Published in Nature on October 08, 1971
Apha-adrenergic receptor blockade increases human REM sleep. Br J Clin Pharmacol (1975) 0.92
MPTP-treated mice: long-lasting loss of nigral TH-ir neurons but not paradoxical sleep alterations. Exp Brain Res (2008) 0.82
Role of central alpha-1 adrenoceptors in canine narcolepsy. J Clin Invest (1988) 0.82
Biochemical pharmacology of paradoxical sleep. Br J Clin Pharmacol (1983) 0.76
Stromal gene signatures in large-B-cell lymphomas. N Engl J Med (2008) 11.34
Isolation of a protein that is essential for the first step of nuclear protein import. Cell (1994) 6.63
The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry (1965) 5.09
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol (1995) 4.46
A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36
Distinct functions for the two importin subunits in nuclear protein import. Nature (1995) 4.16
Identification of a tRNA-specific nuclear export receptor. Mol Cell (1998) 3.94
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell (1992) 3.78
A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. EMBO J (1996) 3.65
Biogenic amines and emotion. Science (1967) 3.49
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell (1995) 3.46
A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature (1992) 3.20
Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO J (1995) 2.96
A class of membrane proteins with a C-terminal anchor. Trends Cell Biol (1993) 2.77
A signal sequence receptor in the endoplasmic reticulum membrane. Nature (1987) 2.72
Importin provides a link between nuclear protein import and U snRNA export. Cell (1996) 2.65
Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol Cell Biol (1999) 2.27
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J (2000) 2.18
The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J (1996) 2.14
CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol (1999) 2.08
Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. FEBS Lett (1997) 2.03
Importin 13: a novel mediator of nuclear import and export. EMBO J (2001) 1.98
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. EMBO J (1996) 1.93
A prokaryotic phytochrome. Nature (1997) 1.91
A novel pathway for secretory proteins? Trends Biochem Sci (1990) 1.91
Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite. Biochem Pharmacol (1968) 1.86
[Normal values of serum transaminases using substrate-calibrated test kits for activity measurement. Study results in 3979 clinically healthy workers of both sexes]. Klin Wochenschr (1970) 1.85
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem (1993) 1.85
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane. J Cell Biol (1996) 1.68
Protein translocation in the three domains of life: variations on a theme. Cell (1997) 1.67
Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet (2001) 1.62
Characterization of recombinant phytochrome from the cyanobacterium Synechocystis. Proc Natl Acad Sci U S A (1997) 1.60
The effects of psychoactive drugs on norepinephrine-3-H metabolism in brain. Biochem Pharmacol (1967) 1.54
Oral vaccination of monkeys with an invasive Escherichia coli K-12 hybrid expressing Shigella flexneri 2a somatic antigen. Infect Immun (1984) 1.52
Mammalian Sec61 is associated with Sec62 and Sec63. J Biol Chem (2000) 1.47
Reduction in tissue blood flow in J-shaped pelvic ileal reservoirs. Dis Colon Rectum (1995) 1.43
Psychological differences between long and short sleepers. Arch Gen Psychiatry (1972) 1.43
Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA. EMBO J (2000) 1.41
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. J Cell Biol (1999) 1.40
Guilty by insolubility--does a protein's detergent insolubility reflect a caveolar location? Trends Cell Biol (1995) 1.36
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. J Cell Biol (1990) 1.35
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. J Cell Biol (1993) 1.35
The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation. J Cell Biol (1998) 1.31
Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res (2002) 1.27
Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast (1999) 1.25
Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J (1999) 1.24
The effects of long term administration of psychotropic drugs on human sleep. VI. The effects of chlordiazepoxide. Psychopharmacologia (1973) 1.23
Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine? Harv Rev Psychiatry (1999) 1.21
Photocrosslinking demonstrates proximity of a 34 kDa membrane protein to different portions of preprolactin during translocation through the endoplasmic reticulum. FEBS Lett (1989) 1.19
Structure and biosynthesis of the signal-sequence receptor. Eur J Biochem (1990) 1.19
Sleep need: how much sleep and what kind? Am J Psychiatry (1971) 1.19
Wound closure in obese patients. Surg Gynecol Obstet (1986) 1.18
