Published in Nature on September 17, 1984
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A (1988) 10.90
Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res (1989) 3.63
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes. Mol Cell Biol (1986) 2.83
Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation. Mol Cell Biol (1986) 2.13
Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J (1985) 2.05
Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers. Mol Cell Biol (1988) 2.04
Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol (1985) 1.94
Proviral sequences that restrict retroviral expression in mouse embryonal carcinoma cells. Mol Cell Biol (1987) 1.84
Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene. Proc Natl Acad Sci U S A (1986) 1.70
Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder. Am J Hum Genet (1986) 1.64
Differentiation, not determination, regulates muscle gene activation: transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells. Mol Cell Biol (1985) 1.59
Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras. EMBO J (1985) 1.48
Two regulatory domains flank the mouse H19 gene. Mol Cell Biol (1988) 1.44
Expression of histocompatibility antigens H-2K, -D, and -L is reduced in adenovirus-12-transformed mouse cells and is restored by interferon gamma. Proc Natl Acad Sci U S A (1985) 1.39
Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons. Mol Cell Biol (1990) 1.30
Negative regulation of retrovirus expression in embryonal carcinoma cells mediated by an intragenic domain. J Virol (1988) 1.24
Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes. Mol Cell Biol (1988) 1.19
Liver-specific expression of the mouse alpha-fetoprotein gene is mediated by cis-acting DNA elements. Proc Natl Acad Sci U S A (1986) 1.17
Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells. Proc Natl Acad Sci U S A (1986) 1.12
Differentiation-responsive elements in the 5' region of the mouse tissue plasminogen activator gene confer two-stage regulation by retinoic acid and cyclic AMP in teratocarcinoma cells. Mol Cell Biol (1989) 1.11
Tissue-specific expression of the human type II collagen gene in mice. Proc Natl Acad Sci U S A (1987) 1.07
Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells. Mol Cell Biol (1988) 1.05
Retinoic acid-mediated activation of HNF-3 alpha during EC stem cell differentiation. Nucleic Acids Res (1994) 1.00
Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. EMBO J (1991) 0.97
Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene. Nucleic Acids Res (2000) 0.94
Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses. J Exp Med (1986) 0.94
Differential requirements for cellular enhancers in stem and differentiated cells. Nucleic Acids Res (1988) 0.87
Specific sets of DNase I-hypersensitive sites are associated with the potential and overt expression of the rat albumin and alpha-fetoprotein genes. Proc Natl Acad Sci U S A (1987) 0.87
Sequences and factors required for the F9 embryonal carcinoma stem cell E1a-like activity. Mol Cell Biol (1991) 0.87
Regulated expression of a Drosophila melanogaster heat shock locus after stable integration in a Drosophila hydei cell line. Mol Cell Biol (1985) 0.85
c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells. Mol Cell Biol (1990) 0.79
Efficient expression of an Epstein-Barr nuclear antigen in Drosophila cells transfected with Epstein-Barr virus DNA. EMBO J (1985) 0.78
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
The product of the H19 gene may function as an RNA. Mol Cell Biol (1990) 5.61
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science (1998) 5.23
Parental imprinting of the mouse H19 gene. Nature (1991) 5.13
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet (1996) 4.77
Genomic imprinting in mammals. Annu Rev Genet (1997) 4.21
A paternal-specific methylation imprint marks the alleles of the mouse H19 gene. Nat Genet (1995) 4.12
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene (1977) 3.79
The Involvement of the Aortic Valve in Syphilitic Aortitis. Am J Pathol (1927) 3.67
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev (1993) 3.42
Transcriptional control of the murine albumin/alpha-fetoprotein locus during development. Proc Natl Acad Sci U S A (1982) 3.37
The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J Biol Chem (1981) 3.26
Genomic imprinting is disrupted in interspecific Peromyscus hybrids. Nat Genet (1998) 3.22
An enhancer deletion affects both H19 and Igf2 expression. Genes Dev (1995) 3.09
Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell (1991) 2.85
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol (2000) 2.83
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes. Mol Cell Biol (1986) 2.83
The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev (2000) 2.68
Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1989) 2.59
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature (1999) 2.42
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol (1998) 2.23
A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences. Cell (1978) 2.20
Exploring genome space. Nature (2000) 2.15
Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers. Mol Cell Biol (1988) 2.04
Competitive edge at the imprinted Prader-Willi/Angelman region? Nat Genet (1998) 1.99
