Published in Science on February 11, 1983
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Induction of anti-HIV neutralizing antibodies by synthetic peptides. EMBO J (1986) 4.32
Dengue virus structural differences that correlate with pathogenesis. J Virol (1999) 4.26
Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. J Virol (1987) 2.97
Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. Proc Natl Acad Sci U S A (1985) 2.23
Use of antibodies directed against synthetic peptides for identifying cDNA clones, establishing reading frames, and deducing the gene order of measles virus. J Virol (1985) 1.75
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med (1992) 1.48
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide. J Exp Med (1984) 1.40
Detection of a genome-linked protein (VPg) of hepatitis A virus and its comparison with other picornaviral VPgs. J Virol (1986) 1.29
Distribution of linear antigenic sites on glycoprotein gp55 of human cytomegalovirus. J Virol (1991) 1.28
Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs. Proc Natl Acad Sci U S A (2009) 1.24
Comparison of the major antigenic determinants of different serotypes of foot-and-mouth disease virus. J Virol (1983) 1.24
An antibody to a synthetic peptide recognizes polyomavirus middle-T antigen and reveals multiple in vitro tyrosine phosphorylation sites. Mol Cell Biol (1984) 1.17
Generation of polyclonal antibodies of predetermined specificity against pediocin PA-1. Appl Environ Microbiol (1998) 1.02
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proc Natl Acad Sci U S A (1985) 1.02
Structural analysis of the human papillomavirus type 16-E2 transactivator with antipeptide antibodies reveals a high mobility region linking the transactivation and the DNA-binding domains. Nucleic Acids Res (1991) 1.01
Peptide antisera as sequence-specific probes of protein conformational transitions: calmodulin exhibits calcium-dependent changes in antigenicity. Proc Natl Acad Sci U S A (1986) 1.00
Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc Natl Acad Sci U S A (1984) 0.98
Antibodies against synthetic peptides of herpes simplex virus type 1 glycoprotein D and their capability to neutralize viral infectivity in vitro. J Virol (1988) 0.93
Structural relationship of human apolipoprotein B48 to apolipoprotein B100. J Clin Invest (1987) 0.93
Immunogenicity of a contiguous T-B synthetic epitope of the A/PR/8/34 influenza virus. J Virol (1997) 0.86
Immunoprecipitation of some forms of simian virus 40 large-T antigen by antibodies to synthetic peptides. J Virol (1984) 0.86
Adjuvant activity of 6-O-acyl-muramyldipeptides to enhance primary cellular and humoral immune responses in guinea pigs: adaptability to various vehicles and pyrogenicity. Infect Immun (1986) 0.85
Evaluation of two carrier protein-angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man. Br J Clin Pharmacol (2003) 0.84
New aspects of vaccine development. Clin Exp Immunol (1985) 0.83
Overview of the purification of recombinant proteins. Curr Protoc Protein Sci (2015) 0.75
EBV-Associated Cancer and Autoimmunity: Searching for Therapies. Vaccines (Basel) (2015) 0.75
Structural and immunological characterization of Friend murine leukaemia virus glycopolypeptide using synthetic oligopeptides. EMBO J (1984) 0.75
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J Clin Microbiol (1993) 45.22
Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol (1979) 43.48
Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long. Nucleic Acids Res (1978) 13.22
The structure of an antigenic determinant in a protein. Cell (1984) 10.85
Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci (1998) 9.88
The 65-kilodalton antigen of Mycobacterium tuberculosis. J Bacteriol (1987) 9.50
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (1996) 8.99
Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93
Mitotic misregulation and human aging. Science (2000) 8.47
Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein. J Biol Chem (1977) 8.03
The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med (1967) 6.81
Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A (1977) 6.80
Large-scale use of polymerase chain reaction for detection of Mycobacterium tuberculosis in a routine mycobacteriology laboratory. J Clin Microbiol (1993) 6.65
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A (1991) 6.13
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A (1991) 5.94
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (1989) 5.73
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (1982) 5.50
Differentiation of slowly growing Mycobacterium species, including Mycobacterium tuberculosis, by gene amplification and restriction fragment length polymorphism analysis. J Clin Microbiol (1992) 5.20
Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature (1982) 5.11
