Published in J Biol Chem on April 25, 1979
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proc Natl Acad Sci U S A (1983) 3.17
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci U S A (1992) 2.84
Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66
Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography. Proc Natl Acad Sci U S A (1980) 1.84
Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc Natl Acad Sci U S A (1981) 1.81
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
Comparison of the binding characteristics of tritiated opiates and opioid peptides. Br J Pharmacol (1980) 1.56
Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture. Proc Natl Acad Sci U S A (1987) 1.44
Control of guinea pig intestinal electrolyte secretion by a delta-opiate receptor. Proc Natl Acad Sci U S A (1980) 1.27
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists). Proc Natl Acad Sci U S A (1980) 1.26
Novel opiate binding sites selective for benzomorphan drugs. Proc Natl Acad Sci U S A (1981) 1.22
Antibody specific to the alpha subunit of the guanine nucleotide-binding regulatory protein Go: developmental appearance and immunocytochemical localization in brain. Proc Natl Acad Sci U S A (1988) 1.22
Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it? Prog Neurobiol (2009) 1.18
Molecular characterization of a new immunoglobulin superfamily protein with potential roles in opioid binding and cell contact. EMBO J (1989) 1.09
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Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proc Natl Acad Sci U S A (1985) 1.05
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors. Proc Natl Acad Sci U S A (1980) 1.04
Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin. Proc Natl Acad Sci U S A (1982) 1.03
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proc Natl Acad Sci U S A (1985) 1.02
Studies on rat intestinal epithelial cell receptors for serotonin and opiates. J Physiol (1983) 1.00
Synthesis of enkephalins by adrenal medullary chromaffin cells: reserpine increases incorporation of radiolabeled amino acids. Proc Natl Acad Sci U S A (1980) 0.99
X-ray diffraction studies of enkephalins. Crystal structure of [(4'-bromo) Phe4,Leu5]enkephalin. Biochem J (1984) 0.98
Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Annu Rev Pharmacol Toxicol (2011) 0.97
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide. Br J Cancer (1992) 0.97
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Investigating endogenous peptides and peptidases using peptidomics. Biochemistry (2011) 0.91
Purification to apparent homogeneity of a mu-type opioid receptor from rat brain. Proc Natl Acad Sci U S A (1986) 0.91
Solubilization and characterization of mu, delta, and kappa opioid binding sites from guinea pig brain: physical separation of kappa receptors. Proc Natl Acad Sci U S A (1984) 0.90
Interactions between morphine and the opioid-like peptides in the rat vas deferens. Br J Pharmacol (1980) 0.88
beta-Endorphin: characteristics of binding sites in a neuroblastoma--glioma hybrid cell. Proc Natl Acad Sci U S A (1981) 0.88
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids. Biochem J (1993) 0.87
Peptide inhibitor of morphine- and beta-endorphin-induced analgesia. Proc Natl Acad Sci U S A (1980) 0.86
Visualization of mu1 opiate receptors in rat brain by using a computerized autoradiographic subtraction technique. Proc Natl Acad Sci U S A (1985) 0.86
Effect of loperamide and naloxone on gastric acid secretion in healthy man. Gut (1981) 0.84
Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation. Proc Natl Acad Sci U S A (1980) 0.84
Unmasking of magnesium-dependent high-affinity binding sites for [dAla2, dLeu5]enkephalin after pretreatment of brain membranes with guanine nucleotides. Proc Natl Acad Sci U S A (1983) 0.83
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line. Proc Natl Acad Sci U S A (1981) 0.80
Inhibitory actions of loperamide on absorptive processes in rat small intestine. Gut (1986) 0.80
Autoradiographic localization of supraspinal kappa-opioid receptors with [125I-Tyr1, D-Pro10]dynorphin A-(1-11). Proc Natl Acad Sci U S A (1988) 0.80
Investigation of action of enkephalin on the spontaneous and evoked release of acetylcholine from rat cortical and striatal slices. Br J Pharmacol (1980) 0.80
Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice. Br J Pharmacol (1986) 0.79
Chimeric opioid peptides: tools for identifying opioid receptor types. Proc Natl Acad Sci U S A (1990) 0.79
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus. Br J Pharmacol (1987) 0.79
