Published in J Mol Biol on March 01, 1970
Differences in Fe(II)-N epsilon(His-F8) stretching frequencies between deoxyhemoglobins in the two alternative quaternary structures. Proc Natl Acad Sci U S A (1980) 1.21
Functional and physicochemical studies of hemoglobin St. Louis beta 28 (B10) Leu replaced by Gln: a variant with ferric beta heme iron. J Clin Invest (1976) 0.90
Nuclear magnetic resonance study of heme-heme interaction in hemoglobin M Milwaukee: implications concerning the mechanism of cooperative ligand binding in normal hemoglobin. Proc Natl Acad Sci U S A (1976) 0.84
Differences in coordination states of substituted tyrosine residues and quaternary structures among hemoglobin M probed by resonance Raman spectroscopy. J Biol Inorg Chem (2009) 0.76
Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 10.01
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science (1988) 5.71
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
Hemoglobin components in patients with diabetes mellitus. N Engl J Med (1971) 4.52
The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87
Exchange of heme among hemoglobins and between hemoglobin and albumin. J Biol Chem (1968) 3.09
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A (1987) 2.51
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood (1991) 2.41
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28
Regulation of the erythropoietin gene. Blood (1999) 2.10
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol (1992) 1.94
Interaction of hemoglobin with red blood cell membranes as shown by a fluorescent chromophore. Biochemistry (1977) 1.90
Exchange of heme among hemoglobin molecules. Proc Natl Acad Sci U S A (1966) 1.81
The interaction of 2,3-diphosphoglycerate with various human hemoglobins. J Clin Invest (1970) 1.81
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol (1998) 1.80
Nonenzymatic glycosylation of human serum albumin alters its conformation and function. J Biol Chem (1984) 1.80
Studies of an unusual hemoglobin in patients with diabetes mellitus. Biochem Biophys Res Commun (1969) 1.78
Regulation of erythrocyte cation and water content in sickle cell anemia. Science (1986) 1.65
Evaluation of glycosylated hemoglobin diabetic patients. Diabetes (1981) 1.65
Bimane fluorescent labels: labeling of normal human red cells under physiological conditions. Proc Natl Acad Sci U S A (1979) 1.59
Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem (1980) 1.56
Dissociation of CO from carboxyhemoglobin. J Biol Chem (1976) 1.54
Muscle phosphofructokinase deficiency. Arch Neurol (1967) 1.54
A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. N Engl J Med (1980) 1.54
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol (1995) 1.50
Kinetic analysis of the nonenzymatic glycosylation of hemoglobin. J Biol Chem (1981) 1.50
Treatment of sickle cell anemia with hydroxyurea and erythropoietin. N Engl J Med (1990) 1.47
Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. J Clin Invest (1980) 1.47
Cotranslational amino-terminal processing of cytosolic proteins. Cell-free expression of site-directed mutants of human hemoglobin. J Biol Chem (1988) 1.46
Educating the biomedical scientist. FASEB J (1995) 1.43
The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel. Biochim Biophys Acta (1971) 1.42
In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood (1993) 1.41
Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A (1999) 1.39
The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med (1969) 1.38
Measurement of activin in biological fluids by radioimmunoassay, utilizing dissociating agents to remove the interference of follistatin. Eur J Endocrinol (1996) 1.38
Clinical evaluation of anemia. West J Med (1987) 1.38
Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate. Proc Natl Acad Sci U S A (1976) 1.38
Amino-terminal processing of proteins: hemoglobin South Florida, a variant with retention of initiator methionine and N alpha-acetylation. Proc Natl Acad Sci U S A (1985) 1.37
Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins. Science (1971) 1.36
Nonenzymatic glycosylation of protein: relevance to diabetes. Am J Med (1981) 1.34
Structure and properties of hemoglobin C-Harlem, a human hemoglobin variant with amino acid substitutions in 2 residues of the beta-polypeptide chain. J Biol Chem (1967) 1.34
Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med (1981) 1.33
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem (1999) 1.33
Molecular and cellular pathogenesis of hemoglobin SC disease. Proc Natl Acad Sci U S A (1982) 1.32
Electrostatic attraction governs the dimer assembly of human hemoglobin. J Biol Chem (1986) 1.31
