Published in Proc Natl Acad Sci U S A on July 01, 1965
Psychedelic drugs: steric factors that predict psychotropic activity. Proc Natl Acad Sci U S A (1968) 0.99
On the conformations of hallucinogenic molecules and their correlation. Proc Natl Acad Sci U S A (1969) 0.89
Specificity of the antibody receptor site to D-lysergamide: model of a physiological receptor for lysergic acid diethylamide. Proc Natl Acad Sci U S A (1971) 0.82
Steric and electronic relationships among some hallucinogenic compounds. Proc Natl Acad Sci U S A (1970) 0.80
QUANTUM CHEMICAL STUDIES OF CHARGE-TRANSFER COMPLEXES OF INDOLES. Proc Natl Acad Sci U S A (1965) 0.75
Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach. Springerplus (2016) 0.75
Amphetamines: correlation of activity with stability of molecular complexes. Proc Natl Acad Sci U S A (1972) 0.75
On the mechanism of action of chlorpromazine. Science (1959) 1.47
On the identification of octopamine in mammals. J Biol Chem (1962) 1.38
Serotonin-LSD interactions. Ann N Y Acad Sci (1957) 1.37
The distribution and metabolism of lysergic acid diethylamide. Ann N Y Acad Sci (1957) 1.24
Comparison of psilocin with psilocybin, mescaline and LSD-25. Psychopharmacologia (1962) 1.17
Cross tolerance between LSD and psilocybin. Psychopharmacologia (1961) 1.08
Acquired and crossed tolerance to mescaline, LSD-25, and BOL-148. AMA Arch Gen Psychiatry (1959) 0.97
Psychotomimetic amphetamines: methoxy 3,4-dialkoxyamphetamines. Experientia (1964) 0.95
Effect of some indolealkylamines on man. AMA Arch Neurol Psychiatry (1959) 0.94
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF FLUORINATED TRYPTAMINE DERIVATIVES. J Med Chem (1963) 0.89
The effect of reserpine on the intracellular distribution of catecholamines in the brain stem of the rabbit. J Neurochem (1959) 0.86
Hydroxylation and N-demethylation of N, N-dimethyltryptamine. Experientia (1959) 0.86
DISTRIBUTION AND METABOLISM OF MESCALINE-C14 IN THE CAT BRAIN. J Pharmacol Exp Ther (1964) 0.83
Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science (1981) 23.67
Complementary DNA sequencing: expressed sequence tags and human genome project. Science (1991) 19.42
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A (1990) 10.40
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (1991) 8.41
Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1992) 8.24
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03
Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 7.23
The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE (2001) 6.09
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A (1989) 6.08
Opiate receptor: demonstration in nervous tissue. Science (1973) 6.06
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70
Carbon monoxide: a putative neural messenger. Science (1993) 5.47
Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem (1994) 5.11
Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02
A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels. Anal Biochem (1979) 4.77
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci U S A (1993) 4.73
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. J Biol Chem (1987) 4.46
Solubilization, purification, and characterization of an inositol trisphosphate receptor. J Biol Chem (1988) 4.42
Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc Natl Acad Sci U S A (1968) 4.24
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12
Trace polypeptides in cellular extracts and human body fluids detected by two-dimensional electrophoresis and a highly sensitive silver stain. Proc Natl Acad Sci U S A (1979) 4.11
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science (1976) 4.07
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A (1992) 3.95
Nitric oxide, a novel neuronal messenger. Neuron (1992) 3.87
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (1994) 3.86
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A (1999) 3.85
Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron (1996) 3.75
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet (1989) 3.69
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51
Nitric oxide: a physiologic mediator of penile erection. Science (1992) 3.39
Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci U S A (1974) 3.35
Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature (1989) 3.35
Properties of opiate-receptor binding in rat brain. Proc Natl Acad Sci U S A (1973) 3.34
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci U S A (1991) 3.22
Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase. Mol Pharmacol (1969) 3.21
Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem (1992) 3.21
Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proc Natl Acad Sci U S A (1980) 3.20
Gel protein stains: silver stain. Methods Enzymol (1984) 3.18
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15
Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol (1993) 3.12
Nitric oxide, a novel biologic messenger. Cell (1992) 3.04
A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol (1965) 2.99
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem (1993) 2.96
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature (1989) 2.94
Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol (1979) 2.89
Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell (1995) 2.89
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A (1985) 2.85
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84
Methods for increasing the resolution of two-dimensional protein electrophoresis. Anal Biochem (1988) 2.78
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A (1992) 2.72
A huntingtin-associated protein enriched in brain with implications for pathology. Nature (1995) 2.67
PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science (1996) 2.66
Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A (1981) 2.66
Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors. Mol Pharmacol (1977) 2.64
Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. Proc Natl Acad Sci U S A (1988) 2.63
Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron (1991) 2.60
Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. Life Sci (1981) 2.58
Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci U S A (1988) 2.57
Nitric oxide: a physiologic messenger. Ann Intern Med (1994) 2.50
The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J Biol Chem (1986) 2.50
A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol (1992) 2.47
A rapid sensitive silver stain for polypeptides in polyacrylamide gels. Anal Biochem (1981) 2.42
Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A (1973) 2.37
Silver staining methods for polyacrylamide gel electrophoresis. Methods Enzymol (1983) 2.36
High affinity transport of choline into synaptosomes of rat brain. J Neurochem (1973) 2.35
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem (1992) 2.34
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun (1991) 2.33
Affinity generation of single-stranded DNA for dideoxy sequencing following the polymerase chain reaction. Anal Biochem (1989) 2.29
Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc Natl Acad Sci U S A (1974) 2.29
Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A (1999) 2.27
Opiate agonists and antagonists discriminated by receptor binding in brain. Science (1973) 2.27
Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci (1999) 2.25
Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci (1994) 2.25
An endogenous morphine-like factor in mammalian brain. Life Sci (1975) 2.21
Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake. J Pharmacol Exp Ther (1970) 2.21
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron (2000) 2.20
Properties of gamma-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions. Brain Res (1975) 2.17
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci (1993) 2.16
Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc Natl Acad Sci U S A (1996) 2.15
Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor. Proc Natl Acad Sci U S A (1976) 2.14
Binding of nerve growth factor receptor in sympathetic ganglia. Proc Natl Acad Sci U S A (1973) 2.14
Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proc Natl Acad Sci U S A (1997) 2.10
Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes. Mol Pharmacol (1976) 2.09
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons. Mol Pharmacol (1971) 2.08
Characterization of a membrane protein from brain mediating the inhibition of inositol 1,4,5-trisphosphate receptor binding by calcium. Biochem J (1988) 2.08
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system. Proc Natl Acad Sci U S A (1977) 2.07
Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature (1993) 2.07
CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron (1998) 2.05
Bacterial virus gene expression in human cells. Nature (1971) 2.04
The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J Cell Biol (1990) 2.03
The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem (1986) 2.03
Regional distribution of opiate receptor binding in monkey and human brain. Nature (1973) 2.02