Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation.

PubWeight™: 3.32‹?› | Rank: Top 1%

🔗 View Article (PMC 365527)

Published in Mol Cell Biol on October 01, 1988

Authors

P Staeheli1, R Grob, E Meier, J G Sutcliffe, O Haller

Author Affiliations

1: Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.

Articles citing this

Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A (2003) 6.49

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol (2005) 4.21

Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol (2006) 4.00

Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol (2000) 3.77

Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol (1990) 3.44

The role of interferon in influenza virus tissue tropism. J Virol (1998) 2.88

A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc Natl Acad Sci U S A (2002) 2.65

Sendai virus and simian virus 5 block activation of interferon-responsive genes: importance for virus pathogenesis. J Virol (1999) 2.51

Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog (2008) 2.38

Type I interferons in infectious disease. Nat Rev Immunol (2015) 2.37

Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci U S A (2007) 2.33

Host genetic background strongly influences the response to influenza a virus infections. PLoS One (2009) 2.28

Emerging influenza. J Clin Virol (2008) 2.02

Innate immunity to influenza virus infection. Nat Rev Immunol (2014) 1.99

The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol (2007) 1.93

Animal Models for Influenza Virus Pathogenesis and Transmission. Viruses (2010) 1.88

Heterosubtypic immunity to influenza A virus: where do we stand? Microbes Infect (2008) 1.88

The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice. J Virol (2000) 1.81

Protective role of beta interferon in host defense against influenza A virus. J Virol (2006) 1.80

Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62

Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J Virol (2008) 1.62

Identification of a second interferon-regulated murine Mx gene. Mol Cell Biol (1988) 1.62

Induction and evasion of type I interferon responses by influenza viruses. Virus Res (2011) 1.59

Viral parkinsonism. Biochim Biophys Acta (2008) 1.57

Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol (1995) 1.56

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol (1991) 1.47

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog (2013) 1.43

Towards a quantitative understanding of the within-host dynamics of influenza A infections. J R Soc Interface (2009) 1.40

Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection. J Virol (2010) 1.40

Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39

The role of host genetics in susceptibility to influenza: a systematic review. PLoS One (2012) 1.39

Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J Virol (2009) 1.32

The contribution of animal models to the understanding of the host range and virulence of influenza A viruses. Microbes Infect (2011) 1.32

Experimental infection of pigs with the human 1918 pandemic influenza virus. J Virol (2009) 1.29

Mx proteins: antiviral gatekeepers that restrain the uninvited. Microbiol Mol Biol Rev (2013) 1.22

Host genetic risk factors for West Nile virus infection and disease progression. PLoS One (2011) 1.22

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly. J Virol (2012) 1.22

Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity. J Biol Chem (2010) 1.21

Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol (2010) 1.18

A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx. Mol Cell Biol (1989) 1.09

Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. J Virol (1999) 1.06

Type I interferon response to extracellular bacteria in the airway epithelium. Trends Immunol (2011) 1.05

Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays. J Virol (2008) 1.03

Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II. J Virol (2009) 1.01

Low-pathogenic avian influenza viruses in wild house mice. PLoS One (2012) 1.01

Animal models for influenza viruses: implications for universal vaccine development. Pathogens (2014) 0.99

Pathogenesis of a model gammaherpesvirus in a natural host. J Virol (2010) 0.99

Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cells. J Virol (2012) 0.97

Innate antiviral response: role in HIV-1 infection. Viruses (2011) 0.93

Hantaan virus infection causes an acute neurological disease that is fatal in adult laboratory mice. J Virol (2002) 0.92

Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J Virol (2011) 0.91

Influenza-induced production of interferon-alpha is defective in geriatric individuals. J Clin Immunol (2010) 0.91

Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories. Clin Exp Immunol (2010) 0.89

The marmoset model of GB virus B infections: adaptation to host phenotypic variation. J Virol (2009) 0.89

Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background. J Virol (2015) 0.89

The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA. J Virol (2014) 0.89

Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice. J Virol (2004) 0.88

Human IRGM gene "to be or not to be". Semin Immunopathol (2010) 0.88

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics (2016) 0.88

Susceptibility of the wild-derived inbred CAST/Ei mouse to infection by orthopoxviruses analyzed by live bioluminescence imaging. Virology (2013) 0.88

Human but not mouse hepatocytes respond to interferon-lambda in vivo. PLoS One (2014) 0.88

Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. J Virol (1992) 0.88

Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus. J Virol (2011) 0.88

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. J Mol Biol (2016) 0.88

Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus. J Virol (1993) 0.87

Contrasting genetic architectures in different mouse reference populations used for studying complex traits. Genome Res (2015) 0.86

Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half. J Virol (1997) 0.86

Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice. BMC Microbiol (2013) 0.85

Host genetic determinants of influenza pathogenicity. Curr Opin Virol (2013) 0.85

Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus. Viruses (2009) 0.84

Intramuscular immunization with a vesicular stomatitis virus recombinant expressing the influenza hemagglutinin provides post-exposure protection against lethal influenza challenge. Vaccine (2009) 0.84

Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21. J Virol (1988) 0.81

Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles. Vet Res (2010) 0.81

A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection. FASEB J (2014) 0.81

Host genetics of severe influenza: from mouse Mx1 to human IRF7. Curr Opin Immunol (2016) 0.81

Comparative genetics of resistance to viruses. Am J Hum Genet (1998) 0.80

Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1. J Virol (2003) 0.80

Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses. J Virol (2015) 0.80

Genomic profiling of collaborative cross founder mice infected with respiratory viruses reveals novel transcripts and infection-related strain-specific gene and isoform expression. G3 (Bethesda) (2014) 0.79

Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales. Proc Natl Acad Sci U S A (2015) 0.79

Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. J Virol (2010) 0.79

Pathology of Equine Influenza virus (H3N8) in Murine Model. PLoS One (2015) 0.75

Molecular determinants of influenza virus pathogenesis in mice. Curr Top Microbiol Immunol (2014) 0.75

Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection. J Innate Immun (2016) 0.75

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor. J Virol (2016) 0.75

New polymorphism of the influenza virus resistance Mx1 gene in Iberian domestic pigs. Postdoc J (2016) 0.75

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. J Exp Med (2017) 0.75

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity. Genes Immun (2016) 0.75

Interferon-stimulated genes-essential antiviral effectors implicated in resistance to Theiler's virus-induced demyelinating disease. J Neuroinflammation (2015) 0.75

Prioritizing genes responsible for host resistance to influenza using network approaches. BMC Genomics (2013) 0.75

Influenza Pathogenesis in Genetically Defined Resistant and Susceptible Murine Strains

. Yale J Biol Med (2017) 0.75

Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA. PLoS One (2017) 0.75

Articles cited by this

A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol (1977) 205.11

Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. Cell (1977) 61.24

High-efficiency cloning of full-length cDNA. Mol Cell Biol (1982) 22.81

Rapid transfer of DNA from agarose gels to nylon membranes. Nucleic Acids Res (1985) 21.05

The molecular genetics of human hemoglobin. Prog Nucleic Acid Res Mol Biol (1984) 5.50

Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92

Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A (1983) 3.17

Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female. Nature (1982) 2.85

Inborn resistance of ice to orthomyxoviruses. Curr Top Microbiol Immunol (1981) 2.41

Gene expression in rat brain. Nucleic Acids Res (1983) 2.40

Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology (1985) 2.26

Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood (1984) 2.20

Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J Biol Chem (1985) 2.10

Transcriptional activation of the mouse Mx gene by type I interferon. Mol Cell Biol (1986) 2.04

Interferon-induced Mx protein: a mediator of cellular resistance to influenza virus. Interferon (1987) 1.99

Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology (1984) 1.71

Transport of the murine Mx protein into the nucleus is dependent on a basic carboxy-terminal sequence. J Interferon Res (1987) 1.62

Identification of a second interferon-regulated murine Mx gene. Mol Cell Biol (1988) 1.62

Influenza virus resistance of wild mice: wild-type and mutant Mx alleles occur at comparable frequencies. J Interferon Res (1987) 1.32

Expression of interferon dependent resistance to influenza virus in mouse embryo cells. Arch Virol (1983) 1.31

Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A (1986) 1.28

Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16. J Virol (1986) 1.20

Articles by these authors

Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol (1979) 43.48

Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34

pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long. Nucleic Acids Res (1978) 13.22

Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci (1998) 9.88

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32

Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (1982) 5.50

Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92

p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA (1988) 4.89

Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26

A restriction enzyme Tha I from the thermophilic mycoplasma Thermoplasma acidophilum. Nucleic Acids Res (1978) 4.25

Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. J Virol (2001) 3.65

Primary structure of the vesicular stomatitis virus polymerase (L) gene: evidence for a high frequency of mutations. J Virol (1984) 3.54

Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol (1990) 3.44

Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature (1989) 3.31

cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol (1989) 3.20

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A (1983) 3.17

Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13

Two nuclear signalling pathways for vitamin D. Nature (1993) 3.12

Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts. Eur J Immunol (1977) 3.05

Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N Engl J Med (1985) 2.95

Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90

Host gene influences sensitivity to interferon action selectively for influenza virus. Nature (1980) 2.88

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J Virol (1992) 2.88

A complex of nuclear pore proteins required for pore function. J Cell Biol (1991) 2.87

The cleavage site of the restriction endonuclease Ava II. Nucleic Acids Res (1978) 2.60

Inborn resistance of ice to orthomyxoviruses. Curr Top Microbiol Immunol (1981) 2.41

