Published in Science on June 16, 1978
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc Natl Acad Sci U S A (1983) 4.83
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Mol Cell Biol (1986) 2.52
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
Aggregation of complement receptors on human neutrophils in the absence of ligand. J Cell Biol (1987) 2.38
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor. Proc Natl Acad Sci U S A (1981) 1.87
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor. Biochem J (1986) 1.87
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action. Proc Natl Acad Sci U S A (1982) 1.57
Insulin-stimulated protein phosphorylation in 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1979) 1.41
Monensin blocks the maturation of receptors for insulin and somatomedin C: identification of receptor precursors. Proc Natl Acad Sci U S A (1983) 1.40
Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action. Proc Natl Acad Sci U S A (1979) 1.31
Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. Proc Natl Acad Sci U S A (1981) 1.21
Equilibrium theory for the clustering of bivalent cell surface receptors by trivalent ligands. Application to histamine release from basophils. Biophys J (1984) 1.21
Modulation of the epidermal growth factor receptor by platelet-derived growth factor and choleragen: effects on mitogenesis. Proc Natl Acad Sci U S A (1982) 1.16
Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor. J Cell Biol (1985) 1.11
Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system. Proc Natl Acad Sci U S A (1980) 1.11
An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. Proc Natl Acad Sci U S A (1989) 1.11
Latent insulin receptors and possible receptor precursors in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1983) 1.11
Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor. Biochem J (1987) 1.09
Microaggregation of hormone-occupied epidermal growth factor receptors on plasma membrane preparations. EMBO J (1986) 1.08
Monoclonal antibodies to the thyrotropin receptor: implications for receptor structure and the action of autoantibodies in Graves disease. Proc Natl Acad Sci U S A (1981) 1.05
Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes. Proc Natl Acad Sci U S A (1980) 1.02
Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1985) 1.01
Antireceptor antibodies as probes of insulinlike growth factor receptor structure. J Clin Invest (1983) 0.98
Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. J Clin Invest (1979) 0.96
The receptor for insulin-like growth factor II mediates an insulin-like response. EMBO J (1987) 0.96
Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity. EMBO J (1987) 0.95
Human T cell activation. IV. T cell activation and proliferation via the early activation antigen EA 1. J Exp Med (1989) 0.95
Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance. Proc Natl Acad Sci U S A (1984) 0.94
Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken. Proc Natl Acad Sci U S A (1990) 0.90
Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. Proc Natl Acad Sci U S A (1979) 0.90
Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model. Proc Natl Acad Sci U S A (1982) 0.90
Immunological demonstration of the accumulation of insulin, but not insulin receptors, in nuclei of insulin-treated cells. Proc Natl Acad Sci U S A (1989) 0.89
Stimulation of hexose transport in L6 rat myoblasts by antibody and by glucose starvation. Biochem J (1986) 0.89
Receptor dynamics of closely related ligands: "fast' and "slow' interferons. EMBO J (1985) 0.87
Prolactin-like activity of anti-prolactin receptor antibodies on casein and DNA synthesis in the mammary gland. Proc Natl Acad Sci U S A (1981) 0.86
Insulin-like effects of dithiothreitol on isolated rat adipocytes. Biochem J (1981) 0.86
Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry. Proc Natl Acad Sci U S A (1984) 0.80
Anti-cell surface monoclonal antibodies which antagonize the action of VIP in a human adenocarcinoma cell line (HT 29 cells). EMBO J (1983) 0.79
Early regenerative responses induced by monoclonal antibodies directed against a surface glycoprotein of goldfish retinal ganglion cells. EMBO J (1984) 0.75
Cluster formation of opiate (enkephalin) receptors in neuroblastoma cells: differences between agonists and antagonists and possible relationships to biological functions. Proc Natl Acad Sci U S A (1980) 0.75
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. J Biol Chem (1970) 19.51
A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem (1974) 13.32
Selective enzyme purification by affinity chromatography. Proc Natl Acad Sci U S A (1968) 10.63
Catalytic properties and specificity of the extracellular nuclease of Staphylococcus aureus. J Biol Chem (1967) 6.29
Insulin--receptor interactions in adipose tissue cells: direct measurement and properties. Proc Natl Acad Sci U S A (1971) 5.00
Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry (1973) 4.84
Gangliosides and membrane receptors for cholera toxin. Biochemistry (1973) 4.81
Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Gastroenterology (1997) 4.10
Membrane receptors. Annu Rev Biochem (1974) 4.01
Interaction of insulin with the cell membrane: the primary action of insulin. Proc Natl Acad Sci U S A (1969) 3.98
Affinity chromatography. Annu Rev Biochem (1971) 3.95
Membrane receptors and hormone action. Adv Protein Chem (1976) 3.73
Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. J Biol Chem (1975) 3.60
Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation-sephadex). Proc Natl Acad Sci U S A (1972) 3.54
Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proc Natl Acad Sci U S A (1973) 3.44
Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial. Endoscopy (2010) 3.12
Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity. Proc Natl Acad Sci U S A (1985) 2.92
Traumatic grief as a risk factor for mental and physical morbidity. Am J Psychiatry (1997) 2.80
The purification of beta-galactosidase from Escherichia coli by affinity chromatography. J Biol Chem (1971) 2.58
Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose. Biochemistry (1972) 2.55
