Published in Science on September 22, 1995
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science (1995) 3.25
The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics. Biophys J (1996) 1.34
Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. Br J Pharmacol (1996) 1.32
Agonist-activated ion channels. Br J Pharmacol (2006) 1.15
Single channel properties of human alpha3 AChRs: impact of beta2, beta4 and alpha5 subunits. J Physiol (1999) 1.12
The effective opening of nicotinic acetylcholine receptors with single agonist binding sites. J Gen Physiol (2011) 1.04
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
An Update on GABAρ Receptors. Curr Neuropharmacol (2010) 0.85
Acetylcholine. Br J Pharmacol (2006) 0.78
On the stochastic properties of single ion channels. Proc R Soc Lond B Biol Sci (1981) 11.30
Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proc R Soc Lond B Biol Sci (1977) 10.37
Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (1985) 9.25
On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Philos Trans R Soc Lond B Biol Sci (1982) 7.45
Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels. Nature (1981) 7.16
Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature (1981) 6.62
A P2X purinoceptor expressed by a subset of sensory neurons. Nature (1995) 4.86
ATP receptor-mediated synaptic currents in the central nervous system. Nature (1992) 4.57
The actions of tubocurarine at the frog neuromuscular junction. J Physiol (1979) 3.69
Conductance of channels opened by acetylcholine-like drugs in muscle end-plate. Nature (1975) 3.64
The binding of labelled tetrodotoxin to non-myelinated nerve fibres. J Physiol (1972) 3.60
Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction. Proc R Soc Lond B Biol Sci (1985) 2.64
Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc Biol Sci (1992) 2.49
Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events. Philos Trans R Soc Lond B Biol Sci (1992) 2.32
An analysis of the action of a false transmitter at the neuromuscular junction. J Physiol (1977) 2.29
A note on correlations in single ion channel records. Proc R Soc Lond B Biol Sci (1987) 2.26
Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J Physiol (1998) 2.26
Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus. J Physiol (1992) 2.24
Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits. J Physiol (2003) 1.99
Re-analysis of clinical trial of homoeopathic treatment in fibrositis. Lancet (1990) 1.81
Complementary medicine in the medical curriculum. J R Soc Med (1997) 1.75
The binding of tetrodotoxin and alpha-bungarotoxin to normal and denervated mammalian muscle. J Physiol (1974) 1.73
Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones. J Physiol (1990) 1.71
Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proc Biol Sci (1996) 1.65
Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J Physiol (1997) 1.60
The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres. J Physiol (1972) 1.58
Effects of pravastatin in 3260 patients with unstable angina: results from the LIPID study. Lancet (2000) 1.56
Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents. Annu Rev Physiol (1995) 1.55
On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons. Proc R Soc Lond B Biol Sci (1988) 1.52
Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu Rev Physiol (1995) 1.51
Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells. J Physiol (1991) 1.51
Conductances of single ion channels opened by nicotinic agonists are indistinguishable. Nature (1984) 1.50
Mechanisms of drug action at the voluntary muscle endplate. Annu Rev Pharmacol (1975) 1.49
Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp. J Physiol (1989) 1.48
Block of acetylcholine-activated ion channels by an uncharged local anaesthetic. Nature (1981) 1.47
The action of ganglionic blocking drugs on the synaptic responses of rat submandibular ganglion cells. Br J Pharmacol (1982) 1.46
The modes of action of gallamine. Proc R Soc Lond B Biol Sci (1981) 1.45
Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons of the rat. Proc R Soc Lond B Biol Sci (1987) 1.40
The kinetics of the interaction between tetrodotoxin and mammalian nonmyelinated nerve fibers. Mol Pharmacol (1972) 1.39
The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. J Physiol (1997) 1.36
Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle. Mol Pharmacol (1976) 1.36
Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proc Biol Sci (1995) 1.35
Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings. Proc Biol Sci (1991) 1.34
Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones. J Physiol (1991) 1.33
Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. J Neurosci (1998) 1.32
Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes. J Physiol (1994) 1.27
Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells. J Physiol (1996) 1.26
The efficacy of agonists at the frog neuromuscular junction studied with single channel recording. Pflugers Arch (1983) 1.23
Expression of cloned receptor subunits produces multiple receptors. Proc Biol Sci (1990) 1.21
A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor. J Biol Chem (1998) 1.21
Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes. J Physiol (1998) 1.20
Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat. J Physiol (1991) 1.17
Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration. Proc Biol Sci (1992) 1.17
Rapid histamine assays: a method and some theoretical considerations. Br J Pharmacol (1970) 1.14
Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes. J Physiol (1994) 1.14
Long-term risk stratification for survivors of acute coronary syndromes. Results from the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study. LIPID Study Investigators. J Am Coll Cardiol (2001) 1.14
Passive sensitization of skin and lung by guinea-pig immunoglobulins. Immunology (1965) 1.13
Adsorption and diffusion of gamma-globulin during passive sensitization of chopped guinea-pig lung. J Physiol (1965) 1.12
The action of tubocurarine at the neuromuscular junction [proceedings]. J Physiol (1978) 1.05
Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes. Neurology (2002) 1.04
The binding of labelled tetrodotoxin and cobra toxin by the rat diaphragm. Br J Pharmacol (1973) 1.03
Molecular pharmacology. The binding issue. Nature (1993) 1.02
The rate of equilibration in a competitive n drug system and the auto-inhibitory equations of enzyme kinetics: some properties of simple models for passive sensitization. Proc R Soc Lond B Biol Sci (1968) 1.01
Activation of ion channels in the frog endplate by several analogues of acetylcholine. J Physiol (1991) 1.00
Kinetics of acetylcholine activated ion channels in chick ciliary ganglion neurones grown in tissue culture. Pflugers Arch (1984) 0.98
Single channel analysis of a novel NMDA channel from Xenopus oocytes expressing recombinant NR1a, NR2A and NR2D subunits. J Physiol (2000) 0.92
Single-channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site. J Physiol (2000) 0.92
Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula. J Physiol (1995) 0.91
The effect of tubocurarine competition on the kinetics of agonist action on the nicotinic receptor. Br J Pharmacol (1982) 0.89
Single channel analysis costs time. Trends Pharmacol Sci (1988) 0.88
The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle. J Physiol (1990) 0.88
Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study. Int J Obes (Lond) (2008) 0.87
Squash racquets. A review of physiology and medicine. Sports Med (1997) 0.85
Competitive block and ion channel block as mechanisms of antagonist action on the skeletal muscle end-plate. Adv Biochem Psychopharmacol (1980) 0.82
Voluntary partial retraction of: Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes. Neurology (2009) 0.81
Molecular neurobiology. A new type of ion-channel block. Nature (1987) 0.81
A comparative study of the efficacy of simvastatin and gemfibrozil in combined hyperlipoproteinemia: prediction of response by baseline lipids, apo E genotype, lipoprotein(a) and insulin. Atherosclerosis (1997) 0.80
Modes of action of gallamine at the neuromuscular junction [proceedings]. Br J Pharmacol (1979) 0.80
Neher and Sakmann win Nobel Prize for patch-clamp work. Trends Pharmacol Sci (1991) 0.78
Unravelling the paradox. Trends Pharmacol Sci (1992) 0.78
Is NADH effective in the treatment of chronic fatigue syndrome? Ann Allergy Asthma Immunol (2000) 0.78
Kinetic effects of tubocurarine on skeletal muscle at high agonist concentrations [proceedings]. Br J Pharmacol (1980) 0.78
Atlantic salmon bath challenged with Moritella viscosa--pathogen invasion and host response. Fish Shellfish Immunol (2009) 0.77
Proceedings: Tetrodotoxin binding to innervated and denervated rat diaphragm homogenates. Br J Pharmacol (1974) 0.75
Skin test reactivity and cellular immune responses to Mycobacterium avium sensitin in AIDS patients at risk for disseminated M. avium infection. Clin Diagn Lab Immunol (2001) 0.75
How long does a molecule stay on the receptor? Explanation of a paradox. Br J Pharmacol (1970) 0.75
Proceedings: The inhibition of alpha-bungarotoxin binding to denervated rat muscle by tubocurarine and other drugs. Br J Pharmacol (1974) 0.75
Ion channels: this year's Nobel prize in physiology or medicine. BMJ (1991) 0.75
GABA and the single oocyte: relating binding to gating. Nat Neurosci (1999) 0.75
The binding of tritium-labelled tetrodotoxin to non-myelinated nerve. J Physiol (1972) 0.75
Analysis of end-plate current fluctuations produced by acetylcholine and acetylmonoethylcholine in rat muscle [proceedings]. Br J Pharmacol (1976) 0.75
Health education, health promotion or drugs? Cholesterol and coronary heart disease. Med J Aust (1990) 0.75
Better Health Commission. Med J Aust (1985) 0.75
Persistence: a new statistic for characterizing ion-channel activity. Philos Trans R Soc Lond B Biol Sci (1995) 0.75
Modification of cardiovascular risk factors. Med J Aust (1988) 0.75
Real-time PCR detection of Moritella viscosa, the likely causal agent of winter-ulcer in Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Dis Aquat Organ (2008) 0.75
Molecular pharmacology: structure and function of acetylcholine-receptor ion channels. Nature (1986) 0.75
Vitamin use in clinical medicine. Med J Aust (1987) 0.75
Management of hypercholesterolaemia in postmenopausal women. Med J Aust (1989) 0.75