A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 2731897)

Published in Nucleic Acids Res on June 15, 2009

Authors

Debashree Basu1, Garima Khare, Shashi Singh, Anil Tyagi, Sanjeev Khosla, Shekhar C Mande

Author Affiliations

1: Laboratory of Structural Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500001, India.

Articles citing this

Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease. Infect Immun (2011) 1.99

Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain. BMC Biotechnol (2011) 1.06

Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD. Structure (2013) 1.00

DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii. Mol Microbiol (2012) 0.85

Crystallization and preliminary X-ray crystallographic analysis of a GroEL1 fragment from Mycobacterium tuberculosis H37Rv. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80

Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum. Nucleic Acids Res (2011) 0.80

Unveiling the role of Dps in the organization of mycobacterial nucleoid. PLoS One (2011) 0.80

Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 Is a chaperonin. J Mol Biol (2010) 0.79

Anti-atherogenic potential of jujube, saffron and barberry: anti-diabetic and antioxidant actions. EXCLI J (2015) 0.78

Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism. PLoS One (2013) 0.78

Multiple chaperonins in bacteria--novel functions and non-canonical behaviors. Cell Stress Chaperones (2015) 0.77

Identification and Characterization of Novel Small RNAs in Rickettsia prowazekii. Front Microbiol (2016) 0.76

In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice. PLoS One (2015) 0.75

Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding and Integrative Recombination. J Bacteriol (2017) 0.75

Articles cited by this

Histonelike proteins of bacteria. Microbiol Rev (1987) 8.65

Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid. J Bacteriol (1999) 5.65

A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. Genes Dev (1992) 4.96

E. coli DNA binding protein HU forms nucleosomelike structure with circular double-stranded DNA. Cell (1979) 4.07

H-NS: a universal regulator for a dynamic genome. Nat Rev Microbiol (2004) 4.03

Large-scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid-associated protein, H-NS. Mol Microbiol (2001) 3.60

Ancient linkage groups and frozen accidents. Nature (1973) 3.57

Characterization of a novel, low-molecular-weight DNA-binding protein from Escherichia coli. Proc Natl Acad Sci U S A (1975) 3.46

H-NS mediates the silencing of laterally acquired genes in bacteria. PLoS Pathog (2006) 3.29

GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria. Cell (2005) 3.23

Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J Biol Chem (1999) 3.07

Identification of in vivo substrates of the chaperonin GroEL. Nature (1999) 2.95

The GroE chaperonin machine is a major modulator of the CIRCE heat shock regulon of Bacillus subtilis. EMBO J (1997) 2.50

The role of nucleoid-associated proteins in the organization and compaction of bacterial chromatin. Mol Microbiol (2005) 2.37

In vivo observation of polypeptide flux through the bacterial chaperonin system. Cell (1997) 1.99

Minor groove-binding architectural proteins: structure, function, and DNA recognition. Annu Rev Biophys Biomol Struct (1998) 1.89

Retracted The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. Microbiology (2006) 1.71

Isolation of morphologically intact mitochondrial nucleoids from the yeast, Saccharomyces cerevisiae. J Cell Sci (1987) 1.68

Regulated phase transitions of bacterial chromatin: a non-enzymatic pathway for generic DNA protection. EMBO J (2001) 1.55

HU: promoting or counteracting DNA compaction? FEBS Lett (2002) 1.54

The histone-like protein HU binds specifically to DNA recombination and repair intermediates. EMBO J (2000) 1.52

A molecular mechanism for the repression of transcription by the H-NS protein. Mol Microbiol (2001) 1.51

Isolation and characterization of spermidine nucleoids from Escherichia coli. J Struct Biol (1997) 1.19

A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection. Infect Immun (2008) 1.13

Mechanisms of antigen receptor evolution. Semin Immunol (2004) 1.13

Functional studies of multiple thioredoxins from Mycobacterium tuberculosis. J Bacteriol (2008) 1.12

Molecular analysis of the multiple GroEL proteins of Chlamydiae. J Bacteriol (2003) 1.11

Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins. J Mol Biol (2004) 1.06

HU binds and folds single-stranded DNA. Nucleic Acids Res (2007) 1.04

Proteomics analysis of carbon-starved Mycobacterium smegmatis: induction of Dps-like protein. Protein Eng (2002) 1.03

Multiple gene duplication and rapid evolution in the groEL gene: functional implications. J Mol Evol (2006) 1.00

Mycobacterium smegmatis histone-like protein Hlp is nucleoid associated. FEMS Microbiol Lett (2009) 0.94

