Published in Science on July 29, 1966
Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A (1971) 4.14
Quantitative studies on the mixed lymphocyte interaction in rats. I. Conditions and parameters of response. J Exp Med (1967) 3.20
Phenotypic expressions of the major histocompatibility locus in man (HL-A): leukocyte antigens and mixed leukocyte culture reactivity. J Exp Med (1968) 3.00
Synergism between subpopulations of thymus-derived cells mediating the proliferative and effector phases of the mixed lymphocyte reaction. Proc Natl Acad Sci U S A (1973) 2.48
Hodgkin's disease. An immunodepleting and immunosuppressive disorder. J Clin Invest (1975) 2.44
Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor. J Exp Med (1972) 2.20
Identification and characterization of subpopulations of lymphocytes in human peripheral blood after fractionation on discontinuous gradients of albumin. The cellular defect in X-linked agammaglobulinemia. J Clin Invest (1973) 2.05
Immunopathologic studies in relapsing polychondritis. J Clin Invest (1973) 1.98
Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1987) 1.92
Lymphocytes in congenital immunological deficiency diseases. Clin Exp Immunol (1968) 1.87
Activation of leukemia viruses by graft-versus-host and mixed lymphocyte reactions in vitro. Proc Natl Acad Sci U S A (1972) 1.85
Abnormalities of in vitro lymphocyte responses during rubella virus infections. J Exp Med (1968) 1.82
Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus. Proc Natl Acad Sci U S A (1970) 1.78
Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy. Clin Exp Immunol (1971) 1.66
Cell kinetic studies in mixed leukocyte cultures: an in vitro model of homograft reactivity. Proc Natl Acad Sci U S A (1969) 1.61
Effect of transfer factor on lymphocyte function in anergic patients. J Clin Invest (1972) 1.52
Replication of human cytomegalovirus in human peripheral blood T cells. J Virol (1986) 1.45
Casein-induced experimental amyloidosis. III. Response to mitogens, allogeneic cells, and graft-versus-host reactions in the murine model. Immunology (1974) 1.42
Clinical heterotransplantation of the liver. Transplant Proc (1970) 1.35
Stimulus-response in the mixed lymphocyte reaction. J Exp Med (1973) 1.35
Comparative analysis of systemic immunological parameters in ulcerative colitis and idiopathic proctitis: effects of sulfasalazine in vivo and in vitro. Clin Exp Immunol (1978) 1.34
In vitro studies on the T-lymphocyte population of human milk. J Exp Med (1976) 1.34
Effect of neuraminidase on the stimulatory capacity of cells in human mixed lymphocyte cultures. Clin Exp Immunol (1971) 1.32
Lymphotoxin formation by lymphocytes and muscle in polymyositis. J Clin Invest (1972) 1.26
Active suppression as a possible mechanism of tolerance in tetraparental mice. J Exp Med (1973) 1.25
Impaired mixed leucocyte reaction in some different diseases, notably multiple sclerosis and various arthritides. Clin Exp Immunol (1971) 1.20
The in vitro transformation of frozen-stored lymphocytes in the mixed lymphocyte reaction and in culture with phytohemagglutinin and specific antigens. J Exp Med (1970) 1.19
Stimulation of subpopulations of human lymphocytes by a vaccine strain of Francisella tularensis. Infect Immun (1978) 1.17
Effects of azathioprine therapy on bone marrow-dependent and thymus-dependent cells in man. Clin Exp Immunol (1973) 1.17
Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction. J Exp Med (1976) 1.16
A satisfactory quantitative test of lymphocyte response to phytohaemagglutinin for the definition of normal control values and recognition of immunological defects. J Clin Pathol (1972) 1.16
Production of colony-stimulating factor in mixed leucocyte cultures. Immunology (1974) 1.16
Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction. Clin Exp Immunol (1972) 1.12
Inability of spleen cells from chancre-immune rabbits to confer immunity to challenge with Treponema pallidum. Infect Immun (1977) 1.11
The cytotoxic activity of lymphocytes from human lymph in vitro. Clin Exp Immunol (1974) 1.11
Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms. Br J Clin Pharmacol (1984) 1.10
Cell-mediated immunity in diabetes mellitus. Clin Exp Immunol (1974) 1.08
Quantitative assay of antigenic disparity at hl-a-the major histocompatibility locus in man. J Exp Med (1968) 1.08
Effects of azathioprine on the human mixed lymphocyte reaction (MLR). Br J Clin Pharmacol (1983) 1.06
Tumour-distinctive cellular immunity to renal carcinoma. Clin Exp Immunol (1970) 1.03
Studies on the pathogenesis of an immune defect in multiple myeloma. J Clin Invest (1977) 1.01
Interactions of allogeneic human mononuclear cells in the two-way mixed leucocyte culture (MLC): influence of cell numbers, subpopulations and cyclosporin. Clin Exp Immunol (1999) 0.97
Mixed isotype class II antigen expression. A novel class II molecule is expressed on a murine B cell lymphoma. J Exp Med (1989) 0.96
Requirement for non-T cells in the generation of cytotoxic T lymphocytes in vitro. I. Use of nude mice as source of non-T cells. J Exp Med (1976) 0.96
Treatment of chronic mucocutaneous moniliasis by immunologic reconstitution. Clin Exp Immunol (1971) 0.94
Qualitative and quantitative studies on mixed homologous chicken thymus cell cultures. Clin Exp Immunol (1970) 0.94
The role of vitamin B 12 and its transport globulins in the production of antibodies. Clin Exp Immunol (1975) 0.92
Reconstitution of defective cellular immunity with foetal thymus and dialysable transfer factor. Long-term studies in a patient with chronic mucocutaneous candidiasis. Clin Exp Immunol (1976) 0.90
Some immunological properties of lymphoid cells from patients with acute lymphatic leukaemia (ALL). Clin Exp Immunol (1973) 0.87
Mixed lymphocyte culture and graft rejection. Surg Forum (1973) 0.87
Cells involved in the immune response, IX. Depletion from the normal rabbit bone marrow of antigen-reactive cells directed toward human peripheral leukocytes. Proc Natl Acad Sci U S A (1969) 0.87
Pre-emption of human cell-mediated lympholysis by a suppressive mechanism activated in mixed lymphocyte cultures. J Exp Med (1975) 0.86
Response of agammaglobulinaemic lymphocytes in mixed lymphocyte culture. Clin Exp Immunol (1969) 0.85
In vitro cytotoxicity by human lymphocytes from individuals immunized against histocompatibility antigens. I. Kinetics and specificity of the reaction. Influence of metabolic inhibitors and anti-lymphocyte serum. Clin Exp Immunol (1970) 0.85
Cellular immune responses to methylcholanthrene-induced fibrosarcoma in BALB/c mice. J Exp Med (1975) 0.84
Successful bone marrow transplantation in a patient with humoral and cellular immunity deficiency. Clin Exp Immunol (1970) 0.84
Mixed culture of human foetal and adult cells. Immunology (1971) 0.83
Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome. Br J Clin Pharmacol (1985) 0.83
Immunologic response in vitro after thymechtomy in patients with myasthenia gravis. Can Med Assoc J (1976) 0.83
Third party mixed-leukocyte culture test: a potential new method of histocompatibility testing. Proc Natl Acad Sci U S A (1972) 0.83
Graft-vs.-host reaction in tissue culture. J Exp Med (1973) 0.81
Indication of tumour specific cell-bound immunological reactivity and depressed general reactivity in a pair of twins. Clin Exp Immunol (1970) 0.80
Immunologic reconstitution in a patient with keratoconjunctivitis, superficial candidiasis and hypoparathyroidism: the role of immunocompetent lymphocyte transfusion and transfer factor. Trans Am Ophthalmol Soc (1973) 0.79
Relationship of mixed lymphocyte culture response to HL-A histocompatibility antigens. Effect of allele plus one antigen match. J Exp Med (1972) 0.79
Effect of levamisole and azathioprine on the human mixed lymphocyte reaction (MLR). Br J Clin Pharmacol (1984) 0.79
The Timing of T Cell Priming and Cycling. Front Immunol (2015) 0.78
Immunologic and plasma protein studies in a splenic homograft recipient. Clin Exp Immunol (1972) 0.78
In vitro cytotoxicity by human lymphocytes from individuals immunized against histocompatibility antigens. II. Relation to HL-A incompatibility between effector and target cells. Clin Exp Immunol (1970) 0.78
