Published in Eur J Cancer on November 01, 1967
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A (1974) 3.07
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair. EMBO J (1988) 1.51
In vitro studies of cell proliferation in tumours. II. Characteristics of a standardised in vitro system for the measurement of 3H-thymidine incorporation into tissue explants. Eur J Cancer (1965) 1.43
Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage. Proc Natl Acad Sci U S A (1991) 1.37
Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. J Natl Cancer Inst (1975) 1.26
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1974) 1.24
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells. Nature (1978) 1.23
O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer (1985) 1.17
G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene. Nucleic Acids Res (1991) 1.15
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res (1980) 1.13
Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat. Cancer Res (1972) 1.11
1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. Carcinogenesis (1989) 1.09
Liver carcinogenesis by diethylnitrosamine in the rat. Science (1966) 1.06
Spleen-cell reactivity against transplanted neurogenic rat tumors induced by ethylnitrosourea: uncovering of tumor specificity after removal of complement-receptor-bearing lymphocytes. Int J Cancer (1975) 1.02
Allelic deletion mapping on chromosome 5 in human carcinomas. Oncogene (1996) 1.00
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro. Cancer Res (1989) 1.00
pH in human tumour xenografts: effect of intravenous administration of glucose. Br J Cancer (1993) 1.00
Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. Cancer Res (1982) 0.98
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res Clin Oncol (1984) 0.96
Antibodies specific for DNA components structurally modified by chemical carcinogens. J Cancer Res Clin Oncol (1981) 0.95
Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem (1988) 0.95
pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine. Cancer Res (1992) 0.95
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea. Proc Natl Acad Sci U S A (1990) 0.94
Proliferative parameters of mammalian cell systms and their rôle in tumor growth and carcinogenesis. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1972) 0.94
Characteristics of three nuclear emulsions for autoradiography at the electron microscope. Biophysik (1966) 0.93
Proton-mediated liberation of aldophosphamide from a nontoxic prodrug: a strategy for tumor-selective activation of cytocidal drugs. Cancer Res (1989) 0.93
Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells. Oncogene (1996) 0.92
Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context. Nucleic Acids Res (1996) 0.91
Chemical neuro-oncogenesis: role of structural DNA modifications, DNA repair and neural target cell population. Prog Exp Tumor Res (1984) 0.91
Role of DNA repair in carcinogen-induced ras mutation. Mutat Res (2000) 0.91
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes. Cancer Res (1982) 0.91
DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level. Cancer Res (1997) 0.90
Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting. Cell Growth Differ (1990) 0.90
Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1977) 0.89
Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo. Eur J Cancer (1990) 0.89
Elimination of O6-ethylguanine from the DNA of brain, liver, and other rat tissues exposed to ethylnitrosourea at different stages of prenatal development. Cancer Res (1983) 0.89
Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors. Cancer Res (1989) 0.89
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. Carcinogenesis (1986) 0.88
Proliferative properties of malignant cell populations cultured in intraperitoneal diffusion chambers. Eur J Cancer (1973) 0.88
Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Res (1994) 0.88
Neural cell surface differentiation antigen gp130(RB13-6) induces fibroblasts and glioma cells to express astroglial proteins and invasive properties. FASEB J (1999) 0.88
Three-dimensional imaging of nerve tissue by x-ray phase-contrast microtomography. Biophys J (1999) 0.87
Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro. Int J Cancer (1990) 0.87
Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. J Biol Chem (1995) 0.86
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat. J Biol Chem (1994) 0.86
Microsatellite instability and loss of heterozygosity at the hMLH1 locus on chromosome 3p21 occur in a subset of nonsmall cell lung carcinomas. Oncol Res (1996) 0.86
DNA sequence dependence of guanine-O6 alkylation by the N-nitroso carcinogens N-methyl- and N-ethyl-N-nitrosourea. Mutat Res (1991) 0.86
Cell proliferation in transplanted rat tumors: influence of the host immune system. Eur J Immunol (1972) 0.85
Schwann cell lineage-specific neu (erbB-2) gene expression in the developing rat nervous system. Cell Growth Differ (1993) 0.85
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect (1985) 0.84
Highly sensitive sites for guanine-O6 ethylation in rat brain DNA exposed to N-ethyl-N-nitrosourea in vivo. EMBO J (1984) 0.84
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine). Carcinogenesis (1990) 0.84
Electrophysiological properties of ethylnitrosourea-induced, neoplastic neurogenic rat cell lines cultured in vitro and in vivo. Cancer Res (1976) 0.84
