Published in J Clin Invest on November 01, 1982
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest (1985) 1.34
Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes (2013) 1.22
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest (1984) 1.15
Novel insights into thyroid hormones from the study of common genetic variation. Nat Rev Endocrinol (2009) 1.10
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07
Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism. Endocrinology (2010) 1.06
Production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. Responses to hypothyroidism. J Clin Invest (1984) 1.05
Transient hypothyroxinaemia associated with developmental delay in very preterm infants. Arch Dis Child (1992) 1.02
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta (2012) 0.98
Transcriptional regulation of mammalian selenoprotein expression. Biochim Biophys Acta (2009) 0.92
Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue. J Clin Invest (1986) 0.89
Development of thyroxine type II deiodinase activity in brains of Zucker rats. Biochem J (1994) 0.75
Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation. J Endocrinol (2012) 0.75
The effect of fluoride on the succinic oxidase system. Biochem J (1952) 7.28
A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum. J Clin Invest (1955) 4.40
INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT. J Biol Chem (1965) 2.92
Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr (1972) 2.84
Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev (1981) 2.78
Direct immunoassay of triiodothyronine in human serum. J Clin Invest (1972) 1.87
An improved method for chromatography of iodothyronines. J Clin Endocrinol Metab (1968) 1.84
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology (1982) 1.58
The cerebral cortex of normal and hypothyroid rats. Acta Anat (Basel) (1955) 1.58
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology (1978) 1.46
Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest (1982) 1.46
Neonatal thyroid function in congenital hypothyroidism. J Pediatr (1976) 1.45
Ontogenesis of hypothalamic--pituitary--thyroid function and metabolism in man, sheep, and rat. Recent Prog Horm Res (1976) 1.43
Cerebral cortex responds rapidly to thyroid hormones. Science (1981) 1.29
Effect of triiodothyronine on the synthesis and degradation of renal cortical (Na+ + k+)-adenosine triphosphatase. J Biol Chem (1976) 1.28
Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. Metabolism (1978) 1.25
Phenolic and tyrosyl ring deiodination of iodothyronines in rat brain homogenates. J Clin Invest (1980) 1.22
Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. J Clin Invest (1977) 1.22
A colorimetric method for the estimation of succinic dehydrogenase activity. J Biol Chem (1960) 1.22
Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum, and hypothalamus. J Clin Invest (1981) 1.12
Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab (1978) 1.09
Rapid thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat cerebral cortex and cerebellum. J Clin Invest (1980) 1.06
Immunoassay of thyroxine in unextracted human serum. J Clin Endocrinol Metab (1973) 1.01
Peripheral metabolism of homologous thyrotropin in euthyroid and hypothyroid rats: acute effects of thyrotropin-releasing hormone, triiodothyronine, and thyroxine. Endocrinology (1978) 0.97
Different pathways of iodothyronine 5'-deiodination in rat cerebral cortex. Biochem Biophys Res Commun (1981) 0.95
Anatomical distribution of phenolic and tyrosyl ring iodothyronine deiodinases in the nervous system of normal and hypothyroid rats. Endocrinology (1981) 0.94
Effect of thyroid hormone on the biochemical maturation of rat brain: conversion of glucose-carbon into amino acids. J Neurochem (1970) 0.93
Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: effects of iodine supplementation. J Clin Endocrinol Metab (1981) 0.92
Presence of L-thyroxine and 3,5,3'-triiodo-L-thyronine in tissues from thyroidectomized rats. Endocrinology (1981) 0.90
A sensitive colorimetric assay for mitochondrial alpha-glycerophosphate dehydrogenase. Anal Biochem (1974) 0.89
Effects of congenital hypothyroidism and partial and complete food deprivation on phenolic and tyrosyl ring iodothyronine deiodination in rat brain. Endocrinology (1982) 0.88
Hormonal regulation of brain development. I. The effect of neonatal thyroidectomy upon nucleic acids, protein and two enzymes in developing cerebral cortex and cerebellum of the rat. Brain Res (1967) 0.86
Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique. Endocrinology (1978) 0.86
Latency and solubilization of the mitochondrial aspartate transminase of rat cerebral cortex. Biochim Biophys Acta (1963) 0.81
Hypothyroidism in severely iodine-deficient rats. Endocrinology (1981) 0.79
Hormonal regulation of brain development. II. Effect of neonatal thyroidectomy on succinate dehydrogenase and other enzymes in developing cerebral cortex and cerebellum of the rat. Brain Res (1967) 0.78
Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature (1991) 4.63
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J (1993) 3.14
Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr (1979) 3.07
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature (1991) 3.06
Levothyroxine therapy in patients with thyroid disease. Ann Intern Med (1993) 2.96
Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev (1981) 2.78
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest (2001) 2.77
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature (1989) 2.46
Maternal and fetal thyroid function. N Engl J Med (1994) 2.43
Identification of a thyroid hormone receptor that is pituitary-specific. Science (1989) 2.37
Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med (1982) 2.12
Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med (1990) 2.03
Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (1983) 1.97
Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med (2000) 1.88
Direct immunoassay of triiodothyronine in human serum. J Clin Invest (1972) 1.87
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology (1992) 1.80
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol (1989) 1.73
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med (2000) 1.72
Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest (1987) 1.67
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science (1977) 1.61
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology (1982) 1.58
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem (1991) 1.55
Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53
The effect of diphenylhydantoin on thyroxine metabolism in man. J Clin Invest (1970) 1.47
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology (1978) 1.46
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A (1988) 1.46
Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J Clin Endocrinol Metab (1997) 1.46
Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest (1982) 1.46
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol (1989) 1.45
Neonatal thyroid function in congenital hypothyroidism. J Pediatr (1976) 1.45
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol (1980) 1.43
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology (1997) 1.41
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem (1989) 1.39
Thyroid hormone regulation of gene expression. Annu Rev Physiol (1991) 1.39
Triiodothyronine: review of recent studies of its physiology and pathophysiology in man. Metabolism (1972) 1.37
Plasma T4 and T3 levels in naturally metamorphosing Eurycea bislineata (Amphibia; Plethodontidae). Gen Comp Endocrinol (1986) 1.37
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Proc Natl Acad Sci U S A (1982) 1.37
Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA (1978) 1.35
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol (2000) 1.35
Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. J Clin Invest (1979) 1.34
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest (1985) 1.34
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology (1996) 1.33
Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. Metabolism (1971) 1.31
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. Proc Natl Acad Sci U S A (1987) 1.31
Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest (1983) 1.30
Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem (1988) 1.30
Cerebral cortex responds rapidly to thyroid hormones. Science (1981) 1.29
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology (2001) 1.27
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26
Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. Metabolism (1978) 1.25
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem (2001) 1.23
Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology (1983) 1.23
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology (2000) 1.23
Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary. J Clin Invest (1979) 1.23
Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology (1977) 1.20
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest (1995) 1.19
Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. J Clin Invest (1974) 1.19
Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest (1972) 1.18
Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology (1999) 1.16
Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA (1982) 1.16
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest (1984) 1.15
Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen (2001) 1.13
Is there a negative TRE in the luciferase reporter cDNA? Thyroid (1996) 1.12
Correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with Graves' disease and subacute thyroiditis. Metabolism (1978) 1.11
Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics (1979) 1.11
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology (2000) 1.10
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology (2000) 1.09
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09
Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol (1987) 1.08
Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology (1995) 1.08
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07
Rapid thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat cerebral cortex and cerebellum. J Clin Invest (1980) 1.06
Total and free triiodothyronine and thyroxine in early infancy. J Clin Endocrinol Metab (1974) 1.05
Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. Metabolism (1975) 1.05
Production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. Responses to hypothyroidism. J Clin Invest (1984) 1.05
Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol (1988) 1.04
Metabolic clearance of endogenous and radioiodinated thyroglobulin in rats. Endocrinology (1978) 1.04
Regulation of rat cerebrocortical and adenohypophyseal type II 5'-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology (1985) 1.03
Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum. Metabolism (1971) 1.03
Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3',5'-monophosphate generation. Endocrinology (1995) 1.03
Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. Endocrinology (1995) 1.02
Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries. Nucleic Acids Res (1988) 1.01
Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J Clin Invest (1973) 1.01
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol (1992) 1.01
Immunoassay of thyroxine in unextracted human serum. J Clin Endocrinol Metab (1973) 1.01
Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity. J Biol Chem (1986) 1.00
Effects of iodine and iodine-containing compounds on thyroid function. Med Clin North Am (1985) 1.00
Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. J Clin Invest (1973) 1.00