Published in Cell on September 01, 1981
A Tn3 lacZ transposon for the random generation of beta-galactosidase gene fusions: application to the analysis of gene expression in Agrobacterium. EMBO J (1985) 9.03
Molecular and phenotypic variation of the white locus region in Drosophila melanogaster. Genetics (1988) 8.55
Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster. Genetics (1989) 8.33
Cloning of the bronze locus in maize by a simple and generalizable procedure using the transposable controlling element Activator (Ac). Proc Natl Acad Sci U S A (1984) 6.92
A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A (1998) 6.47
Restriction map variation in the Adh region of Drosophila. Proc Natl Acad Sci U S A (1982) 6.45
Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol (2007) 6.18
Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element. Proc Natl Acad Sci U S A (1983) 5.96
Molecular genetic variation in the centromeric region of the X chromosome in three Drosophila ananassae populations. I. Contrasts between the vermilion and forked loci. Genetics (1989) 5.84
Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci U S A (1995) 5.76
Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae. Genetics (1984) 5.64
Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins. Mol Cell Biol (1985) 5.44
Organization and mapping of a sequence on the Drosophila melanogaster X and Y chromosomes that is transcribed during spermatogenesis. Genetics (1984) 4.38
Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47
Physical map of the white locus of Drosophila melanogaster. Proc Natl Acad Sci U S A (1982) 3.46
Polymorphism and divergence in the Mst26A male accessory gland gene region in Drosophila. Genetics (1992) 3.43
Insertion site preferences of the P transposable element in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.22
Molecular cloning of the c locus of Zea mays: a locus regulating the anthocyanin pathway. EMBO J (1986) 3.18
Use of P-element-mediated transformation to identify the molecular basis of naturally occurring variants affecting Adh expression in Drosophila melanogaster. Genetics (1987) 3.17
Self-incompatibility genes of Brassica oleracea: Expression, isolation, and structure. Proc Natl Acad Sci U S A (1988) 2.99
Molecular mapping of the rosy locus in Drosophila melanogaster. Genetics (1986) 2.81
Molecular structure of a somatically unstable transposable element in Drosophila. Proc Natl Acad Sci U S A (1986) 2.77
Molecular characterization of the Drosophila vermilion locus and its suppressible alleles. Proc Natl Acad Sci U S A (1986) 2.71
Transcription of the white locus in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.69
Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J (1987) 2.63
Transcription of the Drosophila white locus and some of its mutants. EMBO J (1984) 2.59
Molecular cloning of the muscle gene unc-22 in Caenorhabditis elegans by Tc1 transposon tagging. Proc Natl Acad Sci U S A (1986) 2.56
Insertion and excision of the transposable element mariner in Drosophila. Genetics (1990) 2.56
Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. Genetics (1985) 2.52
Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A (1983) 2.52
Transposable Elements in Mendelian Populations. II. Distribution of Three COPIA-like Elements in a Natural Population of DROSOPHILA MELANOGASTER. Genetics (1983) 2.49
Molecular evolution of inversions in Drosophila pseudoobscura: the amylase gene region. Proc Natl Acad Sci U S A (1991) 2.48
Molecular analysis of instability in flower pigmentation of Antirrhinum majus, following isolation of the pallida locus by transposon tagging. EMBO J (1985) 2.48
Transposable elements in mendelian populations. I. A theory. Genetics (1983) 2.45
OM Mutations in DROSOPHILA ANANASSAE Are Linked to Insertions of a Transposable Element. Genetics (1986) 2.43
Phenotypic assay for excision of the maize controlling element Ac in tobacco. EMBO J (1987) 2.36
Genomic variation in natural populations of Drosophila melanogaster. Genetics (2012) 2.33
Single-strand conformation polymorphism analysis coupled with stratified DNA sequencing reveals reduced sequence variation in the su(s) and su(wa) regions of the Drosophila melanogaster X chromosome. Proc Natl Acad Sci U S A (1994) 2.31
Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A (1984) 2.30
Reduced levels of DNA polymorphism and fixed between-population differences in the centromeric region of Drosophila ananassae. Genetics (1992) 2.22
A highly conserved Brassica gene with homology to the S-locus-specific glycoprotein structural gene. Plant Cell (1989) 2.18
