Published in J Clin Invest on September 01, 1981
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1. J Clin Invest (1989) 2.20
Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis. J Clin Invest (1984) 2.03
Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol (1984) 1.95
Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro. Biochem J (1985) 1.63
Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro. Biochem J (1983) 1.54
In vivo studies of articular tissue damage mediated by catabolin/interleukin 1. Ann Rheum Dis (1987) 1.27
Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro. Biochem J (1983) 1.12
Lymphocytes induce resorption of cartilage by producing catabolin. Biochem J (1982) 1.11
Mechanisms of disruption of the articular cartilage surface in inflammation. Neutrophil elastase increases availability of collagen type II epitopes for binding with antibody on the surface of articular cartilage. J Clin Invest (1991) 1.10
Cartilage ultrastructure after high pressure freezing, freeze substitution, and low temperature embedding. I. Chondrocyte ultrastructure--implications for the theories of mineralization and vascular invasion. J Cell Biol (1984) 1.06
Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study. Ann Rheum Dis (1988) 1.01
Adenylate cyclase of human articular chondrocytes. Responsiveness to prostaglandins and other hormones. Biochem J (1982) 0.98
Transcriptional modulation of cartilage-specific collagen gene expression by interferon gamma and tumour necrosis factor alpha in cultured human chondrocytes. Biochem J (1993) 0.92
Cathepsin B as a marker of the dedifferentiated chondrocyte phenotype. Ann Rheum Dis (1988) 0.90
Defective production of leucocytic endogenous mediator (interleukin 1) by peripheral blood leucocytes of patients with systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease. Clin Exp Immunol (1986) 0.89
Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation. J Clin Invest (1983) 0.86
Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of human neutrophils to damage human articular cartilage. Ann Rheum Dis (1988) 0.86
A morphological study of macrophage and synovial cell interactions with hydroxyapatite crystals. Ann Rheum Dis (1985) 0.80
Porcine catabolin stimulates prostaglandin E2 secretion but does not affect intracellular cyclic AMP production in pig synovial fibroblasts. Ann Rheum Dis (1985) 0.78
Modulation of Th1 cytokines and inflammatory mediators by Euphorbia hirta in animal model of adjuvant-induced arthritis. Inflammopharmacology (2012) 0.77
Exogenous interleukin regulates growth of C6 tumors in vivo. Acta Neuropathol (1988) 0.75
Cytokine modulation of chondrocyte metabolism--in vivo and in vitro effects of piroxicam. Inflammation (1984) 0.75
The glomerular permeability determined by dextran clearance using Sephadex gel filtration. Scand J Clin Lab Invest (1968) 10.35
Secretion of plasminogen activator by stimulated macrophages. J Exp Med (1974) 8.82
A specific method for the analysis of hydroxyproline in tissues and urine. Anal Biochem (1960) 8.08
The functional relationship of the interleukins. J Exp Med (1980) 5.62
Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1). Proc Natl Acad Sci U S A (1981) 4.89
Secretion of a specific collagenase by stimulated macrophages. J Exp Med (1975) 4.56
The T cell dependence of B cell differentiation induced by pokeweed mitogen. J Immunol (1976) 4.40
In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. J Clin Invest (1968) 4.01
The effect of synovial tissue on the breakdown of articular cartilage in organ culture. Arthritis Rheum (1977) 3.49
Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science (1977) 2.91
Collagenase production by lymphokine-activated macrophages. Science (1975) 2.64
Collagenases in human synovial fluid. J Clin Invest (1969) 2.52
Evidence that latent collagenases are enzyme-inhibitor complexes. Biochem J (1977) 2.32
Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum (1976) 2.18
Relationship between urinary hydroxyproline and growth. J Clin Invest (1962) 2.14
Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest (1980) 2.13
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes. J Exp Med (1978) 2.09