The structure and expression of a novel gene activated in early mouse embryogenesis. EMBO J (1988) 1.98
'Formins': proteins deduced from the alternative transcripts of the limb deformity gene. Nature (1990) 1.98
Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J Immunol (1990) 1.96
Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol (1985) 1.94
The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. J Immunol (1992) 1.92
Genetic analysis of alpha-fetoprotein synthesis in mice. Mol Cell Biol (1982) 1.89
Location of enhancers is essential for the imprinting of H19 and Igf2 genes. Nature (1998) 1.88
Proviral sequences that restrict retroviral expression in mouse embryonal carcinoma cells. Mol Cell Biol (1987) 1.84
Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nat Genet (1992) 1.84
Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci (1997) 1.84
Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. Proc Natl Acad Sci U S A (1984) 1.80
The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin. J Biol Chem (1981) 1.77
Two dominant mutations in the mouse fused gene are the result of transposon insertions. Genetics (1997) 1.76
Transient expression of a mouse alpha-fetoprotein minigene: deletion analyses of promoter function. Mol Cell Biol (1983) 1.74
Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1. Mol Cell Biol (1989) 1.74
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development (1997) 1.74
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics (1995) 1.72
Ectopic expression of the H19 gene in mice causes prenatal lethality. Genes Dev (1991) 1.72
Intragenic amplification and divergence in the mouse alpha-fetoprotein gene. Nature (1981) 1.69
Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes Dev (2001) 1.68
alpha-Fetoprotein and albumin genes are in tandem in the mouse genome. Proc Natl Acad Sci U S A (1981) 1.67
Protease nexin. Properties and a modified purification procedure. J Biol Chem (1985) 1.66
Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A (1999) 1.64
Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus. Nat Genet (2000) 1.57
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem (1989) 1.56
The structural H19 gene is required for transgene imprinting. Proc Natl Acad Sci U S A (1996) 1.55
Igf2 imprinting does not require its own DNA methylation or H19 RNA. Genes Dev (1998) 1.55
Allelic expression of IGF2 in marsupials and birds. Dev Genes Evol (2000) 1.54
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem (2001) 1.53
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes Dev (1999) 1.51
Characterization and biological activity of cloned simian virus 40 DNA fragments. J Biol Chem (1981) 1.51
Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J Neurosci (1998) 1.50
The presence of intervening sequences in the alpha-fetoprotein gene of the mouse. J Biol Chem (1979) 1.50
Evidence for a stem cell-specific repressor of Moloney murine leukemia virus expression in embryonal carcinoma cells. Mol Cell Biol (1990) 1.50
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans. Proc Natl Acad Sci U S A (1997) 1.50
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci (2000) 1.50
Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol (1999) 1.50
Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy. Neurology (1999) 1.50
Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I. Proc Natl Acad Sci U S A (1986) 1.47
Two regulatory domains flank the mouse H19 gene. Mol Cell Biol (1988) 1.44
Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly. Development (1998) 1.44
Structure and developmental expression of the chick alpha-actin gene. Nucleic Acids Res (1980) 1.43
Murine alpha-fetoprotein and albumin: two evolutionarily linked proteins encoded on the same mouse chromosome. Somatic Cell Genet (1981) 1.41
Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence. Nucleic Acids Res (1982) 1.40
Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys (1997) 1.40
Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation. Mol Cell Biol (1984) 1.39
Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat Genet (2001) 1.38
Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J Biol Chem (1998) 1.36
Postnatal repression of the alpha-fetoprotein gene is enhancer independent. Genes Dev (1989) 1.33
Dosage requirement and allelic expression of PAX6 during lens placode formation. Development (2000) 1.33
The structure and regulation of the alpha-fetoprotein and albumin genes. Oxf Surv Eukaryot Genes (1985) 1.33
Dorsal-ventral signaling in limb development. Curr Opin Cell Biol (1997) 1.32
Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver. Science (1990) 1.31
Chromatin conformation of the H19 epigenetic mark. Hum Mol Genet (1998) 1.31
Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence. J Biol Chem (1996) 1.30
Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons. Mol Cell Biol (1990) 1.30
Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase. J Biol Chem (1990) 1.29
Rapid loss of translatable messenger RNA of phosphoenolpyruvate carboxykinase during glucose repression in liver. Proc Natl Acad Sci U S A (1974) 1.29
Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J (1993) 1.26
The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1978) 1.24