Asymmetrical pairings of transposons in and proximal to the white locus of Drosophila account for four classes of regularly occurring exchange products. Proc Natl Acad Sci U S A (1987) 2.17
Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression. Mol Cell Biol (1983) 2.09
A genomic scanning method for higher organisms using restriction sites as landmarks. Proc Natl Acad Sci U S A (1991) 2.08
Molecular cloning and analysis of the CRY1 gene: a yeast ribosomal protein gene. Nucleic Acids Res (1983) 2.07
Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element. EMBO J (1982) 2.04
Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster. EMBO J (1988) 2.02
Isolation of the Chlamydomonas regulatory gene NIT2 by transposon tagging. Genetics (1993) 2.00
Intrachromosomal rearrangements mediated by hobo transposons in Drosophila melanogaster. Proc Natl Acad Sci U S A (1988) 1.97
Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution. Genetics (1991) 1.96
Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of drosophila: selection and geographic differentiation. Genetics (1994) 1.93
Introduction of the transposable element mariner into the germline of Drosophila melanogaster. Genetics (1991) 1.89
Cloning of a mutable bz2 allele of maize by transposon tagging and differential hybridization. Genetics (1987) 1.89
Functional analysis of the white gene of Drosophila by P-factor-mediated transformation. EMBO J (1984) 1.87
Towards a physical map of the Drosophila melanogaster genome: mapping of cosmid clones within defined genomic divisions. Nucleic Acids Res (1990) 1.87
Haplotype test reveals departure from neutrality in a segment of the white gene of Drosophila melanogaster. Genetics (1995) 1.85
A transposable element that splits the promoter region inactivates a Drosophila cuticle protein gene. Proc Natl Acad Sci U S A (1982) 1.81
Structure and expression of the Saccharomyces cerevisiae CRY1 gene: a highly conserved ribosomal protein gene. Mol Cell Biol (1987) 1.79
Partial revertants of the transposable element-associated suppressible allele white-apricot in Drosophila melanogaster: structures and responsiveness to genetic modifiers. Genetics (1988) 1.75
Molecular analysis of the yellow gene (y) region of Drosophila melanogaster. Proc Natl Acad Sci U S A (1985) 1.71
Multi-locus selection and the structure of variation at the white gene of Drosophila melanogaster. Genetics (1996) 1.70
Isolation and characterization of the RNA2, RNA3, and RNA11 genes of Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.66
Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles. Mol Cell Biol (1990) 1.66
DNA map of mutations at the scute locus of Drosophila melanogaster. EMBO J (1982) 1.62
Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes. Genetics (1998) 1.61
Coupled instability of two X-linked genes in Drosophila mauritiana: germinal and somatic mutability. Genetics (1985) 1.57
Identification of phloem involved in assimilate loading in leaves by the activity of the galactinol synthase promoter. Plant Physiol (2000) 1.55
The Drosophila Hrb98DE locus encodes four protein isoforms homologous to the A1 protein of mammalian heterogeneous nuclear ribonucleoprotein complexes. Mol Cell Biol (1990) 1.54
The maize transposable element system Ac/Ds as a mutagen in Arabidopsis: identification of an albino mutation induced by Ds insertion. Proc Natl Acad Sci U S A (1993) 1.54
A Brassica Self-Incompatibility Gene Is Expressed in the Stylar Transmitting Tissue of Transgenic Tobacco. Plant Cell (1990) 1.50
Structure and transcription of the Drosophila mulleri alcohol dehydrogenase genes. Nucleic Acids Res (1985) 1.50
Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila melanogaster. Genetics (1997) 1.42
Drosophila melanogaster as a model to study drug addiction. Hum Genet (2012) 1.39
A transposon with an unusual arrangement of long terminal repeats in the green alga Chlamydomonas reinhardtii. EMBO J (1988) 1.39
Analysis of the yeast SPT3 gene and identification of its product, a positive regulator of Ty transcription. Nucleic Acids Res (1986) 1.38
The cloning of the Bar region and the B breakpoint in Drosophila melanogaster: evidence for a transposon-induced rearrangement. Genetics (1989) 1.37
Transposase titration in Drosophila melanogaster: a model of cytotype in the P-M system of hybrid dysgenesis. Proc Natl Acad Sci U S A (1985) 1.36
Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol Evol (2009) 1.36
Structures of defective P transposable elements prevalent in natural Q and Q-derived M strains of Drosophila melanogaster. Proc Natl Acad Sci U S A (1985) 1.35
Repressor of P elements in Drosophila melanogaster: Cytotype determination by a defective P element carrying only open reading frames 0 through 2. Proc Natl Acad Sci U S A (1987) 1.35