Isolation of a single-stranded DNA-binding protein from the methylotrophic yeast, Pichia pastoris and its identification as zeta crystallin. Nucleic Acids Res (2006) 0.87

Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C. Biochem J (2002) 0.85

Permeabilization of the mycobacterial envelope for protein cytolocalization studies by immunofluorescence microscopy. BMC Microbiol (2006) 0.80

Articles by these authors

Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol (2005) 2.04

Clinical outcome of autologous cultivated limbal epithelium transplantation. Indian J Ophthalmol (2006) 1.53

Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides. Mol Biochem Parasitol (2003) 1.49

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. Nat Chem Biol (2009) 1.39

The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. J Immunol (2009) 1.32

ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol In Vitro (2010) 1.28

The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord (2002) 1.28

Inferring genome-wide functional linkages in E. coli by combining improved genome context methods: comparison with high-throughput experimental data. Genome Res (2007) 1.23

Characterization of a thermostable hepatitis B vaccine formulation. Vaccine (2009) 1.17

Successful reconstruction of damaged ocular outer surface in humans using limbal and conjuctival stem cell culture methods. Biosci Rep (2003) 1.16

Monitoring of pesticidal contamination of farmgate vegetables from Hisar. Environ Monit Assess (2004) 1.13

The unusual chaperonins of Mycobacterium tuberculosis. Tuberculosis (Edinb) (2005) 1.13

Functional studies of multiple thioredoxins from Mycobacterium tuberculosis. J Bacteriol (2008) 1.12

Early results of penetrating keratoplasty after cultivated limbal epithelium transplantation. Arch Ophthalmol (2005) 1.12

Development of a freeze-stable formulation for vaccines containing aluminum salt adjuvants. Vaccine (2008) 1.09

Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis. Acta Crystallogr D Biol Crystallogr (2005) 1.09

Crystal structure of the 65-kilodalton heat shock protein, chaperonin 60.2, of Mycobacterium tuberculosis. J Bacteriol (2004) 1.07

Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins. J Mol Biol (2004) 1.06

PAR-3D: a server to predict protein active site residues. Nucleic Acids Res (2007) 1.05

Monitoring of butter and ghee (clarified butter fat) for pesticidal contamination from cotton belt of Haryana, India. Environ Monit Assess (2005) 1.05

Ex-vivo potential of cadaveric and fresh limbal tissues to regenerate cultured epithelium. Indian J Ophthalmol (2004) 1.03

Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytother Res (2005) 1.01

Chimeric Vitreoscilla hemoglobin (VHb) carrying a flavoreductase domain relieves nitrosative stress in Escherichia coli: new insight into the functional role of VHb. Appl Environ Microbiol (2002) 1.01

Is microsporidial keratitis an emerging cause of stromal keratitis? A case series study. BMC Ophthalmol (2005) 1.01

A heat-stable hepatitis B vaccine formulation. Hum Vaccin (2009) 1.01

Designed multi-domain protein as a carrier of nucleic acids into cells. J Control Release (2008) 1.01

Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization. J Bacteriol (2009) 1.01

Multiple gene duplication and rapid evolution in the groEL gene: functional implications. J Mol Evol (2006) 1.00

Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem. PLoS One (2009) 0.98

Characterization of the freeze sensitivity of a hepatitis B vaccine. Hum Vaccin (2009) 0.97

Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. J Mol Biol (2008) 0.96

Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci (2006) 0.96

Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains. J Biol Chem (2002) 0.96

The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress. Epigenetics (2011) 0.94

Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration. PLoS One (2010) 0.93

Antibacterial activities of synthetic peptides corresponding to the carboxy-terminal region of human beta-defensins 1-3. Peptides (2006) 0.92

Prediction of conditional gene essentiality through graph theoretical analysis of genome-wide functional linkages. Mol Biosyst (2009) 0.92

TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology (2011) 0.92

Variation of mitochondrial size during the cell cycle: A multiparameter flow cytometric and microscopic study. Cytometry A (2004) 0.91

Dynamic changes in protein functional linkage networks revealed by integration with gene expression data. PLoS Comput Biol (2008) 0.91

Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem (2002) 0.91

Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols. Acta Crystallogr D Biol Crystallogr (2005) 0.90

Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan. AAPS PharmSciTech (2006) 0.90

Mesenchymal cell response to nanosized biphasic calcium phosphate composites. Colloids Surf B Biointerfaces (2009) 0.90

kappa-casein-deficient mice fail to lactate. Proc Natl Acad Sci U S A (2006) 0.89

Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates. Antimicrob Agents Chemother (2002) 0.89

DNA methylation and cancer. Subcell Biochem (2013) 0.89

DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer. Epigenetics (2006) 0.88