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. J Biol Chem (1983) 2.55
Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. Proc Natl Acad Sci U S A (1986) 2.54
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters. J Biol Chem (1982) 2.54
Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity. J Biol Chem (1979) 2.54
Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem (1983) 2.53
Water-soluble contrast study predicts the need for early surgery in adhesive small bowel obstruction. Br J Surg (1998) 2.49
Comparison of open and laparoscopic live donor nephrectomy. Ann Surg (1997) 2.43
Properties of the insulin receptor of isolated fat cell membranes. J Biol Chem (1971) 2.41
Local aggregation of hormone-receptor complexes is required for activation by epidermal growth factor. Nature (1979) 2.41
Computer-enhanced "robotic" cardiac surgery: experience in 148 patients. J Thorac Cardiovasc Surg (2001) 2.40
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch Biochem Biophys (1974) 2.34
Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils. J Biol Chem (1979) 2.31
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
An improved method for the purification of staphylococcal nuclease. J Biol Chem (1967) 2.27
Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. Proc Natl Acad Sci U S A (1978) 2.26
Insulin receptor: covalent labeling and identification of subunits. Proc Natl Acad Sci U S A (1979) 2.24
Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor. Proc Natl Acad Sci U S A (1980) 2.22
Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors. Proc Natl Acad Sci U S A (1973) 2.19
Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an 'inhalation bolus' technique. Br J Anaesth (2003) 2.17
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. Proc Natl Acad Sci U S A (1984) 2.14
Binding of nerve growth factor receptor in sympathetic ganglia. Proc Natl Acad Sci U S A (1973) 2.14
Properties of the insulin receptor isolated from liver and fat cell membranes. J Biol Chem (1972) 2.14
Vibrio cholerae choleragenoid. Mechanism of inhibition of cholera toxin action. Biochemistry (1973) 2.10
Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science (1986) 2.06
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem (1981) 2.04
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1978) 2.03
Epidermal growth factor: biological activity requires persistent occupation of high-affinity cell surface receptors. Proc Natl Acad Sci U S A (1978) 2.02
Ice-shelf melting around Antarctica. Science (2013) 1.98
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem (1995) 1.97
Affinity chromatography and purification of the insulin receptor of liver cell membranes. Proc Natl Acad Sci U S A (1972) 1.89
A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. Transplantation (1999) 1.88
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene (2007) 1.86
Pegylated interferon-alpha2b: pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Hepatitis C Intervention Therapy Group. Clin Pharmacol Ther (2000) 1.86
Immunohistochemical localization of enkephalin in rat brain and spinal cord. J Comp Neurol (1978) 1.86
Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin. Science (1972) 1.84
Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science (1979) 1.84
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature (1985) 1.83
Complicated grief as a disorder distinct from bereavement-related depression and anxiety: a replication study. Am J Psychiatry (1996) 1.81
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin. Biochim Biophys Acta (1979) 1.75
Mobility of cholera toxin receptors on rat lymphocyte membranes. Proc Natl Acad Sci U S A (1975) 1.74
Affinity chromatography and structural analysis of Vibrio cholerae enterotoxin-ganglioside agarose and the biological effects of ganglioside-containing soluble polymers. Biochemistry (1973) 1.74
Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. Oncogene (2006) 1.69
Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci U S A (1986) 1.68
Protein-polysaccharides of pig laryngeal cartilage. Biochem J (1967) 1.68
Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines. Mol Pharmacol (1979) 1.68
Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A (1975) 1.65
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med (1996) 1.65
Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum. J Immunol (1981) 1.64
Survival after resection of gastric cancer and prognostic relevance of systematic lymph node dissection: twenty years experience in Taiwan. World J Surg (1995) 1.61
Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature (1985) 1.61
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. J Biol Chem (1985) 1.61
The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin. Biochim Biophys Acta (1976) 1.60
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization. J Biol Chem (1980) 1.60
Predicting outcome among intensive care unit patients using computerised trend analysis of daily Apache II scores corrected for organ system failure. Intensive Care Med (1988) 1.60
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol (1979) 1.59
Emergence of insulin receptors on human lymphocytes during in vitro transformation. Proc Natl Acad Sci U S A (1972) 1.58
A multispecialty approach to the diagnosis and management of pancreatic cancer. Am J Gastroenterol (2000) 1.58
Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts. J Biol Chem (1986) 1.57
The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit. J Biol Chem (1980) 1.57
Purification and properties of the human placental insulin receptor. J Biol Chem (1981) 1.57
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells. Proc Natl Acad Sci U S A (1986) 1.56
Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest (1989) 1.56
Purification and properties of insulin receptors from rat liver membranes. Biochem Biophys Res Commun (1977) 1.54
Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. Proc Natl Acad Sci U S A (2001) 1.53
A potential complication associated with percutaneous tracheostomy with an endotracheal tube with a Murphy eye in situ. Anesthesiology (1998) 1.53