Published in J Cell Biol on December 01, 1985
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences. EMBO J (1987) 1.80
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Molecular characterization and expression of the stratification-related cytokeratins 4 and 15. J Cell Biol (1988) 1.50
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
A group of type I keratin genes on human chromosome 17: characterization and expression. Mol Cell Biol (1988) 1.27
Sequence and expression of a type II keratin, K5, in human epidermal cells. Mol Cell Biol (1988) 1.15
Cloning of cDNA and amino acid sequence of a cytokeratin expressed in oocytes of Xenopus laevis. Proc Natl Acad Sci U S A (1986) 1.12
Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. J Cell Biol (1988) 1.05
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science (1977) 83.82
Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
A simple and very efficient method for generating cDNA libraries. Gene (1983) 55.36
Efficient isolation of genes by using antibody probes. Proc Natl Acad Sci U S A (1983) 34.00
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol (1978) 33.47
Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol (1978) 29.77
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell (1982) 19.91
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell (1975) 15.93
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell (1981) 12.26
Purification and mapping of specific mRNAs by hybridization-selection and cell-free translation. Proc Natl Acad Sci U S A (1979) 9.94
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. J Biol Chem (1978) 8.20
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature (1977) 4.90
Tropomyosin coiled-coil interactions: evidence for an unstaggered structure. J Mol Biol (1975) 4.79
Self-assembly of bovine epidermal keratin filaments in vitro. J Mol Biol (1976) 4.43
The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell (1982) 4.17
Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J Biol Chem (1978) 3.82
A rapid and efficient procedure for the purification of DNA from agarose gels. Anal Biochem (1980) 3.77
Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature (1983) 3.51
Sequence organization of two recombinant plasmids containing genes for the major heat shock-induced protein of D. melanogaster. Cell (1979) 3.21
The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell (1982) 3.08
The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins. Cell (1983) 2.92
Two distinct classes of keratin genes and their evolutionary significance. Cell (1981) 2.84
Prediction of beta-turns. Biophys J (1979) 2.71
Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol (1984) 2.48
Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation (1980) 2.17
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics. Proc Natl Acad Sci U S A (1983) 2.05
Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell (1983) 2.02
Structure of a gene for the human epidermal 67-kDa keratin. Proc Natl Acad Sci U S A (1985) 1.82
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
Tissue specificity of epithelial keratins: differential expression of mRNAs from two multigene families. Mol Cell Biol (1983) 1.75
Serial cultivation of normal human epidermal keratinocytes. Methods Cell Biol (1980) 1.71
Unraveling the structure of the intermediate filaments. Cell (1983) 1.67
Keratin gene expression in mouse epidermis and cultured epidermal cells. Proc Natl Acad Sci U S A (1983) 1.64
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
Cytokeratins in normal lung and lung carcinomas. I. Adenocarcinomas, squamous cell carcinomas and cultured cell lines. Virchows Arch B Cell Pathol Incl Mol Pathol (1984) 1.53
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci U S A (1985) 1.52
The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A (1984) 1.52
Coiled coil formation and sequence regularities in the helical regions of alpha-keratin. J Mol Biol (1978) 1.45
Identification of two types of keratin polypeptides within the acidic cytokeratin subfamily I. J Mol Biol (1984) 1.31
Structural homology between hard alpha-keratin and the intermediate filament proteins desmin and vimentin. Biosci Rep (1983) 1.28
Cell type-specific expression of bovine keratin genes as demonstrated by the use of complementary DNA clones. J Mol Biol (1984) 1.28
Translational products of mRNAs coding for non-epidermal cytokeratins. EMBO J (1983) 1.22
Coexpression of simple epithelial keratins and vimentin by human mesothelium and mesothelioma in vivo and in culture. Cancer Res (1984) 1.15
Amino acid sequence diversity between bovine epidermal cytokeratin polypeptides of the basic (type II) subfamily as determined from cDNA clones. Differentiation (1984) 1.03
Prekeratin biosynthesis in human scalp epidermis. Biochem J (1982) 0.97
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa. Lancet (1993) 5.99
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell (2001) 5.01
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release (2000) 4.18
Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci (1997) 4.00
A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet (1999) 3.93
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis (1981) 3.76
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61
Programming gene expression in developing epidermis. Development (1994) 3.60
