Published in Mol Biol Cell on December 01, 2000
Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A (2007) 6.79
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol (2004) 4.60
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol (2004) 4.24
Retromer. Curr Opin Cell Biol (2008) 3.89
'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res (2004) 3.50
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron (2008) 3.08
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol (2008) 2.56
Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci (2009) 2.30
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol (2006) 2.05
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc Natl Acad Sci U S A (2001) 1.82
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol (2007) 1.70
Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol (2007) 1.65
A large family of endosome-localized proteins related to sorting nexin 1. Biochem J (2001) 1.63
Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A (2002) 1.57
Trans-Golgi network sorting. Cell Mol Life Sci (2001) 1.56
Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Plant Cell (2006) 1.54
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol (2014) 1.52
A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell (2004) 1.50
SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol (2009) 1.49
An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell (2006) 1.49
Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol Biol Cell (2008) 1.49
Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. Mol Biol Cell (2001) 1.47
Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol (2014) 1.46
A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica. Mol Biol Cell (2005) 1.41
Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p. Mol Biol Cell (2002) 1.40
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J Cell Sci (2005) 1.38
Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Mol Biol Cell (2002) 1.36
The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J (2001) 1.31
Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging (2012) 1.30
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A (2005) 1.30
Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. J Cell Sci (2011) 1.29
Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinase. Plant Physiol (2003) 1.26
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener (2010) 1.25
Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Mol Biol Cell (2002) 1.24
Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail. Plant Cell (2006) 1.22
Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome. Mol Biol Cell (2008) 1.21
Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease. Arch Neurol (2008) 1.19
Exportin 7 defines a novel general nuclear export pathway. EMBO J (2004) 1.17
Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell (2005) 1.15
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis (2012) 1.14
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic (2009) 1.12
The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide. Biochem J (2006) 1.09
Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J (2007) 1.05
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS One (2009) 0.98
Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic (2012) 0.97
Structural features of vps35p involved in interaction with other subunits of the retromer complex. Traffic (2007) 0.95
Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic (2007) 0.94
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell (2014) 0.93
Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. J Biol Chem (2016) 0.92
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance. J Neurochem (2016) 0.91
Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem (2009) 0.89
Molecular dissection of endosomal compartments in plants. Plant Physiol (2007) 0.89
Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor. Exp Cell Res (2006) 0.89
Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11. Plant Cell (2010) 0.88
Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J Virol (2011) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Multiple Roles of the Small GTPase Rab7. Cells (2016) 0.87
Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions. PLoS Pathog (2014) 0.84
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2). Mol Neurodegener (2014) 0.84
Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Mol Cell Biol (2010) 0.83
An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J (2008) 0.82
Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov (2017) 0.81
Abstrakt interacts with and regulates the expression of sorting nexin-2. J Cell Physiol (2005) 0.80
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation. J Biol Chem (2016) 0.79
Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy. Mol Cell Proteomics (2014) 0.79
EHDs meet the retromer: Complex regulation of retrograde transport. Cell Logist (2012) 0.79
The retromer complex in development and disease. Development (2015) 0.78
Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparum. PLoS One (2014) 0.78
Structural Mechanism for Cargo Recognition by the Retromer Complex. Cell (2016) 0.77
Mutations in genes encoding sorting nexins alter production of intracellular and extracellular proteases in Aspergillus nidulans. Genetics (2009) 0.77
Membrane trafficking as a virulence mechanism of the enteric protozoan parasite Entamoeba histolytica. Parasitol Res (2005) 0.77
Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis. BMC Med Genomics (2011) 0.77
Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways. PLoS One (2014) 0.76
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology? J Parkinsons Dis (2016) 0.76
Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Elife (2017) 0.75
Identification of novel and robust internal control genes from Volvariella volvacea that are suitable for RT-qPCR in filamentous fungi. Sci Rep (2016) 0.75
Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion. Mol Biol Cell (2017) 0.75
The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptor. Biochim Biophys Acta (2013) 0.75
Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol (2016) 0.75
An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. PLoS Negl Trop Dis (2017) 0.75
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev (2017) 0.75
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell (1993) 15.70
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics (1996) 11.71
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell (1993) 6.40
Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell (1986) 5.73
Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A (1986) 5.71
The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol (1997) 5.15
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell (1994) 5.10
A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol (1998) 4.41
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol (1997) 3.61
Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science (1996) 3.20
Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol (1998) 2.97
Vacuole biogenesis in Saccharomyces cerevisiae: protein transport pathways to the yeast vacuole. Microbiol Mol Biol Rev (1998) 2.59
A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell (1997) 2.14
Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics. J Cell Biol (1984) 1.99
Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment. Mol Biol Cell (1999) 1.91
The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi. J Cell Sci (1997) 1.82
The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem (1993) 1.58
Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. J Biol Chem (1989) 1.52
Involvement of dileucine motifs in the internalization and degradation of the insulin receptor. J Biol Chem (1994) 1.21
H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Development (1991) 1.17
