Hydrogen exchange in proteins.

Protein folding intermediates: native-state hydrogen exchange. Science (1995) 5.91

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation. Protein Sci (1993) 5.85

Evidence for de novo synthesis of isocitratase and malate synthesis in germinating peanut cotyledons. Plant Physiol (1968) 3.09

Single-molecule fluorescence studies of protein folding and conformational dynamics. Chem Rev (2006) 3.08

Thermodynamic fluctuations in protein molecules. Proc Natl Acad Sci U S A (1976) 3.00

Hydrogen exchange and mass spectrometry: A historical perspective. J Am Soc Mass Spectrom (2006) 2.78

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins. Proc Natl Acad Sci U S A (1998) 2.77

Mechanisms and uses of hydrogen exchange. Curr Opin Struct Biol (1996) 2.48

Temperature dependence of 1H chemical shifts in proteins. J Biomol NMR (1997) 2.39

Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS. Anal Chem (2009) 2.38

Studies on the analysis of fluorescence decay data by the method of moments. Biophys J (1973) 2.27

Gas-phase folding and unfolding of cytochrome c cations. Proc Natl Acad Sci U S A (1995) 2.16

Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry. Proc Natl Acad Sci U S A (2003) 2.09

Deuterium oxide as a density label of peroxidases in germinating barley embryos. Plant Physiol (1970) 2.08

Hydrogen exchange: the modern legacy of Linderstrøm-Lang. Protein Sci (1997) 2.06

Ligand binding to heme proteins. VI. Interconversion of taxonomic substates in carbonmonoxymyoglobin. Biophys J (1996) 2.02

Determinants of protein hydrogen exchange studied in equine cytochrome c. Protein Sci (1998) 1.92

Nuts and bolts of chemical exchange saturation transfer MRI. NMR Biomed (2013) 1.88

Ligand binding to proteins: the binding landscape model. Protein Sci (1997) 1.80

An introduction to NMR-based approaches for measuring protein dynamics. Biochim Biophys Acta (2010) 1.75

Absence of a stable intermediate on the folding pathway of protein A. Protein Sci (1997) 1.71

The hydrogen exchange core and protein folding. Protein Sci (1999) 1.71

Protein folding and misfolding: mechanism and principles. Q Rev Biophys (2008) 1.68

Physical and chemical properties of human plasma alpha2-macroglobulin. Biochem J (1978) 1.64

Protein hydrogen exchange mechanism: local fluctuations. Protein Sci (2003) 1.63

Hydrogen exchange measurement of the free energy of structural and allosteric change in hemoglobin. Science (1992) 1.60

Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. Chem Rev (2010) 1.60

Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins. Proc Natl Acad Sci U S A (2005) 1.53

A quantitative, high-throughput screen for protein stability. Proc Natl Acad Sci U S A (2000) 1.52

Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. Proc Natl Acad Sci U S A (1996) 1.50

Early events in protein folding explored by rapid mixing methods. Chem Rev (2006) 1.50

Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics. Structure (2014) 1.49

An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain. Proc Natl Acad Sci U S A (2010) 1.47

Internal water molecules and H-bonding in biological macromolecules: a review of structural features with functional implications. Protein Sci (1992) 1.46

From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci (1998) 1.43

Stability and dynamics in a hyperthermophilic protein with melting temperature close to 200 degrees C. Proc Natl Acad Sci U S A (1997) 1.42

Cytochrome c folding pathway: kinetic native-state hydrogen exchange. Proc Natl Acad Sci U S A (2002) 1.37

Mass spectrometric measurement of protein amide hydrogen exchange rates of apo- and holo-myoglobin. Protein Sci (1994) 1.35

Residue-level interrogation of macromolecular crowding effects on protein stability. J Am Chem Soc (2008) 1.33

Substrate-induced deactivation of penicillinases. Studies of beta-lactamase I by hydrogen exchange. Biochem J (1977) 1.32

A statistical mechanical model for hydrogen exchange in globular proteins. Protein Sci (1995) 1.28

Structural equilibrium fluctuations in mesophilic and thermophilic alpha-amylase. Biophys J (2000) 1.25

