Published in Nature on May 25, 2000
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
CTCF: master weaver of the genome. Cell (2009) 15.09
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev (2006) 4.94
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. EMBO J (2008) 4.28
Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res (2009) 4.16
Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res (2008) 3.76
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67
Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature (2015) 3.64
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci U S A (2002) 3.46
Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev (2006) 3.30
Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus. PLoS Genet (2009) 3.25
RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. EMBO J (2001) 3.20
Genomic imprinting: the emergence of an epigenetic paradigm. Nat Rev Genet (2011) 3.10
Methylation matters. J Med Genet (2001) 3.00
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res (2000) 2.73
The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev (2000) 2.68
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
The insulation of genes from external enhancers and silencing chromatin. Proc Natl Acad Sci U S A (2002) 2.60
Mammalian genomic imprinting. Cold Spring Harb Perspect Biol (2011) 2.59
Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes Dev (2009) 2.58
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J Exp Med (2008) 2.50
Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Res (2012) 2.49
Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res (2012) 2.45
The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol (2006) 2.43
Transcriptional enhancers in animal development and evolution. Curr Biol (2010) 2.41
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Mol Cell (2008) 2.31
Analysis of the H19ICR insulator. Mol Cell Biol (2007) 2.29
Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation. Genes Dev (2002) 2.29
Genomic imprinting mechanisms in mammals. Mutat Res (2008) 2.28
Genomic imprinting: employing and avoiding epigenetic processes. Genes Dev (2009) 2.26
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res (2010) 2.25
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
Agglomerative epigenetic aberrations are a common event in human breast cancer. Cancer Res (2008) 2.22
The function of non-coding RNAs in genomic imprinting. Development (2009) 2.21
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21
Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome. Proc Natl Acad Sci U S A (2001) 2.14
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet (2009) 2.14
Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell (2007) 2.14
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex. PLoS Genet (2007) 2.12
The non-coding RNAs as riboregulators. Nucleic Acids Res (2001) 2.11
Regulation of DNA methylation of Rasgrf1. Nat Genet (2001) 2.06
The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J (2007) 2.06
The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci U S A (2004) 2.05
Genome-scale approaches to the epigenetics of common human disease. Virchows Arch (2009) 2.02
Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins. Mol Cell Biol (2001) 2.00
Noncoding RNA and Polycomb recruitment. RNA (2013) 2.00
A GNAS1 imprinting defect in pseudohypoparathyroidism type IB. J Clin Invest (2000) 1.93
Genomic imprinting in mammals. Cold Spring Harb Perspect Biol (2014) 1.92
Imprinting and seed development. Plant Cell (2004) 1.91
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
Regulation of alternative polyadenylation by genomic imprinting. Genes Dev (2008) 1.89
Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev (2010) 1.88
Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell (2012) 1.85
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J (2005) 1.81
Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain. Am J Hum Genet (2000) 1.80
Role of CTCF binding sites in the Igf2/H19 imprinting control region. Mol Cell Biol (2004) 1.79
Three-dimensional modeling of chromatin structure from interaction frequency data using Markov chain Monte Carlo sampling. BMC Bioinformatics (2011) 1.78
A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript. Proc Natl Acad Sci U S A (2011) 1.77
Imprinting disorders and assisted reproductive technology. Fertil Steril (2009) 1.73
The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell (2014) 1.70
Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res (2008) 1.70
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev (2008) 1.68
Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol (2011) 1.68
The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers. PLoS Genet (2010) 1.66
Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites. Mol Cell Biol (2005) 1.66
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc Natl Acad Sci U S A (2005) 1.65
The human retinoblastoma gene is imprinted. PLoS Genet (2009) 1.63
An intragenic methylated region in the imprinted Igf2 gene augments transcription. EMBO Rep (2001) 1.63
How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62
An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol (2004) 1.62
CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem (2008) 1.62
Cancer epigenetics takes center stage. Proc Natl Acad Sci U S A (2001) 1.60
CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin. Chromosoma (2010) 1.56
Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer. PLoS One (2008) 1.56
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites. Nucleic Acids Res (2003) 1.54
A test of insulator interactions in Drosophila. EMBO J (2003) 1.53
Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53
The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites. Genetics (2004) 1.52
Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome. J Med Genet (2000) 1.51
Identification of clustered YY1 binding sites in imprinting control regions. Genome Res (2006) 1.51
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48
Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol (2003) 1.47
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10