Transposition rates of movable genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A (1990) 1.34
Pairing for recombination in LGV of Caenorhabditis elegans: a model based on recombination in deficiency heterozygotes. Genetics (1990) 1.34
Molecular structure of frizzled, a Drosophila tissue polarity gene. Genetics (1990) 1.34
Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. Am J Hum Genet (1996) 1.32
Molecular organization of the X chromosome in different species of the obscura group of Drosophila. Genetics (1992) 1.32
Amplification of genomic sequences flanking transposable elements in host and heterologous plants: a tool for transposon tagging and genome characterization. Nucleic Acids Res (1990) 1.31
Molecular analysis of the ecdysterone-inducible 2B5 "early' puff in Drosophila melanogaster. EMBO J (1986) 1.30
Insertional mutagenesis in Neurospora crassa: cloning and molecular analysis of the preg+ gene controlling the activity of the transcriptional activator NUC-1. Genetics (1993) 1.25
The history of a genetic system. Proc Natl Acad Sci U S A (1994) 1.25
Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo. Genetics (2011) 1.24
A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. Genetics (1991) 1.24
RNA-mediated transposition of the tobacco retrotransposon Tnt1 in Arabidopsis thaliana. EMBO J (1995) 1.24
Capture of flanking DNA by a P element in Drosophila melanogaster: creation of a transposable element. Proc Natl Acad Sci U S A (1991) 1.24
Hybrid dysgenesis-induced quantitative variation on the X chromosome of Drosophila melanogaster. Genetics (1990) 1.20
A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila. Nucleic Acids Res (1990) 1.17
Molecular analysis of large transposable elements carrying the white locus of Drosophila melanogaster. EMBO J (1983) 1.16
Transposable elements can be used to study cell lineages in transgenic plants. Plant Cell (1989) 1.16
Molecular analysis of hybrid dysgenesis-induced derivatives of a P-element allele at the vg locus. Mol Cell Biol (1988) 1.14
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
A whole-genome assembly of Drosophila. Science (2000) 38.48
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res (1998) 22.69
Transposition of cloned P elements into Drosophila germ line chromosomes. Science (1982) 16.85
Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43
Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell (1983) 13.18
The nucleotide sequence of Saccharomyces cerevisiae 5.8 S ribosomal ribonucleic acid. J Biol Chem (1973) 13.11
Analysis of P transposable element functions in Drosophila. Cell (1984) 11.95
Apollo: a sequence annotation editor. Genome Biol (2002) 10.77
The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family. Cell (1982) 8.95
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing. Cell (1986) 7.45
Vectors for P element-mediated gene transfer in Drosophila. Nucleic Acids Res (1983) 7.33
Expression of baculovirus P35 prevents cell death in Drosophila. Development (1994) 7.16
The molecular basis of P-M hybrid dysgenesis: the nature of induced mutations. Cell (1982) 7.07
The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene. Cell (1983) 6.67
Transformation of white locus DNA in drosophila: dosage compensation, zeste interaction, and position effects. Cell (1984) 5.92
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell (1991) 5.87
Repeated gene families in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1978) 5.85
The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence. Cell (1979) 5.83
Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci U S A (1995) 5.76
Preparation of RNA and ribosomes from yeast. Methods Cell Biol (1975) 5.75
Transposition of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell (1979) 5.61
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc Natl Acad Sci U S A (2001) 5.45
Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins. Mol Cell Biol (1985) 5.44
An integrated computational pipeline and database to support whole-genome sequence annotation. Genome Biol (2002) 5.24
Identification and immunochemical analysis of biologically active Drosophila P element transposase. Cell (1986) 5.21
DNA sequence of the white locus of Drosophila melanogaster. J Mol Biol (1984) 5.01
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell (1995) 5.01
Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science (1989) 4.84
Systematic gain-of-function genetics in Drosophila. Development (1998) 4.71
Effects of genomic position on the expression of transduced copies of the white gene of Drosophila. Science (1985) 4.58
