Published in Cell on December 15, 1995
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev (1999) 3.79
Signal transduction of stress via ceramide. Biochem J (1998) 2.86
Targeting protein prenylation for cancer therapy. Nat Rev Cancer (2011) 2.60
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54
KSR is a scaffold required for activation of the ERK/MAPK module. Genes Dev (2002) 2.40
MEK kinase activity is not necessary for Raf-1 function. EMBO J (2001) 2.36
A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics (1996) 2.17
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol (2006) 2.15
Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Mol Cell Biol (1999) 1.96
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol (1999) 1.91
The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Mol Cell Biol (2004) 1.86
Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J (1996) 1.77
Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res (2010) 1.77
Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A (2009) 1.76
KSR stimulates Raf-1 activity in a kinase-independent manner. Proc Natl Acad Sci U S A (1997) 1.72
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. EMBO J (1997) 1.66
Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta (2007) 1.64
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest (2007) 1.47
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J (1998) 1.45
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A (2011) 1.44
TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol (2000) 1.41
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest (2004) 1.40
Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol Cell Biol (2000) 1.39
KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell (2009) 1.39
The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Mol Cell Biol (2005) 1.35
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes Dev (2006) 1.35
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol (2005) 1.34
Ras acylation, compartmentalization and signaling nanoclusters (Review). Mol Membr Biol (2008) 1.33
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev (1999) 1.33
Ras proteins: paradigms for compartmentalised and isoform-specific signalling. Cell Mol Life Sci (2007) 1.30
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30
A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics (2000) 1.29
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling. Curr Biol (2011) 1.22
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn (2005) 1.21
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol Cell Biol (2004) 1.21
Basic and translational advances in cancer metastasis: Nm23. J Bioenerg Biomembr (2003) 1.20
Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases. Proc Natl Acad Sci U S A (2004) 1.19
De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol Cell Biol (1999) 1.18
A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics (2000) 1.16
Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J (2003) 1.15
Protein geranylgeranyltransferase I is involved in specific aspects of abscisic acid and auxin signaling in Arabidopsis. Plant Physiol (2005) 1.12
Functional requirement of plant farnesyltransferase during development in Arabidopsis. Plant Cell (2000) 1.10
An F1 genetic screen for maternal-effect mutations affecting embryonic pattern formation in Drosophila melanogaster. Genetics (2004) 1.09
The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Genetics (2008) 1.07
SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. Br J Cancer (2013) 1.06
The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling. Genes Dev (2010) 1.05
Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Mol Cell Biol (2012) 1.05
Functional analysis of CNK in RAS signaling. Proc Natl Acad Sci U S A (1999) 1.05
Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol (2005) 1.05
A Drosophila model of multiple endocrine neoplasia type 2. Genetics (2005) 1.03
Efficient prenylation by a plant geranylgeranyltransferase-I requires a functional CaaL box motif and a proximal polybasic domain. Plant Physiol (2001) 1.03
KSR: a novel player in the RAS pathway. Cell (1995) 1.00
A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans. Genetics (2002) 1.00
Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. Genetics (1996) 0.99
Translational approaches using metastasis suppressor genes. J Bioenerg Biomembr (2006) 0.98
Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98
Signal control through Raf: in sickness and in health. Cell Res (2011) 0.97
Bimodal regulation of RAF by CNK in Drosophila. EMBO J (2003) 0.97
Role of phosphatidic acid in the coupling of the ERK cascade. J Biol Chem (2008) 0.96
The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol (2009) 0.96
Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J (1999) 0.95
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol (2014) 0.95
Drosophila, genetic screens, and cardiac function. Circ Res (2011) 0.95
How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94
Pseudokinases from a structural perspective. Biochem Soc Trans (2013) 0.94
Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis. Genetics (2001) 0.93
Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Mol Cell Biol (2011) 0.93
A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93
Inflammatory bowel disease reveals the kinase activity of KSR1. J Clin Invest (2004) 0.93
Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region. Oncogene (2006) 0.91
KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol (2011) 0.91
Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation. Exp Cell Res (2007) 0.91
Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol (2012) 0.91
A novel role for protein farnesylation in plant innate immunity. Plant Physiol (2008) 0.91
Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts. Mol Cell Biol (2003) 0.90
Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer. Breast Cancer Res Treat (2015) 0.90
hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells. Mol Cancer Ther (2008) 0.89
Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Oncotarget (2014) 0.89
Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. Int J Mol Sci (2013) 0.89
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc Natl Acad Sci U S A (2005) 0.88
quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Genetics (1998) 0.87
Identification of autosomal regions involved in Drosophila Raf function. Genetics (2000) 0.87
Functional Integration of the Conserved Domains of Shoc2 Scaffold. PLoS One (2013) 0.86
Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors. Nat Protoc (2011) 0.84
KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res (2010) 0.84
Repression of Drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors Yan and Tramtrack. Genetics (1997) 0.84
Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms. Clin Exp Metastasis (2003) 0.83
Cytosolic Ras supports eye development in Drosophila. Mol Cell Biol (2010) 0.83
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling. Cell Cycle (2008) 0.83
Receptor tyrosine kinases in Drosophila development. Cold Spring Harb Perspect Biol (2013) 0.83
Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection. Eur J Immunol (2010) 0.81
Negative feedback regulation of the ERK1/2 MAPK pathway. Cell Mol Life Sci (2016) 0.81
The metastasis suppressor Nm23 as a modulator of Ras/ERK signaling. J Mol Signal (2014) 0.81
Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther (2008) 0.80
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Choline esters in tissue extracts. J Physiol (1933) 62.88
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
