Published in J Biol Chem on May 10, 1971
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Bacteria mature preproinsulin to proinsulin. Proc Natl Acad Sci U S A (1980) 1.75
Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagon. Proc Natl Acad Sci U S A (1973) 1.73
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease. Proc Natl Acad Sci U S A (1982) 1.70
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J (1987) 1.33
Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochem J (1987) 1.16
Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycemia. J Clin Invest (1979) 1.11
Mechanism of alpha factor biosynthesis in Saccharomyces cerevisiae. J Bacteriol (1974) 1.05
Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor. Proc Natl Acad Sci U S A (1978) 0.99
Adventures with insulin in the islets of Langerhans. J Biol Chem (2011) 0.88
Characterization of proinsulin-insulin intermediates in human plasma. J Clin Invest (1978) 0.88
The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature (1997) 34.00
Construction of phylogenetic trees. Science (1967) 23.69
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature (2000) 19.93
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science (2000) 16.04
Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature (1999) 14.42
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature (1997) 14.38
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science (1999) 8.01
A method for estimating the number of invariant amino acid coding positions in a gene using cytochrome c as a model case. Biochem Genet (1967) 6.87
The antigenic structure of proteins: a reappraisal. Annu Rev Immunol (1984) 5.31
Insulin biosynthesis: evidence for a precursor. Science (1967) 5.05
Ferricytochrome c. I. General features of the horse and bonito proteins at 2.8 A resolution. J Biol Chem (1971) 4.75
Processing mechanisms in the biosynthesis of proteins. Ann N Y Acad Sci (1980) 4.40
Gestational diabetes mellitus--management guidelines. The Australasian Diabetes in Pregnancy Society. Med J Aust (1998) 4.05
Cytochrome c. Adv Protein Chem (1966) 3.51
Post-translational proteolysis in polypeptide hormone biosynthesis. Annu Rev Physiol (1982) 3.43
The mutational alteration of the primary structure of yeast iso-1-cytochrome c. J Biol Chem (1968) 3.42
Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination. Proc Natl Acad Sci U S A (1976) 3.41
Proteolytic processing in the biosynthesis of insulin and other proteins. Fed Proc (1974) 3.27
Molecular expression of evolutinary phenomena in the primary and tertiary structures of cytochrome c. Brookhaven Symp Biol (1968) 2.98
Mitochondrial cytochrome c: preparation and activity of native and chemically modified cytochromes c. Methods Enzymol (1978) 2.87
Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes (1977) 2.79
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J Biol Chem (1990) 2.78
Proteolytic processing in the secretory pathway. J Biol Chem (1999) 2.75
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet (1995) 2.73
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc Natl Acad Sci U S A (1991) 2.62
Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proc Natl Acad Sci U S A (1983) 2.57
The structural gene for yeast cytochrome C. Proc Natl Acad Sci U S A (1966) 2.56
Binding and degradation of 125I-insulin by rat hepatocytes. J Biol Chem (1975) 2.46
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S A (1997) 2.42
Insulin biosynthesis in the rat: demonstration of two proinsulins. Proc Natl Acad Sci U S A (1969) 2.41
Comparative aspects of primary structures of proteins. Annu Rev Biochem (1968) 2.31
Survey of plasmids and resistance factors in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother (1985) 2.27
Structure and evolution of the insulin gene. Annu Rev Genet (1985) 2.27
Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II. Proc Natl Acad Sci U S A (1979) 2.27
Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase. J Biol Chem (1976) 2.25
Monoclonal antibodies to human estrogen receptor. Proc Natl Acad Sci U S A (1980) 2.24
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J Biol Chem (1985) 2.09
Isolation and properties of proinsulin, intermediate forms, and other minor components from crystalline bovine insulin. Diabetes (1968) 2.07
Retention and degradation of 125I-insulin by perfused livers from diabetic rats. J Clin Invest (1976) 2.04
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J Biol Chem (1985) 1.95
Golgi/granule processing of peptide hormone and neuropeptide precursors: a minireview. J Cell Biochem (1984) 1.93
Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc Natl Acad Sci U S A (1991) 1.90
Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B. J Biol Chem (1971) 1.88
