Published in J Exp Med on November 01, 1986
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A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica. J Exp Med (1992) 1.53
Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scid mice. Natural history and pathobiology. Am J Pathol (1990) 1.48
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Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun (1988) 1.21
Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice. Infect Immun (1994) 0.99
Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from p53-deficient mice. J Exp Med (1995) 0.90
Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein. Infect Immun (2001) 0.86
T-cell receptor beta gene rearrangements in clones derived from human CD4-8- cells expressing natural killer cell activity. Immunology (1988) 0.78
Therapeutic effect of granulocyte colony-stimulating factor (G-CSF) on the protection against Listeria infection in SCID mice. Immunology (1993) 0.78
Murine lymphocytes with natural killer activity express CTL-derived serine protease genes. Immunology (1989) 0.75
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature (1981) 4.78
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T cell antigen receptors and the immunoglobulin supergene family. Cell (1985) 3.23
Limited diversity of the rearranged T-cell gamma gene. Nature (1985) 2.58
Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol (1984) 2.56
Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor. Nature (1985) 2.50
Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes. J Exp Med (1986) 2.01
Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes. Proc Natl Acad Sci U S A (1986) 1.54
Analysis of T cell receptors in highly purified rat and human large granular lymphocytes (LGL): lack of functional 1.3 kb beta-chain mRNA. J Immunol (1986) 1.14
Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines. J Exp Med (1985) 1.07
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A (1993) 20.33
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (1983) 11.57
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12
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Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell (1985) 6.88
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA (2001) 4.75
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell (1986) 4.68
Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol (1985) 4.61
The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med (1977) 4.44
The scid mutation in mice causes a general defect in DNA repair. Nature (1990) 3.85
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Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions. N Engl J Med (1968) 3.57
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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron (1999) 3.50
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science (1995) 3.24
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11
Migration and stopover in a small pelagic seabird, the Manx shearwater Puffinus puffinus: insights from machine learning. Proc Biol Sci (2009) 3.03
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci (1997) 2.89
Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells. J Immunol (1972) 2.83
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med (1999) 2.81
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol (1992) 2.78
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. J Neurophysiol (2001) 2.76
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell (1988) 2.71
A uniform deleting element mediates the loss of kappa genes in human B cells. Nature (1985) 2.65
Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol (1984) 2.56
Oral maintenance therapy for cholera in adults. Lancet (1968) 2.53
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev (1996) 2.47
Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci U S A (1985) 2.44
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature (1999) 2.32
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CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Neuron (2001) 2.22
Genetic origin of mutations predisposing to retinoblastoma. Science (1985) 2.22
Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells. Nature (1983) 2.20
Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13
The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol (1979) 2.11
Repair of potentially lethal damage in x-irradiated HeLa cells. Radiat Res (1966) 2.09
The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron (2001) 2.02
The beige mutation in the mouse. II. Selectivity of the natural killer (NK) cell defect. J Immunol (1979) 2.02
Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. I. Study design and results of the first year of observation. Bull World Health Organ (1969) 2.00
Mutations in the RB1 gene and their effects on transcription. Mol Cell Biol (1989) 2.00
Identification of germline and somatic mutations affecting the retinoblastoma gene. Science (1988) 2.00
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity (2001) 1.93
Allograft immunity in the mouse. II. Physical studies of the development of cytotoxic effector cells from their immediate progenitors. J Immunol (1973) 1.89
Quantitative studies of the activation of cytotoxic lymphocyte precursor cells. Immunol Rev (1977) 1.87
Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Proc Natl Acad Sci U S A (1987) 1.86
Hypertensive cardiovascular damage in patients with primary autonomic failure. Lancet (2000) 1.86
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J (1989) 1.86
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet (2001) 1.82
Src activation in the induction of long-term potentiation in CA1 hippocampal neurons. Science (1998) 1.81
A new immunodeficiency disorder in humans involving NK cells. Nature (1980) 1.78
Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin Immunol (2000) 1.77
Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. Nature (1984) 1.77
Exploratory analysis of the safety climate and safety behavior relationship. J Safety Res (2004) 1.74
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A (2000) 1.73
Human hybridomas constructed with antigen-specific Epstein-Barr virus-transformed cell lines. Proc Natl Acad Sci U S A (1982) 1.73
Water and sodium absorption in the human intestine. J Physiol (1968) 1.72
Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma. Nature (1983) 1.71
Target-effector interaction in the natural killer cell system: isolation of target structures. Proc Natl Acad Sci U S A (1979) 1.71
Target--effector interaction in the natural killer cell system. I. Covariance and genetic control of cytolytic and target-cell-binding subpopulations in the mouse. Scand J Immunol (1978) 1.70
A quantitative assay for the progenitors of bone marrow-associated lymphocytes. J Exp Med (1972) 1.69
Preferential germline mutation of the paternal allele in retinoblastoma. Nature (1989) 1.69
Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two unrelated males based on studies of maternal T cell X chromosome inactivation. Blood (1990) 1.68
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science (1989) 1.60
Quantitative studies on the precursors of cytotoxic lymphocytes. I. Characterization of a clonal assay and determination of the size of clones derived from single precursors. J Immunol (1977) 1.57
Constraints of interest: lessons at the Hospital for Sick Children. CMAJ (1998) 1.54
Retinoma: spontaneous regression of retinoblastoma or benign manifestation of the mutation? Br J Cancer (1982) 1.52
X-chromosome inactivation in the Wiskott-Aldrich syndrome: a marker for detection of the carrier state and identification of cell lineages expressing the gene defect. Genomics (1989) 1.49
Differentiation of rosette-forming cells from myeloid stem cells. J Immunol (1970) 1.49
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem (1999) 1.48
The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis Cartilage (1995) 1.45
Requirements for the establishment of high-titered human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus technique. J Immunol (1981) 1.45
Homogeneity of antibody-producing cells as analysed by their buoyant density in gradients of Ficoll. Immunology (1970) 1.45
Using the rat as a cholera "model". Nature (1968) 1.45
Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer. Nature (1986) 1.44
The retinoblastoma protein and cell cycle regulation. Trends Genet (1992) 1.42
Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. Nature (1980) 1.42
The genetics of retinoblastoma. Relevance to the patient. Pediatr Clin North Am (1991) 1.42
Cumulative effect of phosphorylation of pRB on regulation of E2F activity. Mol Cell Biol (1999) 1.42
SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol (1998) 1.41
In vivo requirement for a radiation-resistant cells in the immune response to sheep erythrocytes. J Exp Med (1971) 1.41
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. J Exp Med (2001) 1.40
Natural killer cells. Prog Allergy (1981) 1.38
Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice. Genes Brain Behav (2007) 1.37
The function of antigen-presenting cells in mice with severe combined immunodeficiency. J Immunol (1985) 1.36
Identification by density separation of antigen-specific surface receptors on the progenitors of antibody-producing cells. Immunology (1971) 1.35
Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene (1992) 1.35
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med (1996) 1.34
The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene (1997) 1.34
Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 3. The lack of effect of prior vaccination or circulating vibriocidal antibody on the severity of clinical cholera. Bull World Health Organ (1969) 1.33
Cholera in the perspective of 1966. Ann Intern Med (1966) 1.33
High level functional engraftment of severe combined immunodeficient mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GM1. J Immunol Methods (1994) 1.32
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol Psychiatry (2007) 1.32
Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16. Gastroenterology (1998) 1.32
Ontogeny of murine B lymphocytes: development of Ig synthesis and of reactivities to mitogens and to anti-Ig-antibodies. Cold Spring Harb Symp Quant Biol (1977) 1.31