Published in Biochemistry on October 09, 1973
Hemoglobin variants: biochemical properties and clinical correlates. Cold Spring Harb Perspect Med (2013) 1.09
Restoring allosterism with compensatory mutations in hemoglobin. Proc Natl Acad Sci U S A (1994) 0.88
Statistical mechanics applied to cooperative ligand binding to proteins. Proc Natl Acad Sci U S A (1973) 0.79
A proton nuclear magnetic resonance investigation of proximal histidyl residues in human normal and abnormal hemoglobins. A probe for the heme pocket. Biophys J (1982) 0.77
Evidence for a kinetic heterogeneity in ligand binding to R-state haemoglobin Kempsey [Asp-G1(99) beta----Asn]. Biochem J (1986) 0.77
Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 10.01
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (1996) 6.33
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science (1988) 5.71
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Exceptional convergent evolution in a virus. Genetics (1997) 4.69
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res (1999) 3.48
Exchange of heme among hemoglobins and between hemoglobin and albumin. J Biol Chem (1968) 3.09
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science (1990) 3.02
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00
Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J (1997) 2.97
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
Serum leptin and vascular risk factors in obstructive sleep apnea. Chest (2000) 2.53
The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A (1987) 2.51
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46
The electromechanics of DNA in a synthetic nanopore. Biophys J (2005) 2.43
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood (1991) 2.41
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28
Regulation of the erythropoietin gene. Blood (1999) 2.10
Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport (1997) 1.97
Influence of globin structure on the state of the heme. I. Human deoxyhemoglobin. Biochemistry (1974) 1.96
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol (1992) 1.94
Detection of single mammalian cells by high-resolution magnetic resonance imaging. Biophys J (1999) 1.90
Exchange of heme among hemoglobin molecules. Proc Natl Acad Sci U S A (1966) 1.81
The interaction of 2,3-diphosphoglycerate with various human hemoglobins. J Clin Invest (1970) 1.81
Nonenzymatic glycosylation of human serum albumin alters its conformation and function. J Biol Chem (1984) 1.80
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol (1998) 1.80
Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn Reson Med (1993) 1.76
Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. Circulation (2000) 1.76
Lipid A mutants of Salmonella typhimurium. Purification and characterization of a lipid A precursor produced by a mutant in 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. J Biol Chem (1977) 1.75
Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation (2001) 1.74
Regulation of erythrocyte cation and water content in sickle cell anemia. Science (1986) 1.65
Evaluation of glycosylated hemoglobin diabetic patients. Diabetes (1981) 1.65
Natural history and predictors for progression of mild childhood obstructive sleep apnoea. Thorax (2009) 1.61
Beyond the Gene Chip. Bell Labs Tech J (2005) 1.57
Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem (1980) 1.56
A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. N Engl J Med (1980) 1.54
Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli. J Bacteriol (1985) 1.51
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol (1995) 1.50
Kinetic analysis of the nonenzymatic glycosylation of hemoglobin. J Biol Chem (1981) 1.50
Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem (1997) 1.47
Treatment of sickle cell anemia with hydroxyurea and erythropoietin. N Engl J Med (1990) 1.47
Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. J Clin Invest (1980) 1.47
Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin. J Biol Chem (1988) 1.46
A complex bilateral polysyndactyly disease locus maps to chromosome 7q36. Nat Genet (1994) 1.44
In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med (1995) 1.44
Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients. Gastroenterology (1998) 1.44
Educating the biomedical scientist. FASEB J (1995) 1.43
The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel. Biochim Biophys Acta (1971) 1.42
Production of unmodified human adult hemoglobin in Escherichia coli. Proc Natl Acad Sci U S A (1993) 1.42
In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood (1993) 1.41