p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA (1988) 4.89
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Hybridization of labeled RNA to DNA in agarose gels. Nucleic Acids Res (1975) 4.38
Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35
Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature (1977) 4.31
Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26
A restriction enzyme Tha I from the thermophilic mycoplasma Thermoplasma acidophilum. Nucleic Acids Res (1978) 4.25
Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing. Arch Pathol Lab Med (1995) 4.10
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05
Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05
Rapid and sensitive detection of Mycobacterium leprae using a nested-primer gene amplification assay. J Clin Microbiol (1990) 4.04
Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00
Multiplex PCR assay specific for the multidrug-resistant strain W of Mycobacterium tuberculosis. J Clin Microbiol (1994) 3.85
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science (1995) 3.82
Access to genitourinary medicine clinics in the United Kingdom. Sex Transm Infect (2001) 3.79
The rpoB gene of Mycobacterium tuberculosis. Antimicrob Agents Chemother (1994) 3.78
Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med (1983) 3.52
Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med (1976) 3.51
Function of the thick ascending limb of Henle's loop. Am J Physiol (1973) 3.48
Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol (1988) 3.32
Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature (1989) 3.31
Rapid, amplification-based fingerprinting of Mycobacterium tuberculosis. J Gen Microbiol (1993) 3.19
Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13
Furosemide effect on isolated perfused tubules. Am J Physiol (1973) 2.95
Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90
Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin. Nature (1982) 2.84
Antibody catalysis of the oxidation of water. Science (2001) 2.74
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol (1986) 2.71
Chemical characterization of a family of brain lipids that induce sleep. Science (1995) 2.69
The etiologic agents of leprosy and tuberculosis share an immunoreactive protein antigen with the vaccine strain Mycobacterium bovis BCG. Infect Immun (1987) 2.66
The cleavage site of the restriction endonuclease Ava II. Nucleic Acids Res (1978) 2.60
Tuberculosis symposium: emerging problems and promise. J Infect Dis (1993) 2.55
Chemical basis of antigenic variation in foot-and-mouth disease virus. Nature (1984) 2.52
Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A (1991) 2.42
Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med (1966) 2.42
An Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformation-associated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (1986) 2.42
Catalytic antibodies. Science (1986) 2.41
Gene expression in rat brain. Nucleic Acids Res (1983) 2.40
The human retinal degeneration slow (RDS) gene: chromosome assignment and structure of the mRNA. Genomics (1991) 2.39
A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase. Antimicrob Agents Chemother (1993) 2.39
Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice. J Exp Med (1980) 2.38
The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes. J Exp Med (1975) 2.37
Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix. J Mol Biol (1988) 2.33
Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn. J Mol Biol (1988) 2.30
Turnaround times for mycobacterial cultures. J Clin Microbiol (1997) 2.30
Mature microglia resemble immature antigen-presenting cells. Glia (1998) 2.28
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science (1997) 2.27
Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron (1990) 2.26
Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding. Biochemistry (1988) 2.21
Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J Immunol (1996) 2.13
Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med (1974) 2.12
Gene expression in synchronized lymphocytes: studies on the control of synthesis of immunoglobulin polypeptides. J Cell Physiol (1971) 2.11
Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell (1985) 2.10
Tolerance of T-cell clones is associated with membrane antigen changes. Nature (1983) 2.10
In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A (1992) 2.08
The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein. Neuron (1991) 2.07
Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci (2000) 2.05
Transcriptional activation of the mouse Mx gene by type I interferon. Mol Cell Biol (1986) 2.04
Semantide- and chemotaxonomy-based analyses of some problematic phenotypic clusters of slowly growing mycobacteria, a cooperative study of the International Working Group on Mycobacterial Taxonomy. Int J Syst Bacteriol (1996) 2.02