Published in Nature on June 22, 1968
Pyrimidine metabolism in microorganisms. Bacteriol Rev (1970) 7.44
Use of dimethyl suberimidate, a cross-linking reagent, in studying the subunit structure of oligomeric proteins. Proc Natl Acad Sci U S A (1970) 7.37
Negative cooperativity in regulatory enzymes. Proc Natl Acad Sci U S A (1969) 3.38
Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate. Proc Natl Acad Sci U S A (1978) 1.71
Location of amino acid alterations in mutants of aspartate transcarbamoylase: Structural aspects of interallelic complementation. Proc Natl Acad Sci U S A (1984) 1.56
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Structure at 2.9-A resolution of aspartate carbamoyltransferase complexed with the bisubstrate analogue N-(phosphonacetyl)-L-aspartate. Proc Natl Acad Sci U S A (1985) 1.48
Genes encoding Escherichia coli aspartate transcarbamoylase: the pyrB-pyrI operon. Proc Natl Acad Sci U S A (1982) 1.37
Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution. Proc Natl Acad Sci U S A (1984) 1.36
A small family of nodule specific genes from soybean. Nucleic Acids Res (1987) 1.24
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Aspartate transcarbamoylase from Escherichia coli: electron density at 5.5 A resolution. Proc Natl Acad Sci U S A (1973) 1.14
Aspartate transcarbamoylase molecules lacking one regulatory subunit. Proc Natl Acad Sci U S A (1974) 1.12
Localization of the zinc binding site of aspartate transcarbamoylase in the regulatory subunit. Proc Natl Acad Sci U S A (1971) 1.06
The thiol group in the catalytic chains of aspartate transcarbamoylase. Proc Natl Acad Sci U S A (1972) 1.05
Elimination of cooperativity in aspartate transcarbamylase by nitration of a single tyrosine residue. Proc Natl Acad Sci U S A (1978) 1.03
Amino acid sequence of the catalytic subunit of aspartate transcarbamoylase from Escherichia coli. Proc Natl Acad Sci U S A (1983) 1.02
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Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution. Proc Natl Acad Sci U S A (1991) 0.97
An intermediate complex in the dissociation of aspartate transcarbamylase. Proc Natl Acad Sci U S A (1974) 0.97
A 3.0-A resolution study of nucleotide complexes with aspartate carbamoyltransferase. Proc Natl Acad Sci U S A (1979) 0.96
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A 70-amino acid zinc-binding polypeptide from the regulatory chain of aspartate transcarbamoylase forms a stable complex with the catalytic subunit leading to markedly altered enzyme activity. Proc Natl Acad Sci U S A (1991) 0.92
In vivo formation of hybrid aspartate transcarbamoylases from native subunits of divergent members of the family Enterobacteriaceae. J Bacteriol (1986) 0.92
Mammalian aspartate transcarbamylase (ATCase): sequence of the ATCase domain and interdomain linker in the CAD multifunctional polypeptide and properties of the isolated domain. Proc Natl Acad Sci U S A (1989) 0.92
Assembly of the aspartate transcarbamoylase holoenzyme from transcriptionally independent catalytic and regulatory cistrons. J Bacteriol (1984) 0.90
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Pathways of assembly of aspartate transcarbamoylase from catalytic and regulatory subunits. Proc Natl Acad Sci U S A (1974) 0.87
Communication between catalytic subunits in hybrid aspartate transcarbamoylase molecules: effect of ligand binding to active chains on the conformation of unliganded, inactive chains. Proc Natl Acad Sci U S A (1980) 0.86
Structure and mechanisms of Escherichia coli aspartate transcarbamoylase. Acc Chem Res (2011) 0.86
Complex of aspartate carbamoyltransferase from Escherichia coli with its allosteric inhibitor, cytidine triphosphate: electron density at 5.9-angstroms resolution. Proc Natl Acad Sci U S A (1974) 0.86
Partial cDNA sequence to a hamster gene corrects defect in Escherichia coli pyrB mutant. Proc Natl Acad Sci U S A (1983) 0.85
Communication between dissimilar subunits in aspartate transcarbamoylase: effect of inhibitor and activator on the conformation of the catalytic polypeptide chains. Proc Natl Acad Sci U S A (1979) 0.85
Cooperative interactions in aspartate transcarbamoylase. 1. Hybrids composed of native and chemically inactivated catalytic polypeptide chains. Proc Natl Acad Sci U S A (1974) 0.84
Aspartate transcarbamoylase genes of Pseudomonas putida: requirement for an inactive dihydroorotase for assembly into the dodecameric holoenzyme. J Bacteriol (1995) 0.84
Dissecting enzyme regulation by multiple allosteric effectors: nucleotide regulation of aspartate transcarbamoylase. Biochemistry (2008) 0.81
Allosteric cofactor-mediated enzyme cooperativity: a theoretical treatment. Proc Natl Acad Sci U S A (1983) 0.81
The pathway of product release from the R state of aspartate transcarbamoylase. J Mol Biol (2010) 0.81
