Published in Cell on February 01, 1982
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A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA. Proc Natl Acad Sci U S A (1986) 3.49
Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Mol Cell Biol (1985) 3.31
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell (2008) 3.18
The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. EMBO J (1985) 3.06
Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol (2013) 2.96
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cDNA encoding a human homolog of yeast ubiquitin 1. Nucleic Acids Res (1987) 2.33
Structure and expression of ubiquitin genes of Drosophila melanogaster. Mol Cell Biol (1988) 2.32
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Histone acetylation and globin gene switching. Nucleic Acids Res (1992) 2.11
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The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells. Mol Cell Biol (1986) 1.97
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Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89
The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1. EMBO J (1991) 1.71
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Three-dimensional structure of ubiquitin at 2.8 A resolution. Proc Natl Acad Sci U S A (1985) 1.60
A "housekeeping" gene on the X chromosome encodes a protein similar to ubiquitin. Proc Natl Acad Sci U S A (1988) 1.60
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Mol Cell Biol (2005) 1.55
Discovery of cellular regulation by protein degradation. J Biol Chem (2008) 1.48
A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol (1999) 1.44
Transcriptional activation of polycomb-repressed genes by ZRF1. Nature (2010) 1.44
The structure of ubiquitinated histone H2B. EMBO J (1987) 1.40
Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes. PLoS Genet (2009) 1.36
Us9, a stable lysine-less herpes simplex virus 1 protein, is ubiquitinated before packaging into virions and associates with proteasomes. Proc Natl Acad Sci U S A (1997) 1.32
The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation. Mol Cell Biol (2002) 1.26
Polyubiquitylation of histone H2B. Mol Biol Cell (2008) 1.17
Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions. J Cell Biol (1987) 1.13
The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster. Mol Cell Biol (1996) 1.12
Immunoelectron microscopic localization of ubiquitin in hepatoma cells. EMBO J (1988) 1.09
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc Natl Acad Sci U S A (1996) 1.06
Presence of antibodies to ubiquitin during the autoimmune response associated with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1988) 1.05
A conserved sequence in histone H2A which is a ubiquitination site in higher eucaryotes is not required for growth in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.04
Ubiquitin crosstalk connecting cellular processes. Cell Div (2006) 1.04
UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed. Mol Cell Biol (1989) 1.03
Structure and expression of the Drosophila ubiquitin-52-amino-acid fusion-protein gene. Biochem J (1992) 1.03
A specific endpoint assay for ubiquitin. Proc Natl Acad Sci U S A (1987) 1.03
A branched, synthetic octapeptide of ubiquitinated histone H2A as target of autoantibodies. J Exp Med (1989) 1.02
Structure of two developmentally regulated Dictyostelium discoideum ubiquitin genes. Mol Cell Biol (1987) 1.01
The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. Proc Natl Acad Sci U S A (1986) 1.01
Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4. Nucleic Acids Res (1987) 1.00
The early history of the ubiquitin field. Protein Sci (2006) 1.00
Nucleoprotein hybridization: a method for isolating active and inactive genes as chromatin. Nucleic Acids Res (1991) 0.98
Primary organization of nucleosomal core particles is invariable in repressed and active nuclei from animal, plant and yeast cells. Nucleic Acids Res (1985) 0.94
Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol (1995) 0.93
Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development. Chromosoma (2010) 0.92
Cellular content of ubiquitin and formation of ubiquitin conjugates during chicken spermatogenesis. Biochem J (1988) 0.92
Affinity of HMG17 for a mononucleosome is not influenced by the presence of ubiquitin-H2A semihistone but strongly depends on DNA fragment size. Nucleic Acids Res (1983) 0.91
A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nat Cell Biol (2016) 0.90
Ubiquitin expression in Neurospora crassa: cloning and sequencing of a polyubiquitin gene. Nucleic Acids Res (1989) 0.90