Knowledge of cardiopulmonary resuscitation among the public in Hong Kong: telephone questionnaire survey. Hong Kong Med J (2003) 1.40
Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A (1999) 1.39
The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med (1969) 1.38
Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate. Proc Natl Acad Sci U S A (1976) 1.38
Placental infection with human papillomavirus is associated with spontaneous preterm delivery. Hum Reprod (2008) 1.37
Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation. Proc Natl Acad Sci U S A (1985) 1.37
Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins. Science (1971) 1.36
Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors. Cancer Res (1999) 1.35
Nonenzymatic glycosylation of protein: relevance to diabetes. Am J Med (1981) 1.34
The modulation of protein kinase C activity by membrane lipid bilayer structure. J Biol Chem (1994) 1.33
Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med (1981) 1.33
Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor. J Biol Chem (1990) 1.33
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem (1999) 1.33
Molecular and cellular pathogenesis of hemoglobin SC disease. Proc Natl Acad Sci U S A (1982) 1.32
Electrostatic attraction governs the dimer assembly of human hemoglobin. J Biol Chem (1986) 1.31
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation. J Biol Chem (1979) 1.30
Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins. J Clin Invest (1983) 1.29
Characterization of the lipid-carrier involved in the synthesis of enterobacterial common antigen (ECA) and identification of a novel phosphoglyceride in a mutant of Salmonella typhimurium defective in ECA synthesis. Glycobiology (1998) 1.28
The effects of functional electrical stimulation on shoulder subluxation, arm function recovery, and shoulder pain in hemiplegic stroke patients. Arch Phys Med Rehabil (1994) 1.28
Signal transduction. How do cells sense oxygen? Science (2001) 1.27
The interaction between erythrocyte organic phosphates, magnesium ion, and hemoglobin. J Biol Chem (1971) 1.26
Subunit assembly of hemoglobin: an important determinant of hematologic phenotype. Blood (1987) 1.25
Hemoglobin function in stored blood. J Clin Invest (1969) 1.25
Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. Magn Reson Med (2001) 1.24
Contribution of hydrogen bonding to lipid-lipid interactions in membranes and the role of lipid order: effects of cholesterol, increased phospholipid unsaturation, and ethanol. Biochemistry (1993) 1.24
Modification of membrane lipid: physical properties in relation to fatty acid structure. Biochemistry (1976) 1.24
Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J Neurotrauma (1995) 1.24
Incorporation of fluorotryptophans into proteins of escherichia coli. Biochemistry (1975) 1.22
Production of human normal adult and fetal hemoglobins in Escherichia coli. Protein Eng (1997) 1.22
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest (1985) 1.22
Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. J Biol Chem (1993) 1.21
Direct measurement of the pK values of an alkaline Bohr group in human hemoglobin. Proc Natl Acad Sci U S A (1973) 1.21
Influence of globin structure on the state of the heme. 3. Changes in heme spectra accompanying allosteric transitions in methemoglobin and their implications for heme-heme interaction. Biochemistry (1974) 1.21
Intermolecular interactions of oxygenated sickle hemoglobin molecules in cells and cell-free solutions. Biophys J (1976) 1.20
Glycosylated minor components of human adult hemoglobin. Purification, identification, and partial structural analysis. J Biol Chem (1978) 1.20
A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography. Metabolism (1978) 1.20
The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol (1999) 1.19
The value of the peripheral blood smear in anemic inpatients. The laboratory's reading v a physician's reading. Arch Intern Med (1983) 1.18
Inhibition of protein kinase C by alcohols and anaesthetics. Nature (1993) 1.18
Functional properties of hemoglobin Kempsey. J Biol Chem (1974) 1.18
Automated probabilistic method for assigning backbone resonances of (13C,15N)-labeled proteins. J Biomol NMR (1997) 1.16
Functional nonequivalence of and hemes in human adult hemoglobin. Proc Natl Acad Sci U S A (1972) 1.16
Participation of hemoglobins A and F in polymerization of sickle hemoglobin. J Biol Chem (1977) 1.15
Chain-selective isotopic labeling for NMR studies of large multimeric proteins: application to hemoglobin. Biophys J (2000) 1.15