Published in J Biol Chem on March 25, 1982
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci U S A (1983) 5.00
Allosteric regulation of the epidermal growth factor receptor kinase. J Cell Biol (1986) 3.78
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38
Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proc Natl Acad Sci U S A (1985) 2.72
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization. EMBO J (1986) 2.38
Aggregation of complement receptors on human neutrophils in the absence of ligand. J Cell Biol (1987) 2.38
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 2.28
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol Cell Biol (1991) 2.27
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor. Mol Cell Biol (1990) 2.17
EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions. EMBO J (1988) 2.15
Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. Proc Natl Acad Sci U S A (2007) 1.89
The EGF receptor is an actin-binding protein. J Cell Biol (1992) 1.86
Large deletions in the cytoplasmic kinase domain of the epidermal growth factor receptor do not affect its laternal mobility. J Cell Biol (1986) 1.82
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors. Proc Natl Acad Sci U S A (1985) 1.77
Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. J Cell Biol (1989) 1.68
The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding. J Biol Chem (2009) 1.64
An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions. EMBO J (1987) 1.48
High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion. EMBO J (1984) 1.46
Expression of the human EGF receptor with ligand-stimulatable kinase activity in insect cells using a baculovirus vector. EMBO J (1988) 1.46
Single-molecule analysis of epidermal growth factor binding on the surface of living cells. EMBO J (2006) 1.45
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A (1984) 1.39
Platelet-derived growth factor binds specifically to receptors on vascular smooth muscle cells and the binding becomes nondissociable. Proc Natl Acad Sci U S A (1982) 1.34
Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGF. EMBO J (1984) 1.34
Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor. Mol Cell Biol (1988) 1.25
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts. Mol Cell Biol (1984) 1.24
Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions. Proc Natl Acad Sci U S A (1988) 1.21
Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors. EMBO J (1989) 1.17
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways. Mol Cell Biol (1989) 1.16
Expression of functional human EGF receptor on murine bone marrow cells. EMBO J (1988) 1.13
Evidence for glomerular actions of epidermal growth factor in the rat. J Clin Invest (1988) 1.09
A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol (1996) 1.04
Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells. Mol Cell Biol (1988) 1.04
A structural perspective on the regulation of the epidermal growth factor receptor. Annu Rev Biochem (2015) 1.04
Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity. Cell Regul (1991) 1.03
Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells. Biochem J (1988) 0.99
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism. Proc Natl Acad Sci U S A (1984) 0.98
Epidermal growth factor receptor in lung malignancies. Comparison between cancer and normal tissue. Br J Cancer (1991) 0.95
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding. J Biol Chem (2011) 0.95
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters. Proc Natl Acad Sci U S A (1986) 0.94
EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor. EMBO J (1989) 0.94
Epidermal growth factor receptor inhibitors in colorectal cancer treatment: what's new? World J Gastroenterol (2007) 0.93
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction. J Biol Chem (2010) 0.93
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms. Biochem J (2001) 0.89
Mechanisms of activation of receptor tyrosine kinases: monomers or dimers. Cells (2014) 0.86
The role of EGF receptor transmodulation in embryonal carcinoma-derived growth factor-induced mitogenesis. EMBO J (1986) 0.84
Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells. Mol Cell Biol (1990) 0.82
Transmodulation of the epidermal-growth-factor receptor in permeabilized 3T3 cells. Biochem J (1988) 0.81
Fatty acid control of growth of human cervical and endometrial cancer cells. Br J Cancer (1990) 0.79
Negative co-operativity in the EGF receptor. Biochem Soc Trans (2012) 0.79
Cetuximab and biomarkers in non-small-cell lung carcinoma. Biologics (2012) 0.79
Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein. Mol Cell Biol (1988) 0.78
Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity. J Cell Biol (1992) 0.76
Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor. Protein Sci (2000) 0.75
Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA (1995) 38.40
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. J Biol Chem (1970) 19.51
A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem (1974) 13.32
Selective enzyme purification by affinity chromatography. Proc Natl Acad Sci U S A (1968) 10.63
CHAMPS physical activity questionnaire for older adults: outcomes for interventions. Med Sci Sports Exerc (2001) 7.96
Catalytic properties and specificity of the extracellular nuclease of Staphylococcus aureus. J Biol Chem (1967) 6.29
Insulin--receptor interactions in adipose tissue cells: direct measurement and properties. Proc Natl Acad Sci U S A (1971) 5.00
Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry (1973) 4.84
Gangliosides and membrane receptors for cholera toxin. Biochemistry (1973) 4.81
Membrane receptors. Annu Rev Biochem (1974) 4.01
Interaction of insulin with the cell membrane: the primary action of insulin. Proc Natl Acad Sci U S A (1969) 3.98
Affinity chromatography. Annu Rev Biochem (1971) 3.95
Determinants of leisure time physical activity in rural compared with urban older and ethnically diverse women in the United States. J Epidemiol Community Health (2000) 3.94
Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med (1990) 3.80
Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60
An evaluation of three self-report physical activity instruments for older adults. Med Sci Sports Exerc (2001) 3.54
Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation-sephadex). Proc Natl Acad Sci U S A (1972) 3.54
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44
Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity. Proc Natl Acad Sci U S A (1985) 2.92
Physical activity social support and middle- and older-aged minority women: results from a US survey. Soc Sci Med (1999) 2.79
Patterns and correlates of physical activity among US women 40 years and older. Am J Public Health (2000) 2.79
What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study). J Nutr Health Aging (2009) 2.79
Physical activity outcomes of CHAMPS II: a physical activity promotion program for older adults. J Gerontol A Biol Sci Med Sci (2001) 2.79
Promoting physical activity in rural communities: walking trail access, use, and effects. Am J Prev Med (2000) 2.65
Antibodies to purified insulin receptor have insulin-like activity. Science (1978) 2.58
The purification of beta-galactosidase from Escherichia coli by affinity chromatography. J Biol Chem (1971) 2.58
Physical activity and minority women: a qualitative study. Health Educ Behav (1998) 2.55
Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose. Biochemistry (1972) 2.55
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. J Biol Chem (1983) 2.55
Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. Proc Natl Acad Sci U S A (1986) 2.54
Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity. J Biol Chem (1979) 2.54
Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem (1983) 2.53
Properties of the insulin receptor of isolated fat cell membranes. J Biol Chem (1971) 2.41
Local aggregation of hormone-receptor complexes is required for activation by epidermal growth factor. Nature (1979) 2.41
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34
Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils. J Biol Chem (1979) 2.31
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
An improved method for the purification of staphylococcal nuclease. J Biol Chem (1967) 2.27
Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. Proc Natl Acad Sci U S A (1978) 2.26
Insulin receptor: covalent labeling and identification of subunits. Proc Natl Acad Sci U S A (1979) 2.24
Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor. Proc Natl Acad Sci U S A (1980) 2.22
Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors. Proc Natl Acad Sci U S A (1973) 2.19
Evaluation of CHAMPS, a physical activity promotion program for older adults. Ann Behav Med (1997) 2.14
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. Proc Natl Acad Sci U S A (1984) 2.14
Binding of nerve growth factor receptor in sympathetic ganglia. Proc Natl Acad Sci U S A (1973) 2.14
Properties of the insulin receptor isolated from liver and fat cell membranes. J Biol Chem (1972) 2.14
Vibrio cholerae choleragenoid. Mechanism of inhibition of cholera toxin action. Biochemistry (1973) 2.10
Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder. Am J Psychiatry (1994) 2.08
Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science (1986) 2.06
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem (1981) 2.04
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1978) 2.03
