Published in Proc Natl Acad Sci U S A on October 01, 1969
Abnormal DNA patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation. Proc Natl Acad Sci U S A (1970) 1.26
Effects of ethidium bromide on the cytochrome content and ultrastructure of L cell mitochondria. J Cell Biol (1971) 1.26
The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in HeLa cells. J Cell Biol (1971) 1.08
Kinetoplast deoxyribonucleic acid of the hemoflagellate Trypanosoma lewisi. J Cell Biol (1970) 0.94
Specific inhibition by ethidium bromide of mitochondrial DNA synthesis in physarum polycephalum. J Cell Biol (1971) 0.80
Accumulation of replicative intermediates of mitochondrial DNA in Tetrahymena pyriformis grown in ethidium bromide. J Cell Biol (1974) 0.75
Identification of inhibitors for single-stranded DNA-binding proteins in eubacteria. J Antimicrob Chemother (2016) 0.75
A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells. Proc Natl Acad Sci U S A (1967) 48.10
A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization. J Mol Biol (1967) 10.36
Generation of higher multiple circular DNA forms in bacteria. Proc Natl Acad Sci U S A (1968) 3.98
Catenated circular DNA molecules in HeLa cell mitochondria. Nature (1967) 3.74
Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature (1967) 3.48
Vegetative lambda DNA. IV. Fractionation of replicating lambda DNA on benzoylated-naphthoylated DEAE cellulose. J Mol Biol (1969) 2.54
Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18
Single-strand breaks in duplex DNA of coliphage T7 as demonstrated by electron microscopy. J Mol Biol (1965) 2.04
Electron microscopy of the circular kinetoplastic DNA from Trypanosoma cruzi: occurrence of catenated forms. Proc Natl Acad Sci U S A (1969) 1.49
Preparation and properties of nuclear and satellite deoxyribonucleic acid of Trypanosoma cruzi. J Mol Biol (1967) 1.31
[Induction of a "dyskinetoplast" by ethidium bromide in Trypanosoma cruzi cultivated in vitro]. C R Acad Sci Hebd Seances Acad Sci D (1967) 0.94
[DNA ultrastructure of the kinetoplast of Trypanosoma cruzi cultivated in vitro]. C R Acad Sci Hebd Seances Acad Sci D (1969) 0.88
[Ultrastructure of DNA alterations of Trypanosoma cruzi kinetoplasts treated with ethidium bromide]. C R Acad Sci Hebd Seances Acad Sci D (1969) 0.84
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci U S A (1992) 3.27
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci U S A (1995) 2.56
Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice. Cancer Res (1985) 2.06
Complete nucleotide sequence of minicircle kinetoplast DNA from Trypanosoma equiperdum. Proc Natl Acad Sci U S A (1981) 1.56
Association of DNA-bound progesterone receptors. Nature (1987) 1.51
Electron microscopy of the circular kinetoplastic DNA from Trypanosoma cruzi: occurrence of catenated forms. Proc Natl Acad Sci U S A (1969) 1.49
Conformational analysis of a 139 base-pair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase. J Mol Biol (1994) 1.37
Structure and expression of c-erbB-2 and EGF receptor genes in inflammatory and non-inflammatory breast cancer: prognostic significance. Int J Cancer (1989) 1.35
Preparation and properties of nuclear and satellite deoxyribonucleic acid of Trypanosoma cruzi. J Mol Biol (1967) 1.31
Observation of binding and polymerization of Fur repressor onto operator-containing DNA with electron and atomic force microscopes. Proc Natl Acad Sci U S A (1994) 1.27
Replicating, convalently closed, circular DNA from kinetoplasts of Trypanosoma cruzi. Proc Natl Acad Sci U S A (1972) 1.23
Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein: an electron microscopy investigation. Biopolymers (1998) 1.22
ATP-independent type II topoisomerase from trypanosomes. Proc Natl Acad Sci U S A (1986) 1.16
Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene Res (1988) 1.16
Strong association between c-myb and oestrogen-receptor expression in human breast cancer. Oncogene (1990) 1.16
Different Z DNA forming sequences are revealed in phi X174 RFI by high resolution darkfield immuno-electron microscopy. EMBO J (1984) 1.15
Coiled structure of the nucleocapsid of avian myeloblastosis virus. J Gen Virol (1970) 1.13
Method of virus particle counting using millipore filtration. Virology (1970) 1.12
Structure of rotaviruses as studied by the freeze-drying technique. Virology (1979) 1.11