Opioids regulate cGMP formation in cloned neuroblastoma cells. Proc Natl Acad Sci U S A (1982) 0.78
Regional expression and chromosomal localization of the delta opiate receptor gene. Proc Natl Acad Sci U S A (1993) 0.77
The delta opioid receptor tool box. Neuroscience (2016) 0.75
A study of the role of cyclic adenosine 3',5'-monophosphate in the depression by opiates and opioid peptides of excitatory junction potentials in the mouse vas deferens. Br J Pharmacol (1980) 0.75
Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors. Proc Natl Acad Sci U S A (1992) 0.75
The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells. Br J Pharmacol (1984) 0.75
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. J Biol Chem (1970) 19.51
A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem (1974) 13.32
Selective enzyme purification by affinity chromatography. Proc Natl Acad Sci U S A (1968) 10.63
Catalytic properties and specificity of the extracellular nuclease of Staphylococcus aureus. J Biol Chem (1967) 6.29
Insulin--receptor interactions in adipose tissue cells: direct measurement and properties. Proc Natl Acad Sci U S A (1971) 5.00
Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry (1973) 4.84
Gangliosides and membrane receptors for cholera toxin. Biochemistry (1973) 4.81
Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastroenterology (1997) 4.10
Membrane receptors. Annu Rev Biochem (1974) 4.01
Interaction of insulin with the cell membrane: the primary action of insulin. Proc Natl Acad Sci U S A (1969) 3.98
Affinity chromatography. Annu Rev Biochem (1971) 3.95
Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60
Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation-sephadex). Proc Natl Acad Sci U S A (1972) 3.54
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44
Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial. Endoscopy (2010) 3.12
Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity. Proc Natl Acad Sci U S A (1985) 2.92
Antibodies to purified insulin receptor have insulin-like activity. Science (1978) 2.58
The purification of beta-galactosidase from Escherichia coli by affinity chromatography. J Biol Chem (1971) 2.58
Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose. Biochemistry (1972) 2.55
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. J Biol Chem (1983) 2.55
Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. Proc Natl Acad Sci U S A (1986) 2.54
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters. J Biol Chem (1982) 2.54
Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem (1983) 2.53
Water-soluble contrast study predicts the need for early surgery in adhesive small bowel obstruction. Br J Surg (1998) 2.49
Properties of the insulin receptor of isolated fat cell membranes. J Biol Chem (1971) 2.41
Local aggregation of hormone-receptor complexes is required for activation by epidermal growth factor. Nature (1979) 2.41
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34
Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils. J Biol Chem (1979) 2.31
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
An improved method for the purification of staphylococcal nuclease. J Biol Chem (1967) 2.27
Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. Proc Natl Acad Sci U S A (1978) 2.26
Insulin receptor: covalent labeling and identification of subunits. Proc Natl Acad Sci U S A (1979) 2.24
Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor. Proc Natl Acad Sci U S A (1980) 2.22
Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors. Proc Natl Acad Sci U S A (1973) 2.19
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. Proc Natl Acad Sci U S A (1984) 2.14
Binding of nerve growth factor receptor in sympathetic ganglia. Proc Natl Acad Sci U S A (1973) 2.14
Properties of the insulin receptor isolated from liver and fat cell membranes. J Biol Chem (1972) 2.14
Vibrio cholerae choleragenoid. Mechanism of inhibition of cholera toxin action. Biochemistry (1973) 2.10
Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science (1986) 2.06
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem (1981) 2.04
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1978) 2.03
Epidermal growth factor: biological activity requires persistent occupation of high-affinity cell surface receptors. Proc Natl Acad Sci U S A (1978) 2.02
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem (1995) 1.97
Affinity chromatography and purification of the insulin receptor of liver cell membranes. Proc Natl Acad Sci U S A (1972) 1.89
