Published in Proc Natl Acad Sci U S A on February 01, 1985
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proc Natl Acad Sci U S A (1986) 2.33
Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol (1988) 1.81
Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol (1987) 1.58
Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol (1998) 1.50
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A (1988) 1.36
Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol (1988) 1.24
Circular DNA of 3T6R50 double minute chromosomes. Nucleic Acids Res (1988) 1.24
Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation. Proc Natl Acad Sci U S A (1986) 1.15
Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation. EMBO J (1995) 1.05
Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani. Mol Cell Biol (1992) 1.05
Analysis of gene expression using episomal mouse dihydrofolate reductase minigenes. Nucleic Acids Res (1988) 0.97
Stable transformation of a mosquito cell line results in extraordinarily high copy numbers of the plasmid. Proc Natl Acad Sci U S A (1992) 0.94
Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells. PLoS One (2013) 0.94
Nature of B chromosomes in the harvest mouse Reithrodontomys megalotis by fluorescence in situ hybridization (FISH). Chromosome Res (1997) 0.84
Molecular structure and evolution of double-minute chromosomes in methotrexate-resistant cultured mouse cells. Mol Cell Biol (1992) 0.83
Amplicon structure in multidrug-resistant murine cells: a nonrearranged region of genomic DNA corresponding to large circular DNA. Mol Cell Biol (1992) 0.81
CpG island mapping of a mouse double-minute chromosome. Mol Cell Biol (1993) 0.77
Detection of viral sequences of low reiteration frequency by in situ hybridization. Proc Natl Acad Sci U S A (1978) 7.95
Solenoidal model for superstructure in chromatin. Proc Natl Acad Sci U S A (1976) 6.65
Gene amplification in cultured animal cells. Cell (1984) 5.43
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proc Natl Acad Sci U S A (1978) 4.60
Visualization of nucleolar genes. Science (1969) 3.99
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. J Biol Chem (1982) 3.25
Metaphase chromosome structure: evidence for a radial loop model. Cell (1979) 3.16
Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1981) 2.83
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line. Science (1977) 2.80
Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science (1976) 2.79
Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions. Cancer Res (1979) 2.31
Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell (1984) 2.28
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. J Cell Biol (1979) 2.09
In situ hybridization at the electron microscope level: hybrid detection by autoradiography and colloidal gold. J Cell Biol (1982) 2.06
Arrangement of centromeres in mouse cells. Chromosoma (1971) 1.92
Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines. Mol Cell Biol (1981) 1.83
Extrachromosomal nucleolar genes in amphibian oocytes. Genetics (1969) 1.64
Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes. Cell (1981) 1.59
Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1981) 1.54
Higher order structure in metaphase chromosomes. I. The 250 A fiber. Chromosoma (1978) 1.45
Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells. Cell (1980) 1.43
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Mol Cell Biol (1981) 1.42
Have double minutes functioning centromeres? Hereditas (1978) 1.25
Chromatin organization during meiotic prophase of Bombyx mori. Chromosoma (1980) 1.10
Nucleosome packing in interphase chromatin. J Cell Biol (1979) 1.03
Ultrastructure of double minutes from a human tumor cell line. J Cell Biol (1979) 0.99
A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants. J Cell Biol (1984) 0.92
Ultrastructural organization of double minute chromosomes and HSR regions in human colon carcinoma cells. Cytogenet Cell Genet (1984) 0.80
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem (1978) 9.13
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. J Biol Chem (1978) 8.20
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
Gene amplification in cultured animal cells. Cell (1984) 5.43
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proc Natl Acad Sci U S A (1978) 4.60
Control of enzyme levels in animal tissues. Annu Rev Biochem (1970) 4.59
Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell (1980) 4.25
Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25
Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells. Cell (1980) 4.23
An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression. Nucleic Acids Res (2001) 4.16
Synthesis of full length cDNAs from four partially purified oviduct mRNAs. J Biol Chem (1978) 3.92
c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc Natl Acad Sci U S A (1998) 3.81
Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci U S A (1979) 3.68
Multiple hexokinases of rat tissues. Purification and comparison of soluble forms. J Biol Chem (1966) 3.56
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev (1994) 3.27
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. J Biol Chem (1982) 3.25
Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver. J Biol Chem (1969) 3.24
Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature (1986) 3.18
Visualization of bacterial genes in action. Science (1970) 3.18
Methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mRNA's. J Biol Chem (1979) 3.08
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol Cell Biol (1992) 3.06
Influence of turnover rates on the responses of enzymes to cortisone. Mol Pharmacol (1965) 3.05
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site. Mol Cell Biol (1990) 2.96
Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol (2000) 2.85
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
The generation of energy by the arginine dihydrolase pathway in Mycoplasma hominis 07. J Biol Chem (1966) 2.70
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol Cell Biol (1983) 2.68
