Published in Nature on June 21, 1969
Immune competence of hereditarily asplenic mice. Immunology (1974) 1.09
Splenic replenishment of synergistic ability to bone marrow and thymic cells of neonatally splenectomized CBA mice. J Exp Med (1972) 0.97
Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells. J Exp Med (1976) 0.95
Animal model of human disease: hyposplenia, asplenia, and immunodeficiency. Am J Pathol (1976) 0.75
Metastasizing mammary tumors. Spontaneous mammary tumors in asplenic mice heterozygous for athymia. Am J Pathol (1982) 0.75
Direct allelic variation scanning of the yeast genome. Science (1998) 5.90
Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes Dev (1992) 5.84
Purification and biological activity of thymosin, a hormone of the thymus gland. Proc Natl Acad Sci U S A (1972) 3.24
Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc Natl Acad Sci U S A (1966) 3.16
Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone. Proc Natl Acad Sci U S A (1971) 3.13
Differentiation of T cells induced by preparations from thymus and by nonthymic agents. J Exp Med (1973) 3.12
Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export. EMBO J (1998) 3.02
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc Natl Acad Sci U S A (1977) 2.45
Purification and properties of bovine thymosin. Ann N Y Acad Sci (1975) 2.08
The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus. J Biol Chem (1979) 2.03
Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proc Natl Acad Sci U S A (1981) 1.90
Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus. Proc Natl Acad Sci U S A (1970) 1.78
Neutralization of HTLV-III/LAV replication by antiserum to thymosin alpha 1. Science (1986) 1.75
Ontogenesis of cell-mediated immunity in murine thymocytes and spleen cells and its acceleration by thymosin, a thymic hormone. J Immunol (1971) 1.73
Influenza: response of T-cell lymphopenia to thymosin. N Engl J Med (1976) 1.69
Dual immunological unresponsiveness induced by cell membrane coupled hapten or antigen. Nature (1966) 1.68
Thymosin activity in patients with cellular immunodeficiency. N Engl J Med (1975) 1.67
Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice. J Immunol (1970) 1.62
Gut mucosal lymphocytes in inflammatory bowel disease: isolation and preliminary functional characterization. Dig Dis Sci (1979) 1.60
Thymosin beta4 accelerates wound healing. J Invest Dermatol (1999) 1.50
Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J (1997) 1.46
Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice. Nature (1968) 1.45
Acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice. Proc Natl Acad Sci U S A (1970) 1.38
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother (2001) 1.37
The chemistry and biology of thymosin. II. Amino acid sequence analysis of thymosin alpha1 and polypeptide beta1. J Biol Chem (1979) 1.34
Splenic T-killer cells can be generated by allogeneic thymic cells in conjunction with assisting factor. Nature (1977) 1.32
Thymosin stimulates secretion of luteinizing hormone-releasing factor. Science (1981) 1.31
Thymosin restores T cell function and reduces the incidence of amyloid disease in casein-treated mice. J Immunol (1976) 1.31
C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure. Mol Cell Biol (1997) 1.31
Immunological characterization of homosexual males. Cancer Res (1983) 1.29
Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A (1992) 1.29
Current status of thymosin and other hormones of the thymus gland. Recent Prog Horm Res (1981) 1.25
Splenic determination of immunocompetence: influence on other lymphoid organs. Cell Immunol (1971) 1.23
Adult murine lymph node cells respond blastogenically to a new differentiation antigen on isologous and autologous B lymphocytes. J Immunol (1975) 1.22
Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1. J Immunol (1982) 1.21
Thymosin corrects the abnormal DNA synthetic response of NZB mouse thymocytes. Proc Natl Acad Sci U S A (1974) 1.19
New role for 15-hydroxyeicosatetraenoic acid. Activator of leukotriene biosynthesis in PT-18 mast/basophil cells. J Biol Chem (1982) 1.18
Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice. J Gerontol (1988) 1.16
Immunogenicity and role of size: response of guinea pigs to oligotyrosine and tyrosine derivatives. Science (1965) 1.13
Induction of terminal deoxynucleotidyl transferase and Lyt antigens with thymosin: identification of multiple subsets of prothymocytes in mouse bone marrow and spleen. Proc Natl Acad Sci U S A (1981) 1.13
T-lymphocyte maturation: cell surface markers and immune function induced by T-lymphocyte cell-free products and thymosin polypeptides. Ann N Y Acad Sci (1979) 1.12
Thymosin: effects on normal human blood T-cells. Ann N Y Acad Sci (1975) 1.12
Mechanism of immunologic unresponsiveness: a new approach. Fed Proc (1990) 1.12
Cultured human endothelial cells treated with recombinant leukocyte A interferon. Tubuloreticular inclusion formation, antiproliferative effect, and 2',5' oligoadenylate synthetase induction. Lab Invest (1988) 1.11
Desensitization studies of delayed hypersensitivity, with special reference to the possible role of high-affinity antibodies. J Immunol (1966) 1.10
Effects of the thymus lymphocytopoietic factor. Ann N Y Acad Sci (1966) 1.09
Spontaneous delayed iso-hypersensitivity in guinea pigs. J Immunol (1968) 1.08
Regulation of immunoglobulin synthesis by dextran. J Exp Med (1973) 1.07
Human immunodeficiency virus contains an epitope immunoreactive with thymosin alpha 1 and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30. Proc Natl Acad Sci U S A (1987) 1.07
Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev (2004) 1.07
Immunotherapy: new hope for the cancer patient. Am Fam Physician (1973) 1.07
Immunologic responses of guinea pigs to dextran. J Immunol (1968) 1.07
Age-related changes in localization of thymosin in the human thymus. Thymus (1982) 1.07
Orally induced tolerance generates an efferently acting suppressor T cell and an acceptor T cell that together down-regulate contact sensitivity. J Immunol (1985) 1.06
Reduction in the incidence of wasting disease in neonatally thymectomized CBA-W mice by the injection of thymosin. Endocrinology (1970) 1.06
Thymosin-induced reduction of "null cells" in peripheral-blood lymphocytes of patients with systemic lupus erythematosus. Lancet (1975) 1.05
Regulation of normal and leukaemic lymphocyte transformation and recirculation by sodium periodate oxidation and sodium borohydride reduction. Nat New Biol (1972) 1.05
HGP-30, a synthetic analogue of human immunodeficiency virus (HIV) p17, is a target for cytotoxic lymphocytes in HIV-infected individuals. Proc Natl Acad Sci U S A (1990) 1.05
Studies on the types of immune responses to synthetic antigens in guinea-pigs. Immunology (1966) 1.04
Chemical characterization of thymosin beta 4. J Biol Chem (1982) 1.04
The thymus as an endocrine gland: properties of thymosin, a new thymus hormone. Recent Prog Horm Res (1970) 1.03
Elevated serum thymosin alpha 1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi's sarcoma. N Engl J Med (1983) 1.03
Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Detection of activated T cells and enhanced proliferation to Staphylococcus aureus and lipopolysaccharides. Dig Dis Sci (1981) 1.03
Use of thymosin in the treatment of primary immunodeficiency diseases and cancer. Med Clin North Am (1976) 1.02
Thymosins: structure, function and therapeutic applications. Thymus (1984) 1.01
Thymosin alpha 1 and thymosin beta 4 in serum: comparison of normal, cord, homosexual and AIDS serum. Int J Immunopharmacol (1986) 1.01
Modulation of human natural killer cell cytotoxic activity, lymphokine production, and interleukin 2 receptor expression by thymic hormones. J Immunol (1987) 1.01
Current status of thymosin research: evidence for the existence of a family of thymic factors that control T-cell maturation. Ann N Y Acad Sci (1979) 1.00
In vitro and in vivo studies with thymosin in cancer patients. Ann N Y Acad Sci (1976) 1.00
Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. J Cell Sci (1995) 1.00
Acceleration of lymphoid tissue regeneration in x-irradiated CBA-W mice by injection of thymosin. Radiat Res (1970) 0.99
Effect of thymosin and an antithymosin serum on allograft survival in mice. Proc Natl Acad Sci U S A (1968) 0.99
Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme. Yeast (1993) 0.98
Alterations in lymphocyte populations in tumorigenesis. I. Lymphocyte trapping. J Immunol (1973) 0.98
Immunological properties of a collagen-like synthetic polypeptide. Biochim Biophys Acta (1969) 0.98
Correction of T cell function by thymosin in New Zealand mice. J Immunol (1974) 0.98
Production of biologically active N alpha-desacetylthymosin alpha 1 in Escherichia coli through expression of a chemically synthesized gene. Biochemistry (1980) 0.97
Induction in vivo and in vitro of terminal deoxynucleotidyl transferase by thymosin in bone marrow cells from athymic mice. J Exp Med (1978) 0.97
Thymosin and the immunopathology of aging. Fed Proc (1974) 0.97
Splenic replenishment of synergistic ability to bone marrow and thymic cells of neonatally splenectomized CBA mice. J Exp Med (1972) 0.97
Feeding trinitrochlorobenzene inhibits development of hapten-specific cytotoxic T lymphocytes by interfering with helper T-cell function. Reg Immunol (1990) 0.97
Abnormal T-lymphocyte subpopulations associated with transfusion of blood-derived products. Lancet (1983) 0.96
Relation between optical configuration and immunogenicity of synthetic polypeptides. Biochem J (1965) 0.96
Immunologic and anatomic consequences of calf thymosin injection in rats. Cell Immunol (1970) 0.96
Hormonal influences on the reticuloendothelial system: current status of the role of thymosin in the regulation and modulation of immunity. J Reticuloendothel Soc (1978) 0.95
Requirement of thymus-derived theta-positive lymphocytes for rejection of DNA virus (SV 40) tumors in mice. J Immunol (1974) 0.95
Thymic hormones--a clinical update. Springer Semin Immunopathol (1986) 0.95
Susceptibility to adjuvant arthritis in DA and F344 rats. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex. Arthritis Rheum (1982) 0.95
Biodistribution of synthetic thymosin beta 4 in the serum, urine, and major organs of mice. Int J Immunopharmacol (1997) 0.94
Ataxia-Telangiectasia: a multiparameter analysis of eight families. Clin Immunol Immunopathol (1982) 0.94
Suppression by thymosin of pokeweed mitogen-induced differentiation of human B cells. Clin Immunol Immunopathol (1978) 0.94
Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action. Proc Natl Acad Sci U S A (1990) 0.94
Isolation of thymosin alpha 1 from thymosin fraction 5 of different species by high-performance liquid chromatography. J Chromatogr (1983) 0.94
The in vitro induction of differentiation of putative human stem cells by thymosin and agents that affect cyclic AMP. Clin Immunol Immunopathol (1978) 0.93
Specific immunologic unresponsiveness induced in adult guinea pigs with the aid of p-azobenzenearsonate hapten coupled to autologous red cells. J Immunol (1971) 0.93