Published in J Pharmacol Exp Ther on April 01, 1976
Opioid agonist and antagonist behavioural effects of buprenorphine. Br J Pharmacol (1983) 0.75
Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts. Br J Pharmacol (1981) 0.75
Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature (1966) 30.39
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol (1994) 3.85
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci (1981) 3.71
The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro. Cancer Res (1976) 3.52
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. J Pharmacol Exp Ther (1981) 3.47
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. Proc Natl Acad Sci U S A (1991) 2.37
The preparation and antimycotic properties of derivatives of 1-phenethylimidazole. J Med Chem (1969) 2.28
[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. Mol Pharmacol (1982) 2.25
Ketoconazole -- a new broad spectrum orally active antimycotic. Experientia (1979) 2.24
Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem Soc Trans (1990) 2.22
Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity. J Virol (1990) 2.19
Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole. Arch Int Pharmacodyn Ther (1981) 2.00
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties. J Pharmacol Exp Ther (1988) 1.97
Itraconazole, a new triazole that is orally active in aspergillosis. Antimicrob Agents Chemother (1984) 1.83
Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. J Pharm Pharmacol (1978) 1.76
Serotonergic component of neuroleptic receptors. Nature (1978) 1.74
Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke (1989) 1.70
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol (1996) 1.65
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine. Arzneimittelforschung (1974) 1.65
Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models. Rev Infect Dis (1987) 1.64
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol (1995) 1.53
Licensed midwife-attended, out-of-hospital births in Washington state: are they safe? Birth (1994) 1.52
The antiinflammatory effects of ketoconazole. A comparative study with hydrocortisone acetate in a model using living and killed Staphylococcus aureus on the skin of guinea-pigs. J Am Acad Dermatol (1991) 1.52
A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res (1991) 1.51
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneimittelforschung (1974) 1.51
In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol (1988) 1.49
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorg Med Chem Lett (2001) 1.44
In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother (1992) 1.42
Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection. Antimicrob Agents Chemother (1992) 1.41
Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses (1989) 1.38
The absolute configurations of the optical isomers of the broad spectrum anthelmintic tetramisole. Tetrahedron Lett (1967) 1.36
Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats. Arzneimittelforschung (1967) 1.33
Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837). Antimicrob Agents Chemother (1989) 1.33
Hepatic reactions during ketoconazole treatment. Am J Med (1983) 1.32
Identifying women at-risk for postpartum depression in the immediate postpartum period. Acta Psychiatr Scand (2004) 1.30
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate. Arzneimittelforschung (1974) 1.30
Biochemical profile of risperidone, a new antipsychotic. J Pharmacol Exp Ther (1988) 1.29
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol (2001) 1.29
Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468). Eur J Pharmacol (1982) 1.29
Domperidone, a novel and safe gastrokinetic anti-nauseant for the treatment of dyspepsia and vomiting. Arzneimittelforschung (1978) 1.28
Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis. Life Sci (1983) 1.26
Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharmacol Exp Ther (1985) 1.26
Etomidate, R-(+)-ethyl-1-( -methyl-benzyl)imidazole-5-carboxylate (R 16659), a potent, short-acting and relatively atoxic intravenous hypnotic agent in rats. Arzneimittelforschung (1971) 1.24
The biochemical mechanism of action of the antinematodal drug tetramisole. Biochem Pharmacol (1969) 1.24
Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method. J Med Chem (1998) 1.20
New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines. J Med Chem (1985) 1.20
Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist. J Cardiovasc Pharmacol (1988) 1.18
Intranasal pirodavir (R77,975) treatment of rhinovirus colds. Antimicrob Agents Chemother (1995) 1.18
Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine. Arzneimittelforschung (1968) 1.16
Benzetimide and its optical isomers. Arzneimittelforschung (1971) 1.15
Mechanisms of action of loperamide. Scand J Gastroenterol Suppl (1984) 1.15
Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl) (1994) 1.11
Effect of cinnarizine on peripheral circulation in dogs. Eur J Pharmacol (1972) 1.11
Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. 3. Regional distribution of pimozide and of haloperidol in the dog brain. Arzneimittelforschung (1968) 1.11
Mode of action studies. Basis for the search of new antifungal drugs. Ann N Y Acad Sci (1988) 1.10
The biochemical mechanism of action of the anthelmintic drug tetramisole. Life Sci (1967) 1.08
In vivo pharmacology of astemizole, a new type of H1-antihistaminic compound. Arch Int Pharmacodyn Ther (1981) 1.08
Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites. J Biol Chem (1985) 1.08
Evidence that adjuvant arthritis in the rat is associated with chronic pain. Pain (1987) 1.07
Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues. Arch Int Pharmacodyn Ther (1973) 1.06
[3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol (1983) 1.06
Disparate ligand-mediated Ca(2+) responses by wild-type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites. Br J Pharmacol (2000) 1.06
Pharmacokinetics of R 82913 in patients with AIDS or AIDS-related complex. Lancet (1991) 1.05
Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. Agents Actions (1982) 1.04
The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers. Mol Pharmacol (1988) 1.03
Results of a 10 week community based strength and balance training programme to reduce fall risk factors: a randomised controlled trial in 65-75 year old women with osteoporosis. Br J Sports Med (2001) 1.02
Does endothelin-1 mediate endothelium-dependent contractions during anoxia? J Cardiovasc Pharmacol (1989) 1.02
Experimental systemic dermatophytosis. J Invest Dermatol (1984) 1.01
The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch Int Pharmacodyn Ther (1980) 1.01
Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding. Mol Pharmacol (1998) 1.00
Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination. Neuropharmacology (1980) 1.00
Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. CMAJ (2001) 1.00
The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats. Psychopharmacologia (1967) 0.99
Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes. Mycoses (1991) 0.99
Treatment of experimental zygomycosis in guinea pigs with azoles and with amphotericin B. Chemotherapy (1989) 0.97
The antipyretic effect of suprofen in rats with yeast-induced fever. Arzneimittelforschung (1975) 0.97
Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism. J Pharmacol Exp Ther (2000) 0.96
Pharmacology of antidiarrheal drugs. Annu Rev Pharmacol Toxicol (1983) 0.96
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. Bioorg Med Chem Lett (2001) 0.96
R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis. Biochem Pharmacol (1990) 0.96
Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Sci (1982) 0.95
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential. Eur J Pharmacol (2001) 0.95
Pharmacology of the specific histamine H1-antagonist astemizole. Arzneimittelforschung (1983) 0.95