Published in Nature on October 14, 1982
Efficient isolation of genes by using antibody probes. Proc Natl Acad Sci U S A (1983) 34.00
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc Natl Acad Sci U S A (1985) 8.77
Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins. EMBO J (1984) 7.60
Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci U S A (1988) 5.52
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Characterization of foot-and-mouth disease virus gene products with antisera against bacterially synthesized fusion proteins. J Virol (1986) 3.89
Localization and synthesis of an antigenic determinant of herpes simplex virus glycoprotein D that stimulates the production of neutralizing antibody. J Virol (1984) 3.53
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Processing the nonstructural polyproteins of Sindbis virus: study of the kinetics in vivo by using monospecific antibodies. J Virol (1988) 2.85
Isolation of monoclonal antibodies specific for products of avian oncogene myb. Mol Cell Biol (1984) 2.50
Amino acid sequence requirements in the epitope recognized by the alpha-tubulin-specific rat monoclonal antibody YL 1/2. EMBO J (1984) 2.32
Identification of distinct antigenic determinants on Semliki Forest virus by using monoclonal antibodies with different antiviral activities. J Virol (1984) 2.17
Genomic structure of the large RNA segment of infectious bursal disease virus. Nucleic Acids Res (1986) 1.96
Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity. J Virol (1984) 1.93
Use of antibodies directed against synthetic peptides for identifying cDNA clones, establishing reading frames, and deducing the gene order of measles virus. J Virol (1985) 1.75
The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2. J Virol (1985) 1.74
A poliovirus type 1 neutralization epitope is located within amino acid residues 93 to 104 of viral capsid polypeptide VP1. EMBO J (1983) 1.59
Isolation and characterization of a monoclonal antibody directed against type 1 fimbriae organelles from Escherichia coli. Infect Immun (1983) 1.57
Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Proc Natl Acad Sci U S A (1987) 1.55
Multiple topogenic sequences in bovine opsin. Proc Natl Acad Sci U S A (1987) 1.54
Efficient generation of antibodies to oncoproteins by using synthetic peptide antigens. Proc Natl Acad Sci U S A (1985) 1.51
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50
Intermolecular relationships of major surface proteins of Anaplasma marginale. Infect Immun (1994) 1.42
Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. Mol Cell Biol (1991) 1.41
Cholera toxin B-subunit gene fusion: structural and functional analysis of the chimeric protein. Infect Immun (1990) 1.32
Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Proc Natl Acad Sci U S A (1984) 1.32
Comparison of the major antigenic determinants of different serotypes of foot-and-mouth disease virus. J Virol (1983) 1.24
Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs. Proc Natl Acad Sci U S A (2009) 1.24
Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules. J Virol (1986) 1.21
Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities. Proc Natl Acad Sci U S A (1983) 1.17
Peptide immunogen mimicry of putative E1 glycoprotein-specific epitopes in hepatitis C virus. J Virol (1994) 1.07
Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding. Proc Natl Acad Sci U S A (1985) 1.04
Phage-displayed peptide libraries. Curr Opin Biotechnol (1998) 1.02
Natural feline leukemia virus variant escapes neutralization by a monoclonal antibody via an amino acid change outside the antibody-binding epitope. J Virol (1987) 0.98
A reinforced merging methodology for mapping unique peptide motifs in members of protein families. BMC Bioinformatics (2006) 0.94
Lipid bilayer surface association of lung surfactant protein SP-B, amphipathic segment detected by flow immunofluorescence. Biophys J (1992) 0.94
Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides. Proc Natl Acad Sci U S A (1985) 0.93
Antibodies against synthetic peptides of herpes simplex virus type 1 glycoprotein D and their capability to neutralize viral infectivity in vitro. J Virol (1988) 0.93
A synthetic peptide corresponding to the cleavage region of VP3 from rotavirus SA11 induces neutralizing antibodies. J Virol (1988) 0.90
Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen. J Virol (1986) 0.89
Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus. J Virol (1991) 0.89
Antibodies of predetermined specificity for the NH2 terminus of a cellular protein p53 react with the native molecule: evidence for the presence of different p53s. Proc Natl Acad Sci U S A (1983) 0.88
Large-scale sequence analysis of hemagglutinin of influenza A virus identifies conserved regions suitable for targeting an anti-viral response. PLoS One (2010) 0.87
