Published in Nat Struct Mol Biol on October 01, 2013
A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet (2014) 2.94
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell (2014) 1.99
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2. Science (2015) 1.97
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Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Exp Hematol (2015) 0.95
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Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Mol Cell (2015) 0.92
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De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome. Hum Mol Genet (2015) 0.90
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The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol (2017) 0.89
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A (2015) 0.87
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Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy. PLoS One (2015) 0.86
Polycomb-mediated silencing in neuroendocrine prostate cancer. Clin Epigenetics (2015) 0.86
A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation. PLoS Genet (2014) 0.86
BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin. Proc Natl Acad Sci U S A (2016) 0.85
Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2. Nat Commun (2015) 0.85
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Mol Cell Proteomics (2015) 0.85
MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence. J Biol Chem (2015) 0.85
Variants of core histones and their roles in cell fate decisions, development and cancer. Nat Rev Mol Cell Biol (2017) 0.84
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun (2015) 0.84
Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival. Oncotarget (2015) 0.84
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation. Nat Struct Mol Biol (2016) 0.83
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A dimeric state for PRC2. Nucleic Acids Res (2014) 0.83
Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response. Epigenetics Chromatin (2015) 0.82
Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol Carcinog (2015) 0.82
Recognition of the nucleosome by chromatin factors and enzymes. Curr Opin Struct Biol (2016) 0.82
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. Epigenetics (2015) 0.82
Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell (2017) 0.82
Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol (2014) 0.81
EZH2 in normal hematopoiesis and hematological malignancies. Oncotarget (2016) 0.81
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress. Front Genet (2016) 0.80
Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS Genet (2014) 0.80
Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res (2015) 0.80
Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell (2014) 0.80
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. Mol Cell (2016) 0.80
A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells. Oncotarget (2016) 0.80
Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work. Front Genet (2015) 0.80
Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev (2017) 0.79
Retracted Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun (2015) 0.79
LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome. PLoS One (2016) 0.79
Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3. Mol Biol Cell (2015) 0.79
Combgap contributes to recruitment of Polycomb group proteins in Drosophila. Proc Natl Acad Sci U S A (2016) 0.79
Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l. Stem Cell Reports (2015) 0.79
Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. Mol Cell Biol (2014) 0.79
Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia. Front Neurol (2015) 0.79
A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription. G3 (Bethesda) (2016) 0.79
Epigenetic regulation of epithelial-mesenchymal transition. Cell Mol Life Sci (2016) 0.79
Human papillomavirus carcinogenesis: an identity crisis in the retinoblastoma tumor suppressor pathway. J Virol (2015) 0.79
Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. Oncotarget (2015) 0.78
MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines. J Biol Chem (2016) 0.78
Role of Deubiquitinating Enzymes in DNA Repair. Mol Cell Biol (2015) 0.78
Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem (2014) 0.78
Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells. Cell Rep (2016) 0.78
PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster. J Biol Chem (2014) 0.78
First Barcelona Conference on Epigenetics and Cancer. Epigenetics (2014) 0.78
Epigenetic regulation of open chromatin in pluripotent stem cells. Transl Res (2014) 0.78
The Lineage-Specific Transcription Factor PU.1 Prevents Polycomb-Mediated Heterochromatin Formation at Macrophage-Specific Genes. Mol Cell Biol (2015) 0.78
Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy. Front Cell Infect Microbiol (2016) 0.78
ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell Cycle (2015) 0.78
ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data. Genome Biol (2016) 0.78
Bioinformatic and proteomic analysis of bulk histones reveals PTM crosstalk and chromatin features. J Proteome Res (2014) 0.77
Polycomb Repressive Complex 2 regulates lineage fidelity during embryonic stem cell differentiation. PLoS One (2014) 0.77
Polycomb group proteins--epigenetic repressors with emerging roles in melanocytes and melanoma. Pigment Cell Melanoma Res (2015) 0.77
Non-coding yet non-trivial: a review on the computational genomics of lincRNAs. BioData Min (2015) 0.77
BMI1: A Biomarker of Hematologic Malignancies. Biomark Cancer (2016) 0.77
Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia. Oncotarget (2016) 0.76
The molecular mechanics of mixed lineage leukemia. Oncogene (2016) 0.76
The plant Polycomb repressive complex 1 (PRC1) existed in the ancestor of seed plants and has a complex duplication history. BMC Evol Biol (2015) 0.76
Epigenomics of Neural Cells: REST-Induced Down- and Upregulation of Gene Expression in a Two-Clone PC12 Cell Model. Biomed Res Int (2015) 0.76
Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity. J Biol Chem (2017) 0.76
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Mol Cell Proteomics (2016) 0.76
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Cell Syst (2016) 0.76
Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science (2017) 0.76
Drosophila Cyclin G and epigenetic maintenance of gene expression during development. Epigenetics Chromatin (2015) 0.75
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Front Cell Neurosci (2015) 0.75
RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma. Cancer Discov (2015) 0.75
Histone deacetylases control module-specific phenotypic plasticity in beetle weapons. Proc Natl Acad Sci U S A (2016) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
A gene complex controlling segmentation in Drosophila. Nature (1978) 23.75
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell (2009) 8.62
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30
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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
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The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer (2012) 4.97
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Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
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Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
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Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol (2012) 1.52
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Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol Cell Biol (2005) 1.46
Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4. Cell Stem Cell (2011) 1.45
Transcriptional activation of polycomb-repressed genes by ZRF1. Nature (2010) 1.44
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An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell (2012) 1.43
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
E2F target genes: unraveling the biology. Trends Biochem Sci (2004) 3.49
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BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
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Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04
Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev (2005) 2.67
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol (2004) 2.61
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 2.50
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Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
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Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
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HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell (2006) 1.96
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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
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Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem (2003) 1.83
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
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Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep (2005) 1.51
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Mol Cell (2012) 1.43
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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res (2011) 1.26
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Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol (2013) 1.16
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol (2013) 1.13
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet (2002) 1.13
Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology (2003) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
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The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet (2013) 1.09
The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev (2002) 1.09
The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol (2014) 1.07
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One (2013) 1.07
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell (2013) 1.06
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Molecular mechanisms in gliomagenesis. Adv Cancer Res (2005) 1.04
The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One (2008) 0.99
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clin Cancer Res (2013) 0.98
Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS. Anal Chem (2013) 0.96
Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. Oncogene (2005) 0.96
shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood (2014) 0.95
A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One (2010) 0.95
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. Cancer Res (2013) 0.95
Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. J Biol Chem (2004) 0.93
MMSET is highly expressed and associated with aggressiveness in neuroblastoma. Cancer Res (2011) 0.93
Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem (2012) 0.93
NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. Cell Cycle (2010) 0.93
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J Biol Chem (2006) 0.89
Profiling cancer. Curr Opin Cell Biol (2003) 0.89
Geminin: a major DNA replication safeguard in higher eukaryotes. Cell Cycle (2004) 0.89
The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res (2009) 0.88
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells. Cell Cycle (2007) 0.88
Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett (2012) 0.85
Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. J Biol Chem (2008) 0.85
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Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
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TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells. Stem Cells (2014) 0.80
Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res (2013) 0.80