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene (2007) 1.86
Immunohistochemical localization of enkephalin in rat brain and spinal cord. J Comp Neurol (1978) 1.86
Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin. Science (1972) 1.84
Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science (1979) 1.84
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature (1985) 1.83
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin. Biochim Biophys Acta (1979) 1.75
Mobility of cholera toxin receptors on rat lymphocyte membranes. Proc Natl Acad Sci U S A (1975) 1.74
Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74
Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci U S A (1986) 1.68
Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines. Mol Pharmacol (1979) 1.68
Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A (1975) 1.65
Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum. J Immunol (1981) 1.64
Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature (1985) 1.61
Survival after resection of gastric cancer and prognostic relevance of systematic lymph node dissection: twenty years experience in Taiwan. World J Surg (1995) 1.61
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. J Biol Chem (1985) 1.61
The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin. Biochim Biophys Acta (1976) 1.60
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization. J Biol Chem (1980) 1.60
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol (1979) 1.59
Emergence of insulin receptors on human lymphocytes during in vitro transformation. Proc Natl Acad Sci U S A (1972) 1.58
A multispecialty approach to the diagnosis and management of pancreatic cancer. Am J Gastroenterol (2000) 1.58
Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts. J Biol Chem (1986) 1.57
The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit. J Biol Chem (1980) 1.57
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells. Proc Natl Acad Sci U S A (1986) 1.56
Purification and properties of insulin receptors from rat liver membranes. Biochem Biophys Res Commun (1977) 1.54
Unmasking of insulin receptors in fat cells and fat cell membranes. Perturbation of membrane lipids. J Biol Chem (1971) 1.52
Insulin-receptor interactions in liver cell membranes. Biochem Biophys Res Commun (1971) 1.50
Purification of neuraminidases from Vibrio Cholerae, Clostridium Perfringens and influenza virus by affinity chromatography. Biochem Biophys Res Commun (1971) 1.48
Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine. Proc Natl Acad Sci U S A (1973) 1.47
Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res (1999) 1.47
The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid. J Biol Chem (1981) 1.46
The epidemiology of Japanese encephalitis on Taiwan during 1966-1997. Am J Trop Med Hyg (1999) 1.46
Cholera toxin and cell growth: role of membrane gangliosides. Proc Natl Acad Sci U S A (1974) 1.46
Human amyloid protein: chemical variability and homogeneity. J Histochem Cytochem (1971) 1.45
Affinity chromatography of macromolecules. Adv Enzymol Relat Areas Mol Biol (1972) 1.45
Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. Proc Natl Acad Sci U S A (1979) 1.43
Single-step purification of avidine from egg white by affinity chromatography on biocytin-Sepharose columns. Biochem Biophys Res Commun (1968) 1.43
Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormones. Biochim Biophys Acta (1975) 1.42
Membrane receptors as general markers for plasma membrane isolation procedures. The use of 125-I-labeled wheat germ agglutinin, insulin, and cholera toxin. J Biol Chem (1975) 1.41
Reconstruction of bilateral extensive composite mandibular defects after osteoradionecrosis with two fibular osteoseptocutaneous free flaps. Plast Reconstr Surg (2001) 1.41
Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci U S A (1983) 1.40
Noradrenaline binding and the search for catecholamine receptors. Nature (1974) 1.40
Peptide hormone-induced receptor mobility, aggregation, and internalization. N Engl J Med (1981) 1.39
Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. J Membr Biol (1975) 1.38
The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature (1981) 1.37
Inhibitors of glucagon inactivation. Effect on glucagon--receptor interactions and glucagon-stimulated adenylate cyclase activity in liver cell membranes. Biochim Biophys Acta (1974) 1.33
A monoclonal antibody to human insulin receptor. Biochem Biophys Res Commun (1982) 1.33
Developing concepts in receptor research. Drug Intell Clin Pharm (1983) 1.33