Published in Proc Natl Acad Sci U S A on October 01, 1980
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A (1997) 3.26
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. Proc Natl Acad Sci U S A (1987) 2.48
In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding. Proc Natl Acad Sci U S A (1995) 1.88
Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones. J Physiol (1987) 1.76
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Autoradiographic localization of angiotensin II receptors in rat brain. Proc Natl Acad Sci U S A (1984) 1.48
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Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography. Proc Natl Acad Sci U S A (1987) 1.34
kappa-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. Br J Pharmacol (1988) 1.23
Novel opiate binding sites selective for benzomorphan drugs. Proc Natl Acad Sci U S A (1981) 1.22
Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones. J Physiol (1986) 1.22
Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects. Proc Natl Acad Sci U S A (1982) 1.19
Single potassium channels opened by opioids in rat locus ceruleus neurons. Proc Natl Acad Sci U S A (1989) 1.18
Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine. Proc Natl Acad Sci U S A (1984) 1.17
Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain. Proc Natl Acad Sci U S A (1986) 1.04
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution. Br J Pharmacol (1989) 1.03
Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin. Proc Natl Acad Sci U S A (1982) 1.03
Visualization of opiate receptor upregulation by light microscopy autoradiography. Proc Natl Acad Sci U S A (1984) 1.01
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Hypothalamic regulation of the cardiovascular and respiratory systems: role of specific opiate receptors. Br J Pharmacol (1983) 0.86
Visualization of mu1 opiate receptors in rat brain by using a computerized autoradiographic subtraction technique. Proc Natl Acad Sci U S A (1985) 0.86
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Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat. J Physiol (1987) 0.82
Autoradiographic localization of supraspinal kappa-opioid receptors with [125I-Tyr1, D-Pro10]dynorphin A-(1-11). Proc Natl Acad Sci U S A (1988) 0.80
A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression. Psychopharmacology (Berl) (2016) 0.79
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Tonic inhibitory control exerted by opioid peptides in the paraventricular nuclei of the hypothalamus on regional hemodynamic activity in rats. Br J Pharmacol (2002) 0.78
Regional haemodynamic effects of mu-, delta-, and kappa-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats. Br J Pharmacol (1995) 0.77
Glutamate-evoked release of endogenous brain dopamine: inhibition by an excitatory amino acid antagonist and an enkephalin analogue. Br J Pharmacol (1987) 0.77
Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice. Brain Res Mol Brain Res (2004) 0.77
Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments. Depress Anxiety (2011) 0.77
Severe hypertensive reaction after naloxone injection during labor. Arch Gynecol (1987) 0.77
A microiontophoretic study of the actions of mu-, delta- and kappa-opiate receptor agonists in the rat brain. Br J Pharmacol (1984) 0.76
[The endogenous opioid system and drug addiction]. Ann Pharm Fr (2010) 0.76
Highly selective photoaffinity labeling of mu and delta opioid receptors. Proc Natl Acad Sci U S A (1984) 0.75
Dose-dependent effects of morphine exposure on mRNA and microRNA (miR) expression in hippocampus of stressed neonatal mice. PLoS One (2015) 0.75
Delta Opioid Pharmacology in Relation to Alcohol Behaviors. Handb Exp Pharmacol (2016) 0.75
BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone. Front Neurosci (2016) 0.75
Synaptic localization of kappa opioid receptors in guinea pig neostriatum. Proc Natl Acad Sci U S A (1992) 0.75
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther (1976) 9.13
Endogenous opioid peptides: multiple agonists and receptors. Nature (1977) 8.21
Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity. J Biol Chem (1979) 2.54
A new method for receptor autoradiography: [3H]opioid receptors in rat brain. Brain Res (1979) 2.44
Multiple opiate receptor sites on primary afferent fibres. Nature (1980) 2.34
Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res (1977) 1.63
Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science (1979) 1.63
Multiple neurotransmitter receptors. J Neurochem (1980) 1.61
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol (1979) 1.59
Opiate receptor binding affected differentially by opiates and opioid peptides. Eur J Pharmacol (1979) 1.45
Control of guinea pig intestinal electrolyte secretion by a delta-opiate receptor. Proc Natl Acad Sci U S A (1980) 1.27
Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors. Science (1980) 1.21
The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptide. Eur J Pharmacol (1978) 1.18
Met- and Leu-enkephalin immunoreactivity in separate neurones. Nature (1979) 1.17
Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors). Proc R Soc Lond B Biol Sci (1979) 1.16