The release of collagenase as an inactive proenzyme by bone explants in culture. Biochem J (1972) 1.99
Lymphokines in the rheumatoid joint. Arthritis Rheum (1975) 1.87
Synthesis of collagenase and neutral proteases by articular chondrocytes: stimulation by a macrophage-derived factor. Biochem Biophys Res Commun (1978) 1.66
The degradation of articular collagen by neutrophil proteinases. Biochim Biophys Acta (1977) 1.59
The zymogen of tadpole collagenase. Biochemistry (1971) 1.56
Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture. Ann Rheum Dis (1975) 1.49
Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors. Cell Immunol (1979) 1.44
Electron microscopic studies of lymphoid cells in the rheumatoid synovial membrane. Arthritis Rheum (1973) 1.41
A new factor that may control collagen resorption. Lancet (1977) 1.38
Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. J Immunol (1980) 1.24
Macrophage-fibroblast interactions in collagenase production and cartilage degradation. Biochem J (1979) 1.20
Macrophage factor that induces neutral protease secretion by normal rabbit chondrocytes. Studies of some properties and effects on metabolism of chondrocytes. Eur J Biochem (1980) 1.19
Activation in vitro of rheumatoid synovial collagenase from cell cultures. J Clin Invest (1978) 1.14
Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages. Arthritis Rheum (1980) 1.07
A tissue-culture model of cartilage breakdown in rheumatoid arthritis. Quantitative aspects of proteoglycan release. Biochem J (1979) 1.01
IV. Joint erosion in rheumatoid arthritis. Arthritis Rheum (1974) 0.99
Proteinase inhibitors in rheumatoid arthritis. Ann Rheum Dis (1975) 0.94
The site of cartilage matrix degradation. Biochem J (1980) 0.90
Histologic assessment of lymphokine-mediated suppression of chondrocyte glycosaminoglycan synthesis. Arthritis Rheum (1979) 0.87
Cellular control of collagen breakdown in rheumatoid arthritis. Agents Actions (1978) 0.78
Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest (1977) 5.09
Human heat labile opsonins: evidence for their mediation via the alternate pathway of complement activation. J Immunol (1972) 3.00
The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. II. Preferential localization of antigen-antibody complexes to collagenous tissues. J Exp Med (1972) 2.74
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
Distribution of lysosomal enzymes in the spermatozoa and cytoplasmic droplets of bull and ram. Exp Cell Res (1968) 2.25
Synthesis of connective-tissue components. The effect of retinol and hydrocortisone on cultured limb-bone rudiments. Biochem J (1966) 2.20
The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. I. The role of antigen on the local immune response. Arthritis Rheum (1972) 2.16
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosus. Arthritis Rheum (1975) 2.09
The inhibition of tissue acid proteinases by pepstatin. Biochem J (1972) 2.06
Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory. Ann Rheum Dis (1979) 1.98
Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues. Arthritis Rheum (1976) 1.94
Negative result: treatment of patients with rheumatoid arthritis with gamma globulin: a double-blind controlled study. Arthritis Rheum (1969) 1.63
Immunoglobulin and specific antibody synthesis in a chronic inflammatory focus: antigen-induced synovitis. J Immunol (1969) 1.52
Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture. Ann Rheum Dis (1975) 1.49
The breakdown of embryonic cartilage and bone cultivated in the presence of complement-sufficient antiserum. 2. Biochemical changes and the role of the lysosomal system. Int Arch Allergy Appl Immunol (1967) 1.48
Specific inhibition of cartilage breakdown. Nature (1969) 1.47
The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage. Biochim Biophys Acta (1976) 1.47
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun (1980) 1.45
Relationship between clinical efficacy and laboratory correlates of inflammatory and immunologic activity in rheumatoid arthritis patients treated with nonsteroidal antiinflammatory drugs. Arthritis Rheum (1990) 1.43
Interactions between anticollagen antibodies and chondrocytes. Arthritis Rheum (1992) 1.41
Macromolecular transport across the superficial layer of articular cartilage. Osteoarthritis Cartilage (2000) 1.38
