Published in Cell on December 01, 1982
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol (1986) 5.96
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol (2000) 5.28
The human keratins: biology and pathology. Histochem Cell Biol (2008) 5.13
Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol (1984) 4.00
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition. J Cell Biol (1984) 3.48
Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol (1992) 3.43
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol (2002) 2.66
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol (1983) 2.58
Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc Natl Acad Sci U S A (1988) 2.53
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol (1996) 2.49
Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol (1984) 2.48
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The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol (1986) 2.04
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Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
Evidence for keratinocyte stem cells in vitro: long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes. Proc Natl Acad Sci U S A (1998) 1.83
Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. EMBO J (1986) 1.81
Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells. Proc Natl Acad Sci U S A (1990) 1.81
High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A (1995) 1.76
Tissue specificity of epithelial keratins: differential expression of mRNAs from two multigene families. Mol Cell Biol (1983) 1.75
Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc Natl Acad Sci U S A (1984) 1.74
Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes. J Virol (1992) 1.71
Expression of epidermal keratins and filaggrin during human fetal skin development. J Cell Biol (1985) 1.68
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am J Pathol (1989) 1.51
Molecular characterization and expression of the stratification-related cytokeratins 4 and 15. J Cell Biol (1988) 1.50
Cytokeratins in normal and malignant transitional epithelium. Maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines. Am J Pathol (1988) 1.47
Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures. J Virol (1987) 1.44
Immunocytochemical staining of cells in pleural and peritoneal effusions with a panel of monoclonal antibodies. J Clin Pathol (1983) 1.41
Mammary stem cells have myoepithelial cell properties. Nat Cell Biol (2014) 1.39
Diagnostic immunopathology. West J Med (1986) 1.38
A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice. J Cell Biol (1990) 1.37
Differential requirements for conserved E2 binding sites in the life cycle of oncogenic human papillomavirus type 31. J Virol (1998) 1.37
Effect of growth environment on spatial expression of involucrin by human epidermal keratinocytes. Arch Dermatol Res (1987) 1.36
Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol (1989) 1.36
The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors. EMBO J (1996) 1.33
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
Cloning of cDNAs specifying vitamin A-responsive human keratins. Proc Natl Acad Sci U S A (1984) 1.31
Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ. J Cell Biol (1988) 1.29
Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. J Cell Biol (1994) 1.27
A group of type I keratin genes on human chromosome 17: characterization and expression. Mol Cell Biol (1988) 1.27
Uroplakin I: a 27-kD protein associated with the asymmetric unit membrane of mammalian urothelium. J Cell Biol (1990) 1.27
The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells. J Cell Biol (1989) 1.25
Functional differences between keratins of stratified and simple epithelia. J Cell Biol (1998) 1.22
Replication of plasmid-derived human papillomavirus type 11 DNA in cultured keratinocytes. J Virol (1992) 1.21
CA 125 secretion by peritoneal mesothelial cells. J Clin Pathol (1994) 1.21
Differences of expression of cytokeratin polypeptides in various epithelial skin tumors. Arch Dermatol Res (1984) 1.18
Salivary gland components involved in the formation of squamous metaplasia. Am J Pathol (1985) 1.18
Sequence and expression of a type II keratin, K5, in human epidermal cells. Mol Cell Biol (1988) 1.15
Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J Virol (1994) 1.12
Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker. EMBO J (1984) 1.09
Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater (2008) 1.08
Mesosecrin: a secreted glycoprotein produced in abundance by human mesothelial, endothelial, and kidney epithelial cells in culture. J Cell Biol (1987) 1.08
Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells. Biochem J (1992) 1.06
Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. J Cell Biol (1988) 1.05
Keratin 17 expression as a marker for epithelial transformation in viral warts. Am J Pathol (1993) 1.05
Altered expression of proliferation and differentiation markers in human papillomavirus 16 and 18 immortalized epithelial cells grown in organotypic culture. Am J Pathol (1992) 1.05
Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES. Clin Exp Immunol (1998) 1.03
Denatured collagen modulates the phenotype of normal and wounded human skin equivalents. J Invest Dermatol (2008) 1.03
Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies. Proc Natl Acad Sci U S A (1984) 1.02
Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31. J Virol (2002) 1.02
Keratin polypeptides in malignant epithelial liver tumors. Differential diagnostic and histogenetic aspects. Am J Pathol (1987) 1.01
The intermediate filament cytoskeleton of malignant mesotheliomas and its diagnostic significance. Am J Pathol (1985) 1.01
Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity. J Cell Biol (1986) 1.00
Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS One (2008) 0.99
Salivary gland monomorphic adenoma. Ultrastructural, immunoperoxidase, and histogenetic aspects. Am J Pathol (1984) 0.98
Regulation of human mesothelial cell differentiation: opposing roles of retinoids and epidermal growth factor in the expression of intermediate filament proteins. J Cell Biol (1987) 0.98
HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol (2007) 0.97
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types. Stem Cells (2009) 0.97
Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy. Proc Natl Acad Sci U S A (1989) 0.97
Metalloproteinases and tissue inhibitor of metalloproteinases in mesothelial cells. Cellular differentiation influences expression. J Clin Invest (1993) 0.97
Intermediate filament cytoskeleton of amnion epithelium and cultured amnion epithelial cells: expression of epidermal cytokeratins in cells of a simple epithelium. J Cell Biol (1985) 0.97
Dual regulation of intermediate filament phosphorylation. J Cell Biol (1984) 0.96
Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res (1986) 0.95
Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis. Br J Cancer (2015) 0.94
Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behavior. Virology (2007) 0.94
Sequence and expression of a human type II mesothelial keratin. J Cell Biol (1985) 0.92
Differentiation-induced uroplakin III expression promotes urothelial cell death in response to uropathogenic E. coli. Microbes Infect (2008) 0.90
Polarized secretion of interleukin-8 by human mesothelial cells: a role in neutrophil migration. Immunology (1995) 0.90
Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig Dis Sci (2007) 0.89
Analysis of the growth properties and physical state of the human papillomavirus type 16 genome in cell lines derived from primary cervical tumors. Am J Pathol (1993) 0.89
Keratin in human lung tumors. Patterns of localization of different-molecular-weight keratin proteins. Am J Pathol (1983) 0.88
H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. PLoS One (2009) 0.87
Repression of retrovirus-mediated transgene expression by interferons: implications for gene therapy. J Virol (1997) 0.86
Analysis of histone H2BGFP retention in mouse submandibular gland reveals actively dividing stem cell populations. Stem Cells Dev (2014) 0.85
Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer. Clin Proteomics (2010) 0.85
Skin fragility and impaired desmosomal adhesion in mice lacking all keratins. J Invest Dermatol (2013) 0.84
Ingestion of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli by human peritoneal mesothelial cells. Infect Immun (1996) 0.83
Chlamydia trachomatis infection of human mesothelial cells alters proinflammatory, procoagulant, and fibrinolytic responses. Infect Immun (1998) 0.82
Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions. Br J Cancer (1999) 0.81
Evidence for two points of restriction in the expression of adenovirus type 2 in cultured epidermal keratinocytes. J Virol (1988) 0.81
Expression of human papillomavirus type 16 E7 is sufficient to significantly increase expression of angiogenic factors but is not sufficient to induce endothelial cell migration. Virology (2010) 0.81
Role of mesothelial cells in peritoneal antibacterial defence. J Clin Pathol (1991) 0.79
Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes. J Biol Chem (2015) 0.79
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell (1975) 15.93
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med (1983) 8.82
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Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas. Cancer Res (1981) 5.08
Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature (1977) 4.90
A transmissible plasmid controlling camphor oxidation in Pseudomonas putida. Proc Natl Acad Sci U S A (1973) 4.57
Cryptochromes: blue light receptors for plants and animals. Science (1999) 4.29
Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res (1999) 4.17
Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci (1997) 2.88
A new small (40 kd) keratin filament protein made by some cultured human squamous cell carcinomas. Cell (1981) 2.87
Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma. Natl Cancer Inst Monogr (1975) 2.75
Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod (1997) 2.74
Hyaluronic acid capsule and the role of streptococcal entry into keratinocytes in invasive skin infection. J Clin Invest (1996) 2.57
The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53
Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes. Cell (1980) 2.39
Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature (1998) 2.29
Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma. Cell (1975) 2.06
Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci U S A (1989) 2.05
Reduced alpha-catenin and E-cadherin expression in breast cancer. Lab Invest (1995) 2.03
Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell (1983) 2.02
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Surgical complications of Tenckhoff catheters used in continuous ambulatory peritoneal dialysis. Singapore Med J (2006) 1.80
Tissue specificity of epithelial keratins: differential expression of mRNAs from two multigene families. Mol Cell Biol (1983) 1.75
Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Proc Natl Acad Sci U S A (1984) 1.74
Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation (2001) 1.74
Serial cultivation of normal human epidermal keratinocytes. Methods Cell Biol (1980) 1.71
Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients. J Clin Psychiatry (1999) 1.62
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Enhanced antibody response of mice to polyinosinic-polycytidylic acid by antithymocyte serum and its age-dependent loss in NZB-W mice. J Immunol (1973) 1.40
In vitro propagation of human ocular surface epithelial cells for transplantation. Invest Ophthalmol Vis Sci (1993) 1.37
Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol (1989) 1.36
Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A (2001) 1.33
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Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes. J Surg Oncol (1991) 1.29
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A monoclonal antibody recognizing a keratin filament protein in a subset of transitional and glandular epithelia. Differentiation (1984) 0.97
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