A whole-genome assembly of Drosophila. Science (2000) 38.48
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res (1998) 22.69
Transposition of cloned P elements into Drosophila germ line chromosomes. Science (1982) 16.85
Analysis of genetic mosaics in developing and adult Drosophila tissues. Development (1993) 13.43
Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell (1983) 13.18
The nucleotide sequence of Saccharomyces cerevisiae 5.8 S ribosomal ribonucleic acid. J Biol Chem (1973) 13.11
Analysis of P transposable element functions in Drosophila. Cell (1984) 11.95
Cloning of DNA sequences from the white locus of D. melanogaster by a novel and general method. Cell (1981) 11.51
Apollo: a sequence annotation editor. Genome Biol (2002) 10.77
The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family. Cell (1982) 8.95
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing. Cell (1986) 7.45
Vectors for P element-mediated gene transfer in Drosophila. Nucleic Acids Res (1983) 7.33
Expression of baculovirus P35 prevents cell death in Drosophila. Development (1994) 7.16
The molecular basis of P-M hybrid dysgenesis: the nature of induced mutations. Cell (1982) 7.07
The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene. Cell (1983) 6.67
Transformation of white locus DNA in drosophila: dosage compensation, zeste interaction, and position effects. Cell (1984) 5.92
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell (1991) 5.87
Repeated gene families in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1978) 5.85
Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci U S A (1995) 5.76
Preparation of RNA and ribosomes from yeast. Methods Cell Biol (1975) 5.75
Transposition of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell (1979) 5.61
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc Natl Acad Sci U S A (2001) 5.45
Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins. Mol Cell Biol (1985) 5.44
An integrated computational pipeline and database to support whole-genome sequence annotation. Genome Biol (2002) 5.24
Identification and immunochemical analysis of biologically active Drosophila P element transposase. Cell (1986) 5.21
DNA sequence of the white locus of Drosophila melanogaster. J Mol Biol (1984) 5.01
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell (1995) 5.01
Systematic gain-of-function genetics in Drosophila. Development (1998) 4.71
Effects of genomic position on the expression of transduced copies of the white gene of Drosophila. Science (1985) 4.58
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev (1990) 4.46
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell (1994) 4.30
Drosophila genome organization: conserved and dynamic aspects. Annu Rev Genet (1981) 4.21
Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell (2001) 4.21
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature (1988) 4.15
Drosophila p53 binds a damage response element at the reaper locus. Cell (2000) 3.92
Isolation and structure of a rhodopsin gene from D. melanogaster. Cell (1985) 3.90
Polymorphisms in the chromosomal locations of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila. Cell (1979) 3.82
Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron (1989) 3.79
The role of the genome project in determining gene function: insights from model organisms. Cell (1996) 3.72
Insertion of the Drosophila transposable element copia generates a 5 base pair duplication. Cell (1980) 3.63
A BAC-based physical map of the major autosomes of Drosophila melanogaster. Science (2000) 3.51
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Physical map of the white locus of Drosophila melanogaster. Proc Natl Acad Sci U S A (1982) 3.46
Effect of heat shock on the synthesis of low molecular weight RNAs in drosophilia: accumulation of a novel form of 5S RNA. Cell (1975) 3.41
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell (1993) 3.40
RNA splicing. Alive with DEAD proteins. Nature (1991) 3.35
The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. Cell (1994) 3.33
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
Insertion site preferences of the P transposable element in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.22
P element insertions and rearrangements at the singed locus of Drosophila melanogaster. Genetics (1988) 3.14
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science (1987) 3.06
Isolation of a telomeric DNA sequence from Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1978) 3.06
Terminal repeats of the Drosophila transposable element copia: nucleotide sequence and genomic organization. Cell (1980) 3.01
Effects of transposable element insertions on RNA encoded by the white gene of Drosophila. Cell (1984) 2.92
The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. J Biol Chem (1966) 2.89
The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Cell (1990) 2.87
Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila. Cell (1994) 2.84
The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell (1990) 2.83
Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature (1992) 2.80
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science (1996) 2.77
Analysis of the promoter of the ninaE opsin gene in Drosophila melanogaster. Genetics (1987) 2.74
gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell (1999) 2.71
Transcription of the white locus in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.69
Separable cis-acting control elements for expression of the white gene of Drosophila. EMBO J (1985) 2.63
dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development (1994) 2.63
Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell (1995) 2.61
Three forms of the 5.8-S ribosomal RNA species in Saccharomyces cerevisiae. Eur J Biochem (1974) 2.61
seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell (1990) 2.60
cis-acting DNA sequence requirements for P-element transposition. Genes Dev (1989) 2.60
FB elements are the common basis for the instability of the wDZL and wC Drosophila mutations. Cell (1982) 2.59
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell (1992) 2.53
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell (1997) 2.50
KSR modulates signal propagation within the MAPK cascade. Genes Dev (1996) 2.46
Structure of the Drosophila mutable allele, white-crimson, and its white-ivory and wild-type derivatives. Cell (1982) 2.45
Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development (1998) 2.43
Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell (1992) 2.42
The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. Nature (1989) 2.41
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev Cell (2001) 2.35
Copia-like transposable elements in the Drosophila genome. Cold Spring Harb Symp Quant Biol (1981) 2.35
T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science (2001) 2.30
The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev (1990) 2.30
A cyclophilin function in Hsp90-dependent signal transduction. Science (1996) 2.28
Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives. J Natl Cancer Inst (2000) 2.23
The enzymatic carboxylation of phosphoenolpyruvate. I. Purification and properties of phosphoenolpyruvate carboxylase. J Biol Chem (1966) 2.20
The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head. Cell (1988) 2.19
A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics (1996) 2.17
Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu Rev Neurosci (1994) 2.15
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell (1992) 2.14
Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development (1998) 2.14