"Tumour suppressor gene" concept of carcinogenesis. Lancet (1995) 0.84
Metabolic response of AH13r rat tumours to cyclophosphamide as monitored by pO2 and pH semi-microelectrodes. Eur J Cancer (1992) 0.82
In vitro differentiation of human retinoblastoma cells into neuronal phenotypes. Differentiation (1990) 0.82
Synchronisation in vivo: temporary inhibition of DNA synthesis in the rat embryo with hydroxyurea. Exp Cell Res (1971) 0.82
Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis (1993) 0.82
[Ethylation of guanine-N-7 in the nucleic acids of rat embryos and liver by ethylnitrosourea]. Z Naturforsch B (1971) 0.82
Nigericin enhances mafosfamide cytotoxicity at low extracellular pH. Cancer Chemother Pharmacol (1991) 0.81
Ethylation of nucleophilic sites in DNA by N-ethyl-N-nitrosourea depends on chromatin structure and ionic strength. Mutat Res (1985) 0.81
In vitro differentiation of neural progenitor cells from prenatal rat brain: common cell surface glycoprotein on three glial cell subsets. J Neurosci Res (1997) 0.81
Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis. Cancer Res (1999) 0.81
Relevance of N-nitrosamines to esophageal cancer in China. J Cell Physiol Suppl (1986) 0.80
Monoclonal antibodies for the specific detection of 3-alkyladenines in nucleic acids and body fluids. Carcinogenesis (1990) 0.80
DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation. Mutat Res (1996) 0.80
Recombinant human O6-alkylguanine-DNA alkyltransferase induces conformational change in bound DNA. FEBS Lett (1997) 0.80
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia. Clin Cancer Res (1997) 0.80
Chemosensitisation of alkylating agents by pentoxifylline, O6-benzylguanine and ethacrynic acid in haematological malignancies. Anticancer Res (1994) 0.80
Synchronisation in vivo: kinetics of a malignant cell system following temporary inhibition of DNA synthesis with hydroxyurea. Exp Cell Res (1970) 0.80
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences. Nucleic Acids Res (1991) 0.80
[Cell proliferation in normal and malignant tissues: H3-thymidine incorporation in vitro under standard conditions]. Biophysik (1966) 0.80
Mutagenicities of N-nitrosodimethylamine and N-nitrosodiethylamine in Drosophila and their relationship to the levels of O-alkyl adducts in DNA. Mutat Res (1999) 0.80
Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Differentiation (1991) 0.79
Molecular and cellular mechanisms underlying ineffective cancer chemotherapy. Recent Results Cancer Res (1984) 0.79
Determination of immunoreactive fraction and kinetic parameters of a radiolabeled monoclonal antibody in the absence of antigen excess. J Immunol Methods (1991) 0.79
In vitro differentiation of E-N-CAM expressing rat neural precursor cells isolated by FACS during prenatal development. J Neurosci Res (1994) 0.79
Induction of the common fragile site FRA3B does not affect FHIT expression. Oncogene (2001) 0.79
Development of malignant fibrous histiocytoma induced by 7,12-dimethylbenz[a]anthracene in the rat: characterization of early atypical cells. Virchows Arch B Cell Pathol Incl Mol Pathol (1993) 0.79
Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain. Cancer Res (2000) 0.79
Enzymatic synthesis of double-stranded DNA containing radioactively labeled O(6)-ethylguanine as the only modified base. Carcinogenesis (1981) 0.79
Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level. Br J Cancer (1994) 0.79
Immunohistologic detection and phenotyping of neuroblastoma cells in bone marrow using cytoplasmic neuron specific enolase and cell surface antigens. Prog Clin Biol Res (1985) 0.79
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A (1998) 0.79
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions. Int J Cancer (1988) 0.78
1 alpha,25-Dihydroxyvitamin D3 induces anchorage-independent growth and c-Ki-ras expression of BALB/3T3 and NIH/3T3 cells. Jpn J Cancer Res (1987) 0.78
Nuclear protein patterns in developing and adult brain and in ethylnitrosourea-induced neuroectodermal tumours of the rat. J Neurochem (1975) 0.78
Possible determinants for the differential susceptibility of mammalian cells and tissues to chemical carcinogens. Arch Toxicol Suppl (1980) 0.78
Structural modifications and repair of DNA in neuro-oncogenesis by N-ethyl-N-nitrosourea. Recent Results Cancer Res (1983) 0.78
Calibration of fluorescence intensities to quantify antibody binding surface determinants of cell subpopulations by flow cytometry. Cytometry (1991) 0.78
High-affinity monoclonal antibodies for the specific recognition and quantification of deoxynucleosides structurally modified by N-nitroso compounds. IARC Sci Publ (1984) 0.78
Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction. J Cancer Res Clin Oncol (1982) 0.78
Similar rate of O6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40. Carcinogenesis (1983) 0.78
Increased drug cytotoxicity at reduced pH counteracts cyclophosphamide resistance in cultured rat mammary carcinoma cells. Int J Cancer (1989) 0.78
Concordance between parental origin of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma. Am J Hum Genet (1994) 0.78
Effect of glucose-mediated pH reduction and cyclophosphamide on oxygenation of transplanted rat tumors. Int J Radiat Oncol Biol Phys (1993) 0.78
Characterization of rat NCA/CD9 cell surface antigen and its expression by normal and malignant neural cells. J Neurosci Res (1996) 0.78