Morphine and enkephalin: analgesic and epileptic properties. Science (1977) 1.07
Mode of action of endogenous opiate peptides. Nature (1976) 1.05
Epileptic properties of leucine- and methionine-enkephalin: comparison with morphine and reversibility by naloxone. Brain Res (1978) 1.01
Interaction of iodinated enkephalin analogues with opiate receptors. Life Sci (1978) 0.99
Opioid peptides and opiates differ in receptor selectivity. Psychoneuroendocrinology (1977) 0.87
Brain endorphins: possible role in reward and memory formation. Fed Proc (1979) 0.84
Is there some indication from behavioral effects of endorphins for their involvement in psychiatric disorders? Adv Biochem Psychopharmacol (1978) 0.83
Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens. Nature (1980) 0.81
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A (1990) 10.40
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (1991) 8.41
Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1992) 8.24
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03
Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 7.23
Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (1987) 6.58
The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE (2001) 6.09
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A (1989) 6.08
Opiate receptor: demonstration in nervous tissue. Science (1973) 6.06
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70
Carbon monoxide: a putative neural messenger. Science (1993) 5.47
Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem (1994) 5.11
Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci U S A (1993) 4.73
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. J Biol Chem (1987) 4.46
Solubilization, purification, and characterization of an inositol trisphosphate receptor. J Biol Chem (1988) 4.42
Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc Natl Acad Sci U S A (1968) 4.24
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science (1976) 4.07
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A (1992) 3.95
Nitric oxide, a novel neuronal messenger. Neuron (1992) 3.87
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (1994) 3.86
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A (1999) 3.85
Neurotransmitter transporters: recent progress. Annu Rev Neurosci (1993) 3.80
Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron (1996) 3.75
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51
Nitric oxide: a physiologic mediator of penile erection. Science (1992) 3.39
Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci U S A (1974) 3.35
Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature (1989) 3.35
Properties of opiate-receptor binding in rat brain. Proc Natl Acad Sci U S A (1973) 3.34
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci U S A (1991) 3.22
Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase. Mol Pharmacol (1969) 3.21
Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem (1992) 3.21
Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proc Natl Acad Sci U S A (1980) 3.20
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A (1999) 3.15
Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol (1993) 3.12
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A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol (1965) 2.99
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem (1993) 2.96
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature (1989) 2.94
Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol (1979) 2.89
Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell (1995) 2.89
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A (1985) 2.85
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A (1992) 2.72
A huntingtin-associated protein enriched in brain with implications for pathology. Nature (1995) 2.67
PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science (1996) 2.66
Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A (1981) 2.66
Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors. Mol Pharmacol (1977) 2.64
Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. Proc Natl Acad Sci U S A (1988) 2.63
Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron (1991) 2.60
Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. Life Sci (1981) 2.58
Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci U S A (1988) 2.57
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The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J Biol Chem (1986) 2.50
A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol (1992) 2.47
Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron (1998) 2.46
A new method for receptor autoradiography: [3H]opioid receptors in rat brain. Brain Res (1979) 2.44
Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A (1973) 2.37
High affinity transport of choline into synaptosomes of rat brain. J Neurochem (1973) 2.35
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem (1992) 2.34
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun (1991) 2.33
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CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron (1998) 2.05
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