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell (1994) 4.30
Drosophila genome organization: conserved and dynamic aspects. Annu Rev Genet (1981) 4.21
Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell (2001) 4.21
Regulation of white locus expression: the structure of mutant alleles at the white locus of Drosophila melanogaster. Cell (1982) 4.09
Drosophila p53 binds a damage response element at the reaper locus. Cell (2000) 3.92
Isolation and structure of a rhodopsin gene from D. melanogaster. Cell (1985) 3.90
Deletion mapping of Sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging. Cell (1986) 3.89
Polymorphisms in the chromosomal locations of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell (1979) 3.82
Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron (1989) 3.79
The role of the genome project in determining gene function: insights from model organisms. Cell (1996) 3.72
Insertion of the Drosophila transposable element copia generates a 5 base pair duplication. Cell (1980) 3.63
A BAC-based physical map of the major autosomes of Drosophila melanogaster. Science (2000) 3.51
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Physical map of the white locus of Drosophila melanogaster. Proc Natl Acad Sci U S A (1982) 3.46
Effect of heat shock on the synthesis of low molecular weight RNAs in drosophilia: accumulation of a novel form of 5S RNA. Cell (1975) 3.41
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell (1993) 3.40
The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. Cell (1994) 3.33
Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging. Cell (1982) 3.30
KSR, a novel protein kinase required for RAS signal transduction. Cell (1995) 3.27
Insertion site preferences of the P transposable element in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.22
P element insertions and rearrangements at the singed locus of Drosophila melanogaster. Genetics (1988) 3.14
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science (1987) 3.06
Isolation of a telomeric DNA sequence from Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1978) 3.06
Terminal repeats of the Drosophila transposable element copia: nucleotide sequence and genomic organization. Cell (1980) 3.01
A copy of the copia transposable element is very tightly linked to the Wa allele at the white locus of D. melanogaster. Cell (1981) 2.99
Effects of transposable element insertions on RNA encoded by the white gene of Drosophila. Cell (1984) 2.92
Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila. Cell (1994) 2.84
The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell (1990) 2.83
On/off regulation of gene expression at the level of splicing. Trends Genet (1988) 2.81
Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature (1992) 2.80
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science (1996) 2.77
Analysis of the promoter of the ninaE opsin gene in Drosophila melanogaster. Genetics (1987) 2.74
gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell (1999) 2.71
Transcription of the white locus in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.69
Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing. Cell (1991) 2.69
Separable cis-acting control elements for expression of the white gene of Drosophila. EMBO J (1985) 2.63
dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development (1994) 2.63
Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell (1995) 2.61
Three forms of the 5.8-S ribosomal RNA species in Saccharomyces cerevisiae. Eur J Biochem (1974) 2.61
seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell (1990) 2.60
cis-acting DNA sequence requirements for P-element transposition. Genes Dev (1989) 2.60
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations. Cell (1982) 2.59
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell (1992) 2.53
Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. Genetics (1985) 2.52
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell (1997) 2.50
KSR modulates signal propagation within the MAPK cascade. Genes Dev (1996) 2.46
Structure of the Drosophila mutable allele, white-crimson, and its white-ivory and wild-type derivatives. Cell (1982) 2.45
Evidence that two mutations, wDZL and z1, affecting synapsis-dependent genetic behavior of white are transcriptional regulatory mutations. Cell (1985) 2.44
Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development (1998) 2.43
Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell (1992) 2.42
The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. Nature (1989) 2.41
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev Cell (2001) 2.35