Published in Nature on May 27, 1967
The conversion of glyoxyloyl groups into glycyl groups and their formation from maleyl residues. Biochem J (1968) 1.40
Hereditary non-spherocytic haemolytic anaemia with post-splenectomy inclusion bodies and pigmenturia caused by an unstable haemoglobin Santa Ana-beta-88 (F4) leucine--proline. J Med Genet (1968) 1.04
Molecular basis of hereditary disease. Br Med J (1968) 0.90
Hemoglobin Hasharon (alpha-2-47 his(CD5)beta-2): a hemoglobin found in low concentration. J Clin Invest (1969) 0.89
Hemoglobin Abraham Lincoln, beta32 (B14) leucine leads to proline. An unstable variant producing severe hemolytic disease. J Clin Invest (1973) 0.84
Intermediary carbohydrate metabolism in embryonic life: Phosphorylation cycles. VI. Glucolysis without phosphorylation. VII. Experiments on the nature of non-phosphorylating glucolysis. Biochem J (1937) 7.09
Some factors influencing the formation of Robison ester from glycogen and inorganic phosphate in muscle extract. Biochem J (1939) 5.96
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Molecular pathology of human haemoglobin. Nature (1968) 4.31
Structure and variation of human alpha 1-antitrypsin. Nature (1982) 4.13
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc (2001) 3.90
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18
The anticoagulant activation of antithrombin by heparin. Proc Natl Acad Sci U S A (1997) 3.09
The effect of protein intake on the absorption of calcium and magnesium. Biochem J (1942) 3.02
Studies on iron in plants with special observations on the chlorophyll: iron ratio. Biochem J (1941) 2.83
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
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Post-Traumatic Confusional State Treated with Massive Doses of Nicotinic Acid. Can Med Assoc J (1944) 2.54
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. N Engl J Med (1983) 2.36
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
Haemoglobin G Copenhagen and haemoglobin J Cambridge. Two new beta-chain variants of haemoglobin A. Biochim Biophys Acta (1967) 2.26
Intermediary carbohydrate metabolism in embryonic life: Glyceraldehyde and glucolysis. Biochem J (1937) 2.15
Sickling tests. Pitfalls in performance and interpretation. JAMA (1967) 2.13
Anticytoplasmic antibodies in Wegener's granulomatosis. Lancet (1986) 2.12
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins. Br Med Bull (1969) 2.07
Haemoglobin gene frequencies in the Jamaican population: a study in 100,000 newborns. Br J Haematol (1986) 2.00
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Cation antagonism in blood coagulation. J Physiol (1944) 1.95
A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia. Proc Natl Acad Sci U S A (1981) 1.93
Familial dementia caused by polymerization of mutant neuroserpin. Nature (1999) 1.88
A simple method for the detection of unstable haemoglobins. Br J Haematol (1972) 1.87
A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia. J Clin Invest (1985) 1.85
Molecular evolution of myoglobin and the fossil record: a phylogenetic synthesis. Nature (1973) 1.76
Rapid estimation (2 1/2 hours) of glycosylated haemoglobin for routine purposes. Lancet (1977) 1.76
Reactions involving superoxide and normal and unstable haemoglobins. Biochem J (1976) 1.66
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol (1996) 1.66
[The G-DRG system 2008. Relevant changes for rheumatology]. Z Rheumatol (2008) 1.64
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J Clin Invest (1986) 1.61
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci U S A (2000) 1.54
A circulating variant of human proalbumin. Nature (1978) 1.52
Haemoglobin Hammersmith (beta-42 (CDI) Phe replaced by ser). Nature (1967) 1.52
Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol (1991) 1.52
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Hormone binding globulins undergo serpin conformational change in inflammation. Nature (1988) 1.47
[Changes for rheumatology in the G-DRG system 2005]. Z Rheumatol (2005) 1.45
Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature (1968) 1.44
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature (1985) 1.44
Crystal structure of ovalbumin as a model for the reactive centre of serpins. Nature (1990) 1.42
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. J Biol Chem (1993) 1.41
