Published in Nature on May 13, 1982
Membrane patches and whole-cell membranes: a comparison of electrical properties in rat clonal pituitary (GH3) cells. J Physiol (1984) 3.17
Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J Gen Physiol (1983) 1.75
The effects of some inhalation anaesthetics on the sodium current of the squid giant axon. J Physiol (1983) 1.43
Simultaneous capacitance and amperometric measurements of exocytosis: a comparison. Biophys J (1996) 1.19
Hydrophobic ions amplify the capacitive currents used to measure exocytotic fusion. Biophys J (1995) 1.01
Protein- and lipid-reactive agents alter outer hair cell lateral membrane motor charge movement. J Membr Biol (2004) 0.96
Halothane shortens acetylcholine receptor channel kinetics without affecting conductance. Proc Natl Acad Sci U S A (1984) 0.89
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Charge movement associated with the opening and closing of the activation gates of the Na channels. J Gen Physiol (1974) 13.07
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Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. J Gen Physiol (1972) 10.92
Currents related to movement of the gating particles of the sodium channels. Nature (1973) 9.80
Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol (1973) 8.53
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron (1996) 8.20
Calcium and potassium systems of a giant barnacle muscle fibre under membrane potential control. J Physiol (1973) 4.71
Release of secretory products during transient vesicle fusion. Nature (1993) 4.57
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature (1999) 4.56
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron (1993) 4.55
Gating currents of the sodium channels: three ways to block them. Science (1974) 4.13
Characterizing voltage-dependent conformational changes in the Shaker K+ channel with fluorescence. Neuron (1997) 4.08
Distribution and kinetics of membrane dielectric polarization. 1. Long-term inactivation of gating currents. J Gen Physiol (1982) 3.85
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation. Neuron (1999) 3.74
Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels. J Gen Physiol (1997) 3.54
Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29
Gating of Shaker K+ channels: I. Ionic and gating currents. Biophys J (1994) 3.28
A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon. Biophys J (1991) 2.98
Sodium and potassium conductance changes during a membrane action potential. J Physiol (1970) 2.94
A high capacity data recording device based on a digital audio processor and a video cassette recorder. Biophys J (1985) 2.84
Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J Gen Physiol (2001) 2.79
Cut-open oocyte voltage-clamp technique. Methods Enzymol (1998) 2.67
Structural implications of fluorescence quenching in the Shaker K+ channel. J Gen Physiol (1998) 2.65
Removal of potassium negative resistance in perfused squid giant axons. J Gen Physiol (1967) 2.63
A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes. J Membr Biol (1995) 2.46
Sodium influxes in internally perfused squid giant axon during voltage clamp. J Physiol (1969) 2.43
Sodium channel activation in the squid giant axon. Steady state properties. J Gen Physiol (1985) 2.35
Gating currents in Shaker K+ channels. Implications for activation and inactivation models. Biophys J (1992) 2.27
Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation. J Gen Physiol (1997) 2.26
Kinetic properties and inactivation of the gating currents of sodium channels in squid axon. Philos Trans R Soc Lond B Biol Sci (1975) 2.25
Long-term outcome of patients with asystole induced by head-up tilt test. Eur Heart J (2002) 2.21
Analysis of the effects of calcium or magnesium on voltage-clamp currents in perfused squid axons bathed in solutions of high potassium. J Gen Physiol (1969) 2.19
Distribution and kinetics of membrane dielectric polarization. II. Frequency domain studies of gating currents. J Gen Physiol (1982) 2.09
Positive MIBG scanning at the time of relapse in neuroblastoma which was MIBG negative at diagnosis. Br J Radiol (1997) 2.06
Recurrent tonsillitis. The role of Chlamydia and Mycoplasma. Arch Otolaryngol Head Neck Surg (1992) 2.04
Solute inaccessible aqueous volume changes during opening of the potassium channel of the squid giant axon. Biophys J (1990) 2.02
S4 mutations alter gating currents of Shaker K channels. Biophys J (1994) 1.97
Activation of squid axon K+ channels. Ionic and gating current studies. J Gen Physiol (1985) 1.92
Detergent-activation of latent collagenase and resolution of its component molecules. Biochem Biophys Res Commun (1982) 1.91