Isolation and characterization of adenovirus core nucleoprotein subunits. J Virol (1987) 0.84
Drosophila histone H2A.2 is associated with the interbands of polytene chromosomes. Proc Natl Acad Sci U S A (1986) 0.83
Demonstration of ATP-Dependent, Ubiquitin-Conjugating Activities in Higher Plants. Plant Physiol (1987) 0.82
Promoters active in interphase are bookmarked during mitosis by ubiquitination. Nucleic Acids Res (2012) 0.78
Structure and expression of the Drosophila ubiquitin-80-amino-acid fusion-protein gene. Biochem J (1994) 0.78
Functions of the proteasome on chromatin. Biomolecules (2014) 0.76
The multi-AT-hook chromosomal protein of Drosophila melanogaster, D1, is dispensable for viability. Genetics (2009) 0.76
Histone modifications as regulators of life and death in Saccharomyces cerevisiae. Microb Cell (2015) 0.75
Protein and Genetic Composition of Four Chromatin Types in Drosophila melanogaster Cell Lines. Curr Genomics (2017) 0.75
A polyubiquitin cDNA from a red alga. Plant Physiol (1992) 0.75
In vivo half-life of a protein is a function of its amino-terminal residue. Science (1986) 13.44
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science (1989) 9.68
A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome. Cell (1984) 9.15
A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem (1995) 7.79
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell (1987) 6.73
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell (1984) 5.70
The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature (1987) 5.43
Split ubiquitin as a sensor of protein interactions in vivo. Proc Natl Acad Sci U S A (1994) 5.16
Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene. Cell (1988) 5.08
The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature (1989) 4.70
The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science (1988) 4.69
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature (1989) 4.63
Arrest of segregation leads to accumulation of highly intertwined catenated dimers: dissection of the final stages of SV40 DNA replication. Cell (1981) 4.58
A yeast protein similar to bacterial two-component regulators. Science (1993) 4.57
The recognition component of the N-end rule pathway. EMBO J (1990) 4.55
Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science (1994) 4.42
Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers. Cell (1980) 4.32
The yeast ubiquitin genes: a family of natural gene fusions. EMBO J (1987) 4.25
The N-end rule in bacteria. Science (1991) 4.21
Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03
Universality and structure of the N-end rule. J Biol Chem (1989) 3.97
The degradation signal in a short-lived protein. Cell (1989) 3.68
The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein. Nature (1985) 3.52
In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor. Cell (1990) 3.50
A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA. Proc Natl Acad Sci U S A (1986) 3.49
Formaldehyde-mediated DNA-protein crosslinking: a probe for in vivo chromatin structures. Proc Natl Acad Sci U S A (1985) 3.47
The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo. Proc Natl Acad Sci U S A (1991) 3.42
Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae. EMBO J (1996) 3.09
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature (2001) 3.04
The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A (1991) 2.97
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A (2001) 2.85
Ubiquitin as a degradation signal. EMBO J (1992) 2.73
Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem (1992) 2.51
An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem (1995) 2.50
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature (1984) 2.39
Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell (1998) 2.39
Detecting and measuring cotranslational protein degradation in vivo. Science (2000) 2.34
Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A (2000) 2.27
UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J (1991) 2.20
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
Protein D1 preferentially binds A + T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A + T-rich satellite DNA. Proc Natl Acad Sci U S A (1982) 2.19
Degradation of G alpha by the N-end rule pathway. Science (1994) 2.15
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation. J Cell Biochem (1984) 2.10
The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain. EMBO J (1999) 2.00
cis-trans recognition and subunit-specific degradation of short-lived proteins. Nature (1990) 2.00
Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae. J Biol Chem (1990) 1.98
