Published in Curr Protoc Protein Sci on November 01, 2009
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Rate and equilibrium constants for protein unfolding and refolding determined by hydrogen exchange-mass spectrometry. Anal Biochem (1999) 1.02
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Conformational dynamics of the GdmHCl-induced molten globule state of creatine kinase monitored by hydrogen exchange and mass spectrometry. Biochemistry (2004) 0.88
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Kinetics of cytochrome c folding examined by hydrogen exchange and mass spectrometry. Biochemistry (1997) 0.86
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Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat Rev Drug Discov (2012) 1.80
Conformational locking upon cooperative assembly of notch transcription complexes. Structure (2012) 1.79
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Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64
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Conformational disturbance in Abl kinase upon mutation and deregulation. Proc Natl Acad Sci U S A (2009) 1.47
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Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry. Anal Chem (2010) 1.36
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Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29
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Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem (2009) 1.22
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Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry. Anal Chem (2006) 1.18
Partial unfolding of diverse SH3 domains on a wide timescale. J Mol Biol (2006) 1.17
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Sci (2005) 1.17
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
Activation of the Src family kinase Hck without SH3-linker release. J Biol Chem (2005) 1.14
Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. J Mol Biol (2007) 1.12
Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One (2011) 1.12
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07
Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations. Anal Chem (2009) 1.07
Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. J Mol Biol (2005) 1.07
False EX1 signatures caused by sample carryover during HX MS analyses. Int J Mass Spectrom (2011) 1.06
Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra. J Am Soc Mass Spectrom (2013) 1.06
The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol (2012) 1.05
Effects of HIV-1 Nef on human N-myristoyltransferase 1. Biochemistry (2011) 1.01
ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements. J Am Soc Mass Spectrom (2011) 1.01
The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Sci (2007) 1.01
Structure and dynamic regulation of Abl kinases. J Biol Chem (2013) 1.01
A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. Biochemistry (2014) 0.97
Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution. Biochemistry (2011) 0.96
Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry (2008) 0.95
Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry. Anal Chem (2009) 0.95
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Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry (2006) 0.93
Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci (2013) 0.92
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On the solution conformation and dynamics of the HIV-1 viral infectivity factor. J Mol Biol (2011) 0.91
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Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. J Biol Chem (2013) 0.90
Protein interactions probed with mass spectrometry. Methods Mol Biol (2006) 0.89
Accessing the reproducibility and specificity of pepsin and other aspartic proteases. Biochim Biophys Acta (2012) 0.88
Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation. J Am Soc Mass Spectrom (2012) 0.87
Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements. J Pharm Sci (2013) 0.87
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. BMC Chem Biol (2012) 0.86
Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry. Chem Res Toxicol (2002) 0.86
Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi. Anal Chem (2012) 0.86
Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif. J Mol Biol (2010) 0.86
L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase. J Am Chem Soc (2005) 0.86
Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods Mol Biol (2013) 0.85
Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties. Anal Chem (2013) 0.85
Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. J Mol Biol (2010) 0.84
Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry (2013) 0.84
Conformational transition of membrane-associated terminally acylated HIV-1 Nef. Structure (2013) 0.84
Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes. Biophys J (2010) 0.83
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Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii. FEBS J (2007) 0.82
Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. J Mol Biol (2006) 0.82
Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip. Protein Sci (2006) 0.82
Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). ACS Chem Neurosci (2012) 0.81
Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry. Methods Mol Biol (2013) 0.81
Electron transfer control in soluble methane monooxygenase. J Am Chem Soc (2014) 0.81
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase. J Med Chem (2012) 0.80
Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J Mol Biol (2013) 0.79
Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI). J Biol Chem (2013) 0.79
Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics. Expert Rev Proteomics (2015) 0.77
What mass spectrometry can reveal about protein function. Analyst (2004) 0.76
Replication in bioanalytical studies with HDX MS: aim as high as possible. Bioanalysis (2015) 0.76
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c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution. Biochemistry (2016) 0.75
Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe. Anal Chem (2015) 0.75
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