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
Moleuclar pathology of human haemoglobin: stereochemical interpretation of abnormal oxygen affinities. Nature (1971) 1.40
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure (1999) 1.40
A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem (1967) 1.40
[Rheumatology coding guideline. A guideline for clinical practice]. Z Rheumatol (2002) 1.40
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin--a possible pathogenic factor in acne. J Invest Dermatol (1971) 1.38
Human cholinesterase (pseudocholinesterase): genetic variants and their recognition. Br J Anaesth (1969) 1.35
Imprisonment of J-P Allain. Lancet (1993) 1.34
Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature (1966) 1.33
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization. J Biol Chem (1995) 1.33
Differences between alpha- and beta-chain mutants of human haemoglobin and between alpha- and beta-thalassaemia. Possible duplication of the alpha-chain gene. Br Med J (1968) 1.33
Effects of mutations in the hinge region of serpins. Biochemistry (1993) 1.29
Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine. Br J Haematol (1970) 1.28
The unstable haemoglobin haemolytic anaemias. Semin Hematol (1969) 1.27
The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J Mol Biol (1997) 1.27
[Structural quality of rheumatology clinics for children and adolescents. Paper by a task force of the "Society of Pediatric and Adolescent Rheumatology" and of the "Association of Rheumatology Clinics in Germany"]. Z Rheumatol (2006) 1.27
A 2.6 A structure of a serpin polymer and implications for conformational disease. J Mol Biol (1999) 1.26
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver. FEBS Lett (1984) 1.24
Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. Clin Exp Allergy (2006) 1.23
Haemoglobin O in An Arab Family. Br Med J (1960) 1.23
Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. Biochem J (1977) 1.22
[G-DRG system 2009: relevant changes for rheumatology]. Z Rheumatol (2009) 1.22
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop. J Biol Chem (2001) 1.22
Haemoglobin Tak: a variant with additional residues at the end of the beta-chains. Lancet (1971) 1.20
Evaluation of the effects of probiotic supplementation from the neonatal period on innate immune development in infancy. Clin Exp Allergy (2006) 1.20
The significance of monoclonal gammopathy in a normal population. Aust N Z J Med (1971) 1.16
Basis of the defect in alpha-1-antitrypsin deficiency. Nature (1973) 1.16
[Hospital financing for 2011: relevant changes in rheumatology]. Z Rheumatol (2011) 1.15
Preparation and characterization of latent alpha 1-antitrypsin. J Biol Chem (1995) 1.15
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp) J Clin Invest (1994) 1.14
Prevalence of antithrombin deficiency in the healthy population. Br J Haematol (1994) 1.13
Yeast KEX2 protease has the properties of a human proalbumin converting enzyme. Science (1987) 1.13
Serum-pseudocholinesterase in depression with notable anxiety. Lancet (1965) 1.12
A new doubly substituted sickling haemoglobin: HbS-Oman. Br J Haematol (1989) 1.12
Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin. J Mol Biol (2000) 1.12
Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. J Neurosci Res (1998) 1.11
The amino acid sequence of the alpha chain of the major haemoglobin of the rat (Rattus norvegicus). Biochem J (1975) 1.11
alpha 1-Antitrypsin microheterogeneity. Isolation and physiological significance of isoforms. Biochim Biophys Acta (1982) 1.10
Different types of alpha-thalassaemia and significance of haemoglobin Bart's in neonates. Lancet (1970) 1.10
A Ghanaian adult, homozygous for hereditary persistence of foetal haemoglobin and heterozygous for elliptocytosis. Acta Haematol (1970) 1.10
On the evolution of myoglobin. Philos Trans R Soc Lond B Biol Sci (1978) 1.09
Abnormal haemoglobins and the genetic code. Nature (1965) 1.08
Mechanism of oxyhaemoglobin breakdown on reaction with acetylphenylhydrazine. Biochem J (1978) 1.06
PRE3, highly homologous to the human major histocompatibility complex-linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity. FEBS Lett (1994) 1.06
Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444----His) mutation. Biochem J (1988) 1.06
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor. J Biol Chem (1993) 1.06