Enzyme forms produced from aspartate transcarbamoylase by digestion with trypsin. Biochem J (1973) 0.79
Isolation and preliminary characterization of single amino acid substitution mutants of aspartate carbamoyltransferase. Proc Natl Acad Sci U S A (1980) 0.79
Association of the catalytic subunit of aspartate transcarbamoylase with a zinc-containing polypeptide fragment of the regulatory chain leads to increases in thermal stability. Protein Sci (1994) 0.78
Structural transitions in crystals of native aspartate carbamoyltransferase. Proc Natl Acad Sci U S A (1989) 0.77
A kinetic model of cooperativity in aspartate transcarbamylase. Biophys J (1977) 0.75
X-ray Scattering Studies of Protein Structural Dynamics. Chem Rev (2017) 0.75
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem (1969) 142.11
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Measurement of molecular weights by electrophoresis on SDS-acrylamide gel. Methods Enzymol (1972) 14.68
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Actin antibody: the specific visualization of actin filaments in non-muscle cells. Proc Natl Acad Sci U S A (1974) 11.64
Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci (2001) 6.66
Simian virus 40 gene A function and maintenance of transformation. J Virol (1975) 6.40
Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem (1994) 6.32
Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc Natl Acad Sci U S A (1978) 6.28
Antibody against tuberlin: the specific visualization of cytoplasmic microtubules in tissue culture cells. Proc Natl Acad Sci U S A (1975) 5.99
Antibody to myosin: the specific visualization of myosin-containing filaments in nonmuscle cells. Proc Natl Acad Sci U S A (1974) 5.93
The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation. Differentiation (1979) 5.90
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Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane. Proc Natl Acad Sci U S A (1976) 5.56
At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol (1978) 5.34
Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil (1985) 5.34
Amino-terminal sequence analysis of proteins purified on a nanomole scale by gel electrophoresis. J Biol Chem (1972) 5.24
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Lac repressor. Specific proteolytic destruction of the NH 2 -terminal region and loss of the deoxyribonucleic acid-binding activity. J Biol Chem (1973) 4.96
Patterns of organization of actin and myosin in normal and transformed cultured cells. Proc Natl Acad Sci U S A (1975) 4.86
Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner. Cell (1980) 4.83
Reversible denaturation of enzymes by sodium dodecyl sulfate. J Biol Chem (1971) 4.66
Reliability and validity of grip and pinch strength evaluations. J Hand Surg Am (1984) 4.63
Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates. Exp Cell Res (1979) 4.61
Structurally distinct bacterial luciferases. Biochemistry (1969) 4.03
Antibody to prekeratin. Decoration of tonofilament like arrays in various cells of epithelial character. Exp Cell Res (1978) 4.01
The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins. EMBO J (1982) 4.01
Localization of actin and microfilament-associated proteins in the microvilli and terminal web of the intestinal brush border by immunofluorescence microscopy. J Cell Biol (1978) 3.98
Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. J Abnorm Psychol (1995) 3.97
Specific visualization of tubulin-containing structures in tissue culture cells by immunofluorescence. Cytoplasmic microtubules, vinblastine-induced paracrystals, and mitotic figures. Exp Cell Res (1975) 3.95
Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures. J Cell Biol (1980) 3.93
Adult norms for the Box and Block Test of manual dexterity. Am J Occup Ther (1985) 3.92
Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest (1983) 3.91
MSI and MSII made on ribosome in idling step of protein synthesis. Nature (1972) 3.89
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol (1988) 3.86
The detertent-resistant cytoskeleton of tissue culture cells includes the nucleus and the microfilament bundles. Exp Cell Res (1977) 3.84
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues. Cell (1978) 3.79
Fractionation of brain microtubule-associated proteins. Isolation of two different proteins which stimulate tubulin polymerization in vitro. Eur J Biochem (1978) 3.62
Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol (1985) 3.59
The distribution of actin in non-muscle cells. The use of actin antibody in the localization of actin within the microfilament bundles of mouse 3T3 cells. Exp Cell Res (1975) 3.59
Visualization of a system of filaments 7-10 nm thick in cultured cells of an epithelioid line (Pt K2) by immunofluorescence microscopy. Proc Natl Acad Sci U S A (1977) 3.52