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc Natl Acad Sci U S A (1986) 1.82
Definition of cytochrome c binding domains by chemical modification. III. Kinetics of reaction of carboxydinitrophenyl cytochromes c with cytochrome c oxidase. J Biol Chem (1978) 1.79
Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol (1995) 1.79
Topographic antigenic determinants on cytochrome c. Immunoadsorbent separation of the rabbit antibody populations directed against horse cytochrome. J Biol Chem (1979) 1.78
Proinsulin and the biosynthesis of insulin. Recent Prog Horm Res (1969) 1.78
The relationship of gene structure and protein structure of iso-I-cytochrome c from yeast. Symp Soc Exp Biol (1970) 1.76
The asymmetric distribution of charges on the surface of horse cytochrome c. Functional implications. J Biol Chem (1982) 1.74
Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagon. Proc Natl Acad Sci U S A (1973) 1.73
A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia. Proc Natl Acad Sci U S A (1987) 1.73
Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose. Biochem J (1986) 1.71
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease. Proc Natl Acad Sci U S A (1982) 1.70
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells. Proc Natl Acad Sci U S A (1987) 1.70
A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J Exp Med (1989) 1.69
Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase. J Biol Chem (1978) 1.64
Impact of HIV infection on the development, clinical presentation, and outcome of tuberculosis among children in Abidjan, Côte d'Ivoire. AIDS (1997) 1.63
Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J Immunol (1983) 1.63
Persistent Campylobacter jejuni infection in an immunocompromised patient. Ann Intern Med (1984) 1.62
Determination of the amino acid sequence of the monkey, sheep, and dog proinsulin C-peptides by a semi-micro Edman degradation procedure. J Biol Chem (1972) 1.62
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing. Science (1988) 1.61
Comparable specificity of 2 commercial tuberculin reagents in persons at low risk for tuberculous infection. JAMA (1999) 1.61
Islet-cell-surface antibodies in juvenile diabetes mellitus. N Engl J Med (1978) 1.59
Partial purification and characterization of the mRNA for rat preproinsulin. Proc Natl Acad Sci U S A (1976) 1.59
Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits. J Biol Chem (1990) 1.56
Identification of cDNA clones encoding a precursor of rat liver cathepsin B. Proc Natl Acad Sci U S A (1985) 1.55
The spontaneous reoxidation of reduced beef and rat proinsulins. Proc Natl Acad Sci U S A (1968) 1.55
Inhibition of angiogenesis by interleukin 4. J Exp Med (1998) 1.53
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing. J Biol Chem (1988) 1.53
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat Neurosci (1999) 1.53
Human serum proinsulin. J Clin Invest (1970) 1.52
Nontuberculous mycobacterial disease in adult cystic fibrosis patients. Chest (1993) 1.52
Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem (1998) 1.51
Estrogen and progesterone receptors in the normal female breast. Cancer Res (1991) 1.50
Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets. J Cell Biol (1976) 1.50
Translation of satellite tobacco necrosis virus ribonucleic acid. I. Characterization of in vitro procaryotic and eucaryotic translation products. Biochemistry (1972) 1.50
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem (2000) 1.50
Effects of beta cell granule components on human islet amyloid polypeptide fibril formation. FEBS Lett (1996) 1.49
The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol (1982) 1.49
In vitro synthesis and posttranslational uptake of cytochrome c into isolated mitochondria: role of a specific addressing signal in the apocytochrome. Proc Natl Acad Sci U S A (1981) 1.47
Cathepsin B-related proteases in the insulin secretory granule. J Biol Chem (1984) 1.47
Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci U S A (2000) 1.46
Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology (1998) 1.46
Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans. J Biol Chem (1973) 1.46
Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem (2001) 1.45
Definition of cytochrome c binding domains by chemical modification: kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain. Proc Natl Acad Sci U S A (1979) 1.44
Identification of a peptide binding protein that plays a role in antigen presentation. Proc Natl Acad Sci U S A (1987) 1.43
Evidence for proinsulin in human urine and serum. Lancet (1968) 1.42
"Homology" in proteins and nucleic acids: a terminology muddle and a way out of it. Cell (1987) 1.42
Isolation and characterization of proinsulin C-peptide from bovine pancreas. J Biol Chem (1971) 1.41