Phosphatidylinositol specific phospholipase C of plant stems : membrane associated activity concentrated in plasma membranes. Plant Physiol (1987) 1.17
Vulnerability to schizophrenia. Prediction of adult schizophrenia using childhood information. Arch Gen Psychiatry (1984) 1.16
A case controlled study of laparoscopic incisional hernia repair. Surg Endosc (2000) 1.16
Characterization of the Cph1 holo-phytochrome from Synechocystis sp. PCC 6803. Eur J Biochem (2001) 1.15
Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem (2000) 1.15
The catecholamine hypothesis of affective disorders: a review of supporting evidence. 1965. J Neuropsychiatry Clin Neurosci (1995) 1.14
Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways. J Pathol (2008) 1.11
Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial. Clin Infect Dis (1998) 1.10
Increases in intra-abdominal pressure affect pulmonary compliance. Arch Surg (1995) 1.10
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochem Pharmacol (1996) 1.08
Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane. Eur J Cell Biol (1990) 1.08
Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa. J Clin Invest (1993) 1.07
SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome. EMBO J (2001) 1.07
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis. Neuroscience (2007) 1.06
The current status of biological criteria for classifying the depressive disorders and predicting responses to treatment. Psychopharmacol Bull (1974) 1.06
Febrile response after knee and hip arthroplasty. Clin Orthop Relat Res (1999) 1.04
Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro. Virology (2001) 1.01
The effects of long term administration of psychotropic drugs on human sleep. I. Methodology and the effects of placebo. Psychopharmacologia (1973) 1.01
Nightmares and trauma: a comparison of nightmares after combat with lifelong nightmares in veterans. Am J Psychiatry (1984) 0.99
Protein translocation: common themes from bacteria to man. FEBS Lett (1994) 0.99
Sec61p is the main ribosome receptor in the endoplasmic reticulum of Saccharomyces cerevisiae. Biol Chem (2001) 0.99
Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings. Am J Psychiatry (1973) 0.99
Chloroplast SecY is complexed to SecE and involved in the translocation of the 33-kDa but not the 23-kDa subunit of the oxygen-evolving complex. J Biol Chem (1999) 0.98
Diurnal variation of plasma cortisol and homovanillic acid in healthy subjects. Psychoneuroendocrinology (1996) 0.97
The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. J Biol Chem (1997) 0.97
Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. J Biol Chem (1996) 0.97
Normetanephrine excretion and affective state in depressed patients treated with imipramine. Am J Psychiatry (1966) 0.97
Hsp70s contain a specific sulfogalactolipid binding site. Differential aglycone influence on sulfogalactosyl ceramide binding by recombinant prokaryotic and eukaryotic hsp70 family members. Biochemistry (2001) 0.96
Amphetamine withdrawal: affective state, sleep patterns, and MHPG excretion. Am J Psychiatry (1972) 0.96
Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. J Cell Sci (2001) 0.96
Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. J Biol Chem (1996) 0.95
Safety and antigenicity of typhoid-Shigella sonnei vaccine (strain 5076-1C). J Infect Dis (1984) 0.95
Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy. The RV43 Study Group. Antimicrob Agents Chemother (1994) 0.95
The peripheral critical flicker frequency. Vision Res (1979) 0.94
A preliminary study of the personality of the nightmare sufferer: relationship to schizophrenia and creativity? Am J Psychiatry (1981) 0.94
Microtubule distribution in gravitropic protonemata of the moss Ceratodon. Protoplasma (1990) 0.93
The effects of delta-9-tetrahydrocannabinol on the metabolism of norepinephrine in rat brain. Psychopharmacologia (1971) 0.93
Use of the laryngeal mask airway in a patient with Edward's syndrome. Anaesthesia (1992) 0.93
Amphetamine withdrawal: effects on threshold of intracranial reinforcement. Psychopharmacology (Berl) (1981) 0.92
Spinal ropivacaine for cesarean section: a dose-finding study. Anesthesiology (2001) 0.92
Tranylcypromine: effects on norepinephrine metabolism in rat brain. Am J Psychiatry (1970) 0.91
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action. Am J Psychiatry (1967) 0.91
Reserpine: its effect on the sleep-dream cycle in man. Psychopharmacologia (1966) 0.91
Interaction of Kar2p and Sls1p is required for efficient co-translational translocation of secreted proteins in the yeast Yarrowia lipolytica. J Biol Chem (1998) 0.90
The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae. J Biol Chem (1996) 0.90
Reorganization of microfilaments in protonemal tip cells of the moss Ceratodon purpureus during the phototropic response. Protoplasma (1995) 0.90