Enhancement of immunoblot sensitivity by heating of hydrated filters. Anal Biochem (1986) 1.98
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Mol Cell Biol (1999) 1.96
Heat-shock proteins of Drosophila are associated with nuclease-resistant, high-salt-resistant nuclear structures. J Cell Biol (1981) 1.93
A DNA binding protein that recognizes oligo(dA).oligo(dT) tracts. EMBO J (1989) 1.93
Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature (2000) 1.90
Ubiquitin-assisted dissection of protein transport across membranes. EMBO J (1994) 1.90
Naming a targeting signal. Cell (1991) 1.85
The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A (1998) 1.72
RGS4 is arginylated and degraded by the N-end rule pathway in vitro. J Biol Chem (2000) 1.71
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J (1998) 1.71
Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion. Cell (1981) 1.68
Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Mol Cell Biol (2000) 1.64
On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages. Proc Natl Acad Sci U S A (1981) 1.61
Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae. J Biol Chem (1991) 1.61
Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci (1998) 1.55
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol Cell Biol (2001) 1.54
N-recognin/Ubc2 interactions in the N-end rule pathway. J Biol Chem (1993) 1.51
Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway. J Biol Chem (1995) 1.49
Degradation signals in the lysine-asparagine sequence space. EMBO J (1999) 1.49
A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant. Proc Natl Acad Sci U S A (1992) 1.48
Using ubiquitin to follow the metabolic fate of a protein. Proc Natl Acad Sci U S A (1996) 1.43
Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway. J Biol Chem (1995) 1.42
The 3' end CCA of mature tRNA is an antideterminant for eukaryotic 3'-tRNase. RNA (1999) 1.39
The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat. J Bacteriol (1993) 1.36
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Staphylococcal nuclease makes a single non-random cut in the simian virus 40 viral minichromosome. J Mol Biol (1979) 1.31
Inhibition of the N-end rule pathway in living cells. Proc Natl Acad Sci U S A (1991) 1.31
Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum. Mol Biol Cell (1999) 1.27
Two-dimensional hybridization mapping of nucleosomes. comparison of DNA and protein patterns. J Mol Biol (1981) 1.26
A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway. J Biol Chem (1996) 1.16
Preferential localization of variant nucleosomes near the 5'-end of the mouse dihydrofolate reductase gene. J Biol Chem (1985) 1.14
In vivo effects of cis- and trans-diamminedichloroplatinum(II) on SV40 chromosomes: differential repair, DNA-protein cross-linking, and inhibition of replication. Biochemistry (1985) 1.12
Transcriptionally inactive oocyte-type 5S RNA genes of Xenopus laevis are complexed with TFIIIA in vitro. Mol Cell Biol (1987) 1.12
High-resolution fractionation of nucleosomes: minor particles, "whiskers," and separation of mononucleosomes containing and lacking A24 semihistone. Proc Natl Acad Sci U S A (1980) 1.11
Analysis of a conditional degradation signal in yeast and mammalian cells. Eur J Biochem (1999) 1.09
Nucleosome arrangement in green monkey alpha-satellite chromatin. Superimposition of non-random and apparently random patterns. J Mol Biol (1983) 1.08
Electrophoretic assay for DNA-binding proteins. Methods Enzymol (1987) 1.06
Hypersensitivity to heavy water: a new conditional phenotype. Cell (1988) 1.04
Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes. Proc Natl Acad Sci U S A (1983) 1.00
On the chromatin structure of the amplified, transcriptionally active gene for dihydrofolate reductase in mouse cells. J Biol Chem (1982) 0.95
Bivalent inhibitor of the N-end rule pathway. J Biol Chem (1999) 0.94
Affinity of HMG17 for a mononucleosome is not influenced by the presence of ubiquitin-H2A semihistone but strongly depends on DNA fragment size. Nucleic Acids Res (1983) 0.91
Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. Proc Natl Acad Sci U S A (1983) 0.89
Cellular and SV40 chromatin: replication, segregation, ubiquitination, nuclease-hypersensitive sites, HMG-containing nucleosomes, and heterochromatin-specific protein. Cold Spring Harb Symp Quant Biol (1983) 0.85
New way to isolate simian virus 40 nucleoprotein complexes from infected cells: use of a thiol-specific reagent. J Virol (1982) 0.85
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Poly(U)-binding protein inhibits Drosophila pre-5 S RNA 3'-exonuclease digestion. J Biol Chem (1993) 0.84