.57
Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast. EMBO J (1991) 1.56
Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins. EMBO J (1998) 1.55
Promitochondria of anaerobically grown yeast. 3. Morphology. Biochemistry (1969) 1.54
Dynamic interaction of the protein translocation systems in the inner and outer membranes of yeast mitochondria. EMBO J (1995) 1.54
Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A (1999) 1.53
The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast. Proc Natl Acad Sci U S A (1994) 1.52
Disrupted yeast mitochondria can import precursor proteins directly through their inner membrane. J Cell Biol (1989) 1.51
An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J (1995) 1.51
Protein sorting in mitochondria. Trends Biochem Sci (1992) 1.51
Import of proteins into mitochondria. In vitro studies on the biogenesis of the outer membrane. J Biol Chem (1983) 1.51
Import of proteins into mitochondria. Import and maturation of the mitochondrial intermembrane space enzymes cytochrome b2 and cytochrome c peroxidase in intact yeast cells. J Biol Chem (1982) 1.50
Identification of cytochrome c oxidase subunits in nuclear yeast mutants lacking the functional enzyme. J Biol Chem (1978) 1.50
Partial resolution of the enzymes catalyzing oxidative phosphorylation. XIV. J Biol Chem (1967) 1.48
Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria. EMBO J (1995) 1.47
How mitochondria import proteins from the cytoplasm. FEBS Lett (1979) 1.47
Disruption of the outer membrane restores protein import to trypsin-treated yeast mitochondria. EMBO J (1987) 1.46
Mitochondria can import artificial precursor proteins containing a branched polypeptide chain or a carboxy-terminal stilbene disulfonate. J Cell Biol (1988) 1.45
Import of cytochrome b2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci (1993) 1.45
A cytosolic protein contains a cryptic mitochondrial targeting signal. Nature (1987) 1.45