Randomised clinical trial: the efficacy of a 10-day sequential therapy vs. a 14-day standard proton pump inhibitor-based triple therapy for Helicobacter pylori in Korea. Aliment Pharmacol Ther (2011) 3.56
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A (1998) 3.53
Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol (1998) 3.51
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31
Logic gates and computation from assembled nanowire building blocks. Science (2001) 3.14
The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell (1982) 3.08
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol (1998) 3.06
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A (2001) 3.01
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell (1991) 2.98
The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins. Cell (1983) 2.92
Synthesis and antitumor activity of a series of [2-substituted-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) complexes. J Med Chem (1994) 2.89
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
Initiation of DNA-dependent RNA synthesis and the effect of heparin on RNA polymerase. Eur J Biochem (1967) 2.87
The expression of keratin genes in epidermis and cultured epidermal cells. Cell (1978) 2.87
Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev (1996) 2.82
The initiation of translation in E. coli: apparent base pairing between the 16srRNA and downstream sequences of the mRNA. Nucleic Acids Res (1990) 2.81
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell (1995) 2.75
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci (1996) 2.73
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
"Aromatic" substituent constants for structure-activity correlations. J Med Chem (1973) 2.54
A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med (1990) 2.50
Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A (1999) 2.37
Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev (2011) 2.37
Metagonimus miyatai sp. nov. (Digenea: Heterophyidae), a new intestinal trematode transmitted by freshwater fishes in Japan and Korea. Korean J Parasitol (1997) 2.33
Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase. Proc Natl Acad Sci U S A (1988) 2.28
Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. J Mol Biol (1983) 2.25
Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad. Proc Natl Acad Sci U S A (1983) 2.25
An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol (1987) 2.22
Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem (1994) 2.19
Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules. Cell (1979) 2.18
A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones. J Cell Biol (1995) 2.16
Actin dynamics and cell-cell adhesion in epithelia. Curr Opin Cell Biol (2001) 2.15
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14
Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A (2001) 2.14
Use of the Center for Epidemiologic Studies Depression (CES-D) Scale in Korea. J Nerv Ment Dis (1998) 2.13
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Epidemiology of antibiotic-associated colitis; isolation of Clostridium difficile from the hospital environment. Am J Med (1981) 2.08
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol (1995) 2.06
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol (1986) 1.89
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
Uptake of high-density lipoprotein-associated apoprotein A-I and cholesterol esters by 16 tissues of the rat in vivo and by adrenal cells and hepatocytes in vitro. J Biol Chem (1985) 1.86
Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol (2010) 1.85
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice. J Med Chem (1978) 1.85
An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery (2000) 1.83
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. J Cell Biol (1991) 1.80
Elucidating the early stages of keratin filament assembly. J Cell Biol (1990) 1.80
FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development (1999) 1.79
The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev (1998) 1.78
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78
Tissue specificity of epithelial keratins: differential expression of mRNAs from two multigene families. Mol Cell Biol (1983) 1.75
Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis. Am J Clin Nutr (1980) 1.73
Genetic and clinical mosaicism in a type of epidermal nevus. N Engl J Med (1994) 1.72
Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70
The downstream box: an efficient and independent translation initiation signal in Escherichia coli. EMBO J (1996) 1.70
Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci U S A (1991) 1.70
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy. Proc Natl Acad Sci U S A (1997) 1.68
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68
Unraveling the structure of the intermediate filaments. Cell (1983) 1.67
Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element. Proc Natl Acad Sci U S A (2000) 1.67
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein. Genes Dev (1994) 1.65
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev (1989) 1.62
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proc Natl Acad Sci U S A (1998) 1.61
An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development (2001) 1.60
Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol (1995) 1.60
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56