Mechanism of trapping of immune complexes in joint collagenous tissues. Clin Exp Immunol (1975) 1.38
The secretion of enzymes into the pericellular environment. Philos Trans R Soc Lond B Biol Sci (1975) 1.34
Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum (1985) 1.33
The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. I. Morphological changes, their reversibility and inhibition. Int Arch Allergy Appl Immunol (1966) 1.33
Vasculitis and lymphoproliferative diseases. Semin Arthritis Rheum (1996) 1.32
The effect of synovial catabolin on cartilage synthetic activity. Connect Tissue Res (1984) 1.31
Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F. Biochem J (1977) 1.30
Endocytosis of sugars in embryonic skeletal tissues in organ culture. IV. Lysosomal and other biochemical effects. General discussion. J Cell Sci (1969) 1.30
Immunoinhibition of intracellular protein digestion in macrophages. J Exp Med (1973) 1.29
Cathepsins BI and D. Action on human cartilage proteoglycans. Biochim Biophys Acta (1973) 1.29
Characterization of a specific antiserum for mammalian collagenase from several species: immunolocalization of collagenase in rabbit chondrocytes and uterus. J Cell Sci (1986) 1.22
Liposome-incorporated corticosteroids: I. The interaction of liposomal cortisol palmitate with inflammatory synovial membrane. Br J Exp Pathol (1979) 1.22
Altered distribution of lysosomal cathepsin D in ischemic myocardium. J Clin Invest (1977) 1.21
Absence of the eighth component of complement in association with systemic lupus erythematosus-like disease. J Clin Invest (1977) 1.18
The inflammatory role of immune complexes trapped in joint collagenous tissues. Clin Exp Immunol (1978) 1.18
Lysosomal alterations in hypoxic and reoxygenated hearts. II. Immunohistochemical and biochemical changes in cathepsin D. Am J Pathol (1980) 1.17
Cathepsin D in cartilage: the immunohistochemical demonstration of extracellular enzyme in normal and pathological conditions. J Cell Sci (1974) 1.15
Studies on the mode of action of excess of vitamin A. 9. Penetration of lipid monolayers by compounds in the vitamin A series. Biochem J (1964) 1.15
In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1. Ann Rheum Dis (1991) 1.13
Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints. An immunohistochemical study. Arthritis Rheum (1977) 1.11
Interaction of polymorphonuclear leukocytes with immune complexes trapped in joint collagenous tissues. Arthritis Rheum (1979) 1.10
Rheumatoid hyperviscosity syndrome. Am J Med (1970) 1.09
Microassay for cathepsin D shows an unexpected effedt of cycloheximide on limb-bone rudiments in organ culture. Exp Cell Res (1970) 1.09
Effects of antirheumatoid drugs on the production and action of porcine catabolin. Ann Rheum Dis (1982) 1.08
Catabolin--a cartilage catabolic factor from synovium. Clin Orthop Relat Res (1981) 1.07
Novel treatment for joint inflammation. Nature (1978) 1.07
The immunocytochemical demonstration of cathepsin D. J Histochem Cytochem (1972) 1.07
Articular damage in arthritis and its control. Ann Intern Med (1978) 1.06
The action of excess of vitamin A alcohol on the fine structure of rat dermal fibroblasts. J Cell Biol (1966) 1.06
Liposomal retention of a modified anti-inflammatory steroid. Biochem J (1976) 1.02
The role of cytokines in arthritic diseases: in vitro and in vivo measurements of cartilage degradation. Int J Tissue React (1987) 1.01
Influence of starvation on the activities and localization of cathepsin D and other lysosomal enzymes in hearts of rabbits and mice. J Mol Cell Cardiol (1975) 1.01
Uptake of biologically active substances by lysosomes. Proc R Soc Lond B Biol Sci (1969) 1.00
Vacuoles, vesicles and lysosomes. Br Med Bull (1968) 1.00
Sequential lysosomal alterations during cardiac ischemia. I. Biochemical and immunohistochemical changes. Lab Invest (1978) 1.00
Effect of cortisol on the synthesis of chondroitin sulphate by embryonic cartilage. Nature (1966) 0.99
Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis. Ann Rheum Dis (1979) 0.99
Clearance of proteoglycan from joint cavities. Ann Rheum Dis (1987) 0.99
Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat. J Lipid Res (1974) 0.99