Hydrogen exchange mass spectrometry: are we out of the quicksand? J Am Soc Mass Spectrom (2012) 1.23

Protein dynamics viewed by hydrogen exchange. Protein Sci (2012) 1.22

Individual breathing reactions measured in hemoglobin by hydrogen exchange methods. Biophys J (1980) 1.22

Rapid amide proton exchange rates in peptides and proteins measured by solvent quenching and two-dimensional NMR. Protein Sci (1995) 1.22

Structural distribution of stability in a thermophilic enzyme. Proc Natl Acad Sci U S A (1999) 1.22

Many overlapping peptides for protein hydrogen exchange experiments by the fragment separation-mass spectrometry method. J Am Soc Mass Spectrom (2011) 1.22

Protein hydrogen exchange: testing current models. Protein Sci (2012) 1.20

Increase in apparent compressibility of cytochrome c upon oxidation. Proc Natl Acad Sci U S A (1982) 1.20

On the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate. J Biol Chem (2010) 1.18

Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayers. Proc Natl Acad Sci U S A (2000) 1.18

Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR. Proc Natl Acad Sci U S A (2008) 1.17

Local conformational dynamics in alpha-helices measured by fast triplet transfer. Proc Natl Acad Sci U S A (2009) 1.17

The equilibrium unfolding of Azotobacter vinelandii apoflavodoxin II occurs via a relatively stable folding intermediate. Protein Sci (1998) 1.13

Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Curr Protoc Protein Sci (2009) 1.13

Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel. Proc Natl Acad Sci U S A (2011) 1.11

1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches. Nucleic Acids Res (2002) 1.11

Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange. J Virol (2010) 1.11

Isofagomine induced stabilization of glucocerebrosidase. Chembiochem (2008) 1.09

The foldon substructure of staphylococcal nuclease. J Mol Biol (2007) 1.09

Stabilization of alpha-chymotrypsin upon PEGylation correlates with reduced structural dynamics. Biotechnol Bioeng (2008) 1.09

Mapping protein energy landscapes with amide hydrogen exchange and mass spectrometry: I. A generalized model for a two-state protein and comparison with experiment. Protein Sci (2005) 1.08

The folding pathway of T4 lysozyme: the high-resolution structure and folding of a hidden intermediate. J Mol Biol (2006) 1.08

Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07

Molecular insights into mammalian end-binding protein heterodimerization. J Biol Chem (2009) 1.05

An approach to conformational analysis of peptides and proteins in solution based on a combination of nuclear magnetic resonance spectroscopy and conformational energy calculations. Proc Natl Acad Sci U S A (1970) 1.03

Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat Chem Biol (2012) 1.03

Hydrogen bonding in helical polypeptides from molecular dynamics simulations and amide hydrogen exchange analysis: alamethicin and melittin in methanol. Biophys J (1998) 1.03

Folding of a large protein at high structural resolution. Proc Natl Acad Sci U S A (2013) 1.02

Factors involved in the stability of isolated beta-sheets: Turn sequence, beta-sheet twisting, and hydrophobic surface burial. Protein Sci (2004) 1.02

Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. Proc Natl Acad Sci U S A (2010) 1.02

Suppression of hydrogen exchange in staphylococcal nuclease by ligands. Proc Natl Acad Sci U S A (1968) 1.02

Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR. Protein Sci (1997) 1.02

Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins. Protein Sci (2003) 1.02

Heme attachment motif mobility tunes cytochrome c redox potential. Biochemistry (2007) 1.01

A kinetically significant intermediate in the folding of barnase. Proc Natl Acad Sci U S A (2000) 1.01

Hydrogen/deuterium exchange and mass spectrometric analysis of a protein containing multiple disulfide bonds: Solution structure of recombinant macrophage colony stimulating factor-beta (rhM-CSFbeta). Protein Sci (2002) 1.01

Structure and dynamic regulation of Abl kinases. J Biol Chem (2013) 1.01

Hydrogen bond stabilities in membrane-reconstituted alamethicin from amide-resolved hydrogen-exchange measurements. Biophys J (1996) 1.00

Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry. Biochemistry (2009) 1.00

A signature of the T ---> R transition in human hemoglobin. Proc Natl Acad Sci U S A (2001) 0.99

