Published in Nature on July 03, 1980
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proc Natl Acad Sci U S A (1981) 3.17
Clinical and biological significance of aneuploidy in human tumours. J Clin Pathol (1984) 2.39
Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization. Proc Natl Acad Sci U S A (1982) 2.08
Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A (1981) 1.98
Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous. Proc Natl Acad Sci U S A (1985) 1.91
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway. Proc Natl Acad Sci U S A (1988) 1.40
Isolation of microcell hybrid clones containing retroviral vector insertions into specific human chromosomes. Mol Cell Biol (1987) 1.30
Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes. Am J Hum Genet (1982) 1.27
Mouse alpha-globin genes and alpha-globin-like pseudogenes are not syntenic. Proc Natl Acad Sci U S A (1981) 1.23
DNA polymorphic loci mapped to human chromosomes 3, 5, 9, 11, 17, 18, and 22. Proc Natl Acad Sci U S A (1984) 1.22
The thalassemias: molecular mechanisms of human genetic disease. Am J Hum Genet (1983) 1.21
Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism. Proc Natl Acad Sci U S A (1985) 1.06
Detection of HLA-D/DR-related DNA polymorphism in HLA-D homozygous typing cells. Proc Natl Acad Sci U S A (1983) 1.05
Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene. Br Med J (Clin Res Ed) (1984) 1.02
Two human relaxin genes are on chromosome 9. EMBO J (1984) 0.91
A sib-pair strategy for the use of restriction fragment length polymorphisms to study the mode of transmission of type II diabetes. Am J Hum Genet (1983) 0.82
Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems. Invert Neurosci (2014) 0.78
The human genome through the eyes of Mercator and Vesalius. Trans Am Clin Climatol Assoc (1981) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Models for the specific adhesion of cells to cells. Science (1978) 28.03
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes (1984) 10.09
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell (1986) 8.87
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature (1982) 7.47
Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A (1988) 7.26
Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature (1969) 6.98
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med (2001) 6.79
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) Nature (1996) 6.72
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell (1988) 6.62
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet (1996) 6.58
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. Science (1970) 6.39
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
Sequence of the human insulin gene. Nature (1980) 5.76
Cell adhesion. Competition between nonspecific repulsion and specific bonding. Biophys J (1984) 5.72
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature (1981) 5.65
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA. Proc Natl Acad Sci U S A (1978) 5.29
Molecular genetics of inherited variation in human color vision. Science (1986) 5.28
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature (1986) 4.81
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. J Biol Chem (1977) 4.76
Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci U S A (1986) 4.73
Specific nucleolar and nucleoplasmic RNA polymerases. Proc Natl Acad Sci U S A (1970) 4.63
Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat Genet (1997) 4.19
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science (1992) 4.17
Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Am J Hum Genet (1989) 4.13
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. J Biol Chem (1977) 4.03
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet (1999) 3.95
A human hepatitis B viral enhancer element. EMBO J (1985) 3.94
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature (1982) 3.82
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Nature (1985) 3.75
RFLPs for transforming growth factor alpha (TGFA) gene at 2p13. Nucleic Acids Res (1986) 3.72
Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Insulin-like growth factor II receptor as a multifunctional binding protein. Nature (1987) 3.52
Sequence of the human somatostatin I gene. Science (1984) 3.48
Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry (1987) 3.48
A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family. Proc Natl Acad Sci U S A (1994) 3.42
Tubulin genes are tandemly linked and clustered in the genome of trypanosoma brucei. Cell (1983) 3.40
A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. Proc Natl Acad Sci U S A (1999) 3.37
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region. J Virol (1984) 3.30
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J Virol (1983) 3.24
Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem (1988) 3.18
Disease associations. Chance, artifact, or susceptibility genes? Diabetes (1989) 3.12
Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11
Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res (1986) 3.11
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci U S A (1987) 3.08
Mapping the human genome, cloned genes, DNA polymorphisms, and inherited disease. Adv Hum Genet (1982) 3.04
An ultrastructural analysis of the developing embryonic pancreas. Dev Biol (1972) 3.00
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science (1983) 2.97
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci (1995) 2.94
The LiMB database. Science (1988) 2.89
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev (1992) 2.86
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.86
A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 2.84
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J Biol Chem (1989) 2.81
Transcription of hepatitis B virus by RNA polymerase II. Mol Cell Biol (1983) 2.81
Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature (1984) 2.78
Structural organization and chromosomal assignment of the gene encoding endothelin. J Biol Chem (1989) 2.77
Integration of hepatitis B virus sequences and their expression in a human hepatoma cell. Nature (1980) 2.74
Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc Natl Acad Sci U S A (1988) 2.73
Polymorphic human glucose transporter gene (GLUT) is on chromosome 1p31.3----p35. Diabetes (1987) 2.72
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol (1994) 2.70
Toward molecular mechanisms of developmental processes. Annu Rev Biochem (1973) 2.66
Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci U S A (1988) 2.62
International system for human gene nomenclature (1979) ISGN (1979). Cytogenet Cell Genet (1979) 2.58
Cell growth and division. IV. Determination of volume growth rate and division probability. Biophys J (1969) 2.57
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci U S A (1986) 2.57
Splice junctions: association with variation in protein structure. Science (1983) 2.54
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science (1992) 2.50
Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature (1985) 2.49
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature (1983) 2.44
Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. Proc Natl Acad Sci U S A (1985) 2.44
Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med (1996) 2.42
Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. J Biol Chem (1993) 2.42
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature (1983) 2.41
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol (1988) 2.41
Cell growth and division. I. A mathematical model with applications to cell volume distributions in mammalian suspension cultures. Biophys J (1967) 2.41
Converting trypsin to chymotrypsin: the role of surface loops. Science (1992) 2.40