Published in Mol Cell Biol on May 01, 1995
c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol (1999) 8.17
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
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The transcriptional program of a human B cell line in response to Myc. Nucleic Acids Res (2001) 4.08
c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc Natl Acad Sci U S A (1998) 3.81
Computational and experimental identification of novel human imprinted genes. Genome Res (2007) 3.50
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev (1998) 2.27
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol (2002) 2.27
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. Mol Cell Biol (1996) 2.22
Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol (1999) 2.09
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Cell Cycle (2008) 1.98
Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol Cell Biol (1997) 1.92
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A (2005) 1.91
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc Natl Acad Sci U S A (2000) 1.89
HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol Cell Biol (2000) 1.71
The Max network gone mad. Mol Cell Biol (2001) 1.66
The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol (2001) 1.65
hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Mol Cell Biol (2005) 1.50
MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer (2015) 1.47
The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol (1997) 1.33
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet (2012) 1.31
MYC, Metabolism, and Cancer. Cancer Discov (2015) 1.29
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The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle. J Virol (2003) 1.14
Myc represses transcription of the growth arrest gene gas1. Proc Natl Acad Sci U S A (1997) 1.13
Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Mol Cell Biol (2000) 1.08
Myc: the beauty and the beast. Genes Cancer (2010) 1.07
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta (2014) 1.02
Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. Biochem J (2003) 1.02
The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. Oncotarget (2011) 1.00
DNA-binding activity of the transcription factor upstream stimulatory factor 1 (USF-1) is regulated by cyclin-dependent phosphorylation. Biochem J (1999) 0.96
Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. Genetics (2005) 0.95
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Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis. Mol Cell Biol (1996) 0.92
Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation. Mol Cell Biol (1997) 0.91
c-MYC-induced genomic instability. Cold Spring Harb Perspect Med (2014) 0.89
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. PLoS One (2013) 0.88
Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. Br J Cancer (2002) 0.88
Activation of an enhancer on the syndecan-1 gene is restricted to fibroblast growth factor family members in mesenchymal cells. Mol Cell Biol (1997) 0.87
Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells. Oncogene (2001) 0.87
Targeted resequencing and analysis of the Diamond-Blackfan anemia disease locus RPS19. PLoS One (2009) 0.86
The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Mol Cell Biol (1999) 0.84
Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter. Nucleic Acids Res (1997) 0.81
Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation. Mol Cell Biol (1998) 0.81
Differential regulation of N-Myc and c-Myc synthesis, degradation, and transcriptional activity by the Ras/mitogen-activated protein kinase pathway. J Biol Chem (2011) 0.80
Control of nucleotide biosynthesis by the MYC oncoprotein. Cell Cycle (2008) 0.79
Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis. Biol Open (2014) 0.79
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Aging (Albany NY) (2016) 0.75
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance. Microbiol Mol Biol Rev (2016) 0.75
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci U S A (2017) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science (1991) 12.00
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (1992) 10.28
The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev (1990) 6.88
Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 6.84
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell (1993) 6.40
TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif. Genes Dev (1990) 6.00
Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell (1991) 5.76
myc function and regulation. Annu Rev Biochem (1992) 5.33
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell (1993) 5.28
The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J (1991) 4.96
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1. Nature (1987) 4.85
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci U S A (1993) 4.66
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
An amino-terminal c-myc domain required for neoplastic transformation activates transcription. Mol Cell Biol (1990) 4.24
Myc and Max proteins possess distinct transcriptional activities. Nature (1992) 4.16
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev (1993) 4.14
New light on Myc and Myb. Part I. Myc. Genes Dev (1990) 3.57
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J (1993) 3.48
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev (1990) 3.44
Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature (1992) 3.43
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev (1994) 3.27
Myc and Max associate in vivo. Genes Dev (1992) 3.16
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J (1990) 3.07
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol Cell Biol (1992) 3.06
A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol Cell Biol (1990) 2.90
V-myc- and c-myc-encoded proteins are associated with the nuclear matrix. Mol Cell Biol (1985) 2.86
Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science (1993) 2.70
Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein. Nature (1989) 2.70
A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev (1993) 2.65
C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature (1984) 2.63
Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J (1993) 2.55
Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle. EMBO J (1985) 2.53
Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res (1989) 2.47
Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol Cell Biol (1993) 2.34
A simple assay for DNA transfection by incubation of the cells in culture dishes with substrates for beta-galactosidase. Biotechniques (1989) 2.26
Determination of the c-MYC DNA-binding site. Proc Natl Acad Sci U S A (1991) 2.19
The role of c-myc in cell growth. Curr Opin Genet Dev (1993) 2.17
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J (1994) 2.14
Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact. J Biol Chem (1986) 2.00
An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. Genes Dev (1992) 1.82
c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells. Mol Cell Biol (1988) 1.76
c-myc protein expression in untransformed fibroblasts. Oncogene (1991) 1.72