Pulmonary surfactant-associated polypeptide C in a mixed organic solvent transforms from a monomeric alpha-helical state into insoluble beta-sheet aggregates. Protein Sci (1998) 0.99

A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions. Proc Natl Acad Sci U S A (1996) 0.99

Backbone dynamics and global effects of an activating mutation in minimized Mtu RecA inteins. J Mol Biol (2010) 0.99

Thermal-induced unfolding domains in aldolase identified by amide hydrogen exchange and mass spectrometry. Protein Sci (1996) 0.99

Structure, thermostability, and conformational flexibility of hen egg-white lysozyme dissolved in glycerol. Proc Natl Acad Sci U S A (1999) 0.98

Mass spectrometry-based methods to study protein architecture and dynamics. Protein Sci (2013) 0.97

Redox-dependent dynamics of putidaredoxin characterized by amide proton exchange. Protein Sci (1996) 0.97

Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from 15N-1H NMR spectra. Protein Sci (2000) 0.97

Unpaired bases in superhelical DNA: kinetic evidence. Nucleic Acids Res (1974) 0.96

A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. Proteins (2011) 0.96

Amide proton exchange rates of oxidized and reduced Saccharomyces cerevisiae iso-1-cytochrome c. Protein Sci (1993) 0.96

Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem (2012) 0.96

Secondary structure of the lac repressor DNA-binding domain by two-dimensional 1H nuclear magnetic resonance in solution. Proc Natl Acad Sci U S A (1983) 0.95

Apparent local stability of the secondary structure of Azotobacter vinelandii holoflavodoxin II as probed by hydrogen exchange: implications for redox potential regulation and flavodoxin folding. Protein Sci (1998) 0.95

Reference models for clinical studies by isotope dilution. Ann Surg (1968) 0.95

Investigating protein unfolding kinetics by pulse proteolysis. Protein Sci (2009) 0.95

The folding pathway of T4 lysozyme: an on-pathway hidden folding intermediate. J Mol Biol (2006) 0.95

Hydrogen exchange and ligand binding: ligand-dependent and ligand-independent protection in the Src SH3 domain. Protein Sci (2004) 0.94

A discussion of pressure-volume effects in aqueous protein solutions. J Theor Biol (1975) 1.22

Conformational changes in human serum albumin as revealed by hydrogen-deuterium exchange studies. J Biol Chem (1972) 0.90

Interactions of water with nonpolar solutes. Annu Rev Biophys Bioeng (1983) 0.88

Hydrogen-exchange study of the conformational stability of human carbonic-anhydrase B and its metallocomplexes. Eur J Biochem (1975) 0.87

A study by the hydrogen-exchange method of the complex formed between the basic pancreatic trypsin inhibitor and trypsin. Eur J Biochem (1974) 0.81

Localization of monoaminergic neurons in the central nervous system of Astacus astacus Linné (Crustacea). Z Zellforsch Mikrosk Anat (1966) 0.78

Enzymes immobilized as crystals. Hydrogen isotope exchange of crystalline lysozyme. Biochimie (1980) 0.77

The size of rat brain microsome and synaptic vesicles estimated by light scattering. Biochim Biophys Acta (1972) 0.77

Physicochemical studies of a branched polypeptide antigen: poly(L-Tyr,L-Glu)-poly(DL-Ala)--poly(L-Lys). Biochim Biophys Acta (1977) 0.76

Nuclear waste disposal in the oceans. Science (1974) 0.75

[Study by the deuterium exchange method of conformational changes in a complex formed by trypsin and its inhibitor]. Dokl Akad Nauk SSSR (1975) 0.75

Studies on the structural basis of ribonuclease activity. 1955. Biochim Biophys Acta (1989) 0.75

Hydrogen--deuterium exchange of bovine plasma albumin. Biochemistry (1969) 0.75

A comparative study on the basic pancreatic trypsin inhibitor and insulin by the hydrogen-exchange method. Eur J Biochem (1974) 0.75

Risks and public policy. Science (1979) 0.75

A contribution to the debate about hydrophobic effects. Biochim Biophys Acta (1978) 0.75