Natural read-through at the UGA termination signal of Q-beta coat protein cistron. Nat New Biol (1971) 3.52
Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture cells by electron microscopy and by immunofluorescence microscopy. Proc Natl Acad Sci U S A (1978) 3.46
Golgi-derived membranes that contain an acylated viral polypeptide are used for vaccinia virus envelopment. J Virol (1985) 3.44
Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Development (1989) 3.37
Three-dimensional electron microscopical visualization of the cytoskeleton of animal cells: immunoferritin identification of actin- and tubulin-containing structures. Proc Natl Acad Sci U S A (1978) 3.32
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol Biol Cell (2000) 3.30
Villin: the major microfilament-associated protein of the intestinal microvillus. Proc Natl Acad Sci U S A (1979) 3.27
Isolation of amino-terminal fragment of lactose repressor necessary for DNA binding. Biochemistry (1977) 3.22
Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res (2002) 3.16
Alendronate for the treatment of osteoporosis in men. N Engl J Med (2000) 3.11
Purification of microvilli and an analysis of the protein components of the microfilament core bundle. Exp Cell Res (1978) 3.09
The display of microtubules in transformed cells. Cell (1977) 3.04
Immunofluorescence and immunocytochemical procedures with affinity purified antibodies: tubulin-containing structures. Methods Cell Biol (1982) 2.98
HeLa cells contain intermediate-sized filaments of the prekeratin type. Exp Cell Res (1979) 2.98
Isolation of a set of hybrid lac repressors made in vitro between normal lac repressor and its homogeneous tryptic core. Proc Natl Acad Sci U S A (1976) 2.97
Distribution of actin and tubulin in cells and in glycerinated cell models after treatment with cytochalasin B (CB). Exp Cell Res (1976) 2.96
Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin. Proc Natl Acad Sci U S A (1981) 2.94
Cell-to-substratum contacts in living cells: a direct correlation between interference-reflexion and indirect-immunofluorescence microscopy using antibodies against actin and alpha-actinin. J Cell Sci (1979) 2.93
An F-actin- and calmodulin-binding protein from isolated intestinal brush borders has a morphology related to spectrin. Cell (1982) 2.89
Bacteriophage Q replicase contains the protein biosynthesis elongation factors EF Tu and EF Ts. Proc Natl Acad Sci U S A (1972) 2.88
Mammalian cytoplasmic actins are the products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins. Proc Natl Acad Sci U S A (1978) 2.84
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc Natl Acad Sci U S A (1977) 2.77
Retention of women enrolled in a prospective study of human immunodeficiency virus infection: impact of race, unstable housing, and use of human immunodeficiency virus therapy. Am J Epidemiol (2001) 2.77
F-actin binding and bundling properties of fimbrin, a major cytoskeletal protein of microvillus core filaments. J Biol Chem (1981) 2.72
Proteinchemical characterization of three structurally distinct domains along the protofilament unit of desmin 10 nm filaments. Cell (1982) 2.67
Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins. EMBO J (1983) 2.64
Erythroid spectrin, brain fodrin, and intestinal brush border proteins (TW-260/240) are related molecules containing a common calmodulin-binding subunit bound to a variant cell type-specific subunit. Proc Natl Acad Sci U S A (1982) 2.63
Intermediate filaments. Cold Spring Harb Symp Quant Biol (1982) 2.61
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Coexpression of a mutant beta-actin and the two normal beta- and gamma-cytoplasmic actins in a stably transformed human cell line. Cell (1980) 2.58
Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J Cell Biol (1980) 2.54
Translational restarts: AUG reinitiation of a lac repressor fragment. Proc Natl Acad Sci U S A (1972) 2.45
Structure and biochemistry of mouse hepatic gap junctions. J Mol Biol (1979) 2.44
Individual microtubules viewed by immunofluorescence and electron microscopy in the same PtK2 cell. J Cell Biol (1978) 2.41
Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ (2009) 2.40
Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin. Proc Natl Acad Sci U S A (1981) 2.40
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Calmodulin-binding proteins of the microfilaments present in isolated brush borders and microvilli of intestinal epithelial cells. J Biol Chem (1980) 2.28
The amino acid sequence of Physarum actin. Nature (1978) 2.28
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Actin typing on total cellular extracts: a highly sensitive protein-chemical procedure able to distinguish different actins. Eur J Biochem (1981) 2.16
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