c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ (1993) 1.72
Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev (1992) 1.68
Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl2 on specificity and comparison with binding of Myc family members. Nucleic Acids Res (1994) 1.61
The role of E2F in the mammalian cell cycle. Biochim Biophys Acta (1993) 1.59
Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res (1993) 1.53
max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene (1992) 1.40
The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II. Mol Cell Biol (1992) 1.35
Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter. J Biol Chem (1994) 1.30
HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J (1994) 1.28
Regulation of human ornithine decarboxylase expression by the c-Myc.Max protein complex. J Biol Chem (1993) 1.25
Cloning, chromosomal location, and characterization of mouse E2F1. Mol Cell Biol (1994) 1.25
G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J Biol Chem (1994) 1.23
Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation. Proc Natl Acad Sci U S A (1993) 1.08
An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes. J Biol Chem (1993) 1.03
Characterization of the 5' end of the growth-regulated Syrian hamster CAD gene. Cell Growth Differ (1990) 1.02
Regulation of CAD gene expression in mouse fibroblasts during the transition from the resting to the growing state. Exp Cell Res (1988) 0.84
Regulation of carbamoyl phosphate synthetase-aspartate transcarbamoylase-dihydroorotase gene expression in growing and arrested cells. J Biol Chem (1986) 0.83
Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter in vitro. J Biol Chem (1992) 0.78
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc Natl Acad Sci U S A (1998) 3.81
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev (1994) 3.27
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol Cell Biol (1992) 3.06
Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site. Mol Cell Biol (1990) 2.96
Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol (2000) 2.85
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
Synthetic sites for transcription termination and a functional comparison with tryptophan operon termination sites in vitro. Proc Natl Acad Sci U S A (1981) 2.62
Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors. J Mol Biol (2001) 2.56
Rho-independent termination: dyad symmetry in DNA causes RNA polymerase to pause during transcription in vitro. Nucleic Acids Res (1981) 2.46
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle. J Biol Chem (1985) 2.31
Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1985) 2.30
A model for transcription termination suggested by studies on the trp attenuator in vitro using base analogs. Cell (1980) 2.30
Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions. J Biol Chem (1985) 2.29
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Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol (1999) 2.09
Effects of NusA protein on transcription termination in the tryptophan operon of Escherichia coli. Cell (1982) 1.96
In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene. Mol Cell Biol (1986) 1.64
Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation. J Biol Chem (2000) 1.54
Expression profiling and identification of novel genes in hepatocellular carcinomas. Oncogene (2001) 1.50
Murine dihydrofolate reductase transcripts through the cell cycle. Mol Cell Biol (1986) 1.43
Site-specific initiation of transcription by RNA polymerase II. Proc Soc Exp Biol Med (1993) 1.43
E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem (1997) 1.36
Context-dependent transcriptional regulation. J Biol Chem (1999) 1.36
The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II. Mol Cell Biol (1992) 1.35
The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements. J Biol Chem (2001) 1.32
Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter. J Biol Chem (1994) 1.30
Transcriptional regulation of the dihydrofolate reductase gene. Bioessays (1996) 1.29
Position-dependent transcriptional regulation of the murine dihydrofolate reductase promoter by the E2F transactivation domain. Mol Cell Biol (1997) 1.26
Cloning, chromosomal location, and characterization of mouse E2F1. Mol Cell Biol (1994) 1.25
Activation of the murine dihydrofolate reductase promoter by E2F1. A requirement for CBP recruitment. J Biol Chem (1999) 1.23
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Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation. Oncogene (2000) 1.14
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Identification of target genes of oncogenic transcription factors. Proc Soc Exp Biol Med (1999) 1.07
An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes. J Biol Chem (1993) 1.03
ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells. Oncogene (2010) 0.99
Transcriptional regulation of the dihydrofolate reductase/rep-3 locus. Crit Rev Eukaryot Gene Expr (1994) 0.97
Direct recruitment of N-myc to target gene promoters. Mol Carcinog (2000) 0.95
The bidirectionally transcribed dihydrofolate reductase and rep-3a promoters are growth regulated by distinct mechanisms. Cell Growth Differ (1995) 0.94
Identification of a new promoter upstream of the murine dihydrofolate reductase gene. Mol Cell Biol (1989) 0.92
Inappropriate transcription from the 5' end of the murine dihydrofolate reductase gene masks transcriptional regulation. Nucleic Acids Res (1994) 0.90
No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog (1999) 0.87
v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1. Cell Growth Differ (1995) 0.86
CAD, a c-Myc target gene, is not deregulated in Burkitt's lymphoma cell lines. Mol Carcinog (2000) 0.86
Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Res (1998) 0.84
Isolation of human conjunctival mast cells and epithelial cells: tumor necrosis factor-alpha from mast cells affects intercellular adhesion molecule 1 expression on epithelial cells. Invest Ophthalmol Vis Sci (1998) 0.84
Strain-dependent differences in DNA synthesis and gene expression in the regenerating livers of CB57BL/6J and C3H/HeJ mice. Mol Carcinog (1995) 0.83
krox 20 messenger RNA and protein expression in the adult central nervous system. Brain Res Mol Brain Res (1992) 0.82
Effects of DNA base analogs on transcription termination at the tryptophan operon attenuator of EScherichia coli. Proc Natl Acad Sci U S A (1982) 0.82
Identification of cis-acting elements that can obviate a requirement for the C-terminal domain of RNA polymerase II. J Biol Chem (1995) 0.80
Identification of the serum-responsive transcription initiation site of the zinc finger gene Krox-20. Mol Cell Biol (1990) 0.79
Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter in vitro. J Biol Chem (1992) 0.78
Cell cycle analysis of Krox-20, c-fos, and JE expression in proliferating NIH3T3 fibroblasts. Cell Growth Differ (1991) 0.78
Effects of gentamicin on trypsin, chymotrypsin, and collagenase. J Infect Dis (1978) 0.76
A re-examination of the distributions of octopamine and phenylethanolamine in the aplysia nervous system. J Neurochem (1978) 0.75
Characterization of the 3' untranslated region of mouse E2F1 mRNA. Gene (1998) 0.75