Engineering of site-directed antisera against vertebrate calmodulin by using synthetic peptide immunogens containing an immunoreactive site. Proc Natl Acad Sci U S A (1983) 0.87
Macromolecular assemblage in the design of a synthetic AIDS vaccine. Proc Natl Acad Sci U S A (1992) 0.85
Evaluation of two carrier protein-angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man. Br J Clin Pharmacol (2003) 0.84
Antibody of predetermined specificity to a carboxy-terminal region of H-ras gene products inhibits their guanine nucleotide-binding function. Mol Cell Biol (1985) 0.82
Identification of amino acid propensities that are strong determinants of linear B-cell epitope using neural networks. PLoS One (2012) 0.81
Antigen mobility in the combining site of an anti-peptide antibody. Proc Natl Acad Sci U S A (1991) 0.79
Antigenic heterogeneity of capsid protein VP1 in foot-and-mouth disease virus (FMDV) serotype Asia 1. Adv Appl Bioinform Chem (2013) 0.79
Detection of immunologically cross-reacting capsid protein of alphaviruses on the surfaces of infected L929 cells. J Virol (1985) 0.78
Distinct immunoreactivities suggest the existence of potential tissue variants in rat lipoprotein lipase. Biochem J (1994) 0.76
Towards new vaccines. J R Soc Med (1984) 0.75
EBV-Associated Cancer and Autoimmunity: Searching for Therapies. Vaccines (Basel) (2015) 0.75
Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition. Biochemistry (2016) 0.75
The effects of synthetic oligopeptide derived from enamel matrix derivative on cell proliferation and osteoblastic differentiation of human mesenchymal stem cells. Int J Mol Sci (2014) 0.75
Folded conformations of antigenic peptides from riboflavin carrier protein in aqueous hexafluoroacetone. Protein Sci (1998) 0.75
Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
The structure of an antigenic determinant in a protein. Cell (1984) 10.85
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (1996) 8.99
Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93
Mitotic misregulation and human aging. Science (2000) 8.47
Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein. J Biol Chem (1977) 8.03
The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med (1967) 6.81
Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A (1977) 6.80
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A (1991) 6.13
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A (1991) 5.94
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (1989) 5.73
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (1982) 5.50
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35
Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature (1977) 4.31
Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05
Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05
Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science (1995) 3.82
Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med (1976) 3.51
Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13
Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90
Antibody catalysis of the oxidation of water. Science (2001) 2.74
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol (1986) 2.71
Chemical characterization of a family of brain lipids that induce sleep. Science (1995) 2.69
Chemical basis of antigenic variation in foot-and-mouth disease virus. Nature (1984) 2.52
Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A (1991) 2.42
Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med (1966) 2.42
An Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformation-associated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (1986) 2.42
Catalytic antibodies. Science (1986) 2.41
The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes. J Exp Med (1975) 2.37
Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix. J Mol Biol (1988) 2.33
Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn. J Mol Biol (1988) 2.30
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science (1997) 2.27
Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding. Biochemistry (1988) 2.21
Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med (1974) 2.12
Gene expression in synchronized lymphocytes: studies on the control of synthesis of immunoglobulin polypeptides. J Cell Physiol (1971) 2.11
In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A (1992) 2.08
Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci U S A (1983) 2.00
Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science (1990) 1.98
Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98
From molecular diversity to catalysis: lessons from the immune system. Science (1995) 1.97
Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A (1985) 1.97
Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. Proc Natl Acad Sci U S A (1989) 1.96
Identifier sequences are transcribed specifically in brain. Nature (1984) 1.95
Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc Natl Acad Sci U S A (1992) 1.93