Endocytosis of sugars in embryonic skeletal tissues in organ culture. II. Effect of sucrose on cellular fine structure. J Cell Sci (1969) 0.99
Extracellular localization of cathepsin D in ossifying cartilage. Calcif Tissue Res (1973) 0.98
The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. 3. Immunological analysis. Int Arch Allergy Appl Immunol (1969) 0.98
Human interleukin 1 mediates cartilage matrix degradation. Cell Immunol (1985) 0.98
Absence of immunoglobulins in rheumatoid cartilage-pannus junctions. Arthritis Rheum (1980) 0.97
Subcellular distribution of lead in the rat. J Lab Clin Med (1971) 0.97
Inhibition by pepstatin of human cartilage degradation. Biochem J (1972) 0.97
Studies on antimacrophage globulin. Clin Exp Immunol (1971) 0.97
Binding of radiolabelled collagen to blood platelets. J Cell Sci (1974) 0.96
In vitro immunomodulatory effects of sulfasalazine and its metabolites. J Rheumatol (1988) 0.96
Chronic arthritis in rabbits. Methods Enzymol (1988) 0.96
Generation of IgG aggregates by the myeloperoxidase-hydrogen peroxide system. J Immunol (1983) 0.95
Role of lysosomes in adrenal necrosis caused by dimethylbenzanthracene. Nature (1966) 0.95
Evidence that extracellular cathepsin D is not responsible for the resorption of cartilage matrix in culture. Biochim Biophys Acta (1982) 0.95
Localization of antigen-antibody complexes in intraarticular collagenous tissues. Ann N Y Acad Sci (1975) 0.95
Enumeration of B-lymphocytes in human peripheral blood by a rosette method for the detection of surface-bound immunoglobulin. J Immunol (1974) 0.93
Experimental model for scleritis. Arch Ophthalmol (1979) 0.93
The role of lysosomal enzymes in skeletal tissues. J Bone Joint Surg Br (1973) 0.92
Lysosomal alterations in autolyzing rabbit heart. J Mol Cell Cardiol (1979) 0.92
Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. Biochem J (1978) 0.92
Endocytosis of sugars in embryonic skeletal tissues in organ culture. I. General introduction and histological effects. J Cell Sci (1969) 0.92
Increased C1q binding immune complexes in Felty's syndrome: comparison with uncomplicated rheumatoid arthritis. Arthritis Rheum (1979) 0.91
Nutrition and lysosomal activity. The influence of the vitamin A status on the proteolytic activity of extracts from the livers and kidneys of rats. Biochem J (1966) 0.91
Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits. J Clin Invest (1978) 0.91
Immunorecognition of chondrocytes in articular cartilage activated by synovial interleukin 1. Connect Tissue Res (1991) 0.91
Inhibition of human fibroblast adhesion by cartilage surface proteoglycans. Arthritis Rheum (1994) 0.91
In vitro synthesis of immunoglobulins and IgM-rheumatoid factor by blood mononuclear cells of patients with rheumatoid arthritis. Rheumatol Int (1982) 0.90
Expression of intercellular adhesion molecule 1 (ICAM-1) on human articular cartilage chondrocytes. Connect Tissue Res (1991) 0.90
Nitric oxide production by superficial and deep articular chondrocytes. Arthritis Rheum (1997) 0.90
Nutrition and lysosomal activity. The influence of vitamin E deficiency and its duration on the stability of lysosomes in the kidneys of rats. Biochem J (1967) 0.90
The site of cartilage matrix degradation. Biochem J (1980) 0.90
The localization of retinol-binding protein in rat liver by immunofluorescence microscopy. J Cell Sci (1975) 0.89
The nature of the atypical lymphocyte in infectious mononucleosis. Clin Immunol Immunopathol (1974) 0.89
A sensitive in vitro method for studying the induction and inhibition of bone resorption. Calcif Tissue Res (1970) 0.88
Decreased pokeweed mitogen-induced IgM and IgM rheumatoid factor synthesis in rheumatoid arthritis patients treated with gold sodium thiomalate or penicillamine. Arthritis Rheum (1984) 0.88
The uptake of biologically active substances by lysosomes. Biochem J (1968) 0.88
Intracellular catabolin-like activity in cultured synovial tissue. In Vitro (1983) 0.87
The effects of vitamin A (retinol) on cell growth and incorporation of labelled glucosamine and proline fy mouse fibroblasts in culture. Exp Cell Res (1968) 0.87
The effect of steroid hormones on lysosomal activity of rat ventral prostate gland in culture. Exp Cell Res (1966) 0.87