Stimulation of autologous blood lymphocytes by malignant lymphoma cells and homogenates. Br J Cancer (1976) 0.78
Transfer factor therapy in ataxia--telangiectasia. Clin Exp Immunol (1977) 0.77
The receptor specificity of alloreactive T cells. Distinction between stimulator K, I, and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells. J Exp Med (1979) 0.77
The cells involved in cell-mediated and transplantation immunity in the normal outbred rabbit. X. The organ sources of the stimulator and responder cells in the mixed leukocyte culture reaction. Immunology (1979) 0.76
Exosomes: The missing link between microchimerism and acquired tolerance? Chimerism (2015) 0.75
A survey of nutritional-immunological interactions. Bull World Health Organ (1972) 0.75
Inhibition of lymphocyte growth by Ulex seed extracts (USE). Immunology (1981) 0.75
Effect of interleukin-2 on the inhibition of the human mixed lymphocyte reaction (MLR) by azathioprine. Br J Clin Pharmacol (1985) 0.75
The mechanism of interaction between T and B lymphocytes in the in vitro response to sheep erythrocytes. Non-specific collaboration across a dialysis membrane. Immunology (1975) 0.75
Histocompatibility and transplantation. Can Med Assoc J (1968) 0.75
Allografted lungs in matched dogs with induced pulmonary hypertension. Am J Pathol (1974) 0.75
Characterization of dextran-activated T-cell factors. Immunology (1976) 0.75
Histocompatibility testing. I. Probability models for second-set rejection in a "random" population. Am J Hum Genet (1968) 0.75
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med (2000) 6.32
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report. Transplantation (1971) 5.43
Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse. J Exp Med (1972) 4.59
Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. Proc Natl Acad Sci U S A (1980) 4.35
Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature (1976) 3.87
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med (2000) 3.41
The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment. Transplant Proc (1973) 3.35
Precipitation of radioactively labeled samples: a semi-automatic multiple-sample processor. Cell Immunol (1972) 3.35
Cell-mediated lympholysis. Importance of serologically defined H-2 regions. J Exp Med (1973) 3.34
Hu-1: Major histocompatibility locus in man. Science (1967) 3.13
Cell mediated immunity: separation of cells involved in recognitive and destructive phases. Science (1973) 3.04
Phenotypic expressions of the major histocompatibility locus in man (HL-A): leukocyte antigens and mixed leukocyte culture reactivity. J Exp Med (1968) 3.00
Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol (1997) 2.79
Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem (1996) 2.79
Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J (1993) 2.75
Detection of a novel human class II HLA antigen. Nature (1983) 2.61
Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med (1998) 2.40
Genetic and immunological complexity of major histocompatibility regions. Science (1972) 2.40
Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet (1968) 2.29
A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. J Biol Chem (1996) 2.26
DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med (1991) 2.14
Role of H-2 lymphocyte-defined and serologically-defined components in the generation of cytotoxic lymphocytes. J Exp Med (1974) 2.01
Transplantation of discordant xenografts: a review of progress. Immunol Today (1990) 2.00
A miniaturized mouse mixed leukocyte culture in serum-free and mouse serum supplemented media. J Immunol Methods (1973) 1.97
Lymphocyte reactivity in vitro. I. Cellular reconstitution of purified lymphocyte response. Cell Immunol (1970) 1.97
The major histocompatibility complex--genetics and biology. (First of three parts). N Engl J Med (1976) 1.92
HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes. Science (1975) 1.91
Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol (2001) 1.89
Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants. Nature (1985) 1.82
Antigenic requirements for triggering of cytotoxic T lymphocytes. Immunol Rev (1977) 1.82
Lymphocyte reactivity in vitro. II. Soluble reconstituting factor permitting response of purified lymphocyte. Cell Immunol (1970) 1.74
Antigen-driven helper cell-independent cloned cytolytic T lymphocytes. Nature (1981) 1.72
Allogeneic and xenogeneic response in mixed leukocyte cultures. J Exp Med (1972) 1.70
Five HLA-D clusters associated with HLA-DR4. Hum Immunol (1982) 1.70
Generation of cytotoxic lymphocytes in vitro against autologous human leukaemia cells. Nature (1976) 1.64
Specificity of allogeneic cell recognition by human lymphocytes in vitro. Science (1971) 1.62
Loss of ATP diphosphohydrolase activity with endothelial cell activation. J Exp Med (1997) 1.62
Cell kinetic studies in mixed leukocyte cultures: an in vitro model of homograft reactivity. Proc Natl Acad Sci U S A (1969) 1.61
Lymphocyte studies in congenital thymic dysplasia: The one-way stimulation test. J Pediatr (1968) 1.59
The molecular basis of alloreactivity. Immunol Today (1990) 1.56
Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature (1982) 1.56
Mouse cell-mediated lympholysis assay in serum-free and mouse serum-supplemented media: culture conditions and genetic factors. Scand J Immunol (1975) 1.55
Genetic control of cell-mediated lympholysis in mouse. J Exp Med (1974) 1.51
TCGF production for cloning and growth of functional human T lymphocytes. Scand J Immunol (1980) 1.50
Alternative pathways of T lymphocyte activation. J Exp Med (1978) 1.49
Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp Med (1996) 1.49
Call for moratorium on xenotransplants. Nature (1998) 1.48
Specificity of antigen recognition by human lymphocytes in vitro. Science (1970) 1.48
Continuous culture of T cells cytotoxic for autologous human leukaemia cells. Nature (1979) 1.46
Lymphocyte reactivity to serologically undetected components of the major histocompatibility complex. Nat New Biol (1973) 1.44
Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes (2001) 1.43
Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury. FASEB J (2003) 1.42
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Human mixed lymphocyte cultures. Evaluation of a microculture technique utilizing the Multiple Automated Sample Harvester (MASH). Clin Exp Immunol (1973) 1.41
Generation of cytotoxic T lymphocytes to autologous human leukaemia cells by sensitisation to pooled allogeneic normal cells. Nature (1978) 1.41
SB: a new HLA-linked human histocompatibility gene defined using HLA-mutant cell lines. Nature (1981) 1.40
Human lymphocytes recognise mouse alloantigens. Nature (1975) 1.31
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. J Biol Chem (1996) 1.30
Transplantation: pairing of donor and recipient. Science (1970) 1.28
The major histocompatibility complex - genetics and biology (third of three parts). N Engl J Med (1976) 1.28
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Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta. J Immunol (1987) 1.26
Thymic transplantation in a case of chronic mucocutaneous candidiasis. Lancet (1971) 1.26
Cytotoxicity: specificity after in vitro sensitization. Science (1970) 1.26
Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation (1991) 1.24
NK-kappa B subunit-specific regulation of the I kappa B alpha promoter. J Biol Chem (1994) 1.24
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Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J Exp Med (1990) 1.23
Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med (1990) 1.23
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Genetic control of mixed leukocyte culture reactivity. Transplant Rev (1972) 1.21
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Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction. J Exp Med (1976) 1.16
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Leukemia-associated antigens in the mixed leukocyte culture test. Science (1969) 1.12
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