Radiation exposure to medical staff in interventional and cardiac radiology. Br J Radiol (1998) 1.87
Sodium dependence of the inward spread of activation in isolated twitch muscle fibres of the frog. J Physiol (1972) 1.86
Nile blue fluorescence signals from cut single muscle fibers under voltage or current clamp conditions. J Gen Physiol (1978) 1.84
Simultaneous measurements of magnesium, calcium and sodium influxes in perfused squid giant axons under membrane potential control. J Physiol (1975) 1.80
Temperature effects on gating currents in the squid giant axon. Biophys J (1978) 1.78
Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J Gen Physiol (1983) 1.75
RNA editing generates a diverse array of transcripts encoding squid Kv2 K+ channels with altered functional properties. Neuron (1997) 1.71
Gating current noise produced by elementary transitions in Shaker potassium channels. Science (1994) 1.68
Sodium and gating current time shifts resulting from changes in initial conditions. J Gen Physiol (1983) 1.68
Sodium channel gating currents. Origin of the rising phase. J Gen Physiol (1987) 1.68
Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase. Nature (2000) 1.67
Voltage gating of Shaker K+ channels. The effect of temperature on ionic and gating currents. J Gen Physiol (1998) 1.66
Gating of sodium and potassium channels. J Membr Biol (1985) 1.59
Regulation of exocytotic fusion by cell inflation. Biophys J (1998) 1.59
Characterization of collagenolytic activity from strains of Bacteroides gingivalis. J Periodontal Res (1988) 1.56
Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions. Neuron (1990) 1.51
Properties of the sodium channel gating current. Cold Spring Harb Symp Quant Biol (1976) 1.50
The rate of action of tetrodotoxin on sodium conductance in the squid giant axon. Philos Trans R Soc Lond B Biol Sci (1975) 1.47
NMR of laser-polarized xenon in human blood. Proc Natl Acad Sci U S A (1996) 1.46
Single-channel, macroscopic, and gating currents from sodium channels in the squid giant axon. Biophys J (1991) 1.45
Failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae. Clin Infect Dis (1994) 1.44
Gating kinetics of batrachotoxin-modified Na+ channels in the squid giant axon. Voltage and temperature effects. Biophys J (1992) 1.44
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker. Proc Natl Acad Sci U S A (2001) 1.44
Gating currents associated with potassium channel activation. Nature (1982) 1.42
Charge-shift probes of membrane potential. Characterization of aminostyrylpyridinium dyes on the squid giant axon. Biophys J (1985) 1.41
Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à-Go-Go potassium channels. J Gen Physiol (2000) 1.39
Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels. Biophys J (1999) 1.39
[Acquired neuromuscular syndrome in critically ill patients]. Rev Neurol (2006) 1.39
Potassium conductance of the squid giant axon. Single-channel studies. J Gen Physiol (1988) 1.38
Fluorescence intensity changes associated with contractile activation in frog muscle stained with Nile Blue A. J Physiol (1975) 1.38
Comments on the measurement of gating currents in the frequency domain. Biophys J (1979) 1.37
Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker. J Gen Physiol (2000) 1.37
Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers. Ion conduction and gating properties. J Gen Physiol (1989) 1.32
Ion permeation in normal and batrachotoxin-modified Na+ channels in the squid giant axon. J Gen Physiol (1991) 1.31
Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the NH2-terminal end of the activated enzyme. Biochemistry (1988) 1.30
A conducting state with properties of a slow inactivated state in a shaker K(+) channel mutant. J Gen Physiol (2001) 1.30
Voltage dependence of the Na/Ca exchange in voltage-clamped, dialyzed squid axons. Na-dependent Ca efflux. J Gen Physiol (1985) 1.27
Nerve membrane excitation without threshold. Proc Natl Acad Sci U S A (1970) 1.25
Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups near the outside of S4. J Gen Physiol (2000) 1.23
Etoposide as a single agent in relapsed advanced lymphomas. A phase II study. Cancer Chemother Pharmacol (1982) 1.15
Collagenase: localization in polymorphonuclear leukocyte granules in the rabbit. Science (1972) 1.15
Bilayer reconstitution of voltage-dependent ion channels using a microfabricated silicon chip. Biophys J (2001) 1.13
Time course of the sodium influx in squid giant axon during a single voltage clamp pulse. J Physiol (1970) 1.11
Synthesis and release of procollagenase by cultured fibroblasts. J Biol Chem (1976) 1.09