Mapping conformational transitions in cyclic AMP receptor protein: crystal structure and normal-mode analysis of Mycobacterium tuberculosis apo-cAMP receptor protein. Biophys J (2010) 0.87

Exploiting 3D structural templates for detection of metal-binding sites in protein structures. Proteins (2008) 0.87

Expression, purification, crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis thioredoxin reductase. Acta Crystallogr D Biol Crystallogr (2004) 0.86

Single disulfide and linear analogues corresponding to the carboxy-terminal segment of bovine beta-defensin-2: effects of introducing the beta-hairpin nucleating sequence d-pro-gly on antibacterial activity and Biophysical properties. Biochemistry (2003) 0.86

Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C. Biochem J (2002) 0.85

Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis. Epigenetics (2009) 0.85

Human recombinant resistin protein displays a tendency to aggregate by forming intermolecular disulfide linkages. Biochemistry (2003) 0.85

Function of the 90-loop (Thr90-Glu100) region of staphylokinase in plasminogen activation probed through site-directed mutagenesis and loop deletion. Biochem J (2002) 0.82

An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mech Dev (2008) 0.82

Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis. Mitochondrion (2011) 0.82

Epigenetic profile of the euchromatic region of human Y chromosome. Nucleic Acids Res (2011) 0.81

Structure of Mycobacterium tuberculosis chaperonin-10 at 3.5 A resolution. Acta Crystallogr D Biol Crystallogr (2002) 0.81

Subepithelial amyloid deposits in congenital hereditary endothelial dystrophy: a histopathologic study of five cases. Cornea (2002) 0.81

The crystal structure of Mycobacterium tuberculosis NrdH at 0.87 Å suggests a possible mode of its activity. Biochemistry (2013) 0.81

The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions. Biochemistry (2006) 0.80

Morphology-controlled assembly of ZnO nanostructures: a bioinspired method and visible luminescence. Chemistry (2008) 0.80

Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker. World J Gastroenterol (2007) 0.80

Crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis CRP/FNR family transcription regulator. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.80

Evaluation of nano-biphasic calcium phosphate ceramics for bone tissue engineering applications: in vitro and preliminary in vivo studies. J Biomater Appl (2012) 0.80

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of bacterioferritin A from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.80

Cecembia lonarensis gen. nov., sp. nov., a haloalkalitolerant bacterium of the family Cyclobacteriaceae, isolated from a haloalkaline lake and emended descriptions of the genera Indibacter, Nitritalea and Belliella. Int J Syst Evol Microbiol (2011) 0.79

Cloning and expression of human islet amyloid polypeptide in cultured cells. Biochem Biophys Res Commun (2007) 0.78

Morphology of self-assembled structures formed by short peptides from the amyloidogenic protein tau depends on the solvent in which the peptides are dissolved. J Pept Sci (2009) 0.78

Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling. PLoS One (2012) 0.78

Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis--a potential target for the development of antitubercular drugs. J Mol Model (2010) 0.78

Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages. Cell Microbiol (2008) 0.78

Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia. Arch Pathol Lab Med (2010) 0.78

Protective effect of Gingko biloba extract against doxorubicin-induced cardiotoxicity in mice. Indian J Exp Biol (2002) 0.77

Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides (2006) 0.77

A facile and fast approach for the synthesis of doped nanoparticles using a microfluidic device. Nanotechnology (2008) 0.77

Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts. Tuberculosis (Edinb) (2011) 0.77

Crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis chorismate mutase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.77

Multiple chaperonins in bacteria--novel functions and non-canonical behaviors. Cell Stress Chaperones (2015) 0.77

Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.76

Organic solvent mediated self-association of an amyloid forming peptide from beta2-microglobulin: an atomic force microscopy study. Biopolymers (2008) 0.76

Identification of self-consistent modulons from bacterial microarray expression data with the help of structured regulon gene sets. J Biomol Struct Dyn (2012) 0.75

Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network. Genome Res (2011) 0.75

Cells behaviour in presence of nano-scaffolds. J Biomed Nanotechnol (2011) 0.75

Identification of conserved residue patterns in small beta-barrel proteins. Protein Eng (2002) 0.75

Poly(L-Lysine)-pyranine-3 coacervate mediated nanoparticle-assembly: fabrication of dynamic pH-responsive containers. Chem Commun (Camb) (2011) 0.75

Synthetic adhesive oligopeptides with rigid polyhydroxylated amino acids. Biopolymers (2013) 0.75

Cation-mediated interplay of loops in chaperonin-10. J Biomol Struct Dyn (2006) 0.75

Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease. J Biosci (2011) 0.75