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J Gen Virol (2001) 2.40

Gene expression in rat brain. Nucleic Acids Res (1983) 2.40

The human retinal degeneration slow (RDS) gene: chromosome assignment and structure of the mRNA. Genomics (1991) 2.39

Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo. Nature (1977) 2.39

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. J Virol (1985) 2.38

Differential mitotic phosphorylation of proteins of the nuclear pore complex. J Biol Chem (1995) 2.35

Adult mouse hepatocytes in primary monolayer culture express genetic resistance to mouse hepatitis virus type 3. J Immunol (1982) 2.32

Expression of a cDNA encoding a functional 241-kilodalton vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A (1985) 2.28

Mature microglia resemble immature antigen-presenting cells. Glia (1998) 2.28

Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron (1990) 2.26

Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology (1985) 2.26

Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med (1979) 2.14

Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J Biol Chem (1985) 2.10

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell (1985) 2.10

The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein. Neuron (1991) 2.07

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci (2000) 2.05

Transcriptional activation of the mouse Mx gene by type I interferon. Mol Cell Biol (1986) 2.04

Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides. Cell (1983) 2.01

Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci U S A (1983) 2.00

Interferon-induced Mx protein: a mediator of cellular resistance to influenza virus. Interferon (1987) 1.99

Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98

Natural killer cells in the mouse: an alternative immune surveillance mechanism? Contemp Top Immunobiol (1978) 1.96

Identifier sequences are transcribed specifically in brain. Nature (1984) 1.95

Extreme heterogeneity in populations of vesicular stomatitis virus. J Virol (1989) 1.95

A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells. J Virol (1988) 1.90

Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol (1998) 1.87

Antibodies that react with predetermined sites on proteins. Science (1983) 1.87

The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett (1999) 1.81

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci U S A (1999) 1.78

Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol (1996) 1.76

Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus. J Virol (1995) 1.73

Transgenic mice with intracellular immunity to influenza virus. Cell (1990) 1.73

Brain-specific genes have identifier sequences in their introns. Proc Natl Acad Sci U S A (1984) 1.71

Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology (1984) 1.71

Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice. Mol Cell Biol (1985) 1.70

Human cytomegalovirus immediate early and late transcripts are expressed in all major leukocyte populations in vivo. J Infect Dis (1995) 1.70

Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62

Identification of a second interferon-regulated murine Mx gene. Mol Cell Biol (1988) 1.62

A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins. Virology (1998) 1.60

Germinal centre CD4+ T cells are an important site of HIV replication in vivo. AIDS (1997) 1.58

An endoplasmic reticulum-specific cyclophilin. Mol Cell Biol (1991) 1.57

Randomised clinical trial: mesalazine (Salofalk granules) for uncomplicated diverticular disease of the colon--a placebo-controlled study. Aliment Pharmacol Ther (2013) 1.57

Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Proc Natl Acad Sci U S A (1987) 1.57

Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol (1995) 1.56

Phenol emulsion-enhanced DNA-driven subtractive cDNA cloning: isolation of low-abundance monkey cortex-specific mRNAs. Proc Natl Acad Sci U S A (1988) 1.56

Mx proteins: antiviral proteins by chance or by necessity? New Biol (1990) 1.55

Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression. Cell (1981) 1.52

Activity of rat Mx proteins against a rhabdovirus. J Virol (1990) 1.52

Control of neuronal gene expression. Science (1984) 1.50

Rhes: A striatal-specific Ras homolog related to Dexras1. J Neurosci Res (1999) 1.49

Papillomavirus infection and skin cancer in renal allograft recipients. Lancet (1989) 1.47

Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. J Exp Med (1978) 1.46

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. J Virol (1997) 1.44

Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs. J Virol (1984) 1.40

Age-related white matter atrophy in the human brain. Ann N Y Acad Sci (1992) 1.39

Cleaner air and lungs may be in store for our children's future. Pediatr Nurs (1999) 1.39

Synthetic peptide immunogens as vaccines. Annu Rev Microbiol (1983) 1.39

Cellular localization and function of the proteins encoded by brain-specific mRNAs. Cold Spring Harb Symp Quant Biol (1983) 1.36

Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc Natl Acad Sci U S A (1996) 1.36

Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. J Neurosci Res (1997) 1.35

Homotypic and heterotypic exclusion of vesicular stomatitis virus replication by high levels of recombinant polymerase protein L. J Virol (1987) 1.35

Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression. Infect Immun (1976) 1.35

GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). J Biol Chem (1999) 1.34

Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. EMBO J (1988) 1.32

MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J Infect Dis (1994) 1.29

The tetracycline repressor of pSC101. Mol Biol Evol (1985) 1.29

Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. Genomics (1997) 1.28

Primate brain-specific cytoplasmic transcript of the Alu repeat family. Mol Cell Biol (1987) 1.27

Rapid detection of influenza virus H1 by the polymerase chain reaction. Biochem Biophys Res Commun (1990) 1.26