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation. J Biol Chem (1979) 1.30
Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins. J Clin Invest (1983) 1.29
Classification and localization of hemoglobin binding sites on the red blood cell membrane. Biochemistry (1977) 1.28
Signal transduction. How do cells sense oxygen? Science (2001) 1.27
The interaction between erythrocyte organic phosphates, magnesium ion, and hemoglobin. J Biol Chem (1971) 1.26
Subunit assembly of hemoglobin: an important determinant of hematologic phenotype. Blood (1987) 1.25
Hemoglobin function in stored blood. J Clin Invest (1969) 1.25
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest (1985) 1.22
Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. J Biol Chem (1993) 1.21
Glycosylated minor components of human adult hemoglobin. Purification, identification, and partial structural analysis. J Biol Chem (1978) 1.20
A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography. Metabolism (1978) 1.20
The value of the peripheral blood smear in anemic inpatients. The laboratory's reading v a physician's reading. Arch Intern Med (1983) 1.18
Functional properties of hemoglobin Kempsey. J Biol Chem (1974) 1.18
Interaction of sickle cell hemoglobin with erythrocyte membranes. Proc Natl Acad Sci U S A (1981) 1.17
Participation of hemoglobins A and F in polymerization of sickle hemoglobin. J Biol Chem (1977) 1.15
Rat haemoglobin heterogeneity. Two structurally distinct alpha chains and functional behaviour of selected components. Biochem J (1975) 1.15
Glycosylated hemoglobin in human and animal red cells. Role of glucose permeability. Diabetes (1982) 1.14
Erythropoietin structure-function relationships. Identification of functionally important domains. J Biol Chem (1994) 1.14
The effect of beta 73 Asn on the interactions of sickling hemoglobins. Biochim Biophys Acta (1970) 1.14
Structure and subunit interaction of haemoglobin M Milwaukee. Nat New Biol (1972) 1.13
Arterial vascular occlusion associated with factor V Leiden gene mutation. Retina (1998) 1.11
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein. Biochem Biophys Res Commun (1996) 1.11
Hemoglobin Cranston, an unstable variant having an elongated beta chain due to nonhomologous crossover between two normal beta chain genes. Proc Natl Acad Sci U S A (1975) 1.10
The separation of partially oxidized hemoglobins. Biochim Biophys Acta (1971) 1.09
Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein. J Biol Chem (1991) 1.08
Oxygen sensing and signaling: impact on the regulation of physiologically important genes. Respir Physiol (1999) 1.07
Hemoglobin components in diabetes mellitus: studies in identical twins. N Engl J Med (1975) 1.07
Genetic epidemiology of structural mutations of the beta-globin gene. Semin Hematol (1990) 1.05
Erythropoietin structure-function relationships: high degree of sequence homology among mammals. Blood (1993) 1.05
Regulatory elements of the erythropoietin gene. Blood (1991) 1.05
Control of hemoglobin function within the red cell. N Engl J Med (1970) 1.04
A thalassemia-like disorder in Belgrade laboratory rats. Ann N Y Acad Sci (1969) 1.02
Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins. Proc Natl Acad Sci U S A (1990) 1.02
Nonenzymatic glycosylation of bovine lens crystallins. Effect of aging. J Biol Chem (1981) 1.01
The renal handling of hemoglobin. II. Catabolism. J Exp Med (1969) 1.01
Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. J Clin Invest (1973) 1.00
Hemoglobin D Iran alpha A2 beta 22 2-Glu leads to Gln in association with thalassemia. Blood (1973) 0.99
Bimane fluorescent labels. Characterization of the bimane labeling of human hemoglobin. Biochim Biophys Acta (1980) 0.99
Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Arch Intern Med (1977) 0.98
The effect of erythrocyte membrane preparations on the polymerization of sickle hemoglobin. J Biol Chem (1981) 0.97
National Diabetes Data Group: report of the expert committee on glucosylated hemoglobin. Diabetes Care (1985) 0.97
"Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential. Proc Natl Acad Sci U S A (1986) 0.96
Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus. J Clin Invest (1984) 0.95
Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures. Eur J Histochem (2010) 0.94
Hemoglobin function in the horse: the role of 2,3-diphosphoglycerate in modifying the oxygen affinity of maternal and fetal blood. Blood (1973) 0.94
Evolution of mammalian hemoglobin function. Blood (1981) 0.94
Electrostatic interactions in the assembly of haemoglobin. Nature (1984) 0.94
Oxygen equilibrium of hemoglobin M-Hyde Park. Biochim Biophys Acta (1968) 0.93