Antibodies that react with predetermined sites on proteins. Science (1983) 1.87
Antibody catalysis of a disfavored chemical transformation. Science (1993) 1.82
Chemistry of antibody binding to a protein. Science (1987) 1.82
Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. I. Myohemerythrin. J Mol Biol (1992) 1.79
Antibodies have the intrinsic capacity to destroy antigens. Proc Natl Acad Sci U S A (2000) 1.79
Antibodies of predetermined specificity in biology and medicine. Adv Immunol (1984) 1.77
Brain-specific genes have identifier sequences in their introns. Proc Natl Acad Sci U S A (1984) 1.71
Blue-fluorescent antibodies. Science (2000) 1.71
Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells. Virology (1973) 1.71
The induction of acute glomerulonephritis in rabbits with soluble antigens isolated from normal homologous and autologous urine. J Immunol (1968) 1.68
Karyotypic, virologic, and immunologic analyses of two continuous lymphocyte lines established from New Zealand black mice: possible relationship of chromosomal mosaicism to autoimmunity. Proc Natl Acad Sci U S A (1972) 1.65
Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science (1985) 1.63
Production of macrophage migration inhibition factor by continuous cell lines. J Exp Med (1972) 1.62
Isolation and characterization of plasma membrane associated immunoglobulin from cultured human diploid lymphocytes. J Mol Biol (1973) 1.56
Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Proc Natl Acad Sci U S A (1987) 1.55
Mechanisms of antibody binding to a protein. Science (1987) 1.55
Cell cycle-dependent immune lysis of Moloney virus-transformed lymphocytes: presence of viral antigen, accessibility to antibody, and complement activation. Proc Natl Acad Sci U S A (1971) 1.53
Developmentally regulated proteins of the plasma membrane of Dictyostelium discoideum. The carbohydrate-binding protein. J Mol Biol (1976) 1.53
Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression. Cell (1981) 1.52
Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism. Proc Natl Acad Sci U S A (1978) 1.51
The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol (1997) 1.51
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50
Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Cell (1979) 1.49
Differential expression of two distinct xenotropic viruses in NZB mice. Clin Immunol Immunopathol (1980) 1.48
Human combinatorial antibody libraries to hepatitis B surface antigen. Proc Natl Acad Sci U S A (1992) 1.43
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Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. Virology (1978) 1.42
The atomic mobility component of protein antigenicity. Annu Rev Immunol (1985) 1.40
Synthetic peptide immunogens as vaccines. Annu Rev Microbiol (1983) 1.39
Spontaneous glomerulonephritis in sheep. Lab Invest (1966) 1.39
Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis. Proc Natl Acad Sci U S A (1998) 1.37
The chemistry and mechanism of antibody binding to protein antigens. Adv Immunol (1988) 1.37
On signal sequence polymorphisms and diseases of distribution. Proc Natl Acad Sci U S A (1996) 1.35
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix. Proc Natl Acad Sci U S A (1987) 1.34
The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn. Nature (1986) 1.33
Physical properties of cytoplasmic membrane-associated DNA. J Mol Biol (1973) 1.31
A stereospecific cyclization catalyzed by an antibody. Science (1987) 1.31
Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. II. Plastocyanin. J Mol Biol (1992) 1.29
Relationship between the oncornavirus gene product gp70 and a major protein secretion of the mouse genital tract. Nature (1976) 1.28
An immunological study of the fates of nuclear and nucleolar macromoleculus during the cell cycle. J Mol Biol (1972) 1.27
Synthesis of plasma membrane-associated and secretory immunoglobulin in diploid lymphocytes. J Exp Med (1972) 1.27
Metalloantibodies. Science (1990) 1.27
Synthetic idiotypes: the third hypervariable region of murine anti-dextran antibodies. Cell (1983) 1.26
Mutants of Dictyostelium discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family. Cell (1983) 1.26
Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis. Science (1993) 1.26
Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids. Nature (1984) 1.26
In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses. Proc Natl Acad Sci U S A (1980) 1.25
Selection of human anti-hapten antibodies from semisynthetic libraries. Gene (1993) 1.23
The physical basis for induction of protein-reactive antipeptide antibodies. Annu Rev Biophys Biophys Chem (1988) 1.21
Multiple event activation of a generic prodrug trigger by antibody catalysis. Proc Natl Acad Sci U S A (1999) 1.21
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proc Natl Acad Sci U S A (1990) 1.20
Induction of an antibody that catalyzes the hydrolysis of an amide bond. Science (1988) 1.19