Epidermal growth factor: biological activity requires persistent occupation of high-affinity cell surface receptors. Proc Natl Acad Sci U S A (1978) 2.02
Reliability of information on physical activity and other chronic disease risk factors among US women aged 40 years or older. Am J Epidemiol (1999) 1.97
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem (1995) 1.97
Affinity chromatography and purification of the insulin receptor of liver cell membranes. Proc Natl Acad Sci U S A (1972) 1.89
Immunohistochemical localization of enkephalin in rat brain and spinal cord. J Comp Neurol (1978) 1.86
Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin. Science (1972) 1.84
Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science (1979) 1.84
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature (1985) 1.83
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin. Biochim Biophys Acta (1979) 1.75
Mobility of cholera toxin receptors on rat lymphocyte membranes. Proc Natl Acad Sci U S A (1975) 1.74
Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74
Using direct mail to recruit Hispanic adults into a dietary intervention: an experimental study. Ann Behav Med (2000) 1.70
Subjective and objective responses to ethanol in moderate/heavy and light social drinkers. Alcohol Clin Exp Res (2000) 1.69
Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci U S A (1986) 1.68
Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A (1975) 1.65
Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum. J Immunol (1981) 1.64
Dietary adherence and weight loss success among overweight women: results from the A TO Z weight loss study. Int J Obes (Lond) (2008) 1.63
Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature (1985) 1.61
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. J Biol Chem (1985) 1.61
The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin. Biochim Biophys Acta (1976) 1.60
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization. J Biol Chem (1980) 1.60
Brain metabolism in teenagers with attention-deficit hyperactivity disorder. Arch Gen Psychiatry (1993) 1.60
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol (1979) 1.59
Emergence of insulin receptors on human lymphocytes during in vitro transformation. Proc Natl Acad Sci U S A (1972) 1.58
Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts. J Biol Chem (1986) 1.57
The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit. J Biol Chem (1980) 1.57
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells. Proc Natl Acad Sci U S A (1986) 1.56
Purification and properties of insulin receptors from rat liver membranes. Biochem Biophys Res Commun (1977) 1.54
Unmasking of insulin receptors in fat cells and fat cell membranes. Perturbation of membrane lipids. J Biol Chem (1971) 1.52
Insulin-receptor interactions in liver cell membranes. Biochem Biophys Res Commun (1971) 1.50
Do logistic regression and signal detection identify different subgroups at risk? Implications for the design of tailored interventions. Psychol Methods (2001) 1.50
Effect of naltrexone on alcohol "high" in alcoholics. Am J Psychiatry (1995) 1.49
Purification of neuraminidases from Vibrio Cholerae, Clostridium Perfringens and influenza virus by affinity chromatography. Biochem Biophys Res Commun (1971) 1.48
Failure to activate the left temporoparietal cortex in dyslexia. An oxygen 15 positron emission tomographic study. Arch Neurol (1992) 1.48
Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine. Proc Natl Acad Sci U S A (1973) 1.47
The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid. J Biol Chem (1981) 1.46
Cholera toxin and cell growth: role of membrane gangliosides. Proc Natl Acad Sci U S A (1974) 1.46
Managing job strain: a randomized, controlled trial of an intervention conducted by mail and telephone. J Occup Environ Med (1999) 1.45
Human amyloid protein: chemical variability and homogeneity. J Histochem Cytochem (1971) 1.45
Affinity chromatography of macromolecules. Adv Enzymol Relat Areas Mol Biol (1972) 1.45
Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. Proc Natl Acad Sci U S A (1979) 1.43
Single-step purification of avidine from egg white by affinity chromatography on biocytin-Sepharose columns. Biochem Biophys Res Commun (1968) 1.43
Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormones. Biochim Biophys Acta (1975) 1.42
Membrane receptors as general markers for plasma membrane isolation procedures. The use of 125-I-labeled wheat germ agglutinin, insulin, and cholera toxin. J Biol Chem (1975) 1.41
Effect of a six-month aerobic exercise training program on cardiovascular responsivity in healthy middle-aged adults. J Psychosom Res (1992) 1.41
Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci U S A (1983) 1.40
Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64-99 years. J Am Geriatr Soc (2000) 1.40