Purification and characterization of Plasmodium berghei DNA topoisomerases I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage. Biochemistry (1986) 1.11
Correlation of MDR1 gene expression with chemotherapy in neuroblastoma. J Natl Cancer Inst (1989) 1.08
C-myc proto-oncogene expression and prognosis in early carcinoma of the uterine cervix. Lancet (1987) 1.08
Expression of a human multidrug resistance gene in ovarian carcinomas. Cancer Res (1989) 1.06
Absence of kinetoplast DNA in a late antigenic variant of Trypanosoma equiperdum. Mol Biochem Parasitol (1980) 1.06
Measurement of the expected DNA lengthening caused by mono-and bisintercalating drugs using electron microscopy. Biopolymers (1978) 1.01
Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization. EMBO J (1983) 1.01
[Fractionation and characterization of desoxyribonucleic acid (DNA) of trypanosomes (Trypanosoma equiperdum)]. C R Acad Sci Hebd Seances Acad Sci D (1966) 1.00
Occurrence of a kinetoplast DNA-protein complex in Trypanosoma cruzi. Biochem Biophys Res Commun (1981) 0.97
Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers. Oncogene (2000) 0.96
Analysis of various sequence-specific triplexes by electron and atomic force microscopies. Biophys J (1998) 0.95
Static curvature and flexibility measurements of DNA with microscopy. A simple renormalization method, its assessment by experiment and simulation. J Mol Biol (1999) 0.95
Three dimensional association of double-stranded helices are produced in conditions for Z-DNA formation. J Biomol Struct Dyn (1983) 0.94
[Induction of a "dyskinetoplast" by ethidium bromide in Trypanosoma cruzi cultivated in vitro]. C R Acad Sci Hebd Seances Acad Sci D (1967) 0.94
Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma. Cancer Res (1991) 0.93
Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse. Cancer Res (1994) 0.93
Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R. J Virol (2000) 0.93
Analysis of the c-Ha-ras-1 gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas. Br J Cancer (1990) 0.93
c-myc, p53 and bcl-2, apoptosis-related genes in infiltrating breast carcinomas: evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients. Int J Cancer (1999) 0.92
Electron microscopy of the conformational changes of alpha 2-macroglobulin from human plasma. EMBO J (1985) 0.91
A new approach to overcome potassium-mediated inhibition of triplex formation. Nucleic Acids Res (1996) 0.91
The drosophila X virus contains a 1-microM double-stranded RNA circularized by a 67-kd terminal protein: high-resolution denaturation mapping of its genome. Virology (1982) 0.91
[Study of kinetoplast DNA of Trypansoma cruzi using restriction endonucleases]. C R Acad Sci Hebd Seances Acad Sci D (1975) 0.90
c-erbB2 gene amplification and protein expression in ovarian epithelial tumors: evaluation of their respective prognostic significance by multivariate analysis. Int J Cancer (1995) 0.90
[Morphogenesis of a hamster virus associated with the BHK strain or with tumors]. C R Acad Sci Hebd Seances Acad Sci D (1967) 0.90
Ultrastructural alterations of Trypanosoma cruzi kinetoplast induced by the interaction of a trypanocidal drug (hydroxystilbamidine) with the kinetoplast DNA. J Ultrastruct Res (1971) 0.89
ATP-independent DNA topoisomerase II as potential drug target in trypanosomes. Biol Cell (1988) 0.89
In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene. Biochem Biophys Res Commun (1986) 0.89
Molecular organization of the kinetoplast DNA of Trypanosoma cruzi treated with berenil, a DNA interacting drug. J Ultrastruct Res (1972) 0.89
[DNA ultrastructure of the kinetoplast of Trypanosoma cruzi cultivated in vitro]. C R Acad Sci Hebd Seances Acad Sci D (1969) 0.88
[Presence of papillomavirus genomes and amplification of the c-myc and C-Ha-ras oncogenes in invasive cancers of the uterine cervix]. C R Acad Sci III (1984) 0.88
Circular oligomers in mitochondrial DNA of human and beef nonmalignant thyroid glands. Proc Natl Acad Sci U S A (1972) 0.88
Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation. Biochem Pharmacol (1993) 0.87
Electron-microscopic mapping of AT-rich regions and of E. coli RNA polymerase-binding sites on the circular kinetoplast DNA of Trypanosoma cruzi. J Cell Sci (1975) 0.87
Studies on a viral nephroblastic nephroblastoma of the chicken: an electron microscope comparison of the sequence of development of the virions in different organs. Eur J Cancer (1971) 0.86
Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas. Br J Cancer (1988) 0.86
Prognostic value of c-myc proto-oncogene overexpression in early invasive carcinoma of the cervix. J Clin Oncol (1990) 0.86
[Morphogenesis of a hamster virus associated with strain BHK or with tumors]. C R Acad Sci Hebd Seances Acad Sci D (1967) 0.85
Electron microscopy of the nucleocapsid from disrupted Moloney murine leukemia virus and of associated type VI collagen-like filaments. J Virol (1994) 0.85
Association of c-erbB2-gene amplification with poor prognosis in non-inflammatory breast carcinomas but not in carcinomas of the inflammatory type. Int J Cancer (1994) 0.85
N-myc genomic content and DNA ploidy in stage IVS neuroblastoma. J Clin Oncol (1991) 0.85
Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and acidic glutathione S transferase. Biochem Pharmacol (1991) 0.84
[Ultrastructure of DNA alterations of Trypanosoma cruzi kinetoplasts treated with ethidium bromide]. C R Acad Sci Hebd Seances Acad Sci D (1969) 0.84
[Mitochondrial DNA of malignant cells]. Bull Cancer (1971) 0.84
Expression of MDR1 and GST pi genes in 35 advanced neuroblastomas. Prog Clin Biol Res (1991) 0.84
Changes of self-association, secondary structure, and biological activity properties of topoisomerase II under varying salt conditions. Biochemistry (1995) 0.84
Analysis of topoisomerase II-mediated DNA cleavage of the c-myc gene during HL60 differentiation. FEBS Lett (1993) 0.84
Electron microscopy of the reactions of anti-poly A. poly U and anti-poly I. poly C antibodies with synthetic polynucleotide complexes and natural nucleic acids. Nucleic Acids Res (1980) 0.84
Electron microscopic measurement of chain flexibility of poly(dG-dC).poly(dG-dC) modified by cis-diamminedichloroplatinum(II). Nucleic Acids Res (1984) 0.84
Nuclear and kinetoplastic DNA from trypanosomes. J Protozool (1969) 0.84
Restriction cleavage map of kinetoplast DNA minicircles from Trypanosoma equiperdum. Biochem Biophys Res Commun (1979) 0.84
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417. Biochem Pharmacol (1989) 0.83
Inhibitors of trypanosome topoisomerases. Biochem Soc Trans (1986) 0.83
Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression. Biochemistry (1989) 0.83
Berenil induces the complete loss of kinetoblast DNA sequences in Trypanosoma equiperdum. Biochem Biophys Res Commun (1980) 0.83
Quantitative electron microscopic analysis of DNA-protein interactions. J Electron Microsc Tech (1991) 0.83
Mutation and abnormal expression of the p53 gene in the viral skin carcinogenesis of epidermodysplasia verruciformis. J Invest Dermatol (2001) 0.82
Electron microscopy of alpha 2-macroglobulin with a thiol ester bound ligand. J Struct Biol (1993) 0.82
DNA bending induced by the archaebacterial histone-like protein MC1. J Mol Biol (1999) 0.82
[Inhibition by ellipticine derivatives of the reactions catalysed by the topoisomerases: preferential inhibition of topoisomerase II]. C R Seances Acad Sci III (1983) 0.82
Sequence, structure and evolution of the ecdysone-inducible Lsp-2 gene of Drosophila melanogaster. Eur J Biochem (1997) 0.82
p53 mediated tumor cell response to chemotherapeutic DNA damage: a preliminary study in matched pairs of breast cancer biopsies. Hum Pathol (1995) 0.82
Mitochondrial DNA from cells transformed by Avian myeloblastosis virus. Biochimie (1971) 0.82
Investigation of radiation damage in DNA by using atomic force microscopy. Radiat Prot Dosimetry (2002) 0.82
Cisplatin-induced apoptosis and p53 gene status in a cisplatin-resistant human ovarian carcinoma cell line. Int J Cancer (1996) 0.82
Location of B- and Z-DNA in the chromosomes of a primitive eukaryote dinoflagellate. J Cell Biol (1990) 0.81
The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro. EMBO J (1988) 0.81
Gene expression during the differentiation of myogenic cells of the L6 line. Biochimie (1976) 0.81
Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line. Int J Cancer (1989) 0.81
Three-dimensional reconstruction of a complex of human alpha 2-macroglobulin with monomaleimido Nanogold (Au1.4nm) embedded in ice. J Struct Biol (1993) 0.81
Isolation and characterization of circular DNA molecules heterogeneous in size from a dyskinetoplastic strain of Trypanosoma equiperdum. Biochem Biophys Res Commun (1977) 0.81
The accessibility of 5-methylcytosine to specific antibodies in double-stranded DNA of Xanthomonas phage XP12. Eur J Biochem (1985) 0.81