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
Synthetic sites for transcription termination and a functional comparison with tryptophan operon termination sites in vitro. Proc Natl Acad Sci U S A (1981) 2.62
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A (1983) 2.59
Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene. J Biol Chem (1982) 2.59
One-year outcome of elderly and young patients admitted to intensive care units. Crit Care Med (1993) 2.58
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors. J Mol Biol (2001) 2.56
Optimal positioning for cervical immobilization. Ann Emerg Med (1996) 2.55
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell (1979) 2.55
Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct. J Biol Chem (1976) 2.55
Rho-independent termination: dyad symmetry in DNA causes RNA polymerase to pause during transcription in vitro. Nucleic Acids Res (1981) 2.46
Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proc Natl Acad Sci U S A (1982) 2.45
Cyclization of eucaryotic deoxyribonucleic acid fragments. J Mol Biol (1970) 2.43
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. J Biol Chem (1976) 2.36
Quality of life measures before and one year after admission to an intensive care unit. Crit Care Med (1995) 2.35
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proc Natl Acad Sci U S A (1986) 2.33
Gene amplification in a single cell cycle in Chinese hamster ovary cells. J Biol Chem (1984) 2.32
Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle. J Biol Chem (1985) 2.31
Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1985) 2.30
A model for transcription termination suggested by studies on the trp attenuator in vitro using base analogs. Cell (1980) 2.30
Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions. J Biol Chem (1985) 2.29
Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell (1984) 2.28
Characterization of a cloned repetitive DNA sequence concentrated on the human X chromosome. Proc Natl Acad Sci U S A (1982) 2.28
Introduction to the E2F family: protein structure and gene regulation. Curr Top Microbiol Immunol (1996) 2.24
The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med (1994) 2.23
Isolation of hen oviduct ovalbumin and rat live albumin polysomes by indirect immunoprecipitation. J Biol Chem (1974) 2.20
Quantitative measurement of ovalbumin messenger ribonucleic acid activity. Localization in polysomes, induction by estrogen, and effect of actinomycin D. J Biol Chem (1973) 2.17
Synthesis of rat liver albumin in a rabbit reticulocyte cell-free protein-synthesizing system. J Biol Chem (1973) 2.13
Studies of the stability in vivo and in vitro of rat liver tryptophan pyrrolase. J Biol Chem (1965) 2.13
Development of a toxicological gene array and quantitative assessment of this technology. Arch Biochem Biophys (2000) 2.13
Organization of polysomes from pre-existing ribosomes in chick oviduct by a secondary administration of either estradiol or progesterone. J Biol Chem (1970) 2.12
Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc Natl Acad Sci U S A (1990) 2.10
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. J Cell Biol (1979) 2.09
Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol (1999) 2.09
An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants. Mol Cell Biol (1995) 2.08
Insulin-treated diabetes and driving in the UK. Diabet Med (2002) 2.07
In situ hybridization at the electron microscope level: hybrid detection by autoradiography and colloidal gold. J Cell Biol (1982) 2.06
Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation. Health Technol Assess (2013) 2.06
An analysis of the kinetics of rat liver tryptophan pyrrolase induction: the significance of both enzyme synthesis and degradation. Biochem Biophys Res Commun (1964) 2.06
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes. J Biol Chem (1973) 2.05
Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. J Biol Chem (1978) 2.00
Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc Natl Acad Sci U S A (1988) 1.99
Effects of NusA protein on transcription termination in the tryptophan operon of Escherichia coli. Cell (1982) 1.96
Studies on the correlation between size and relative degradation rate of soluble proteins. J Biol Chem (1973) 1.96
Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta (1974) 1.93
Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. J Biol Chem (1979) 1.92
A re-examination of the 5' termini of mouse dihydrofolate reductase RNA. J Biol Chem (1986) 1.92
Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties. Proc Natl Acad Sci U S A (1965) 1.91
Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. J Biol Chem (1984) 1.86
Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines. Mol Cell Biol (1981) 1.83
Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harb Symp Quant Biol (1978) 1.81
Presence of the arginine dihydrolase pathway in Mycoplasma. J Bacteriol (1966) 1.81
Gene amplification, drug resistance, and cancer. Cancer Res (1984) 1.79
Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. J Biol Chem (1976) 1.79
Air insufflation technique of enteral tube insertion: a randomized, controlled trial. Crit Care Med (1998) 1.77
Synthesis of ovalbumin in a rabbit reticulocyte cell-free system programmed with hen oviduct ribonucleic acid. J Biol Chem (1971) 1.71
Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. J Biol Chem (1981) 1.71
2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature (1979) 1.71
Ovalbumin messenger RNA: evidence that the initial product of transcription is the same size as polysomal ovalbumin messenger. Proc Natl Acad Sci U S A (1974) 1.69
Size distribution of membrane proteins of rat liver and their relative rates of degradation. J Biol Chem (1971) 1.68
Control of enzyme levels in mammalian tissues. Adv Enzymol Relat Areas Mol Biol (1973) 1.67
Cost accounting of adult intensive care: methods and human and capital inputs. Crit Care Med (1996) 1.65
S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1981) 1.65
In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene. Mol Cell Biol (1986) 1.64