Multiple pathways for vacuolar sorting of yeast proteinase A. J Biol Chem (1996) 1.12
The yeast homolog of H < beta > 58, a mouse gene essential for embryogenesis, performs a role in the delivery of proteins to the vacuole. Genes Dev (1994) 1.01
Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells. Biochim Biophys Acta (1993) 0.89
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med (2000) 3.44
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. Gene (1989) 3.11
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol (1998) 2.97
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem (2001) 2.42
A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 1.90
Lipoatrophy revisited. Trends Endocrinol Metab (2000) 1.87
Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. Am J Hum Genet (2000) 1.76
Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio. J Biol Chem (1975) 1.73
Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man. J Clin Endocrinol Metab (1973) 1.71
Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay. J Biol Chem (1974) 1.63
Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes. J Biol Chem (1976) 1.62
Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science (1988) 1.56
Mutations in the insulin receptor gene. Endocr Rev (1992) 1.55
Studies on the mechanism of activation of adipose tissue pyruvate dehydrogenase by insulin. J Biol Chem (1973) 1.47
Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. Recent Prog Horm Res (1975) 1.47
Specificity spillover at the hormone receptor--exploring its role in human disease. N Engl J Med (1989) 1.45
A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab (1999) 1.44
Human growth hormone radioreceptor assay using cultured human lymphocytes. Nat New Biol (1973) 1.43
The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. J Biol Chem (1984) 1.43
An endogenous substrate for the insulin receptor-associated tyrosine kinase. J Biol Chem (1985) 1.42
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem (2001) 1.38
Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol (1995) 1.36
The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology. N Engl J Med (1982) 1.31
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem J (1976) 1.29
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem (1994) 1.26
Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience (1986) 1.25
A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J (1989) 1.24
Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. J Biol Chem (2000) 1.24
Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology (1997) 1.22
Involvement of dileucine motifs in the internalization and degradation of the insulin receptor. J Biol Chem (1994) 1.21
Genetic differences in susceptibility of pancreatic beta cells to virus-induced diabetes mellitus. Nature (1976) 1.21
Insulin is ubiquitous in extrapancreatic tissues of rats and humans. Proc Natl Acad Sci U S A (1980) 1.19
Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest (1991) 1.18
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. J Clin Invest (1990) 1.17
Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1994) 1.14
Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun (1993) 1.14
Insulin in insects and annelids. Diabetes (1981) 1.13
Localization of an occult insulinoma by intraoperative ultrasonography. Surgery (1985) 1.12
Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration. J Biol Chem (1981) 1.12
Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J Biol Chem (1995) 1.12
Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. Traffic (2000) 1.11
Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain. J Biol Chem (2001) 1.11
Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Ann Intern Med (1982) 1.09
Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem (1999) 1.09
Insulin or a closely related molecule is native to Escherichia coli. J Biol Chem (1981) 1.08
Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes. Proc Natl Acad Sci U S A (1980) 1.08
Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells. Endocrinology (1988) 1.07
Hypoglycemia associated with antibodies to the insulin receptor. N Engl J Med (1982) 1.05
Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nat Genet (1993) 1.05
Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. J Biol Chem (2000) 1.05
Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats. J Clin Invest (1983) 1.05
Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci U S A (1987) 1.04
Reactivity of non-primate growth hormones and prolactins with human growth hormone receptors on cultured human lymphocytes. J Clin Endocrinol Metab (1977) 1.03
18F-labeled insulin: a prosthetic group methodology for incorporation of a positron emitter into peptides and proteins. Biochemistry (1989) 1.03
Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance. J Clin Endocrinol Metab (1982) 1.03
Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes: a quantitative morphological and biochemical study. J Cell Biol (1980) 1.02
Streptavidin blotting: a sensitive technique to study cell surface proteins; application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors. Endocrinology (1993) 1.02
Receptor defects in patients with extreme insulin resistance. Diabetes Metab Rev (1985) 1.00
Insulin receptor biosynthesis in cultured lymphocytes from insulin-resistant patients. J Clin Invest (1985) 1.00
Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells. J Clin Endocrinol Metab (1984) 1.00
Tyrosine kinase activity of the insulin receptor of patients with type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes. J Clin Endocrinol Metab (1984) 0.99
Non-insulin-mediated glucose disappearance in subjects with IDDM. Discordance between experimental results and minimal model analysis. Diabetes (1994) 0.99
Defects in human insulin receptor gene expression. Mol Endocrinol (1988) 0.98
Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry (1995) 0.98
Normal coding sequence of insulin gene in Pima Indians and Nauruans, two groups with highest prevalence of type II diabetes. Diabetes (1991) 0.98
Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology (1997) 0.97
Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor. Biochem Biophys Res Commun (1990) 0.97
Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. J Biol Chem (1992) 0.97
Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. J Biol Chem (1999) 0.96
Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. Proc Natl Acad Sci U S A (1981) 0.96
Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor. J Clin Endocrinol Metab (1982) 0.95
Insulin receptors in normal and disease states. Clin Endocrinol Metab (1983) 0.95
pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. J Biol Chem (1993) 0.94
A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing. Diabetes (1994) 0.94
Two patients with insulin resistance due to decreased levels of insulin-receptor mRNA. Diabetes (1991) 0.93
Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain. J Biol Chem (1992) 0.93
Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells. Mol Endocrinol (1999) 0.90
Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells. J Biol Chem (1994) 0.90
A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. J Clin Endocrinol Metab (1991) 0.90
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor. J Biol Chem (1987) 0.90
Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance. J Clin Invest (1984) 0.90
Tissue distribution and subcellular localization of an endogenous substrate (pp 120) for the insulin receptor-associated tyrosine kinase. Endocrinology (1986) 0.89
Insulin in the extrapancreatic tissues of guinea pigs differs markedly from the insulin in their pancreas and plasma. Trans Assoc Am Physicians (1980) 0.89
Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells. J Biol Chem (1997) 0.89
Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells. Biochim Biophys Acta (1993) 0.89