The product of the H19 gene may function as an RNA. Mol Cell Biol (1990) 5.61
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
Parental imprinting of the mouse H19 gene. Nature (1991) 5.13
Genomic imprinting in mammals. Annu Rev Genet (1997) 4.21
A paternal-specific methylation imprint marks the alleles of the mouse H19 gene. Nat Genet (1995) 4.12
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene (1977) 3.79
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev (1993) 3.42
Transcriptional control of the murine albumin/alpha-fetoprotein locus during development. Proc Natl Acad Sci U S A (1982) 3.37
The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J Biol Chem (1981) 3.26
Genomic imprinting is disrupted in interspecific Peromyscus hybrids. Nat Genet (1998) 3.22
An enhancer deletion affects both H19 and Igf2 expression. Genes Dev (1995) 3.09
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes. Mol Cell Biol (1986) 2.83
The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev (2000) 2.68
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature (1999) 2.42
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol (1998) 2.23
A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences. Cell (1978) 2.20
Exploring genome space. Nature (2000) 2.15
Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers. Mol Cell Biol (1988) 2.04
Tissue-specific activation of a cloned alpha-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line. Nature (1984) 2.02
Competitive edge at the imprinted Prader-Willi/Angelman region? Nat Genet (1998) 1.99
The structure and expression of a novel gene activated in early mouse embryogenesis. EMBO J (1988) 1.98
Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol (1985) 1.94
Genetic analysis of alpha-fetoprotein synthesis in mice. Mol Cell Biol (1982) 1.89
Location of enhancers is essential for the imprinting of H19 and Igf2 genes. Nature (1998) 1.88
Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nat Genet (1992) 1.84
Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. Proc Natl Acad Sci U S A (1984) 1.80
The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin. J Biol Chem (1981) 1.77
Two dominant mutations in the mouse fused gene are the result of transposon insertions. Genetics (1997) 1.76
Transient expression of a mouse alpha-fetoprotein minigene: deletion analyses of promoter function. Mol Cell Biol (1983) 1.74
Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1. Mol Cell Biol (1989) 1.74
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics (1995) 1.72
Ectopic expression of the H19 gene in mice causes prenatal lethality. Genes Dev (1991) 1.72
Intragenic amplification and divergence in the mouse alpha-fetoprotein gene. Nature (1981) 1.69
alpha-Fetoprotein and albumin genes are in tandem in the mouse genome. Proc Natl Acad Sci U S A (1981) 1.67
Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A (1999) 1.64
Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus. Nat Genet (2000) 1.57
The structural H19 gene is required for transgene imprinting. Proc Natl Acad Sci U S A (1996) 1.55
Igf2 imprinting does not require its own DNA methylation or H19 RNA. Genes Dev (1998) 1.55
Allelic expression of IGF2 in marsupials and birds. Dev Genes Evol (2000) 1.54
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes Dev (1999) 1.51
Characterization and biological activity of cloned simian virus 40 DNA fragments. J Biol Chem (1981) 1.51
The presence of intervening sequences in the alpha-fetoprotein gene of the mouse. J Biol Chem (1979) 1.50
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans. Proc Natl Acad Sci U S A (1997) 1.50
Two regulatory domains flank the mouse H19 gene. Mol Cell Biol (1988) 1.44
Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly. Development (1998) 1.44
Structure and developmental expression of the chick alpha-actin gene. Nucleic Acids Res (1980) 1.43
Murine alpha-fetoprotein and albumin: two evolutionarily linked proteins encoded on the same mouse chromosome. Somatic Cell Genet (1981) 1.41
Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence. Nucleic Acids Res (1982) 1.40
Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation. Mol Cell Biol (1984) 1.39
Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat Genet (2001) 1.38
Dosage requirement and allelic expression of PAX6 during lens placode formation. Development (2000) 1.33
Postnatal repression of the alpha-fetoprotein gene is enhancer independent. Genes Dev (1989) 1.33
The structure and regulation of the alpha-fetoprotein and albumin genes. Oxf Surv Eukaryot Genes (1985) 1.33
Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver. Science (1990) 1.31
Chromatin conformation of the H19 epigenetic mark. Hum Mol Genet (1998) 1.31
Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons. Mol Cell Biol (1990) 1.30
Rapid loss of translatable messenger RNA of phosphoenolpyruvate carboxykinase during glucose repression in liver. Proc Natl Acad Sci U S A (1974) 1.29
The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1978) 1.24
Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells. Biochemistry (1975) 1.20
Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. Proc Natl Acad Sci U S A (1994) 1.20
Construction and cloning of rat albumin structural gene sequences. Proc Natl Acad Sci U S A (1979) 1.17
Structure of the alpha-fetoprotein gene in the mouse. Proc Natl Acad Sci U S A (1980) 1.14
Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences. J Biol Chem (1996) 1.11
Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts. Proc Natl Acad Sci U S A (1992) 1.07
Limbs move beyond the radical fringe. Nature (1999) 1.07
A mouse genomic library of yeast artificial chromosome clones. Mamm Genome (1991) 1.07
An outbreak of cyclosporiasis in Florida in 1995: a harbinger of multistate outbreaks in 1996 and 1997. Am J Trop Med Hyg (1998) 1.05
Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex. Genetics (1996) 1.05
The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract. J Cell Biol (1990) 1.04
Differential expression of alpha-fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line. Nature (1986) 1.02
Fine structure mapping and deletion analysis of the murine piebald locus. Genetics (1994) 1.01